The 42nd ASMS Conference on Mass Spectrometry May 29 - June 3, 1994 Hyatt Regency Hotel, Chicago, Illinois Preliminary Program The title information listed in this program is provided directly by the authors and is not edited. For additional information, contact ASMS (505) 989-4517 SUNDAY Matrix and Polypeptide Ions Produced by Matrix­ 03:00 Registration Assisted Laser Desorption; "Zhang, Wenzhu; Chait, 07:00 Workshop: Young Mass Spectrometrists Brian T.;The Rockefeller University, New York, N.Y. 08:00 Welcome Mixer 10021 USA. 12:10 Influence of the laser beam angle of incidence on MONDAY ORAL SESSIONS molecular ion ejection in MALDI. Influence of the 08:30 Plenary Lecture: Dr. Susan Solomon, NOAA, laser baem angle of incidence on molecular ion Boulder, CO; speaking on ozone depletion and ejection in MALDI.; 'Chaurand,P IPN ORSAY; upper atmosphere chemistry. Della Negra.S IPN ORSAY; Deprun, C TI'N ORSAY; Hoyes,J VG MANCHESTER; Le Beyec,Y IPN ORSAY; lPN ORSAY 91406 FRANCE, VG Analytical Laser Desorption Ionization Manchester M23 9LE ENGLAND. 09:30 The Role of the Matrix in Matrix-Assisted Laser 12:30 Lunch Break Desorption Ionization: What We Know Versus 04:00 What makes a matrix work for UV-MALDI-MS; What We Understand; "Russell, David H.; 'Karas, Michael; Bahr, Ute; Hahner, Stephanie; Stahl, Department of Chemistry, Texas A&M University, Bernd; Strupat, Keratin: Hillenkamp, Franz; lnst. for College Station, TX, 77843. Med. Physics & Biophysics, 48149 Mnnster, FR 09:50 Mechanisms in laser ablation mass spectrometry Germany. of large molecules: questions and some answers; 04:20 Mixing Matrices: Attempting to Construct Effective "Williams, Peter; Department of Chemistry, Composite Materials for MALDI; "BeaviS, Ronald Arizona State University, Tempe, AZ 85287-1604. c.; Xiang, Fan; Physics Department, Memorial 10:10 Ionization and Selective Volatilization Processes in University, St. John's, NF, CANADA Matrix-Assised Laser Desorption Ionization; 04:40 Affinity Mass Spectrometry: Probe Element "Vertes, Akos: Department of Chemistry, George Surfaces Enhanced for Affinity Capture (SEAC).; Washington University, Washington, DC 20052. "Hutchens, T. William; Yip, Tai-Tung; University of 10:30 Experimental Observables and Theoretical California, Davis, California 95616. Considerations for the Laser Vaporization of 05:00 Thin layer preparation technique to increase the Biomolecules.: 'Robert J. Levis; Wayne State sensitivity, resolution and mass accuracy of University, Detroit, Ml, 48202, USA. MALDI; "Vorm, Ole; Roepstorff, Peter; Mann, 11:10 Influence of the Extraction Field Strength on Matthias; Odense Univ., Odense, 5230 Odense M, Kinetic Energy Distributions in Matrix-Assisted Denmark. Laser Desorption; "Ens, Werner; Spicer, Victor; Standing, Kenneth G.; Dept. of Physics, Univ. Regular Old Ordinary MS Manitoba, Winnipeg, Canada R3T 2N2. 