Options X for the Control of Influenza | WELCOME MESSAGES BREAKTHROUGH INFLUENZA VACCINES TAKE LARGE DOSES OF INNOVATION Protecting people from the ever-changing threat of influenza takes unwavering commitment. That’s why we’re dedicated to developing advanced technologies and vaccines that can fight influenza as it evolves. We’re with you. ON THE FRONT LINETM BREAKTHROUGH INFLUENZA VACCINES TAKE LARGE DOSES OF INNOVATION CONTENT OPTIONS X SUPPORTERS ------------------- 4 OPTIONS X EXHIBITORS & COMMITTEES ------------------- 5 AWARD INFORMATION ------------------- 6 WELCOME MESSAGES ------------------- 7 SCHEDULE AT A GLANCE ------------------- 10 CONFERENCE INFORMATION ------------------- 11 SOCIAL PROGRAMME ------------------- 14 ABOUT SINGAPORE ------------------- 15 SUNTEC FLOORPLAN ------------------- 16 SCIENTIFIC COMMUNICATIONS ------------------- 17 PROGRAMME ------------------- 19 SPEAKERS ------------------- 31 SPONSORED SYMPOSIA ------------------- 39 ORAL PRESENTATION LISTINGS ------------------- 42 POSTER PRESENTATION LISTINGS ------------------- 51 ABSTRACTS POSTER DISPLAY LISTINGS ------------------- 54 SPONSOR AND EXHIBITOR LISTINGS ------------------- 80 EXHIBITION FLOORPLAN ------------------- 83 Protecting people from the ever-changing threat of NOTE ------------------- 84 influenza takes unwavering commitment. That’s why we’re dedicated to developing advanced technologies and vaccines that can fight influenza as it evolves. We’re with you. ON THE FRONT LINETM Options X for the Control of Influenza | OPTIONS X SUPPORTERS OPTIONS X SUPPORTERS We would like to thank the following organisations for their support of OPTIONS X: TRAVEL FELLOWSHIP AWARD PLATINUM LEVEL GOLD LEVEL BRONZE LEVEL OPTIONS X PARTNER Official Supporting Supported by Held in Managed by Service Provider Airline 4 | INTERNATIONAL SOCIETY FOR INFLUENZA AND OTHER RESPIRATORY VIRUS DISEASES Options X for the Control of Influenza | OPTIONS X EXHIBITORS & COMMITTEES OPTIONS X EXHIBITORS OPTIONS X COMMITTEES International Organising Scientific Committee Committee Vernon Lee – Chair Paul Anantharajah Tambyah - Chair Raymond Lin Ministry of Health National University Hospital National Centre for Infectious Diseases Singapore Singapore Singapore Lance Jennings Mark Chen Sebastian Maurer-Stroh ISIRV Chair Saw Swee Hock School of Public Health Agency for Science, Technology and Canterbury Laboratories Singapore Research New Zealand Singapore Vincent Chow Ximena Aguilera National University of Singapore Peter Openshaw University of Desarollo Singapore Imperial College London Chile UK Cheryl Cohen Rebecca Cox National Institute for Communicable Yuelong Shu University of Bergen Diseases Chinese Center for Disease Control and Norway South Africa Prevention China Jean-Michel Heraud Alex Cook Institut Pasteur Saw Swee Hock School of Public Health Gavin Smith Madagascar Singapore Duke-NUS School of Medicine Singapore Daniel B. Jernigan Ben Cowling Centers for Disease Control and The University of Hong Kong Leo Yee Sin Prevention,USA Hong Kong National Centre for Infectious Diseases Singapore Hitoshi Oshitani Jeffery Cutter Graduate School of Medicine Ministry of Health Mark Tompkins Tohoku University, Japan Singapore University of Georgia USA Nahoko Shindo Yi Guan World Health Organisation University of Hong Kong Timothy Uyeki Switzerland Hong Kong Centers for Disease Control and Prevention Kanta Subbarao Frederick Hayden USA WHO Influenza Collaborating Centre University of Virginia Australia USA Hassan Zaraket Aeron Hurt American University of Beirut University of Melbourne Lebanon Australia Nelson Lee University of Alberta Canada INTERNATIONAL SOCIETY FOR INFLUENZA AND OTHER RESPIRATORY VIRUS DISEASES | 5 Options X for the Control of Influenza | AWARD INFORMATION AWARD INFORMATION TRAVEL FELLOWSHIP AWARD The Options X for the Control of Influenza conference is pleased to announce that the Bill & Melinda Gates Foundation has supported fellows from economically disadvantaged areas to attend the Options X Conference. Sukanta Chowdhury Saurabh Bhargava Bimalesh Kumar Jha Bangladesh India Nepal Md. Habibulla Fahad Anitha Jagadesh Subeksha Shrestha Bangladesh India Nepal Rubaiyea Farrukee Rakesh Kumar Bishnu Prasad Upadhyay Bangladesh India Nepal S M Murshid Hasan Nilanshu Manocha Chinonyerem Nkemakolam Chinyere Bangladesh India Nigeria Md. Zakiul Hassan Shruti Mishra Dennis Kabantiyok Bangladesh India Nigeria Ariful Islam Sanjesh Saini George Okoli Bangladesh India Nigeria Mahbubur Rahman Agustiningsih Agustiningsih Khristine Joy Constantino Antigua Bangladesh Indonesia Philippines Binay Thapa Arindita Niatazya Novianti Rukshan Ahamed Mohamed Rafeek Bhutan Indonesia Sri Lanka Seng Heng Vivi Setiawaty Ya Jankey Jagne Cambodia Indonesia The Gambia