Table SI. Phosphorylated proteins identified in rats with cancer-induced bone pain. Accession Description Microtubule-associated protein 1A OS=Rattus norvegicus GN=Map1a PE=1 P34926 SV=1 - [MAP1A_RAT] Microtubule-associated protein 1B OS=Rattus norvegicus GN=Map1b PE=1 F1LRL9 SV=1 - [F1LRL9_RAT] Microtubule-associated protein 1B OS=Rattus norvegicus GN=Map1b PE=1 P15205 SV=2 - [MAP1B_RAT] Neurofilament medium polypeptide OS=Rattus norvegicus GN=Nefm PE=1 G3V7S2 SV=3 - [G3V7S2_RAT] Microtubule associated protein 1A (Fragment) OS=Rattus norvegicus Q63330 GN=Map1a PE=2 SV=1 - [Q63330_RAT] 14-3-3 protein gamma OS=Rattus norvegicus GN=Ywhag PE=1 SV=2 - P61983 [1433G_RAT] Q62745 CD81 antigen OS=Rattus norvegicus GN=Cd81 PE=1 SV=1 - [CD81_RAT] A-kinase anchor protein 12 OS=Rattus norvegicus GN=Akap12 PE=1 SV=1 - Q5QD51 [AKA12_RAT] Erythrocyte membrane protein band 4.1-like 3 OS=Rattus norvegicus G3V874 GN=Epb41l3 PE=1 SV=1 - [G3V874_RAT] 60S acidic ribosomal protein P2 OS=Rattus norvegicus GN=Rplp2 PE=1 SV=2 - P02401 [RLA2_RAT] Gap junction gamma-2 protein OS=Rattus norvegicus GN=Gjc2 PE=1 SV=2 - Q80XF7 [CXG2_RAT] Prostaglandin E synthase 3 OS=Rattus norvegicus GN=Ptges3 PE=1 SV=2 - P83868 [TEBP_RAT] Adenosylhomocysteinase 2 OS=Rattus norvegicus GN=Ahcyl1 PE=1 SV=1 - A0A140TAI8 [A0A140TAI8_RAT] Uncharacterized protein OS=Rattus norvegicus PE=4 SV=1 - A0A0G2K4Q1 [A0A0G2K4Q1_RAT] F1LQN3 Reticulon OS=Rattus norvegicus GN=Rtn4 PE=1 SV=1 - [F1LQN3_RAT] Band 4.1-like protein 1 OS=Rattus norvegicus GN=Epb41l1 PE=1 SV=1 - A0A0G2K0F3 [A0A0G2K0F3_RAT] Q5HZA7 Bin1 protein OS=Rattus norvegicus GN=Bin1 PE=1 SV=1 - [Q5HZA7_RAT] Neurofilament heavy polypeptide OS=Rattus norvegicus GN=Nefh PE=1 SV=1 - F1LRZ7 [F1LRZ7_RAT] Neurofilament light polypeptide OS=Rattus norvegicus GN=Nefl PE=1 SV=3 - P19527 [NFL_RAT] F1M9N9 Ankyrin 2 OS=Rattus norvegicus GN=Ank2 PE=1 SV=3 - [F1M9N9_RAT] Neurofilament heavy polypeptide OS=Rattus norvegicus GN=Nefh PE=1 SV=4 - P16884 [NFH_RAT] Microtubule-associated protein OS=Rattus norvegicus GN=Map2 PE=1 SV=1 - A0A0U1RRX4 [A0A0U1RRX4_RAT] D3ZZ99 Alpha-adducin OS=Rattus norvegicus GN=Add1 PE=1 SV=3 - [D3ZZ99_RAT] Heat shock protein HSP 90-beta OS=Rattus norvegicus GN=Hsp90ab1 PE=1 P34058 SV=4 - [HS90B_RAT] Calcium/calmodulin-dependent protein kinase type II subunit beta OS=Rattus F1LNI8 norvegicus GN=Camk2b PE=1 SV=1 - [F1LNI8_RAT] Myelin basic