ホームページではパンフレットに収載されていない化合物，試薬のスケールアップのご用命を受け付けております。 www.tokyokasei.co.jp/jutaku/synthesis Nucleosides, Nucleotides, Nucleic Acids and Related Reagents Genetic information is stored in DNA as combinatorial codes Nucleosides and Their Analogs held in nucleosides and nucleotides, in which form it is passed Nucleosides are glycosylamines made by attaching a from parents to their offspring. Analogs of nucleosides and nucleobase to a ribose or 2’-deoxyribose, which can be nucleotides are used clinically as medicinal agents such as phosphorylated producing nucleotides. Nucleoside analogs reverse transcriptase inhibitors. Therefore, the preparation and are an established class of clinically useful medicinal agents development of these species as effective, selective and possessing a wide range of antiviral and anticancer activities. nontoxic antiviral and antitumor agents has been the subject Consequently, extensive modifications have been made to of intense research.1) both the heterocyclic base and the sugar moiety. Some In addition to this, the development of Polymerase Chain representative examples of these are 9-[(2-hydroxyethoxy) Reaction (PCR) methodology has brought a dramatic change methyl]guanine (acyclovir) developed by Elion in 1977, which and rapid development in studies of DNA. At the current time shows antiviral activity; 3'-azido-3'-deoxythymidine (AZT) the draft version in decoding and mapping human genome discovered by Mitsuya et al. in 1985 and used for the treatment has been almost completed, and the functional analyses of of HIV infection; and cytosine β-D-arabinofuranoside genome and analyses of “Single Nucleotide Polymorphism” (cytarabine) approved by the FDA in 1969 and which has been (SNP) are being vigorously pursued. Discovery of the RNAi shown to display a range anticancer activities. In addition, process has facilitated the fast progression of studies of RNA. modified nucleosides such as 2’-deoxy-5-methylcytidine are At the same time, chemically synthesized oligoDNA and ubiquitous in living systems, and their functions have received oligoRNA have been studied as potential antisense DNAs, due attention from the scientific community.2) siRNAs and DNA aptamers, as oligonucleotide therapeutic Protected nucleosides, in which reactive amino and hydroxyl agents, primers for PCR method, and elements of DNA groups have been masked, e.g. N6-benzoyl-5'-O-(4,4'- computers. dimethoxytrityl)-2'-deoxyadenosine (Bz-DMT-dA), have been used for chemical synthesis of DNA and RNA. Z0022 200mg 1g D3583 1g 5g N Nucleosides and Pyrimidine HO O N Their Analogs Nucleosides O OH OH Zebularine 2'-Deoxycytidine CAS RN: 3690-10-6 CAS RN: 951-77-9 D0048 5g 25g D0060 1g 5g 25g C0522 1g 5g 25g D3614 1g U0020 5g 25g 2'-Deoxycytidine Hydrochloride 2'-Deoxyuridine Cytidine 2'-Deoxy-2'-fluorocytidine Hydrate Uridine