Hazem Hamza Ewess David Collins Owuor Hind Bouguerra Egypt Kenya Tunisia Adamu Tayachew Mekonnen Galina Landgraf Iaryna Iosyk Ethiopia Kyrgyzstan Ukraine Augustina Kwakyewaa Arjarquah Verohasina Joelinotahina Rabarison Liudmyla Leibenko Ghana Madagascar Ukraine Mani Bhargava Norosoa Harline Razanajatovo Cong Khanh Nguyen India Madagascar Vietnam 6 | INTERNATIONAL SOCIETY FOR INFLUENZA AND OTHER RESPIRATORY VIRUS DISEASES Options X for the Control of Influenza | AWARD INFORMATION Options X for the Control of Influenza | WELCOME MESSAGES Welcome Message from the Chair, Organising Committee, Options X Welcome to Singapore and to the 10th Edition of Options for the Control of Influenza (Options X) 2019. Options is the premier global meeting on influenza that brings together researchers, clinicians, policy makers, and public health practitioners to address the impact of influenza. As we all know, seasonal influenza results in substantial burden of disease and mortality, while the threat posed by pandemic influenza looms large. Despite the awareness of this threat and the years of research on influenza-related topics, substantial gaps still remain in our understanding of influenza disease burden and epidemiology, its host-pathogen interactions, how to rapidly diagnose it in the field, optimal clinical management, the development of a universal vaccine, and pandemic preparedness and response, among other issues. Many of these issues have been highlighted in various global influenza research agenda. This five-day meeting, organised by the International Society of Influenza and other Respiratory Viruses, aim to address these research and knowledge gaps through the sharing of recent advances in virology and pathogenesis, clinical sciences, diagnostics, vaccines, public health, and understanding of co-infections with other respiratory pathogens. For the first time, we are also introducing a policy makers’ track to provide easy-to-understand summaries of key issues for decision making and to accelerate translation of research into policy; and a Chinese research session devoted to the latest research from China. Options X provides the unique opportunity for like-minded individuals to network and to explore future collaborations. I wish to thank the Organising Committee, the Scientific Committee, and the sponsors for giving their time and resources to make Options X a success. I hope that through our collective efforts we can effectively combat influenza, and I wish you a successful conference. I also hope that all of you will have sufficient time to explore this vibrant city, which has much to offer first time and repeat visitors. We hope that you will enjoy the uniquely Singaporean hospitality and experience! Vernon Lee Chair of the Organising Committee Options X INTERNATIONAL SOCIETY FOR INFLUENZA AND OTHER RESPIRATORY VIRUS DISEASES | 7 Options X for the Control of Influenza | WELCOME MESSAGES Welcome Message from the Chair, ISIRV It is an honour to welcome you to the 10th Edition of Options for the Control of Influenza (Options X) 2019, which builds on the success of previous meetings in the Options series. It is the International Society for Influenza and other Respiratory Virus Diseases’ (ISIRV) premier event and remains the largest international conference exclusively dedicated to influenza prevention, control and treatment, including seasonal influenza and pandemic preparedness. The conference brings together academic scientists, researchers, healthcare professionals and public health specialists to share their experiences and research results on all aspects of influenza. It also provides an interdisciplinary platform with global reach, for the discussion of the most recent innovations, advances and concerns. ISIRV is very focused on fostering the exchange of scientific knowledge and practice and has introduced a Chinese focused stream. It is hoped that science policy focus of this stream, dedicated to public health officials will address the pressing issues in the wider Asian region. At this Conference, ISIRV recognises its membership in several ways; firstly, by bestowing prestigious awards, “the ISIRV Lifetime Achievement Award” recognising the long and productive career of a member in the field of respiratory infectious diseases and their service to isirv, and providing the “Geoffrey Schild Travel Award” to an imminent Plenary Speaker. And secondly, by supporting promising young scientists and scientists from poor resourced countries, by providing 38 travel and accommodation grants. On behalf of ISIRV, I would like to thank everyone who has contributed to the preparation of this conference, with special thanks to the Conference Chairs, A/Prof Vernon Lee and his Organising Committee; and Prof Paul Tambyah and his