Cochrane Library Cochrane Database of Systematic Reviews Antidepressant treatment for postnatal depression (Review) Brown JVE, Wilson CA, Ayre K, Robertson L, South E, Molyneaux E, Trevillion K, Howard LM, Khalifeh H Brown JV, Wilson CA, Ayre K, Robertson L, South E, Molyneaux E, Trevillion K, Howard LM, Khalifeh H. Antidepressant treatment for postnatal depression. Cochrane Database of Systematic Reviews 2021, Issue 2. Art. No.: CD013560. DOI: 10.1002/14651858.CD013560.pub2. www.cochranelibrary.com Antidepressant treatment for postnatal depression (Review) Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Cochrane Trusted evidence. Informed decisions. Library Better health. Cochrane Database of Systematic Reviews T A B L E O F C O N T E N T S HEADER......................................................................................................................................................................................................... 1 ABSTRACT..................................................................................................................................................................................................... 1 PLAIN LANGUAGE SUMMARY....................................................................................................................................................................... 2 SUMMARY OF FINDINGS.............................................................................................................................................................................. 4 BACKGROUND.............................................................................................................................................................................................. 14 OBJECTIVES.................................................................................................................................................................................................. 15 METHODS..................................................................................................................................................................................................... 15 RESULTS........................................................................................................................................................................................................ 20 Figure 1.................................................................................................................................................................................................. 21 Figure 2.................................................................................................................................................................................................. 23 Figure 3.................................................................................................................................................................................................. 24 DISCUSSION.................................................................................................................................................................................................. 31 AUTHORS' CONCLUSIONS........................................................................................................................................................................... 34 ACKNOWLEDGEMENTS................................................................................................................................................................................ 34 REFERENCES................................................................................................................................................................................................ 35 CHARACTERISTICS OF STUDIES.................................................................................................................................................................. 40 DATA AND ANALYSES.................................................................................................................................................................................... 65 Analysis 1.1. Comparison 1: Antidepressants vs placebo, Outcome 1: Depression response (acute phase)................................... 66 Analysis 1.2. Comparison 1: Antidepressants vs placebo, Outcome 2: Depression remission (acute phase).................................. 66 Analysis 1.3. Comparison 1: Antidepressants vs placebo, Outcome 3: Severity of depression - overall (acute phase)................... 67 Analysis 1.4. Comparison 1: Antidepressants vs placebo, Outcome 4: Severity of depression - EPDS (acute phase)..................... 67 Analysis 1.5. Comparison 1: Antidepressants vs placebo, Outcome 5: Severity of depression - HAM-D (acute phase)................... 67 Analysis 1.6. Comparison 1: Antidepressants vs placebo, Outcome 6: Severity of depression - CGI-S (acute phase)..................... 68 Analysis 1.7. Comparison 1: Antidepressants vs placebo, Outcome 7: Treatment acceptability - dropouts................................... 68 Analysis 2.1. Comparison 2: Antidepressants vs treatment as usual, Outcome 1: Depression remission (early phase).................. 69 Analysis 2.2. Comparison 2: Antidepressants vs treatment as usual, Outcome 2: Severity of depression - EPDS (early phase)...... 69 Analysis 2.3. Comparison 2: Antidepressants vs treatment as usual, Outcome 3: Treatment acceptability - dropouts.................. 69 Analysis 2.4. Comparison 2: Antidepressants vs treatment as usual, Outcome 4: Parenting-related outcomes - MAMA (early 70 phase)..................................................................................................................................................................................................... Analysis 2.5. Comparison 2: Antidepressants vs treatment as usual, Outcome 5: Parenting-related outcomes - MAMA 70 (continuation phase)............................................................................................................................................................................. Analysis 2.6. Comparison 2: Antidepressants vs treatment as usual, Outcome 6: Quality of life - SF-12 mental health................. 70 Analysis 2.7. Comparison 2: Antidepressants vs treatment as usual, Outcome 7: Quality of life - SF-12 physical health............... 70 Analysis 2.8. Comparison 2: Antidepressants vs treatment as usual, Outcome 8: Quality of life - EQ5D utility score..................... 71 Analysis 2.9. Comparison 2: Antidepressants vs treatment as usual, Outcome 9: Quality of life - EQ5D visual analogue scale....... 71 Analysis 3.1. Comparison 3: Antidepressants vs psychological interventions, Outcome 1: Severity of depression - EPDS (acute 72 phase)..................................................................................................................................................................................................... Analysis 3.2. Comparison 3: Antidepressants vs psychological interventions, Outcome 2: Severity of depression - BDI (acute 72 phase)..................................................................................................................................................................................................... Analysis 3.3. Comparison 3: Antidepressants vs psychological interventions, Outcome 3: Severity of depression - BDI 72 (continuation phase)............................................................................................................................................................................. Analysis 3.4. Comparison 3: Antidepressants vs psychological interventions, Outcome 4: Treatment acceptability..................... 72 Analysis 3.5. Comparison 3: Antidepressants vs psychological interventions, Outcome 5: Parenting-related outcomes - PSI 73 (acute phase)......................................................................................................................................................................................... Analysis 3.6. Comparison 3: Antidepressants vs psychological interventions, Outcome 6: Parenting-related outcomes - PSI 73 (continuation phase)............................................................................................................................................................................. Analysis 4.1. Comparison 4: Antidepressants vs psychosocial interventions, Outcome 1: Depression remission (continuation 74 phase)..................................................................................................................................................................................................... Analysis 4.2. Comparison 4: Antidepressants vs psychosocial interventions, Outcome 2: Severity of depression - EPDS 74 (continuation phase)............................................................................................................................................................................. Analysis 4.3. Comparison 4: Antidepressants vs psychosocial interventions, Outcome 3: Treatment acceptability - dropouts...... 74 Analysis 4.4. Comparison 4: Antidepressants vs psychosocial interventions, Outcome 4: Parenting-related outcomes - MAMA 74 (continuation phase)............................................................................................................................................................................