CAS RN: 3992-42-5 CAS RN: 951-78-0 CAS RN: 65-46-3 CAS RN: 10212-20-1 CAS RN: 58-96-8 P2396 50mg A0559 10mg M2290 1g 5g M2317 200mg 1g A2942 25mg 100mg O O O NH2 HN NH HN N HN HO O HO O N HO O N HO O N O O O O OH N OH OH OH OCH3 OH OCH3 3 Pseudouridine 6-Azauridine 2'-O-Methyluridine 2'-O-Methylcytidine 2'-Azido-2'-deoxyuridine CAS RN: 1445-07-4 CAS RN: 54-25-1 CAS RN: 2140-76-3 CAS RN: 2140-72-9 CAS RN: 26929-65-7 2 Please inquire for pricing and availability of listed products to our local sales representatives. Nucleosides, Nucleotides, Nucleic Acids and Related Reagents D3615 1g 5g T2549 5g 25g A2232 20mg 100mg A2033 100mg 1g D3610 100mg 500mg 5g NH2 N N HO O N O OH 2'-Deoxy-2'-fluorouridine 2',3',5'-Tri-O-acetyluridine 5-Aza-2'-deoxycytidine 5-Azacytidine 2'-Deoxy-5-methylcytidine CAS RN: 784-71-4 CAS RN: 4105-38-8 CAS RN: 2353-33-5 CAS RN: 320-67-2 CAS RN: 838-07-3 D3642 1g 5g D4220 50mg 200mg I0882 1g D3580 1g 5g F0635 5g 25g NH2 NH2 CH2OH N I N HO O N HO O N O O OH 2'-Deoxy-5-(hydroxymethyl)- OH 2'-Deoxy-5-fluorocytidine cytidine 5-Iodo-2'-deoxycytidine Stavudine Tegafur CAS RN: 10356-76-0 CAS RN: 7226-77-9 CAS RN: 611-53-0 CAS RN: 3056-17-5 CAS RN: 17902-23-7 B1575 1g 5g T0233 1g 5g 25g T2511 100mg 1g A2052 1g 5g D2235 100mg 500mg 1g 5-Bromo-2'-deoxyuridine Thymidine Trifluorothymidine Azidothymidine 2'-Deoxy-5-fluorouridine CAS RN: 59-14-3 CAS RN: 50-89-5 CAS RN: 70-00-8 CAS RN: 30516-87-1 CAS RN: 50-91-9 I0258 1g 5g 25g E1057 50mg 200mg E1093 50mg 200mg B0666 100mg 1g M1405 1g 5g 25g O NH2 C CH C CH HN N HO O N HO O N O O OH OH Idoxuridine 5-Ethynyl-2'-deoxyuridine 5-Ethynyl-2'-deoxycytidine 5-Bromouridine 5-Methyluridine CAS RN: 54-42-2 CAS RN: 61135-33-9 CAS RN: 69075-47-4 CAS RN: 957-75-5 CAS RN: 1463-10-1 M1931 1g F0534 1g 5g D4342 1g 5g F0636 1g 5g D3579 1g 5g NH2 F N H3C O N O OH OH 5-Methylcytidine 5-Fluorocytidine 5'-Deoxy-5-fluorocytidine 5-Fluorouridine 5'-Deoxy-5-fluorouridine CAS RN: 2140-61-6 CAS RN: 2341-22-2 CAS RN: 66335-38-4 CAS RN: 316-46-1 CAS RN: 3094-09-5 A2073 5g 25g A2356 1g 5g M3153 250mg 1g C2035 1g 5g D4200 10mg O O I HN HN O N HO HO O N H3C F O O 1-(3,5-Anhydro-2-deoxy-β-D- OH OH OH threo-pentofuranosyl)thymine 1-β-D-Arabinofuranosyluracil 2'-C-Methyluridine Cytarabine Fialuridine CAS RN: 7481-90-5 CAS RN: 3083-77-0 CAS RN: 31448-54-1 CAS RN: 147-94-4 CAS RN: 69123-98-4 G0367 100mg 1g D4823 200mg 1g C2208 5g 25g C2207 1g 5g A2431 1g O HN HO O N H3C O OH F (2'R)-2'-Deoxy-2'-fluoro- 2,2'-O-Anhydro- Gemcitabine Hydrochloride 2'-methyluridine 2,2'-O-Cyclouridine 2,2'-O-Cyclocytidine Hydrochloride 5-methyluridine CAS RN: 122111- 03-9 CAS RN: 863329-66-2 CAS RN: 3736-77-4 CAS RN: 10212-25-6 CAS RN: 22423-26-3 R0077 100mg 500mg A2528 50mg M2399 50mg 250mg B3094 1g 5g B3102 100mg 1g O O NH C NH2 C 2 N N HO N NH2 HO N OH O O OH OH OH OH Ribavirin Acadesine Mizoribine N4-Benzoylcytidine N4-Benzoyl-2'-deoxycytidine CAS RN: 36791-04-5 CAS RN: 2627-69-2 CAS RN: 50924-49-7 CAS RN: 13089-48-0 CAS RN: 4836-13-9 Please inquire for pricing and availability of listed products to our local sales representatives. 