protein OS=Rattus norvegicus GN=Mbp PE=1 SV=3 - P02688 [MBP_RAT] Eukaryotic translation initiation factor 3 subunit B OS=Rattus norvegicus Q4G061 GN=Eif3b PE=1 SV=1 - [EIF3B_RAT] P07936 Neuromodulin OS=Rattus norvegicus GN=Gap43 PE=1 SV=1 - [NEUM_RAT] F8WFS9 Beta-adducin OS=Rattus norvegicus GN=Add2 PE=1 SV=1 - [F8WFS9_RAT] SH3-containing GRB2-like protein 3-interacting protein 1 OS=Rattus norvegicus F1M1Y0 GN=Sgip1 PE=1 SV=3 - [F1M1Y0_RAT] 28 kDa heat- and acid-stable phosphoprotein OS=Rattus norvegicus GN=Pdap1 Q62785 PE=1 SV=1 - [HAP28_RAT] D4A559 Dematin actin-binding protein OS=Rattus norvegicus GN=Dmtn PE=1 SV=1 - [D4A559_RAT] F1MA86 Gephyrin OS=Rattus norvegicus GN=Gphn PE=1 SV=3 - [F1MA86_RAT] Actin, cytoplasmic 1 OS=Rattus norvegicus GN=Actb PE=1 SV=1 - P60711 [ACTB_RAT] Thioredoxin domain containing 1 OS=Rattus norvegicus GN=Tmx1 PE=1 SV=1 Q52KJ9 - [Q52KJ9_RAT] Microtubule-associated protein OS=Rattus norvegicus GN=Mapt PE=1 SV=1 - D4A1Q2 [D4A1Q2_RAT] Serine and arginine repetitive matrix 1 OS=Rattus norvegicus GN=Srrm1 PE=1 B2RYB3 SV=1 - [B2RYB3_RAT] NAC alpha domain-containing OS=Rattus norvegicus GN=Nacad PE=1 SV=2 - F1M6E5 [F1M6E5_RAT] Transcriptional activator protein Pur-beta OS=Rattus norvegicus GN=Purb PE=1 Q68A21 SV=3 - [PURB_RAT] Transcriptional activator protein Pur-beta OS=Rattus norvegicus GN=Purb PE=1 A0A0G2JUX5 SV=1 - [A0A0G2JUX5_RAT] Myosin, heavy polypeptide 10, non-muscle, isoform CRA_b OS=Rattus G3V9Y1 norvegicus GN=Myh10 PE=1 SV=1 - [G3V9Y1_RAT] 60S acidic ribosomal protein P0 OS=Rattus norvegicus GN=Rplp0 PE=1 SV=2 - P19945 [RLA0_RAT] P35565 Calnexin OS=Rattus norvegicus GN=Canx PE=1 SV=1 - [CALX_RAT] Eukaryotic translation initiation factor 4B OS=Rattus norvegicus GN=Eif4b Q5RKG9 PE=1 SV=1 - [Q5RKG9_RAT] Sodium/potassium-transporting ATPase subunit alpha-3 OS=Rattus norvegicus P06687 GN=Atp1a3 PE=1 SV=2 - [AT1A3_RAT] Q9JKS6 Protein piccolo OS=Rattus norvegicus GN=Pclo PE=1 SV=1 - [PCLO_RAT] Protein phosphatase inhibitor 2 OS=Rattus norvegicus GN=Ppp1r2 PE=1 SV=1 - A0A0H2UHA0 [A0A0H2UHA0_RAT] D4A8B3 Calcium-transporting ATPase OS=Rattus norvegicus GN=Atp2b2 PE=1 SV=3 - [D4A8B3_RAT] Synaptic vesicle glycoprotein 2A OS=Rattus norvegicus GN=Sv2a PE=1 SV=2 - Q02563 [SV2A_RAT] Sptbn1 protein (Fragment) OS=Rattus norvegicus GN=Sptbn1 PE=2 SV=1 - Q5D002 [Q5D002_RAT] NAD-dependent protein deacetylase sirtuin-2 OS=Rattus norvegicus