FOLR2 Antibody Cat. No.: 61-763 FOLR2 Antibody Western blot analysis of lysates from MDA-MB-453 cell line, Western blot analysis of lysate from human placenta human placenta tissue lysate (from left to right), using FOLR2 tissue lysate, using FOLR2 Antibody at 1:1000. Antibody at 1:1000 at each lane. Western blot analysis of lysates from KG-1, MCF-7, Western blot analysis of lysate from human placenta tissue MDA-MB-453 cell line (from left to right), using FOLR2 lysate, using FOLR2 Antibody at 1:1000. Antibody at 1:1000 at each lane. September 28, 2021 1 https://www.prosci-inc.com/folr2-antibody-61-763.html FOLR2 Antibody IHC analysis in formalin fixed and Western blot analysis of lysate from mouse heart tissue lysate, paraffin embedded human spleen followed by using FOLR2 Antibody at 1:1000. peroxidase conjugation of the secondary antibody and DAB staining. Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human, Mouse This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 18-46 amino acids from the N-terminal region of human FOLR2. TESTED APPLICATIONS: Flow, IHC-P, WB For WB starting dilution is: 1:1000 APPLICATIONS: For IHC-P starting dilution is: 1:10~50 PREDICTED MOLECULAR 29 kDa WEIGHT: Properties This antibody is purified through a protein A column, followed by peptide affinity PURIFICATION: purification. CLONALITY: Polyclonal ISOTYPE: Rabbit Ig CONJUGATE: Unconjugated PHYSICAL STATE: Liquid BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide. CONCENTRATION: batch dependent Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. September 28, 2021 2 https://www.prosci-inc.com/folr2-antibody-61-763.html Additional Info OFFICIAL SYMBOL: FOLR2 Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental ALTERNATE NAMES: folate-binding protein, FBP, FOLR2 ACCESSION NO.: P14207 PROTEIN GI NO.: 116241366 GENE ID: 2350 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5- methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence BACKGROUND: homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. 1) Puig-Kroger, A., et al. Cancer Res. 69(24):9395-9403(2009) Boyles, A.L., et al. Genet. REFERENCES: Epidemiol. 33(3):247-255(2009) Franke, B., et al. Birth Defects Res. PartClin. Mol. Teratol. 85(3):216-226(2009) ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 28, 2021 3 https://www.prosci-inc.com/folr2-antibody-61-763.html.