California Institute of Technology Annual Report 2003–2004 In 2003, Caltech registered more U.S. patents than any other single university. Patent #6,669,793 Microstructure controlled shear band pattern formation in ductile metal/bulk metallic glass matrix composites prepared by SLR process- ing Patent #6,666,831 Method, apparatus and system for automation of body weight support training (BWST) of biped locomotion over a treadmill using a programmable stepper device (PSD) operating like an exoskeleton drive system from a fixed base Patent #6,665,013 Active pixel sensor having intra-pixel charge transfer with analog-to-digital converter Patent #6,664,039 Methods and compositions for modulating neurodegeneration Patent #6,660,926 Thermoelectric devices based on materials with filled skutterudite structures Patent #6,660,844 Optical sensors of cell signaling Patent #6,660,255 Inhibition of gene transcription by polyamide DNA-binding ligands Patent #6,658,550 Pipelined asynchro- nous processing Patent #6,656,450 Macrocyclic magnetic resonance imaging contrast agents Patent #6,654,102 Miniature optical sensor Patent #6,649,801 Anionic borate ligands and zwitterionic complexes formed therefrom Patent #6,649,350 Electrochemical sensor using intercalative, redox-active moieties Patent #6,642,537 Dual band QWIP focal plane array Patent #6,638,756 Chimeric cell-targeting pathogenic organism and method of therapeutic use Patent #6,635,417 Complex formation between DSDNA and oligomer of cyclic heterocycles Patent #6,633,696 Resonant optical wave power control devices and methods Patent #6,633,671 Camera-based handwriting tracking Patent #6,633,331 High-speed CCD array camera with random pixel selection Patent #6,631,333 Methods for remote characterization of an odor Patent #6,630,290 Lithography using quantum entangled particles Patent #6,627,469 Methods for forming semi- conductor lenses on substrates Patent #6,625,569 Real-time spatio-temporal coherence estimation for autonomous mode identification and invariance tracking Patent #6,625,368 Titanium-indiffusion waveguides and methods of fabrication Patent #6,624,265 Ruthenium metal alkylidene complexes coordinated with triazolylidene ligands that exhibit high olefin metathesis activity Patent #6,623,937 Programmed cell death antagonist protein Patent #6,622,872 Micromachined membrane particle filter using parylene reinforcement Patent #6,621,687 Micro-supercapacitor Patent #6,620,264 Casting of amorphous metallic parts by hot mold quenching Patent #6,615,076 Neural prosthetic using tem- poral structure in the local field potential Patent #6,613,910 One-pot synthesis of group 8 transition metal carbene com- plexes useful as olefin metathesis catalysts Patent #6,612,743 Wavelength division multiplexed optical solitons Patent #6,612,535 MEMS valve Patent #6,610,999 Multiple stage high power diode Patent #6,610,626 Highly active metathesis catalysts generated in situ from inexpensive and air stable precursors Patent #6,610,540 Low oxygen culturing of cen- tral nervous system progenitor cells Patent #6,610,367 Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids Patent #6,609,017 Processed neural signals and methods for generating and using them Patent #6,608,726 Solid immersion lens structures and methods for producing solid immersion lens structures Patent #6,608,668 Sub miniaturized laser doppler velocimeter sensor Patent #6,608,228 Two-photon or higher-order absorbing optical materials for generation of reactive species Patent #6,607,740 Enzyme-mediated modification of fivrin for tissue engineering Patent #6,606,122 Single chip camera active pixel sensor Patent #6,603,473 Detail data pertaining to the shape of an object surface and related methods and systems Patent #6,600,565 Real-time evaluation of stress fields and properties in line features formed on substrates Patent #6,598,750 Micromachined membrane particle filter using pary- lene reinforcement Patent #6,598,455 Non-inertial calibration of vibratory gyroscopes Patent #6,596,267 Methods and compositions to prevent formation of adhesions in biological tissues Patent #6,594,586 Incorporation of contextual infor- mation in object identification Patent #6,594,061 Acceleration-insensitive opto-electronic oscillators Patent #6,593,731 Displacement transducer utilizing miniaturized magnet and hall junctionQWIP focal plane array Patent #6,593,110 Checkpoint-activating oligonucleotides Patent #6,593,065 Method of fabricating nanometer-scale flowchannels and trenches with self-aligned electrodes and the structures formed by the same Patent #6,592,735 DNA sequencing machine with improved cooling characteristics Patent #6,592,689 Fractional variation to improve bulk metallic glass forming capability Patent #6,590,197 Fabricating a hybrid imaging device Patent #6,589,728 Methods for isolation and activation of, and control of differentiation from, stem and progenitor cells Patent #6,589,684 Direct methanol feed fuel cell and system Patent #6,587,180 Adjustable liquid crystal blazed grating deflector Patent #6,586,785 Aerosol silicon nanoparticles for use in semiconductor device fabrication Patent #6,586,207 Overexpression of aminoacyl-tRNA syn- thetases for efficient production of engineered proteins containing amino acid analogues Patent #6,584,845 Inertial sen- sor and method of use Patent #6,583,881 Lithography using quantum entangled particles Patent #6,583,702 Quadrupole mass spectrometer driver with higher signal levels Patent #6,583,672 Method for controlling bias in an active grid array Patent #6,583,399 Optical resonator microsphere sensor with altering Q-factor Patent #6,582,208 Bladeless pump Patent #6,580,851 Resonator fiber bidirectional coupler Patent #6,580,532 Opto-electronic techniques for reducing phase noise in a carrier signal by carrier supression Patent #6,580,503 Particle sizing and concentration sensor using a hollow shaped beam Patent #6,580,337 MEMS switch Patent #6,580,089 Multi-quantum-well infrared sensor array in spatially-separated multi-band configuration Patent #6,579,683 Artery- and vein-specific proteins and uses therefor Patent #6,579,068 Method of manufacture of a suspended nitride membrane and a microperistaltic pump using the same Patent #6,578,966 Computer-based 3D visual field test system and analysis Patent #6,576,899 Direct detection of low-energy charged particles using metal oxide semiconductor circuitry Patent #6,576,113 Method of elec- troplating of high aspect ratio metal structures into semiconductors Patent #6,574,501 Assessing blood brain barrier dynamics or identifying or measuring selected substances or toxins in a subject by analyzing Raman spectrum signals of selected regions in the eye Patent #6,573,897 Real-time, interactive animation of deformable two- and three-dimensional objects Patent #6,571,603 Method of resolving analytes in a fluid #6,570,617 CMOS active pixel sensor type imaging sys- tem on a chip Patent #6,567,598 Titanium-indiffusion waveguides Patent #6,567,436 Opto-electronic oscillators having optical resonators Patent #6,567,157 Fast mixing condensation nucleus counter Patent #6,566,496 Neurogenin Patent #6,563,039 Thermoelectric unicouple used for power generation Patent #6,562,567 Method of detecting a nucleic acid Patent #6,560,030 Solid immersion lens structures and methods for producing solid immersion lens structures Patent #6,559,724 Techniques for enhancing gain in a quasi-optic grid array Patent #6,559,125 Polyamide-alkylator conjugates and related products and method Patent #6,555,842 Active pixel sensor with intra-pixel charge transfer Patent #6,555,692 Preparation and use of bifunctional molecules having DNA sequence binding specificity Patent #6,555,337 we wield an influence far out of proportion to our size, influence that is felt both in and beyond the academe. LETTER FROM THE CHAIRMAN December 31, 2004, marked the end of trustees to the board, six in the last aca- my term as chairman of Caltech’s Board demic year alone. Joining us in 2003–04 of Trustees. What an exciting four years it were John D. Diekman, the founder and was, both for me personally and for the managing partner of 5AM Ventures of Institute. Menlo Park, California; Los Angeles Times One of my most important—and publisher John P. Puerner; Clara Spalter most gratifying—responsibilities as board Miller, the principal of Regulus chairman was helping to plan and direct International Capital Corporation in “There’s only one. Caltech,” our $1.4 Greenwich, Connecticut (and a Caltech billion fund-raising campaign. I am very alumna); John W. Mack, president of the pleased with how this ambitious effort has Los Angeles Urban League; Lewis W. van progressed since its public launch in Amerongen of LvA Enterprises, Inc.; and October 2002. By the end of last fiscal Marc I. Stern, president of TCW, Inc. This year, we had raised $979.5 million toward seemed to me an unusual rate of change, our goal—not bad for a school with only even for our dynamic board, and it about 20,000 living alumni. The effect of prompted me to do some research into these campaign funds on the Caltech how this group has evolved since I gradu- community is already starting to be felt. ated from Caltech. New professorships, scholarships, and fel- In 1954, I discovered, the board had lowships are being funded; old buildings only 24 voting members; today, there are are being renovated and planned buildings 56. All but one of those 24 lived in are moving closer to construction; and Southern California; today our trustees much-needed scientific equipment is come from all over the country (and one being purchased. I have every confidence lives overseas). The 1954 board was all that we will continue to make steady male and all Caucasian; today’s board is progress over the remaining three years of 21 percent female, and has several African the campaign, and that our outstanding American and Asian members. These priorities will be funded. changes in the board’s composition reflect During the past four years, I also similar developments in the campus com- had the pleasure of welcoming 12 new munity.