GN=Sirt2 A0A0G2JWM2 PE=1 SV=1 - [A0A0G2JWM2_RAT] F1M3W5 Dmx-like 2 OS=Rattus norvegicus GN=Dmxl2 PE=1 SV=3 - [F1M3W5_RAT] F1LPB9 Rabphilin-3A OS=Rattus norvegicus GN=Rph3a PE=1 SV=1 - [F1LPB9_RAT] Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Rattus A2VD12 norvegicus GN=Pbxip1 PE=1 SV=1 - [PBIP1_RAT] Electrogenic sodium bicarbonate cotransporter 1 OS=Rattus norvegicus Q9JI66 GN=Slc4a4 PE=1 SV=1 - [S4A4_RAT] High mobility group protein HMG-I/HMG-Y OS=Rattus norvegicus GN=Hmga1 Q8K585 PE=1 SV=3 - [HMGA1_RAT] Synapsin-3 OS=Rattus norvegicus GN=Syn3 PE=1 SV=2 - A0A096MIT7 [A0A096MIT7_RAT] 14-3-3 protein epsilon OS=Rattus norvegicus GN=Ywhae PE=1 SV=1 - P62260 [1433E_RAT] Putative uncharacterized protein RGD1307615_predicted OS=Rattus norvegicus D3ZKQ4 GN=Rabl6 PE=1 SV=1 - [D3ZKQ4_RAT] Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Rattus norvegicus Q9JJ19 GN=Slc9a3r1 PE=1 SV=3 - [NHRF1_RAT] Sodium/potassium-transporting ATPase subunit alpha-2 OS=Rattus norvegicus P06686 GN=Atp1a2 PE=1 SV=1 - [AT1A2_RAT] RCG25591, isoform CRA_a OS=Rattus norvegicus GN=Stt3b PE=1 SV=1 - B2RYD7 [B2RYD7_RAT] Serine/arginine repetitive matrix 2 OS=Rattus norvegicus GN=Srrm2 PE=1 A0A0G2K2M9 SV=1 - [A0A0G2K2M9_RAT] Protein transport protein Sec31A OS=Rattus norvegicus GN=Sec31a PE=1 SV=1 A0A0G2K0X9 - [A0A0G2K0X9_RAT] Sodium/potassium-transporting ATPase subunit alpha-1 OS=Rattus norvegicus P06685 GN=Atp1a1 PE=1 SV=1 - [AT1A1_RAT] Elongation factor 1-delta OS=Rattus norvegicus GN=Eef1d PE=1 SV=2 - Q68FR9 [EF1D_RAT] 2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Rattus norvegicus GN=Cnp P13233 PE=1 SV=2 - [CN37_RAT] 2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Rattus norvegicus GN=Cnp A0A097BVJ5 PE=2 SV=1 - [A0A097BVJ5_RAT] Tubulin alpha-1A chain OS=Rattus norvegicus GN=Tuba1a PE=1 SV=1 - P68370 [TBA1A_RAT] Q6IN33 Calcipressin-1 OS=Rattus norvegicus GN=Rcan1 PE=2 SV=1 - [RCAN1_RAT] Myristoylated alanine-rich C-kinase substrate OS=Rattus norvegicus F1LMW7 GN=Marcks PE=1 SV=3 - [F1LMW7_RAT] Microtubule-associated protein 4 OS=Rattus norvegicus GN=Map4 PE=1 SV=1 Q5M7W5 - [MAP4_RAT] Hepatoma-derived growth factor-related protein 2 OS=Rattus norvegicus Q925G1 GN=Hdgfrp2 PE=1 SV=2 - [HDGR2_RAT] Eukaryotic translation initiation factor 5B OS=Rattus norvegicus GN=Eif5b A0A0H2UHV4 PE=1 SV=1 - [A0A0H2UHV4_RAT] START domain containing 10, isoform CRA_b OS=Rattus