Published OnlineFirst September 11, 2012; DOI: 10.1158/1078-0432.CCR-12-2891 2012_AACR_CPR_Text_2.0_Layout 1 10/20/12 4:27 AM Page 1 Clinical Cancer Research The Journal of Clinical and Translational Research AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day Please cite this report as: American Association for Cancer Research. AACR cancer progress report 2012. Clin Cancer Res 2012;18(Supplement 1):S1–S100 Downloaded from clincancerres.aacrjournals.org on October 1, 2021. © 2012 American Association for Cancer Research. Published OnlineFirst September 11, 2012; DOI: 10.1158/1078-0432.CCR-12-2891 2012_AACR_CPR_Text_2.0_Layout 1 10/20/12 4:27 AM Page 2 Table of Contents AACR Cancer Progress Report Writing Committee ..............................................................................................................................................................S4 Message From the AACR.......................................................................................................................................................................................................S6 An Appeal from Cancer Survivors and Their Loved Ones....................................................................................................................................................S8 Executive Summary ............................................................................................................................................................................................................S10 A Snapshot of a Year of Progress .......................................................................................................................................................................................S13 The Status of Cancer in 2012..............................................................................................................................................................................................S14 Why Cancer Research? .......................................................................................................................................................................................................S19 Cancer Research: From Concept to Patient and Back Again ...................................................................................................................................S21 Experimental Models of Cancer...........................................................................................................................................................................S22 Probing Cancer Models: Generating and Testing Ideas.........................................................................................................................................S23 Moving Cancer Research into the Clinic ..............................................................................................................................................................S24 Clinical Outcomes Go Back to the Laboratory......................................................................................................................................................S25 Prevention and Early Detection ..........................................................................................................................................................................................S28 To Know Your Risk, Know the Causes of Cancer ......................................................................................................................................................S28 Causes of Cancer You Could Avoid ......................................................................................................................................................................S28 Tobacco Use and Cancer: Smoking-Gun Evidence.....................................................................................................................................S28 Obesity and Physical Inactivity Weigh in on Cancer ...................................................................................................................................S29 Ultraviolet Light: Reflecting on a Cause of Cancer......................................................................................................................................S31 Infectious Agents: Catching a Cause of Cancer..........................................................................................................................................S33 Diet and Cancer: You Are What You Eat and Drink ......................................................................................................................................S36 Causes of Cancer That Are Hard to Avoid ............................................................................................................................................................S36 Ionizing Radiation: Energizing Cancer........................................................................................................................................................S36 Environmental Pollutants: A Murky Link to Cancer.....................................................................................................................................S37 Hormones: A Natural Boost to Cancer........................................................................................................................................................S38 Inheritable Causes of Cancer ..............................................................................................................................................................................S39 Inherited Risk: It’s in Your Genes ...............................................................................................................................................................S39 Cancer Predisposing Medical Conditions...................................................................................................................................................S41 Stratifying Risk to Improve Health Care for Everyone..............................................................................................................................................S41 Reducing Risk ............................................................................................................................................................................................................S43 Screening to Spot Cancer Early...........................................................................................................................................................................S43 Medical Intervention: Taking Action Early to Prevent the Onset of Cancer.............................................................................................................S45 Making Research Count for Patients..................................................................................................................................................................................S46 A New Day for Our Current Knowledge.....................................................................................................................................................................S46 A New Day for Old Targets ..................................................................................................................................................................................S47 S2 Clinical Cancer Research Downloaded from clincancerres.aacrjournals.org on October 1, 2021. © 2012 American Association for Cancer Research. Published OnlineFirst September 11, 2012; DOI: 10.1158/1078-0432.CCR-12-2891 2012_AACR_CPR_Text_2.0_Layout 1 10/20/12 4:27 AM Page 3 Two New Ways to Hit a Breast Cancer Target.............................................................................................................................................S47 What to Do When One of the Most Effective Molecularly Targeted Drugs Doesn’t Work..............................................................................S49 Refining Drug Potency and Specificity .......................................................................................................................................................S50 Improving Patient Quality of Life by Reducing Side Effects.........................................................................................................................S51 A New Day for Existing Drugs .............................................................................................................................................................................S53 A New Day for Anti-hormone Therapy ......................................................................................................................................................................S54 A New Day for Targeted Therapy...............................................................................................................................................................................S58 A New Day for Immunotherapy .................................................................................................................................................................................S61 Targeting the Immune System to Release Its Brakes...........................................................................................................................................S61 Targeting