Adooq Bioscience Innovation through Bioscience Kinase Inhibitors Catalog 2014-2015 Adooq Bioscience LLC.©2015 4000 Barranca Parkway, Suite 250 Irvine, CA 92604, USA Phone: 1-866-930-6790 www.adooq.com Fax: 1-866-333-9607 Email: [email protected] I About Us Distributors II About Us Worldwide Distributors Who We Are Australia Sapphire Bioscience Pty. Ltd. Austria Hölzel Diagnostika Handels GmbH www.sapphirebioscience.com www.hoelzel-biotech.com [email protected] [email protected] Tel: 1800 062 088 Fax: +61296981022 Tel: +49(0)221-1260266 Fax: +49(0)221-1260267 Adooq Bioscience is one of the world leading suppliers of high-performance life- Canada Cedarlane China Shenzhen Minn Bolin Bio-Tech Co., Ltd. science reagents and reference compounds for the research fields. 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Tel: +886-2-2827-1197 Fax: +886-2-2827-7780 Tel: 00 44 1904 431402 Fax: 00 44 1904 431409 Adooq Bioscience LLC. © 2015 Email: [email protected] Phone: 1-866-930-6790 Fax: 1-866-333-9607 III Contents Contents IV Cathepsin 34 Progesterone Receptors 44 Histone demethylases 34 Renin-angiotensin-aldosterone system (RAAS) 45 Stem Cell Differentiation 34 Androgen Receptors 45 Contents PPAR 45 GSK-3 / Wnt / Hedgehog ..............................35 Liver X receptors (LXRs) 45 Aromatase 46 Apoptosis .................................................................1 PI3K / Akt / mTOR........................................20 γ-Secretase 35 Retinoic Acid Receptors 46 Bcl-2 Family 1 Akt 20 Hedgehog 35 Glucocorticoid receptors 46 Caspase 1 Ferroptosis 20 Wnt 35 p53 1 PI3-Kinase (PI3K) 20 β-catenin 36 GSK-3 36 Transferases ..........................................................46 TNF-α 1 mTOR 22 IAP 1 PDK1 23 Smoothened 36 Glucocorticoid receptors 46 RasGAP (Ras- P21) 2 Vitamin D Receptors 46 PERK 2 Transporters .........................................................37 GnRH receptor 46 Receptor Tyrosine Kinases .................................23 GPR 46 EGFR/HER2 23 ATPase 37 Phosphorylases 46 Angiogenesis ............................................................2 DNA-dependent protein kinase (DNA-PK) 23 Multidrug Transporters 37 Methyltransferases 47 EGFR / HER2 2 Ribosomal S6 protein kinases (RSK) 23 Sodium-dependent Glucose Cotransporter (SGLT) 37 Protein Prenyltransferases 47 MDM2 2 FGFR 24 Monocarboxylate transporters (MCT) 37 FPTase 47 Apoptosis Inducers 2 PDGFR 24 Neurotransmitter Transporters 38 Histone Methyltransferase 47 FGFR 3 VEGFR 24 AMPA receptor 38 Histone Acetyltransferases 47 PDGFR 3 Type 1 insulin-like growth factor receptor (IGF-1R) 24 DNA Methyltransferases 47 VEGFR 3 FLT3 (FMS-like tyrosine kinase 3) 25 Ion Channels ........................................................38 Vascular Disrupting Agent (VDA) 4 c-MET 25 Calcium Channels 38 Ubiquitin ..............................................................48 HIF 5 ALK 25 P-gp 38 BCR-ABL 26 activating enzyme E1 48 CRM1 38 E3 ubiquitin ligase 48 MAPK ......................................................................5 FAK 26 Ligand-gated Ion Channels 38 SRC 26 DUB 48 MEK/ERK 5 Sodium Channels 39 c-Kit 27 5-alpha-reductase 5 Potassium Channels 39 Spleen tyrosine kinase (Syk) 27 Others ....................................................................48 Antiangiogenics 5 Chloride Channels 39 Tie-2 27 p38-MAPK 6 Cystic Fibrosis Transmembrane Regulator (CFTR) 39 Other inhibitors 48 Bone Morphogenetic Proteins (BMP) 28 JNK/c-Jun 6 Transient Receptor Potential Channels 40 p97 48 Bruton's tyrosine kinase 28 Raf 6 Carbonic Anhydrase 54 AMPK / Insulin Receptor ...............................40 Cholinesterase 54 NF-kB/IkB ..........................................................28 Casein Kinase 2 54 Cell Cycle .................................................................7 AMPK 40 NF-kB 28 Soluble guanylyl cyclase (sGC) 54 Checkpoint Kinase 7 Axl 28 Reagents 54 cyclin-dependent kinases (CDKs) 8 ATM / ATR ........................................................40 Tyrosine kinase 28 Integrin Receptors 54 Checkpoint Control Kinases 9 Trk Receptors 28 ATM 40 Toll-like Receptors 54 Aurora Kinase 9 Cytokines 29 NMDA Receptors 40 Beta-secretase (BACE) 54 PARP 9 IKK 29 ATR 40 LRRK2 54 Polo-like kinases (PLKs) 10 MELK 54 Rho-Kinase (ROCKs) 10 7-TM Receptors .................................................41 β-lactamase 55 Topoisomerase 11 JAK / Stat ............................................................29 Gluconeogenesis 55 Microtubules 11 JAK 29 5-HT Receptors 41 Cholinesterases 55 Synthases / Synthetases 12 Stat 29 Adrenergic Receptors 41 Aldose Reductase 55 RNA/DNA Polymerase 12 Pim Kinase 29 Acetylcholine Muscarinic Receptors 42 Nitric Oxide Signaling 55 Telomerase 12 Histamine Receptors 42 Adenylyl Cyclase 55 Ligases 12 TGF-β / Smad ...................................................30 Dopamine Receptors 42 IDH1 55 Reverse Transcriptase 12 Opioid Receptors 42 LSD1 inhibitor 55 TGF-β/ Smad Inhibitors 30 GABA Receptors 42 Protein Kinase C (PKC) 30 Casein Kinase 1 55 Cell Metabolism ..................................................13 Purinergic (P2Y) Receptors 42 Lipoxygenase 55 Metabotropic glutamate receptors (mGluR) 43 Sigma-1 receptor 55 Cytochrome P450 13 Proteases ................................................................30 Angiotensin Receptors 43 Mitosis 13 Caspase 30 Melatonin Receptors 43 -Amyloid 14 β Protein Kinase A 30 Peptide Receptors 43 Phosphodiesterases (PDEs) 14 Protein kinase D (PKD) 30 Smoothened Receptors 43 Hydroxylases 14 Proteasome 30 Chemokine Receptors (CCR5) 43 Dihydrofolate reductase (DHFR) 15 HCV Protease 31 G Protein 43 Dehydrogenases 15 HIV Protease