Table 6: Daily mean Nasogastric feed administration and numbers of patients

receiving antibiotic administration by class.

Synbiotic n=130 Day 1 2 3 4 5 6 7 488.9 959.6 NG feed (mls +/- ± ± 1242.3 ± 1128.9 ± 1253.5 ± 1050.3 ± 1055.6 ± SD) 622.8 688.02 755.0 755.6 815.0 737.9 722.6

Numbers of patients Antibiotic None 25 22 17 12 6 2 1 Cephalosporins 27 22 26 21 24 18 14 Penicillins 8 13 13 13 17 19 19 Carbapenems 2 3 3 3 1 2 1 Macrolides 11 21 24 25 27 17 16 Gentamicin 6 4 3 4 3 4 9 Metronidazole 13 10 15 12 13 10 8 Vancomycin 3 2 3 4 6 6 8

Placebo n=129

Day 1 2 3 4 5 6 7 360.0 950.3 NG feed (mls +/- ± ± 1146.1 ± 1284.2 ± 1230.0 ± 1162.7 ± 1243.9 ± SD) 431.7 634.5 640.1 688.5 781.4 759.0 810.3

Numbers of patients Antibiotic None 29 19 13 9 5 3 1 Cephalosporins 35 34 30 31 26 23 15 Penicillins 8 16 18 19 13 10 16 Carbapenems 1 2 3 1 1 1 3 Macrolides 13 28 30 28 29 20 12 Gentamicin 4 6 6 5 7 5 4 Metronidazole 17 15 15 13 10 10 5 Vancomycin 6 5 8 10 9 11 11