Cellular and Molecular Mechanisms of Photodynamic Hypericin Therapy for Nasopharyngeal Carcinoma cells Xiaoli Wangb$, Yi Guoa$, Shu Yanga, Caihong Wangb, Xuping Fua, Jinling Wangb, Yumin Maoa, b* a* Junsong Zhang , Yao Li aState Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, P.R.China bSchool of Applied Chemistry and Biological, Shenzhen Polytechnic, Shenzhen, Guangdong 518055, P.R.China. The Journal of Pharmacology and Experimental Therapeutics Supplement Table S1. Genes up-regulated in all experimental groups GeneID Genetic information Gene No. chromosome Ratio RN7SK Homo sapiens RNA, 7SK, nuclear (RN7SK) on chromosome 6. NR_001445.1 6 320.633 HIST2H3C Homo sapiens histone 2, H3c (HIST2H3C), mRNA. NM_021059.2 48.67 BP873537 Sugano cDNA library, embryonal kidney Homo sapiens cDNA clone 47.045 HS.562219 HKR13896, mRNA sequence BP873537 HIST1H4B Homo sapiens histone 1, H4b (HIST1H4B), mRNA. NM_003544.2 6 42.321 BX109218 Soares_fetal_lung_NbHL19W Homo sapiens cDNA clone 42.115 HS.245367 IMAGp998C03690, mRNA sequence BX109218 TRQ1 Homo sapiens tRNA glutamine 1 (TRQ1) on chromosome 17. NR_000037.1 15 38.195 HIST1H2AH Homo sapiens histone 1, H2ah (HIST1H2AH), mRNA. NM_080596.1 6 33.628 HS.545589 Human small nuclear RNA U6atac, partial sequence U62823 32.42 LOC440686 Homo sapiens similar to histone H2B histone family (LOC440686), mRNA. NM_001025303.1 1 32.014 RNU12 Homo sapiens RNA, U12 small nuclear (RNU12) on chromosome X. NR_000041.1 X 31.693 HIST1H1B Homo sapiens histone 1, H1b (HIST1H1B), mRNA. NM_005322.2 6 27.632 TRK1 Homo sapiens tRNA lysine 1 (TRK1) on chromosome 17. NR_001449.1 11 27.546 RPPH1 Homo sapiens ribonuclease P RNA component H1 (RPPH1) on chromosome 14. NR_002312.1 14 23.993 HIST1H2BG Homo sapiens histone 1, H2bg (HIST1H2BG), mRNA. NM_003518.3 6 16.779 BX093900 Soares placenta Nb2HP Homo sapiens cDNA clone IMAGp998M23189, 13.798 HS.443602 mRNA sequence BX093900 FOXD4L1 Homo sapiens forkhead box D4-like 1 (FOXD4L1), mRNA. NM_012184.3 2 13.36 HS.545112 Homo sapiens mRNA; cDNA DKFZp434F0472 (from clone DKFZp434F0472) AL137331 12.512 ws25d05.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2498217 3, mRNA 12.003 HS.197703 sequence AI989490 Homo sapiens inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 9.983 ID2 (ID2), mRNA. NM_002166.4 2 tt27g09.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2242048 3, mRNA 9.793 HS.371006 sequence AI655567 TSPYL3 PREDICTED: Homo sapiens TSPY-like 3 (pseudogene) (TSPYL3), misc RNA. XR_001421.1 9.651 PREDICTED: Homo sapiens similar to Kinase suppressor of ras-1 (Kinase 9.336 LOC649456 suppressor of ras) (LOC649456), mRNA. XM_938534.1 PREDICTED: Homo sapiens similar to Bcl-2-associated transcription factor 1 (Btf), 8.578 LOC650759 transcript variant 1 (LOC650759), mRNA. XM_940798.1 BX110944 Soares placenta Nb2HP Homo sapiens cDNA clone IMAGp998E24200, 7.462 HS.297929 mRNA sequence BX110944 ta96c03.x1 NCI_CGAP_Lu26 Homo sapiens cDNA clone IMAGE:2051908 3, mRNA 7.292 HS.436134 sequence AI349750 AGENCOURT_14535501 NIH_MGC_191 Homo sapiens cDNA clone 5.816 HS.543887 IMAGE:30415823 5, mRNA sequence CD640673 HIST1H4H Homo sapiens histone 1, H4h (HIST1H4H), mRNA. NM_003543.3 6 5.726 HS.550111 AV647906 GLC Homo sapiens cDNA clone GLCBDC04 3, mRNA sequence AV647906 5.265 EOMES Homo sapiens eomesodermin homolog (Xenopus laevis) (EOMES), mRNA. NM_005442.2 3 4.905 RNU15B Homo sapiens RNA, U15b small nucleolar (RNU15B) on chromosome 11. NR_000025.1 11 4.8 KRT6E Homo sapiens keratin 6E (KRT6E), mRNA. NM_173086.2 12 4.702 TMEM70 Homo sapiens transmembrane protein 70 (TMEM70), mRNA. NM_017866.3 8 4.627 BX113978 Soares_pregnant_uterus_NbHPU Homo sapiens cDNA clone 4.607 HS.370110 IMAGp998N131206, mRNA sequence BX113978 POLR1B Homo sapiens polymerase (RNA) I polypeptide B, 128kDa (POLR1B), mRNA. NM_019014.3 2 4.474 C14ORF172 Homo sapiens chromosome 14 open reading frame 172 (C14orf172), mRNA. NM_152307.1 14 4.413 LOC648852 PREDICTED: Homo sapiens hypothetical protein LOC648852 (LOC648852), mRNA. XM_940430.1 4.323 JMJD4 Homo sapiens jumonji domain containing 4 (JMJD4), mRNA. NM_023007.1 1 4.294 Homo sapiens LanC lantibiotic synthetase component C-like 2 (bacterial) (LANCL2), 4.07 LANCL2 mRNA. NM_018697.3 7 NCOA5 Homo sapiens nuclear receptor coactivator 5 (NCOA5), mRNA. NM_020967.2 2 3.959 BY796152 Homo sapiens eye Homo sapiens cDNA clone 3.883 HS.544432 HEmEye2030G10_072.ab1 5, mRNA sequence BY796152 PUS3 Homo sapiens pseudouridylate synthase 3 (PUS3), mRNA. NM_031307.2 11 3.788 DDX51 Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 (DDX51), mRNA. NM_175066.2 12 3.724 PREDICTED: Homo sapiens similar to arginine/serine-rich splicing factor 6, transcript 3.614 LOC644422 variant 1 (LOC644422), mRNA. XM_930254.1 17 HUS1B Homo sapiens HUS1 checkpoint homolog b (S. pombe) (HUS1B), mRNA. NM_148959.2 6 3.588 C12ORF43 Homo sapiens chromosome 12 open reading frame 43 (C12orf43), mRNA. NM_022895.1 12 3.398 RWDD1 Homo sapiens RWD domain containing 1 (RWDD1), transcript variant 2, mRNA. NM_016104.2 6 3.387 PREDICTED: Homo sapiens similar to protein immuno-reactive with anti-PTH 3.351 LOC649841 polyclonal antibodies (LOC649841), mRNA. XM_938906.1 C7ORF36 Homo sapiens chromosome 7 open reading frame 36 (C7orf36), mRNA. NM_020192.1 7 3.342 Homo sapiens malignant fibrous histiocytoma amplified sequence 1 (MFHAS1), 3.301 MFHAS1 mRNA. NM_004225.1 8 Homo sapiens complement component 4 binding protein, beta (C4BPB), transcript 3.298 C4BPB variant 1, mRNA. NM_000716.3 1 MTG1 Homo sapiens mitochondrial GTPase 1 homolog (S. cerevisiae) (MTG1), mRNA. NM_138384.1 1 3.296 CGI-115 Homo sapiens CGI-115 protein (CGI-115), mRNA. NM_016052.2 1 3.264 ZNHIT2 Homo sapiens zinc finger, HIT type 2 (ZNHIT2), mRNA. NM_014205.2 11 3.204 GRWD1 Homo sapiens glutamate-rich WD repeat containing 1 (GRWD1), mRNA. NM_031485.2 19 3.184 LCMT2 Homo sapiens leucine carboxyl methyltransferase 2 (LCMT2), mRNA. NM_014793.3 15 3.147 GPATC3 Homo sapiens G patch domain containing 3 (GPATC3), mRNA. NM_022078.1 1 3.138 Homo sapiens tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 3.129 TRMU (TRMU), nuclear gene encoding mitochondrial protein, transcript variant 5, mRNA. NM_001008571.1 22 Homo sapiens piggyBac transposable element derived 2 (PGBD2), transcript variant 3.089 PGBD2 1, mRNA. NM_170725.2 1 KIAA0133 Homo sapiens KIAA0133 (KIAA0133), mRNA. NM_014777.1 1 3.064 LOC221710 PREDICTED: Homo sapiens hypothetical protein LOC221710 (LOC221710), mRNA. XM_927609.1 6 3.043 ALKBH8 Homo sapiens alkB, alkylation repair homolog 8 (E. coli) (ALKBH8), mRNA. NM_138775.1 11 3.036 FLJ20516 Homo sapiens timeless-interacting protein (FLJ20516), mRNA. NM_017858.1 15 3.027 MGC5242 Homo sapiens hypothetical protein MGC5242 (MGC5242), mRNA. NM_024033.1 7 3.018 Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.993 SERPINB8 (SERPINB8), transcript variant 3, mRNA. NM_001031848.1 18 C1ORF33 Homo sapiens chromosome 1 open reading frame 33 (C1orf33), mRNA. NM_016183.2 1 2.99 HSF2BP Homo sapiens heat shock transcription factor 2 binding protein (HSF2BP), mRNA. NM_007031.1 21 2.962 LOC644790 PREDICTED: Homo sapiens similar to ribosomal protein S15a (LOC644790), mRNA. XM_927887.1 1 2.91 P2RY11 Homo sapiens purinergic receptor P2Y, G-protein coupled, 11 (P2RY11), mRNA. NM_002566.4 19 2.9 KIAA0690 Homo sapiens KIAA0690 (KIAA0690), mRNA. NM_015179.2 1 2.888 TXNL1 Homo sapiens thioredoxin-like 1 (TXNL1), mRNA. NM_004786.1 18 2.879 DNAJC5 Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 5 (DNAJC5), mRNA. NM_025219.1 2 2.871 C17ORF32 Homo sapiens chromosome 17 open reading frame 32 (C17orf32), mRNA. NM_152464.1 17 2.85 BX111520 Soares placenta Nb2HP Homo sapiens cDNA clone IMAGp998L15208, 2.829 HS.16515 mRNA sequence BX111520 DLEU1 PREDICTED: Homo sapiens deleted in lymphocytic leukemia, 1 (DLEU1), misc RNA. XR_001515.1 13 2.82 KLHL18 Homo sapiens kelch-like 18 (Drosophila) (KLHL18), mRNA. NM_025010.2 3 2.815 MSTO1 Homo sapiens misato homolog 1 (Drosophila) (MSTO1), mRNA. NM_018116.2 1 2.781 Homo sapiens ribonuclease P/MRP 38kDa subunit (RPP38), transcript variant 1, 2.778 RPP38 mRNA. NM_183005.1 1 PINX1 Homo sapiens PIN2-interacting protein 1 (PINX1), mRNA. NM_017884.3 8 2.759 IRX5 Homo sapiens iroquois homeobox protein 5 (IRX5), mRNA. NM_005853.4 16 2.758 PREDICTED: Homo sapiens similar to paraspeckle protein 1, transcript variant 2 2.73 LOC642395 (LOC642395), mRNA. XM_930623.1 13 C12ORF45 Homo sapiens chromosome 12 open reading frame 45 (C12orf45), mRNA. NM_152318.1 12 2.724 TMEM79 Homo sapiens transmembrane protein 79 (TMEM79), mRNA. NM_032323.1 1 2.721 Homo sapiens ankyrin repeat and SOCS box-containing 7 (ASB7), transcript variant 2.712 ASB7 1, mRNA. NM_024708.2 15 C6ORF157 Homo sapiens chromosome 6 open reading frame 157 (C6orf157), mRNA. NM_198920.1 6 2.702 HS.535360 Homo sapiens cDNA clone IMAGE:6250506 BC080616 2.698 Homo sapiens RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) (RRS1), 2.695 RRS1 mRNA. NM_015169.3 8 MYL5 Homo sapiens myosin, light polypeptide 5, regulatory (MYL5), mRNA. NM_002477.1 4 2.688 ZC3H8 Homo sapiens zinc finger CCCH-type containing 8 (ZC3H8), mRNA. NM_032494.1 2 2.681 ANXA3 Homo sapiens annexin A3 (ANXA3), mRNA. NM_005139.1 4 2.672 C1ORF163 Homo sapiens chromosome 1 open reading frame 163 (C1orf163), mRNA. NM_023077.1 1 2.667 ZNF207 Homo sapiens zinc finger protein 207 (ZNF207), transcript variant 1, mRNA. NM_003457.2 17 2.667 ZNF232 Homo sapiens zinc finger protein 232 (ZNF232), mRNA. NM_014519.2 17 2.667 FLJ20309 Homo sapiens hypothetical protein FLJ20309 (FLJ20309), mRNA. NM_017759.2 2 2.643 EIF5A2 Homo sapiens eukaryotic translation initiation factor 5A2 (EIF5A2), mRNA. NM_020390.5 3 2.631 Homo sapiens M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 2.599 MPHOSPH10 (MPHOSPH10), mRNA. NM_005791.1 2 REP15 Homo sapiens Rab15 effector protein (REP15), mRNA. NM_001029874.1 12 2.599 C12ORF5 Homo sapiens chromosome 12 open reading frame 5 (C12orf5), mRNA.