ProceedIngs OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA November 1980 Volume 77, Number 11 pp. 6255-6942 Table of Contents INFORMATION TO CONTRIBUTORS 111-v AUTHOR INDEX vii Physical Sciences APPLIED MATHEMATICAL SCIENCES Computers-Present and future: Introduction to the symposium E. R. Piore 6255 Computers-Work in progress Herman H. Goldstine 6256-6259 Computers-Small computers: Past, present, and future Bernard M. Oliver 6260-6261 Computers-The software situation Jacob T. Schwartz 6262-6263 Computers-Non-numerical computation Herbert A. Simon 6264-6268 APPLIED PHYSICAL SCIENCES Dedicated-site, interim storage of high-level nuclear waste as part of the E-an Zen 6269-6271 management system Phase separation in mixtures of ionized iron in a hydrogen plasma B. J. Alder, E. L. Pollock, and J. P. 6272-6274 (asymmetric plasma mixtures/hypernetted chain/molecular dynamics) Hansen ASTRONOMY Statistical invalidation of the Hubble law (galaxies/cosmology/redshift- J. F. Nicoll, D. Johnson, I. E. Segal, 6275-6279 distance relationship) and W. Segal CHEMISTRY Synthesis and characterization of a photosensitive interface for hydrogen Dana C. Bookbinder, James A. Bruce, 6280-6284 generation: Chemically modified p-type semiconducting silicon Raymond N. Dominey, Nathan S. photocathodes (solar energy/photoelectrochemistry/energy conversion) Lewis, and Mark S. Wrighton Chemical potential, Teller's theorem, and the scaling of atomic and molecular Norman H. March and Robert G. Parr 6285-6288 energies (Thomas-Fermi theory/electronegativity) 25Mg NMR in DNA solutions: Dominance of site binding effects (alkaline earth D. Murk Rose, M. L. Bleam, M. T. 6289-6292 ions/ion condensation theory/NMR relaxation) Record, Jr., and R. G. Bryant Analytic construction of Hartree-Fock density matrices (density functional/ Philip W. Payne 6293-6297 Hohenberg-Kohn/molecular orbital/electron density/exchange correlation) i Contents GEOPHYSICS A two-reservoir recycling model for mantle-crust evolution (mantle depletion! S. B. Jacobsen and G. J. Wasserburg 6298-6302 crustal growth/trace elements/neodymium isotopes/strontium isotopes) MATHEMATICS Spinor representations of affine Lie algebras (Clifford algebra/Clifford module/ I. B. Frenkel 6303-6306 fundamental representation/quantum field theory/elliptic 0-functions) PHYSICS Why is there no bulk specific heat anomaly at the superconducting transition Christoph E. Methfessel, Gregory R. 6307-6308 temperature of BaPbl-.Bi,,03? (superconductivity/oxide/exciton Stewart, Bernd T. Matthias, and C. mechanism) K. N. Patel Biological Sciences 6309-6942 ii Proceedings OF THE National Academy of Sciences OF THE UNITED STATES OF AMERICA November 1980 Volume 77, Number 11 pp. 6255-6942 Table of Contents INFORMATION TO CONTRIBUTORS ix-xii AUTHOR INDEX xiii-xiv Physical Sciences 6255-6308 Biological Sciences BIOCHEMISTRY Fast algorithm for predicting the secondary structure of single-stranded RNA Ruth Nussinov and Ann B. Jacobson 6309-6313 (computer program/polynucleotideiRNA folding) Wavelength regulation in rhodopsin: Effects of dipoles and amino acid side Thomas R. Hays, S. H. Lin, and H. 6314-6318 chains (point charge/perturbation) Eyring Specific labeling of the lac carrier protein in membrane vesicles of Escherichia G. J. Kaczorowski, G. LeBlanc, and H. 6319-6323 coli by a photoaffinity reagent (active transport/nitrophenyl ether! R. Kaback nucleophilic aromatic photosubstitution/triplet state/scavenging) Permeabilization of animal cells for kinetic studies of intracellular enzymes: In Juan J. Aragon, Juan E. Feliu, Ren6 -6324-6328 situ behavior of the glycolytic enzymes of erythrocytes (macromolecular A. Frenkel, and Alberto Sols environment/protein-protein interactions/metabolic control/enzyme regulation/phosphofructokinase) Autonomously replicating sequences in Saccharomyces cerevisiae Clarence S. M. Chan and Bik-Kwoon 6329-6333 (chromosomal replicating segments/baker's yeast/repetitive sequences/ Tye transformation) Ligand substitution reactions of metallothioneins with EDTA and apo-carbonic Ta-Yuen Li, Alan J. Kraker, C. Frank 6334-6338 anhydrase (cadmium/zinc/metal ion transfer/metalloprotein Shaw III, and David H. Petering reconstitution) Contents Construction of a flash-activated cyclic electron transport system by using Nigel K. Packham, David M. Tiede, 6339-6343 bacterial reaction centers and the ubiquinone-cytochrome b-ci/c segment of Paul Mueller, and P. Leslie Dutton mitochondria (photochemical reaction center/mitochondria complexI1I/ cytochromes b and c/antimycin A) Properties of the separated catalytic and regulatory units of brain adenylate Stephen Strittmatter and Eva J. Neer 6344-6348 cyclase (guanine nucleotide regulation/detergent solubilization/enzyme reconstitution) Multiple