11:30 Studies on the Dynamics of MALDI Ion Formation; 09:30 Tandem Mass Spectrometry Of Some Non-Ester "Kinsel, Gary R; Gillig, Kent; Edmondson, Ricky D.; Pyrethroid Insecticides; "Monaghan, John J.; Fleet, Russell, David H.; Department of Chemistry, Texas Ian A.; 'Ietler, Lee W.; Centre for Mass Spectrometry, A & M University, College Station, TX 77843. UMlST, Manchester, M60 lQD, UK. 11:50 Radial Velocity Distribution Measurements of 09:50 FAB-Induced Reactions of Benzisothiazoles; © 1994 American Society for Mass Spectrometry 1044-0305/94/$7.00 J Am Soc Mass 5pectrom 1994,5,472-523 PRELIMINARY PROGRAM 473 "Sharp, Thomas R.; Pfizer Central Research, Groton, "Andy J. Tomlinson; Wendy K. Nevala; W. David Connecticut 06340 U.S.A.. Braddock; Michael A. Strausbauch; Peter J. 10:10 Mass Spectrometry of Fullerene Isoxazolines; Wettstein; Stephen Naylor; Mayo Clinic, Rochester, "Pogue, Robert L; Majidi, Vahid; Meier, Mark S.; MN 55905, USA. Pyrek, Jan 5.; Goodman, Jack; Poplawska, 11:50 The Use of Mass Spectrometry to Characterize Magdalena; Univ of Kentucky, Lexington, KY; 40506. Antigenic Peptides from Influenza Virus as 10:30 Pyrolysis GClMS of Azo Dyes; "Ludicky, Robert A; Presented by MHC Class I Db Molecules; "Cerny, Morton International, 1275 Lake Avenue, Ronald L.; Gross, Michael L.; Sigal, Luis J.; Wylie, Woodstock IL, 60098 USA Dwane E.; Depts, of Chern. and BioI. SeL, U. of 11:10 STUDY OF SOME COVALENT Nebraska, Lincoln, NE 68588-0304. ORGANOMETALLIC COMPLEXES BY EI, FAB 12:10 MONITORING OF NEUROPEPTIDE AND IS MASS SPECTROMETRY; "Raffaelli, PROCESSING BY MATRIX-ASSISTED LASER Andrea; Pucci, Sergio; Pertici, Paolo; Ingrosso, DESORPTION IONIZATION TIME-OF-FLlGHT Giovanni; Salvadori, Piero; CNR - C.S.M.S.O.A., MASS SPECTROMETRIC ANALYSIS OF Dipartim. Chimica Chim. Industriale, 56126 P1SA, HUMAN CEREBROSPRINAL FLUID; "Costello, Italy. Catherine E.; Juhasz, Peter; Ekman, Rolf; Heilig, 11:30 New Analytical Scheme For Regular Old Ordinary Markus; Agren, Hans; Mass. Inst, of Technology, Mass Spectrometry Methods; "Lewis, Tanya M.; Cambridge, MA, 02139-4307 USA Russell, David H.; Dept. of Chemistry, Texas MM, 12:30 Lunch Break College Station, TX, 77843-3255. 04:00 Identification of Myocardial Proteins from Two­ 11:50 REACTIONS OF OH RADICALS WITH SEMI­ Dimensional Gels by Database Matching of VOLATILE ORGAN1C COMPOUNDS; Proteolytic Peptide Masses Determined by MALO.; "Anderson, Philip N.; Hites, Ronald A; Indiana Sutton, C. W.; Pemberton, K. S.; ~Cottrell, J. 5.; University, Bloomington, IN 47405. Corbett, J. M.; Wheeler, C; Dunn, M. J.; Pappin, D. J. 12:10 An Analysis and Optimization of Mass Spectral C; Finnigan MAT Ltd., Hemel Hempstead, Herts Library Search Algorithms;"Stein, Stephen E.; NIST HP24TG, UK. Gaithersburg, MD 20899 USA. 04:20 Protein Sequence Determination using High 12:30 Lunch Break Performance Liquid Chromatography/Aerosol Matrix-Assisted Laser Desorption Ionization Mass Biochemistry Spectrometry; "Beeson, Michelle D.; Murray, Kermit K.; Russell, David H.; Texas A&M University, 09:30 A Comparison of Native States, Molten Globules College Station, TX 77843-3255. and Non-Native States of Proteins by Electrospray 04:40 15N-Labeling and Tandem Mass Spectrometry of Ionization Mass Spectrometry; "Robinson, Carol V.; the 7-Deazaguanosine Analog, Archaeosine; Eyles, Stephen j.: Aplin, Robin T.; Dobson, "Gregson, John M.; McCloskey, James A; Dept. of Christopher M.; OCMS, Dyson Perrins Laboratory, Medicinal Chemistry, University of Utah, Salt Lake Oxford University, Oxford, OXI 3Qy, UK.. City, UT 84112. 