July 23-24, 2020 Program and Abstract Book Program and Abstract Book The 15th BiennialVirtual Congress of the Anaerobe Society of the Americas July 23-24, 2020 Contents Course Director Organizing Committee ii Welcome Letter iii About the Anaerobe Society iv Curricular Goals & Objectives v Patrons vi Keynote Speaker vii Presenters & Faculty viii Congress Program x Disclosure Information xiv Oral Abstract Table of Contents 1 Abstract Table of Contents 3 Author Index 205 i The 15th BiennialVirtual Congress of the July 23-24 Anaerobe Society of the Americas Course Director Dear Colleagues: Welcome to Anaerobe 2020, the 15th biennial Congress of the Anaerobe Society David N. Fredricks, M.D. ASA President of the Americas! I am sorry that we will not be gathering in our usual format with Fred Hutchinson Cancer Research Center oral scientific presentations, posters, and networking, but this has been an unusual Seattle, WA USA time in our history that requires innovative approaches to connect scientifically, while maintaining physical distance. We identified early in the year that an in-per- Organizing Committee son meeting would not be feasible, but it took some effort to convince our contrac- David Aronoff, MD Jeanne Marrazzo, MD, MPH tual partners that it would not be advisable to bring together large numbers of inter- ASA Past President ASA Past President national professionals who have been treating patients with COVID-19 to a city that Vanderbilt University Medical Center University of Alabama was experiencing the first outbreak in the U.S. Eventually, they all saw our point. Nashville, TN USA Birmingham, AL USA Susan Bartlett Jeff S. McLean, PhD Instead, the Program Committee worked diligently to develop a plan for a virtual Fred Hutchinson Cancer Research Center University of Washington conference and whittled down the original program to a third, maintaining a mix of Seattle, WA USA Seattle, WA USA anaerobic-related topics presented by recognized authorities and emerging young Karen Carroll, MD Elizabeth Nagy, MD, PhD investigators with academic, clinical, and industry representation. The response Johns Hopkins University University of Szeged has been strong with over 450 participants from 33 countries. We are very ap- Baltimore, MD USA Szeged, Hungary preciative that our scheduled Keynote Speaker, Dr. Wendy Garrett of Harvard Medical School, is able to participate to discuss her exploration of the relationship Laura M. Cox, PhD Daniel Paredes-Sabja, PhD Harvard University Universidad Andrés Bello between anaerobic bacteria and colon cancer. Boston, MA USA Santiago, Chile In order to recognize the fine research submitted for poster presentations, we are Cynthia Sears, MD Caroline A. Genco, PhD digitally publishing this Abstract Book, with a contact email for each abstract Tufts University ASA Past President presenter to provide an opportunity for digital dialogue. Anaerobe 2020 again Medford, MA USA Johns Hopkins University Baltimore, MD USA illustrates the international interest in the field of anaerobic bacteriology with 160 Dale N. Gerding, MD abstracts representing the work of 610 scientists from 23 countries. Aimee Shen, PhD ASA Past President Hines VA Hospital Tufts University Medford, MA USA We would like to thank the members of the Organizing Committee and the Session Maywood, IL USA Chairs for their assistance in formulating and adjusting what promises to be an ex- Ronald J. Goldman, PhD Audrey N. Shuetz, MD citing program. We also would like to thank our industry partners (Pfizer, Merck, ASA Executive Director Mayo Clinic Rebiotix, Acurx, and List Labs), the National Institutes of Health, the Burroughs Rochester, MN USA Los Angeles, CA USA Wellcome Fund, and the Fred Hutchinson Cancer Research Center for their sup- Ellie J.C. Goldstein, MD Sujatha Srinivasan, PhD port to make this Congress possible. ASA Treasurer, Past President Fred Hutchinson Cancer Research Center University of California Seattle, WA USA Special thanks goes to Susan Bartlett for helping to implement this virtual meeting Los Angeles, CA USA Casey M. Theriot, PhD format, and to Dr. Ronald and Pamela Goldman who planned for one format, Yiping W. Han, PhD North Carolina State University adjusted for another, and continue to serve as organizers and advocates for our Columbia University Raleigh, NC USA society. New York, NY USA Vincent Young, MD, PhD Sarah A. Kuehne, PhD ASA Vice President Though this on-line Congress will not provide the interpersonal networking University of Birmingham University of Michigan opportunities for which our biennial events are known, let Anaerobe 2020 serve Birmingham, United Kingdom Ann Arbor, MI USA as a tantalizing preview for ANAEROBE 2022, which we hope can return as an Francisco A. Uzal, D.V.M., PhD