Arthritis & Rheumatism Volume 56, Issue 4, Pages 1037-1370 (April 2007) ACR Presidential Address Mentors and heroes: The foundation and future of rheumatology (p 1037-1043) Mary K. Crow Published Online: 28 Mar 2007 DOI: 10.1002/art.22503 Editorials The role of varus and valgus alignment in knee osteoarthritis (p 1044-1047) Leena Sharma Published Online: 28 Mar 2007 DOI: 10.1002/art.22514 Estrogens and lupus: Bubbling cauldron or another overrated Witches' Brew? (p 1048-1050) Michael D. Lockshin, Jill P. Buyon Published Online: 28 Mar 2007 DOI: 10.1002/art.22631 Review Psoriatic arthritis: Current concepts on pathogenesis-oriented therapeutic options (p 1051-1066) Anthony M. Turkiewicz, Larry W. Moreland Published Online: 28 Mar 2007 DOI: 10.1002/art.22489 Research Articles Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against fas-induced apoptosis (p 1067-1075) Shinya Hayashi, Yasushi Miura, Takayuki Nishiyama, Makoto Mitani, Koji Tateishi, Yoshitada Sakai, Akira Hashiramoto, Masahiro Kurosaka, Shunichi Shiozawa, Minoru Doita Published Online: 28 Mar 2007 DOI: 10.1002/art.22494 Up-regulation of stromal cell-derived factor 1 (CXCL12) production in rheumatoid synovial fibroblasts through interactions with T lymphocytes: Role of interleukin-17 and CD40L-CD40 interaction (p 1076-1086) Kyoung-Woon Kim, Mi-La Cho, Hae-Rim Kim, Ji-Hyeon Ju, Mi-Kyung Park, Hye-Jwa Oh, Joon-Seok Kim, Sung- Hwan Park, Sang-Heon Lee, Ho-Youn Kim Published Online: 28 Mar 2007 DOI: 10.1002/art.22439 Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients (p 1087-1093) Lars C. Huber, Matthias Brock, Hossein Hemmatazad, Olivier T. Giger, Falk Moritz, Michelle Trenkmann, Jörg H. W. Distler, Renate E. Gay, Christoph Kolling, Holger Moch, Beat A. Michel, Steffen Gay, Oliver Distler, Astrid Jüngel Published Online: 28 Mar 2007 DOI: 10.1002/art.22512 Analysis of vascular gene expression in arthritic synovium by laser-mediated microdissection (p 1094- 1105) Atsushi Hashimoto, Ingo H. Tarner, Rainer M. Bohle, Andreas Gaumann, Mirko Manetti, Oliver Distler, Jürgen Steinmeyer, Ann-Kristin Ulfgren, Andreas Schulz, Steffen Gay, Ulf Müller-Ladner, Elena Neumann Published Online: 28 Mar 2007 DOI: 10.1002/art.22450 Light up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes (p 1106-1117) Young Mo Kang, So Young Kim, Jin Hee Kang, Seung Woo Han, Eon Jeong Nam, Hee Soo Kyung, Jae Yong Park, In San Kim Published Online: 28 Mar 2007 DOI: 10.1002/art.22493 Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis (p 1118-1124) Esther Jimenez-Boj, Iris Nöbauer-Huhmann, Beatrice Hanslik-Schnabel, Ronald Dorotka, Axel-Hugo Wanivenhaus, Franz Kainberger, Siegfried Trattnig, Roland Axmann, Wayne Tsuji, Sonja Hermann, Josef Smolen, Georg Schett Published Online: 28 Mar 2007 DOI: 10.1002/art.22496 Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor antagonists (p 1125-1133) Jeffrey R. Curtis, Nivedita Patkar, Aiyuan Xie, Carolyn Martin, Jeroan J. Allison, Michael Saag, Deborah Shatin, Kenneth G. Saag Published Online: 28 Mar 2007 DOI: 10.1002/art.22504 Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sjögren's syndrome (p 1134-1144) Capucine Daridon, Valérie Devauchelle, Pascal Hutin, Rozenn Le Berre, Christine Martins-Carvalho, Boutahar Bendaoud, Maryvonne Dueymes, Alain Saraux, Pierre Youinou, Jacques-Olivier Pers Published Online: 28 Mar 2007 DOI: 10.1002/art.22458 Interferon- regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17 (p 1145-1151) Cong-Qiu Chu, David Swart, Dina Alcorn, Joel Tocker, Keith B. Elkon Published Online: 28 Mar 2007 DOI: 10.1002/art.22453 Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis (p 1152-1163) Deborah A. Young, Martin Hegen, Hak Ling Margery Ma, Matthew J. Whitters, Leo M. Albert, Leslie Lowe, Mayra Senices, Paul W. Wu, Barbara Sibley, Yelena Leathurby, Tom P. Brown, Cheryl Nickerson-Nutter, James C. Keith Jr., Mary Collins Published Online: 28 Mar 2007 DOI: 10.1002/art.22452 A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti- tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis (p 1164-1174) Hiroaki Saito, Takefumi Kojima, Mariko Takahashi, William C. Horne, Roland Baron, Teruo Amagasa, Keiichi Ohya, Kazuhiro Aoki Published Online: 28 Mar 2007 DOI: 10.1002/art.22495 Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen- induced