mRNA species for the precursor to an adenovirus-encoded Hakan Persson, Hans Jornvall, and 6349-6353 glycoprotein: Identification and structure of the signal sequence (mRNA Jan Zabielski purification/protein structure analysis/binding to transplantation antigens) Charge movements during the Na+-Ca2+ exchange in heart sarcolemmal P. Caroni, L. Reinlib, and E. Carafoli 6354-6358 vesicles (permeability to K+/permeability to Clh/chlorprornazine) Glutathione transport by inside-out vesicles from human erythrocytes (cytidine Takahito Kondo, George L. Dale, and 6359-6362 monophosphate/inhibition/kinetics) Ernest Beutler Proteolytic inactivation of luciferases from three species of luminous marine Thomas F. Holzman and Thomas 0. 6363-6367 bacteria, Beneckea harveyi, Photobacterium fischeri, and Photobacterium Baldwin phosphoreum: Evidence of a conserved structural feature (limited proteolysis/active center/bioluminescence) A nondenaturing zwitterionic detergent for membrane biochemistry: Design and Leonard M. Hjelmeland 6368-6370 synthesis (solubilization) Redox conformation changes in refined tuna cytochrome c (x-ray diffraction/ Tsunehiro Takano and Richard E. 6371-6375 electron transfer mechanism/protein conformation changes/buried water Dickerson molecule/heme motion in protein) The capsid protein of Semliki Forest virus has clusters of basic amino acids and H. Garoff, A.-M. Frischauf, K. 6376-6380 prolines in its amino-terminal region (nucleotide sequencing/cDNA/ Simons, H. Lehrach, and H. Delius molecular cloning/protein-RNA interactions) In vitro comparison of initiation properties of bacteriophage X wild-type PR and Diane K. Hawley and William R. 6381-6385 x3 mutant promoters (RNA polymerase mechanism/abortive initiation) McClure Sodium-dependent silicate transport in the apochlorotic marine diatom Pinakilal Bhattacharyya and 6386-6390 Nitzschia alba (Na + gradient/Na+,K*-ATPase/membrane vesicles) Benjamin E. Volcani Ion-transport chain of cytochrome oxidase: The two chain-direct coupling Mitchell Fry and David E. Green 6391-6395 principle of energy coupling (cardiolipin/ion-transport cage/fixed ionophore/ferrocytochrome c:oxygen oxidoreductase) Specificity in interaction of benzo[alpyrene with nuclear macromolecules: Michael C. MacLeod, Arend Kootstra, 6396-6400 Implication of derivatives of two dihydrodiols in protein binding (histone/ Betty K. Mansfield, Thomas J. polynuclear aromatic hydrocarbon/bay region theory of chemical Slaga, and James K. Selkirk carcinogenesis/reverse diol epoxide) Cytoskeletal constraint of the f3-adrenergic receptor in frog erythrocyte Bruce D. Cherksey, Jose A. 6401-6405 membranes (propranolol/microtubules/adenylate cyclase/fluorescence/ Zadunaisky, and Randall B. catecholamines) Murphy Synthesis, intracellular distribution, and secretion of multiple forms of Jeremiah J. Morrissey, Robert E. 6406-6410 parathyroid secretory protein-I (parathyroid hormone/membranes/ Shofstall, James W. Hamilton, and precursor peptide/glycoprotein secretory mechanisms) David V. Cohn Role of kidney tissue in the production of 25-hydroxyvitamin D3-26,23-lactone Yoko Tanaka, Joseph K. Wichmann, 6411-6414 and la,25-dihydroxyvitamin D3-26,23-lactone (vitamin D/kidney/25- Herbert E. Paaren, Heinrich K. hydroxyvitamin D/1,25-dihydroxyvitamin D) Schnoes, and Hector F. DeLuca Mitochondrial DNA polymorphism: Evidence that variants detected by Frank J. Castora, Norman Arnheim, 6415-6419 restriction enzymes differ in nucleotide sequence rather than in methylation and Melvin V. Simpson (mtDNA evolution/mtDNA cloning/sequence analysis/rats) Relationship of GIX antigen expression to the glycosylation of murine leukemia Marsha Rich Rosner, Jwu-Sheng 6420-6424 virus glycoprotein (loss of antigenicity/determination of oligosaccharide Tung, Nancy Hopkins, and Phillips chain number/endo-13-N-acetylglucosaminidase H) W. Robbins Protein p3 is linked to the DNA of phage 029 through a phosphoester bond Jose M. Hermoso and Margarita Salas 6425-6428 between serine and 5'-dAMP (initiation of replication/Bacillus subtilis/ nucleotidyl-peptide/acid and alkali hydrolysis) In vivo regulation of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A Ronald E. Arebalo, Joel E. Hardgrave, 6429-6433 reductase: Enzyme phosphorylation as an early regulatory response after Billie J. Noland, and Terence J. intragastric administration of mevalonolactone (cholesterol biosynthesis) Scallen Biosynthesis of A,B procollagen (processing/type V collagen/chicken embryo/ Carol A. Kumamoto and John H. 6434-6438 muscle) Fessler Specific photoaffinity labeling induced by energy transfer: Application to Maurice P. Goeldner and Christian G. 6439-6442 irreversible inhibition of acetylcholinesterase (covalent labeling/ Hirth fluorescence quenching/cholinergic