3 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents Nucleosides, Nucleotides, Nucleic Acids and Related Reagents B3404 100mg B3631 1g 5g L0217 100mg 1g C0525 100mg 1g C2878 1g 5g O NH C O(CH2)4CH3 F N H3C O N O N4-Benzoyl-3',5'-O- (1,1,3,3-tetraisopropyl-1,3- OH OH Brivudine disiloxanediyl)cytidine Lamivudine Cytidine Sulfate Capecitabine CAS RN: 69304-47-8 CAS RN: 69304-43-4 CAS RN: 134678-17-4 CAS RN: 32747-18-5 CAS RN: 154361-50-9 D3566 5g 25g B3087 1g 5g F0842 500mg 5g H1290 5g 25g N N Purine O H2N N N CH2O C CH3 CH2CH2CH Nucleosides CH2O C CH3 5'-O-(4,4'-Dimethoxytrityl)- N4-Benzoyl-5'-O-(4,4'- O thymidine dimethoxytrityl)-2'-deoxycytidine Famciclovir 9-(2-Hydroxyethyl)adenine CAS RN: 40615-39-2 CAS RN: 67219-55-0 CAS RN: 104227-87-4 CAS RN: 707-99-3 H1291 1g 5g E0899 50mg 200mg A1915 1g 5g 25g P2164 200mg 1g G0315 5g 25g O NH2 O O HN N N N . H O HN N HN N . H N N N 2 xH2O N N 2 CH 2 H2N N N H2N N N CH3 CH2OH CH2OH CH CH CH 2 2 CH2OCH CH OH CH2OH 2 OH HO CH2OH (R)-9-(2-Hydroxypropyl)adenine Entecavir Monohydrate Acyclovir Penciclovir Ganciclovir Hydrate CAS RN: 14047-28-0 CAS RN: 209216-23-9 CAS RN: 59277-89-3 CAS RN: 39809-25-1 CAS RN: 82410-32-0 A3228 1g D4256 1g 5g A2414 100mg 1g V0111 100mg 1g D3065 100mg NH2 O N N O CH N 3 O HN O N N O N OCH2CH3 CH3 N N H CH2CH2OCH2 P O CH3 OCH CH O 2 3 O Diethyl [[2-(6-Amino-9H-purin- Valacyclovir Hydrochloride Triacetylganciclovir 9-yl)ethoxy]methyl]phosphonate Adefovir Dipivoxil Hydrate 2',3'-Dideoxyadenosine CAS RN: 86357-14-4 CAS RN: 116384-53-3 CAS RN: 142340-99-6 CAS RN: 124832-27-5 CAS RN: 4097-22-7 D3066 100mg 500mg D0046 5g 25g C2815 25mg 100mg D4137 5g D3584 1g 5g NH2 N N HO N N O . xH2O OH Didanosine 2'-Deoxyadenosine Monohydrate Cordycepin Hydrate 2'-Deoxyadenosine Anhydrous 2'-Deoxyinosine CAS RN: 69655-05-6 CAS RN: 16373-93-6 CAS RN: 73-03-0 CAS RN: 958-09-8 CAS RN: 890-38-0 D4292 100mg 1g C2499 50mg B4001 200mg 1g D0052 1g 5g 25g N1144 25mg 100mg Cl NH O OCH3 N 2 N N N N NH N HO N Cl HO N O HO N N Cl HO Br N N NH2 HO N NH2 O O O OH OH OH 5,6-Dichlorobenzimidazole OH OH 1-β-D-Ribofuranoside Cladribine 8-Bromo-2'-deoxyguanosine 2'-Deoxyguanosine Hydrate Nelarabine CAS RN: 53-85-0 CAS RN: 4291-63-8 CAS RN: 13389-03-2 CAS RN: 961-07-9 CAS RN: 121032-29-9 C2206 1g 5g A0152 5g 25g 100g M2291 1g I0037 25g 500g B3460 100mg 1g NH2 N N HO N N O 6 OH OCH3 N -Dibenzoyladenosine 6-Chloropurine Riboside Adenosine 2'-O-Methyladenosine Inosine 2',3'-Dibenzoate CAS RN: 5399-87-1 CAS RN: 58-61-7 CAS RN: 2140-79-6 CAS RN: 58-63-9 CAS RN: 58463-04-0 F0656 200mg 1g T2690 1g T2691 1g 5g T2692 1g 5g B4002 1g 5g O N NH HO Br N N NH2 O .