norvegicus Q5BJN1 GN=Stard10 PE=1 SV=1 - [Q5BJN1_RAT] Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 F1LRY7 OS=Rattus norvegicus GN=Hcn2 PE=1 SV=3 - [F1LRY7_RAT] Proteasome subunit alpha type-3 OS=Rattus norvegicus GN=Psma3 PE=1 SV=3 P18422 - [PSA3_RAT] Myosin XVIIIa OS=Rattus norvegicus GN=Myo18a PE=1 SV=2 - D3ZFD0 [D3ZFD0_RAT] Q6RJR6 Reticulon-3 OS=Rattus norvegicus GN=Rtn3 PE=1 SV=1 - [RTN3_RAT] A0A096MJN4 Septin 4 OS=Rattus norvegicus GN=Sept4 PE=1 SV=1 - [A0A096MJN4_RAT] Breast carcinoma-amplified sequence 1 homolog (Fragment) OS=Rattus Q3ZB98 norvegicus GN=Bcas1 PE=1 SV=2 - [BCAS1_RAT] Breast carcinoma-amplified sequence 1 homolog OS=Rattus norvegicus A0A0G2K079 GN=Bcas1 PE=1 SV=1 - [A0A0G2K079_RAT] Heterogeneous nuclear ribonucleoprotein L-like OS=Rattus norvegicus D4A3E1 GN=Hnrnpll PE=1 SV=1 - [D4A3E1_RAT] Oxysterol-binding protein OS=Rattus norvegicus GN=Osbp PE=1 SV=2 - D4A9D8 [D4A9D8_RAT] Creatine kinase B-type OS=Rattus norvegicus GN=Ckb PE=1 SV=2 - P07335 [KCRB_RAT] Calcium-dependent secretion activator 1 OS=Rattus norvegicus GN=Cadps PE=1 Q62717 SV=1 - [CAPS1_RAT] G3V7X2 Scg2 protein OS=Rattus norvegicus GN=Scg2 PE=1 SV=2 - [G3V7X2_RAT] Tumor protein D54 OS=Rattus norvegicus GN=Tpd52l2 PE=1 SV=1 - Q6PCT3 [TPD54_RAT] Phosphatidylinositol 4-kinase type 2-alpha OS=Rattus norvegicus GN=Pi4k2a Q99M64 PE=1 SV=1 - [P4K2A_RAT] Uncharacterized protein OS=Rattus norvegicus GN=Hepacam PE=1 SV=2 - D3ZEI4 [D3ZEI4_RAT] F-box only protein 6 OS=Rattus norvegicus GN=Fbxo6 PE=1 SV=1 - Q923V4 [FBX6_RAT] Rap1gap protein (Fragment) OS=Rattus norvegicus GN=Rap1gap PE=2 SV=1 - Q5EB70 [Q5EB70_RAT] Clathrin heavy chain OS=Rattus norvegicus GN=Cltc PE=1 SV=1 - F1M779 [F1M779_RAT] Tight junction protein 2 OS=Rattus norvegicus GN=Tjp2 PE=1 SV=1 - Q3ZB99 [Q3ZB99_RAT] Amphiphysin-like OS=Rattus norvegicus GN=LOC100910792 PE=1 SV=1 - A0A0G2K5Z4 [A0A0G2K5Z4_RAT] Similar to 25 kDa brain-specific protein (P25-alpha) (Predicted), isoform CRA_a D3ZQL7 OS=Rattus norvegicus GN=Tppp PE=1 SV=1 - [D3ZQL7_RAT] Protein NDRG3 OS=Rattus norvegicus GN=Ndrg3 PE=1 SV=3 - D4ACZ5 [D4ACZ5_RAT] Actin-binding LIM protein 2 OS=Rattus norvegicus GN=Ablim2 PE=1 SV=1 - A0A0H2UHF9 [A0A0H2UHF9_RAT] Tripartite motif-containing protein 2 OS=Rattus norvegicus GN=Trim2 PE=1 A0A0G2K2M8 SV=1 - [A0A0G2K2M8_RAT] Glial fibrillary acidic protein OS=Rattus norvegicus GN=Gfap PE=1 SV=2 - P47819 [GFAP_RAT]