BMJ Open: first published as 10.1136/bmjopen-2020-048042 on 23 June 2021. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 29, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-048042 on 23 June 2021. Downloaded from Risk factors, symptom reporting, healthcare-seeking behaviour and adherence to public health guidance: protocol for Virus Watch, a prospective community cohort study ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2020-048042 Article Type: Protocol Date Submitted by the 22-Dec-2020 Author: Complete List of Authors: Hayward, Andrew; University College London, Institute of Epidemiology and Health Care Fragaszy, Ellen; University College London, Centre for Public Health Data Science, Institute of Health Informatics; LSHTM, Department of Infectious Disease Epidemiology Kovar, Jana; University College London, Institute of Epidemiology and Health Care Nguyen, Vincent; University College London, Institute of Epidemiology and Health Care; University College London, Centre for Public Health Data Science, Institute of Health Informatics Beale, Sarah; University College London, Institute of Epidemiology and http://bmjopen.bmj.com/ Health Care; University College London, Centre for Public Health Data Science, Institute of Health Informatics Byrne, Thomas; University College London, Centre for Public Health Data Science, Institute of Health Informatics Aryee, Anna; University College London, Centre for Public Health Data Science, Institute of Health Informatics Hardelid, Pia; University College London, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health Wijlaars, Linda; UCL, Population, Policy and Practice; University College on September 29, 2021 by guest. Protected copyright. London, Primary Care and Population Health Fong, Wing Lam Erica; University College London, Centre for Public Health Data Science, Institute of Health Informatics Geismar, Cyril; University College London, Institute of Epidemiology and Health Care; University College London, Centre for Public Health Data Science, Institute of Health Informatics Patel, Parth; University College London, Centre for Public Health Data Science, Institute of Health Informatics Shrotri, Madhumita; University College London, Centre for Public Health Data Science, Institute of Health Informatics Navaratnam, Annalan M D; University College London, Institute of Epidemiology and Health Care; University College London, Centre for Public Health Data Science, Institute of Health Informatics Nastouli, Eleni ; Francis Crick Institute; University College London, Department of Population, Policy and Practice Spyer, Moira; Francis Crick Institute Killingley, Ben; University of Nottingham School of Medicine; University College London Hospital For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 21 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-048042 on 23 June 2021. Downloaded from 1 2 3 Cox, Ingemar; University College London, Department of Computer 4 Science 5 Lampos, Vasileios; University College London, Department of Computer 6 Science 7 McKendry, Rachel; University College London, London Centre for 8 Nanotechnology and Division of Medicine 9 Liu, Yunzhe; University College London, SpaceTimeLab, Civil, Environmental and Geomatic Engineering. 10 Cheng, Tao; University College London, SpaceTimeLab, Department of 11 Civil, Environmental and Geomatic Engineering 12 Johnson, Anne; University College London, Institute for Global Health 13 Michie, Susan; University College London, Centre for Behaviour Change 14 Gibbs, Jo; University College London, Institute for Global Health 15 Gilson, Richard; University College London, Institute for Global Health 16 Rodger, Alison; University College London, Department of Infection and For peerPopulation Health; review Royal Free London only NHS Foundation Trust 17 Aldridge, Robert; University College London, Centre for Public Health 18 Data Science, Institute of Health Informatics 19 COVID-19, Public health < INFECTIOUS DISEASES, Epidemiology < 20 Keywords: 21 INFECTIOUS DISEASES 22 23 24 25 26 27 28 29 30 31 32 http://bmjopen.bmj.com/ 33 34 35 36 37 38 39 40 on September 29, 2021 by guest. Protected copyright. 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 21 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2020-048042 on 23 June 2021. Downloaded from 5 6 7 8 9 I, the Submitting Author has the right to grant and does grant on behalf of all authors of the Work (as defined 10 in the below author licence), an exclusive licence and/or a non-exclusive licence for contributions from authors 11 who are: i) UK Crown employees; ii) where BMJ has agreed a CC-BY licence shall apply, and/or iii) in accordance 12 with the terms applicable for US Federal Government officers or employees acting as part of their official 13 duties; on a worldwide, perpetual, irrevocable, royalty-free basis to BMJ Publishing Group Ltd (“BMJ”) its 14 licensees and where the relevant Journal is co-owned by BMJ to the co-owners of the Journal, to publish the 15 Work in this journal and any other BMJ products and to exploit all rights, as set out in our licence. 16 17 The Submitting Author accepts and understands that any supply made under these terms is made by BMJ to 18 the Submitting Author Forunless you peer are acting as review an employee on behalf only of your employer or a postgraduate 19 student of an affiliated institution which is paying any applicable article publishing charge (“APC”) for Open 20 Access articles. Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 http://bmjopen.bmj.com/ 37 38 39 40 41 42 43 44 on September 29, 2021 by guest. Protected copyright. 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 21 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-048042 on 23 June 2021. Downloaded from 1 2 3 4 Risk factors, symptom reporting, healthcare-seeking 5 6 behaviour and adherence to public health guidance: protocol 7 8 for Virus Watch, a prospective community cohort study 9 10 11 Andrew Hayward1, Ellen Fragaszy2,3, Jana Kovar1, Vincent Nguyen1,2, Sarah Beale1,2, Thomas 12 Byrne2, Anna Aryee2, Pia Hardelid4, Linda Wijlaars4, Wing Lam Erica Fong2, Cyril Geismar1,2, 13 14 Parth Patel2, Madhumita Shrotri2, Annalan M D Navaratnam1,2, Eleni Nastouli5,6, Moira Spyer6,, 15 7,8 9 9 10 11 16 Ben Killingley , IngemarFor Cox peer, Vasileios Lamposreview,Rachel A onlyMcKendry , Yunzhe Liu , Tao 17 Cheng11, Anne M Johnson13, Susan Michie12, Jo Gibbs13, Richard Gilson13, Alison Rodger13,14, 18 19 Robert W Aldridge2 20 21 22 Affiliations 23 24 25 26 1 Institute of Epidemiology and Health Care, University College London, London, UK 27 2 Centre for Public Health Data Science, Institute of Health Informatics, University College 28 29 London, UK. 30 3 Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical 31 32 Medicine, Keppel Street, London, UK. http://bmjopen.bmj.com/ 33 34 4 UCL Great Ormond Street Institute of Child Health, London, UK. 35 5 Department of Population, Policy and Practice, UCL Great Ormond Street Institute of Child 36 37 Health, London, UK. 38 6 Francis Crick Institute, London, UK. 39 40 7 Health Protection and Influenza Research Group, Division of Epidemiology and Public Heath, on September 29, 2021 by guest. Protected copyright. 41 42 University of Nottingham School of Medicine, Nottingham, United Kingdom. 43 8 University College London Hospital, London, United Kingdom. 44 45 9 Department of Computer Science, University College London, London, UK. 46 10 London Centre for Nanotechnology and Division of Medicine, London, UCL. 47 48 11 SpaceTimeLab, Department of Civil, Environmental and Geomatic Engineering, University 49 College London, London, UK. 50 51 12 Centre for Behaviour Change, University College London, London, UK. 52 53 13 Institute for Global Health, University College London, London, UK. 54 14 Royal Free London NHS Foundation Trust, London, UK. 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 21 BMJ Open: first published as 10.1136/bmjopen-2020-048042 on 23 June 2021.