in-person conference, July 2022, in Seattle, WA USA. University of California Davis, CA USA David N. Fredricks, M.D. President, Anaerobe Society of the Americas ©2020 Anaerobe Society of the Americas ii iii The 15th BiennialVirtual Congress of the July 23-24 Anaerobe Society of the Americas About the Anaerobe Society Goals & Objectives, Accreditation Founded in 1992, the Anaerobe Society of the Americas, a non-profit foundation, Anaerobe 2020—the 15th biennial Congress of the Anaerobe Society of the serves as a forum for those interested in anaerobes, anaerobic infections, and Americas—provides the forum for vigorous discussions of both the clinical and related matters. The Society aims: (1) to stimulate interest in anaerobes and microbiological aspects of anaerobic infections, their diagnosis, and their therapy to encourage interchange among anaerobists from all disciplines, including among medical practitioners, researchers, laboratory scientists, and industrial medical, dental, veterinary, environmental, and basic sciences; (2) to bring representatives. together investigators, clinicians, and laboratory scientists interested in anaerobic infections for formal and informal meetings; (3) to review and assess new Accreditation & Certificates of Attendance advances in the field; (4) to discuss areas of controversy; and (5) to mark future Though planning for this Congress follows ACCME standards, this program is directions. not accredited and no CME/CEUs will be issued. Certificates of Attendance may be requested. There are four levels of membership: Doctoral, Non-Doctoral, Verified Student, and Retired. Details and application form are available on our web site: www. Curricular Goals & Objectives anaerobe.org. Provide information on the latest developments in the field of anaerobic research, including the role of anaerobes in human diseases, the epidemiology of anaerobic Anaerobe Society Congresses infections, and potential prevention strategies. This is the 15th biennial Anaerobe Society Congess. Provide recommendations in the diagnosis, screening, and treatment of anaero- Past Anaerobe Society sponsored programs were: bic infections, including new laboratory techniques, utilization of antibiotics, and ANAEROBE 2018—Las Vegas, NV USA potential of probiotics. ANAEROBE 2016—Nashville, TN USA Provide an understanding for better utilization of the microbiology lab into the ANAEROBE 2014—Chicago, IL USA delivery of patient care. ANAEROBE 2012—San Francisco, CA USA Disclosures ANAEROBE 2010—Philadelphia, PA USA Disclosures of relevant financial relationships by all session participants are pro- ANAEROBE 2008—Long Beach, CA USA vided on pages xiv. ANAEROBE 2006—Boise, ID USA Evaluation Forms ANAEROBE 2004—Annapolis, MD USA Please complete the Evaluation Form at the end of the Congress. ANAEROBE OLYMPIAD 2002—Park City, UT USA 2001: AN ANAEROBE ODYSSEY—Los Angeles, CA USA ANAEROBE 2000—Manchester, England ANAEROBE 1998—Buenas Aires, Argentina ANAEROBE 1996—Chicago, IL USA ANAEROBE 1994—Los Angeles, CA USA ANAEROBE 1992—Los Angeles, CA USA For Additional Information About the Anaerobe Society or Anaerobe 2020 Web Site: www.anaerobe.org Email: [email protected] Phone +310-216-9265 Fax: +310-216-9274 iv v The 15th BiennialVirtual Congress of the July 23-24 Anaerobe Society of the Americas Patrons Keynote Speaker Anaerobe Society of the Americas gratefully acknowledges the following Wendy S. Garrett, MD, PhD organizations for their generous support of this congress. Wendy Garrett is a Professor in the Departments of Immunology and Infectious Diseases and of Molecular Metabolism at the Harvard Chan School of Public Health, and also has a Professorship in the Departments of Medicine at Harvard Medical School. Dr. Garrett pursued an MD and PhD at Yale University. She completed a fellowship at the Dana-Farber Cancer Institute and postdoctoral training at Harvard University Medical School. Dr. Garrett investigates host-microbiota interactions in health and disease. Her research team studies the interplay between the gastrointestinal immune system and the gut microbiota in health, inflammatory bowel disease (IBD), and colorectal cancer (CRC). The Garrett lab focuses on how the gut microbiota influence both National Institutes innate and adaptive populations and the contribution of these cells to immune of Health homeostasis and disease. Dr. Garrett’s team has identified specific species, pathways, and metabolites made by the microbiota that influence health and disease states. The lab also studies microbes and immune cells that are not only instrumental in potentiating carcinogenesis but are integral to intestinal homeostasis. The multi-faceted research approach includes meta’omics, microbiology, cellular immunology, biochemistry,