arthritis (p 1175-1186) Andrea Augello, Roberta Tasso, Simone Maria Negrini, Ranieri Cancedda, Giuseppina Pennesi Published Online: 28 Mar 2007 DOI: 10.1002/art.22511 Selective therapeutic control of C5a and the terminal complement complex by anti-C5 single-chain Fv in an experimental model of antigen-induced arthritis in rats (p 1187-1197) Fabio Fischetti, Paolo Durigutto, Paolo Macor, Roberto Marzari, Renzo Carretta, Francesco Tedesco Published Online: 28 Mar 2007 DOI: 10.1002/art.22492 A randomized crossover trial of a wedged insole for treatment of knee osteoarthritis (p 1198-1203) Kristin Baker, Joyce Goggins, Hui Xie, Karen Szumowski, Michael LaValley, David J. Hunter, David T. Felson Published Online: 28 Mar 2007 DOI: 10.1002/art.22516 Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee (p 1204-1211) G. M. Brouwer, A. W. Van Tol, A. P. Bergink, J. N. Belo, R. M. D. Bernsen, M. Reijman, H. A. P. Pols, S. M. A. Bierma-Zeinstra Published Online: 28 Mar 2007 DOI: 10.1002/art.22515 Knee alignment does not predict incident osteoarthritis: The Framingham osteoarthritis study (p 1212- 1218) David J. Hunter, Jingbo Niu, David T. Felson, William F. Harvey, K. Douglas Gross, Paula McCree, Piran Aliabadi, Burton Sack, Yuqing Zhang Published Online: 28 Mar 2007 DOI: 10.1002/art.22508 Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model (p 1219-1233) Jun-Qi Yang, Xiangshu Wen, Hongzhu Liu, Gbolahan Folayan, Xin Dong, Min Zhou, Luc Van Kaer, Ram Raj Singh Published Online: 28 Mar 2007 DOI: 10.1002/art.22490 Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus (p 1234-1241) Sergey V. Kozyrev, Susanna Lewén, Prasad M. V. Linga Reddy, Bernardo Pons-Estel, Argentine Collaborative Group, Torsten Witte, German Collaborative Group, Peter Junker, Helle Laustrup, Carmen Gutiérrez, Ana Suárez, Maria Francisca González-Escribano, Javier Mart ´n, Spanish Collaborative Group, Marta E. Alarcón-Riquelme Published Online: 28 Mar 2007 DOI: 10.1002/art.22497 Interleukin-6 and chemokines in the neuropsychiatric manifestations of systemic lupus erythematosus (p 1242-1250) H. Fragoso-Loyo, Y. Richaud-Patin, A. Orozco-Narváez, L. Dávila-Maldonado, Y. Atisha-Fregoso, L. Llorente, J. Sánchez-Guerrero Published Online: 28 Mar 2007 DOI: 10.1002/art.22451 Reproductive and menopausal factors and risk of systemic lupus erythematosus in women (p 1251-1262) Karen H. Costenbader, Diane Feskanich, Meir J. Stampfer, Elizabeth W. Karlson Published Online: 28 Mar 2007 DOI: 10.1002/art.22510 Histopathologic and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis (p 1263-1272) Iva Gunnarsson, Birgitta Sundelin, Thorunn Jónsdóttir, Stefan H. Jacobson, Elisabet Welin Henriksson, Ronald F. van Vollenhoven Published Online: 28 Mar 2007 DOI: 10.1002/art.22505 The clinical continuum of cryopyrinopathies: Novel CIAS1 mutations in North American patients and a new cryopyrin model (p 1273-1285) Ivona Aksentijevich, Christopher D. Putnam, Elaine F. Remmers, James L. Mueller, Julie Le, Richard D. Kolodner, Zachary Moak, Michael Chuang, Frances Austin, Raphaela Goldbach-Mansky, Hal M. Hoffman, Daniel L. Kastner Published Online: 28 Mar 2007 DOI: 10.1002/art.22491 Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis (p 1286-1291) Rebecca Lamb, Wendy Thomson, British Society of Paediatric and Adolescent Rheumatology, Emma M. Ogilvie, Rachelle Donn Published Online: 28 Mar 2007 DOI: 10.1002/art.22444 Interstitial pneumonitis in Blau syndrome with documented mutation in CARD15 (p 1292-1294) Mara L. Becker, Tammy M. Martin, Trudy M. Doyle, Carlos D. Rosé Published Online: 28 Mar 2007 DOI: 10.1002/art.22509 Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase (p 1295-1303) Michito Hirakata, Akira Suwa, Tetsuya Takada, Shinji Sato, Sonoko Nagai, Ekkehard Genth, Yeong W. Song, Tsuneyo Mimori, Ira N. Targoff Published Online: 28 Mar 2007 DOI: 10.1002/art.22506 A new murine model to define the critical pathologic and therapeutic mediators of polymyositis (p 1304- 1314) Takahiko Sugihara, Chiyoko Sekine, Takashi Nakae, Kuniko Kohyama, Masayoshi Harigai, Yoichiro Iwakura, Yoh Matsumoto, Nobuyuki Miyasaka, Hitoshi Kohsaka Published Online: 29 Mar 2007 DOI: 10.1002/art.22521 Role of matrix metalloproteinases, proinflammatory cytokines, and oxidative