09:50 The Study of Protein-Ligand Interactions at High 05:00 MICROCAPILLARY-HPLClCF-FAB/CID OF mlz by Electrospray lonization Mass Spectrometry; AMINOSULPHONATED LIPIDS; Yang, Yang; "Schwartz, Brenda L.; Light-Wahl, Karen J.; Smith, Zhang, lie; ~Griffiths, William, J.; Sj+vall, Jan; Richard D.; Pacific Northwest Laboratory, Richland, Karolinska Institute, Stockholm, 5-171 77, Sweden. WA99352. 10:10 MALDI·MS Mapping of Sulfhydryl-Containing Trapped Ion MS Peptides: Selective Isolation by Affinity Chromatography; ~Zaluzec, Eugene, J.; Gage, 09:30 The Study of Individual Large Ions using Fourier Douglas, A; Watson, J. Throck: Dept. of Transform Ion Cyclotron Resonance Ionization: An Biochemistry, Michigan State University, East Approach for Increasing Mass Range and Lansing, MI, 48824. Sensitivity; *Smith, Richard D.; Bruce, James E.; 10:30 New Methodology for Identifying Cheng, Xueheng; Hofstadler, Steven A; Anderson, Phosphoproteins and Mapping Phosphorylation Gordon A; Wu, Qinyuan; Chen, Ruidan; Van Orden, Sites in Proteins and Peptides; "Annan, Roland S.; Steven L.; Rockwood, Alan L.; Mitchell, Dale W.; Carr, Steven A.; SmithKline Beecham Pacific Northwest Laboratory, Richland ,WA, 99352. Pharmaceuticals, King of Prussia PA 19406. 10:10 Trapped-Ion Tandem Mass Spectrometry of Large 11:10 Identification and Biochemical Characterization of (>25 kDa) Biomolecules; ~McLa££erty,Fred W; a SH2-Domain Associated Tyrosine Phosphatase Senko, Michael W; Chorush, Russell A; Kelleher, Activity for Activated C·Src; "Kassel, D.B.; Boerner, Neil L; Little, Daniel P; O'Connor, Peter B; Speir, J. R.; Davis, D.; Gampe, R.; Willard, D.; Weigl, D.; Paul; Wood, Troy 0; Chemistry Department, Cornell Luther M.A.; Knight, W.B.; Glaxo Research Institute, University, Ithaca NY 14853-1301. 5 Moore Dr., Res. Triangle Park, NC 27709. 10:30 Gas Phase Ion Chemistry Considerations of the 11:30 A Strategy for Isolating and Sequencing MHC Infrared Multiple Photon Dissociation Process in Class I Peptides Using Capillary Electrophoresis in the Quadrupole Ion Trap; "Stephenson , [r., James Conjunction with Electrospray-Mass Spectrometry; L.; Booth, Matthew M.; Eyler, John R.; Yost, Richard, 474 42nd ASMS CONFERENCE ON MASS SPECTROMETRY ) Am Soc Mass Spectrom 1994, 5, 472-523 A.; University of Florida, Gainesville, FL, 32611. Ionization MS and MS-MS.; *McClure, Thomas D.; 11:10 Novel Open Geometry Trapped Ion Cells for Liebler, Daniel, C: Dept. PharmacoL / Toxicol., Improved FTICR Performance; Vartanian, Victor University of Arizona, Tucson, Arizona, 85721. H.; 'Laude, [r., David A.; Department of Chemistry, 3 Identification of terfenadine metabolites from human University of Texas at Austin, Austin, Texas 78712. liver microsomes and rat liver 59.; "Cyr, Terry D.; 11:30 Surface Analysis via Laser Desorption Ion Trap Ethier, J-e; [urima-Romet, Malle; Bureau of Drug Mass Spectrometry; Komienko, OIeg; Burroughs, Research, Banting Bldg., Ottawa, Ontario, KIA OL2 r John A.; "Hanley, Luke; University of Illinois at Canada. Chicago, Chicago, IL, 60607-7061, USA. 4 Mass Spectral Identification of Bufodienolides in 11:50 Broadband Quadupolar