TABLE S4 "ID ""Description"" ""GeneRatio"" ""BgRatio"" ""pvalue"" ""p.adjust"" ""qvalue"" ""geneID"" ""Count""" "GO:0003712 ""GO:0003712"" ""transcription coregulator activity"" ""84/1859"" ""454/22744"" 9.49597175224444e-13 9.80933882006851e-10 8.20651874588704e-10 ""Ncoa2/Zfp451/Dhx9/Hnrnpu/Cited2/Ncoa7/Ccar1/ Sirt1/Arid5b/Sirt6/Med1/Rara/Atxn7l3/Ddx5/Wbp2/Hdac9/Zmynd11/Cdyl/ Mier3/Sfmbt1/Gata4/Med4/Basp1/Zfpm2/Zhx2/Ddx17/Mkl2/Hes1/Nrip1/Usp16/ Elob/Rrp1b/Rxrb/Kat2b/Mta3/Hsbp1l1/Tle4/Sfr1/Eid1/Cops2/Sox12/Raly/ Ncoa6/Rbm39/Lpin3/Skil/Jade1/Maml3/Supt20/Med12l/Hdgf/Glmp/Nfib/Jun/ Pex14/Rere/Psmd9/Ncor2/Trim24/Ruvbl1/Rybp/Bhlhe40/Atf7ip/Ube3a/Mef2a/ Nrg1/Rbpms/Cnot7/Sin3b/Pou4f2/Pkn1/Cdyl2/Taf5l/Irf2bp2/Birc2/Yap1/ Skor1/Tfdp2/Rad54l2/Ctnnb1/Limd1/Med14/Rap2c/Tbl1x"" 84" "GO:0003779 ""GO:0003779"" ""actin binding"" ""65/1859"" ""414/22744"" 2.57546466939442e-07 8.86818334494813e-05 7.41914559148359e-05 ""Actr3/Cxcr4/Hnrnpu/Enah/Utrn/Epb41l2/Marcks/Ctnna3/Eef2/Pawr/ Ccdc88a/Anxa6/Gas7/Lasp1/Tns4/Syne2/Sipa1l1/Syne3/Phactr1/Enc1/Pxk/ Vcl/Ang/Myo10/Mtss1/Triobp/Mkl2/Afdn/Daam2/Svil/Ctnna1/Synpo/Myo5b/ Nrap/Ablim1/Shtn1/Fmnl2/Itprid2/Ino80/Pfn2/Myoz2/Pdlim5/Cap1/Macf1/ Epb41/Wasf2/Myom3/Ywhah/Coro1c/Ssh1/Hip1/Ppp1r9a/Wasl/Ctnna2/Mical3/ Eps8/Tlnrd1/Myom2/Klhl2/Sntb2/Spire2/Coro2b/Clasp2/Hdac6/Diaph2"" 65" "GO:0046332 ""GO:0046332"" ""SMAD binding"" ""22/1859"" ""84/22744"" 6.87941766027971e-07 0.000177660961076723 0.000148631628923412 ""Bmpr2/Cited2/Usp15/Ddx5/Axin2/Ppm1a/Yy1/Gata4/Tgif1/Ldlrad4/Smad7/ Acvr2a/Pmepa1/Skil/Trim33/Jun/Mef2a/Ipo7/Skor1/Rnf111/Tcf12/Ctnnb1"" 22" "GO:0031267 ""GO:0031267"" ""small GTPase binding"" ""62/1859"" ""417/22744"" 3.11342792596968e-06 0.000469948990889291 0.000393160566077452 ""Tbc1d8/Rab3gap1/Tbc1d30/Xpo1/Tbc1d9b/Rapgef6/ Rab34/Itsn2/Rhobtb3/Ipo11/Vcl/Slmap/Arhgef3/Ipo5/Trio/Cdc42ep1/Nup50/ Kalrn/Tiam1/Afdn/Lsm2/Xpo5/Daam2/Sos1/Myo5b/Pard6g/Rab11fip2/Noxa1/ Pkn3/Fmnl2/Rapgef4/Nckap1/Pak7/Kif3b/Pkn2/Rabggtb/Rusc2/Plekhg5/ Rasgef1b/Coro1c/Rph3a/Rilpl2/Srgap3/Brk1/Eps8/Arhgef1/Plekhg2/Pak4/ Akap13/Picalm/Arhgef17/St5/Ipo7/Sbf2/Pkn1/Prkaca/Exoc8/Sorl1/Rasgrf1/ Tbc1d2b/Diaph2/Pak3"" 62" "GO:0017048 ""GO:0017048"" ""Rho GTPase binding"" ""32/1859"" ""165/22744"" 3.62244732849325e-06 0.000469948990889291 0.000393160566077452 ""Itsn2/Vcl/Slmap/Arhgef3/Trio/Cdc42ep1/Kalrn/ Tiam1/Daam2/Sos1/Pard6g/Noxa1/Pkn3/Fmnl2/Nckap1/Pak7/Kif3b/Pkn2/ Plekhg5/Coro1c/Srgap3/Brk1/Eps8/Arhgef1/Plekhg2/Pak4/Akap13/Arhgef17/ Pkn1/Rasgrf1/Diaph2/Pak3"" 32" "GO:0017016 ""GO:0017016"" ""Ras GTPase binding"" ""60/1859"" ""401/22744"" 3.63948879681929e-06 0.000469948990889291 0.000393160566077452 ""Tbc1d8/Rab3gap1/Tbc1d30/Xpo1/Tbc1d9b/Rapgef6/ Rab34/Itsn2/Rhobtb3/Ipo11/Vcl/Slmap/Arhgef3/Ipo5/Trio/Cdc42ep1/Nup50/ Kalrn/Tiam1/Afdn/Lsm2/Xpo5/Daam2/Sos1/Myo5b/Pard6g/Rab11fip2/Noxa1/ Pkn3/Fmnl2/Rapgef4/Nckap1/Pak7/Kif3b/Pkn2/Rabggtb/Rusc2/Plekhg5/ Rasgef1b/Coro1c/Rph3a/Srgap3/Brk1/Eps8/Arhgef1/Plekhg2/Pak4/Akap13/ Picalm/Arhgef17/St5/Ipo7/Sbf2/Pkn1/Prkaca/Exoc8/Rasgrf1/Tbc1d2b/ Diaph2/Pak3"" 60" "GO:0004721 ""GO:0004721"" ""phosphoprotein phosphatase activity"" ""32/1859"" ""172/22744"" 8.97168940090085e-06 0.00102975057234784 0.000861492046566035 ""Ctdsp1/Epm2a/Ptprk/Pald1/Dusp6/Ptprq/Ppp1r12a/ Ptprb/Mtmr4/Ppm1a/Ppp2r2a/Tab1/Pp2d1/Ptprm/Dusp2/Ptpn1/Ppm1l/Ppa2/ Ppp3ca/Ppp3r2/Ptprd/Ptp4a2/Eya3/Ssu72/Ptpn13/Ssh1/Ptpn11/Ppp1r3a/ Phlpp2/Mtmr2/Ppm1m/Ppp2r3d"" 32" "GO:0043548 ""GO:0043548"" ""phosphatidylinositol 3-kinase binding"" ""13/1859"" ""41/22744"" 1.38908749934616e-05 0.0013044794425678 0.00109133094446239 ""Fyn/Pik3ip1/Calm1/Pik3r1/Fam83a/Calm2/Atp1a1/ Ptpn13/Flt3/Calm3/Axl/Igf1r/Insr"" 13" "GO:0070403 ""GO:0070403"" ""NAD+ binding"" ""7/1859"" ""14/22744"" 4.94299474555058e-05 0.00346952737880982 0.00290261576196348 ""Uxs1/ Sirt1/Sirt6/Cryl1/Hadh/Sirt4/Hpgd"" 7" "GO:0042826 ""GO:0042826"" ""histone deacetylase binding"" ""24/1859"" ""123/22744"" 5.15816053492247e-05 0.00346952737880982 0.00290261576196348 ""Hdac2/Rara/Kpna2/Hdac9/Brms1l/Yy1/Mef2c/Mier3/ Sp1/Cbx5/Hes1/Nrip1/Hsp90ab1/Kat2b/Mta3/Dhx36/Pkn2/Klf4/Rbbp4/Hnrnpd/ Ncor2/Mef2a/Pkn1/Hdac6"" 24" "GO:0018024 ""GO:0018024"" ""histone-lysine N-methyltransferase activity"" ""12/1859"" ""40/22744"" 5.50010389344655e-05 0.00346952737880982 0.00290261576196348 ""Rbbp5/Smyd3/Suz12/Prdm6/ Kmt5b/Suv39h2/Ehmt1/Wdr5/Ash1l/Setdb1/Setd1a/Wdr82"" 12" "GO:0004842 ""GO:0004842"" ""ubiquitin-protein transferase activity"" ""55/1859"" ""392/22744"" 5.70977400191355e-05 0.00346952737880982 0.00290261576196348 ""Hecw2/Trip12/Cop1/Rc3h1/Rnf217/Herc4/Cdc34/Med1/ Trim27/Map3k1/Trim13/Rnf19a/Rnf139/Bfar/Ltn1/Ttc3/March2/Fbxl17/Cul2/ Ube2d2a/Rnf165/Ube2e3/Ube2c/Nhlrc3/Rnf13/Trim59/Ube2q1/Ube2d3/Trim32/ Rnf220/Trim62/Ubr4/Fbxl5/Lnx1/Anapc5/Fbxl18/Trim24/Cul1/Rmnd5a/Rnf181/ Vhl/Fbxl14/E330021D16Rik/Amn1/Fbxo27/Ube3a/Fbxl19/Wwp2/Rfwd3/Birc2/ Cul5/Rnf111/Nedd4/Msl2/Rlim"" 55" "GO:0001228 ""GO:0001228"" ""DNA-binding transcription activator activity, RNA polymerase II-specific"" ""62/1859"" ""463/22744"" 8.02401895389909e-05 0.00460489532187653 0.00385246757962056 ""St18/ Nr5a2/Foxo3/Sirt1/Nfic/Srebf1/Msgn1/Mycn/Rreb1/Hnrnpk/Mef2c/Ssbp2/ Zfp131/Gata4/Tsc22d1/Rad21/Zfat/Atf4/Nr4a1/Sp1/Sox8/Crebrf/Pknox1/ Rxrb/Epas1/Egr1/Dmrt1/Tcf7l2/Nr6a1/Hoxd8/Nfe2l2/Wt1/Mga/Pax1/Sox12/ Mafb/Klf4/Nfib/Jun/Nfia/Nfyc/Fosl2/Txk/Rest/Tbx5/Bhlha15/Tfec/Zfp384/ Etv6/Klf13/Mef2a/Tead1/Tfdp1/Pou4f2/Ier2/Nfix/Nfat5/Maf/Irf2bp2/Tcf12/ Tfdp2/Ar"" 62" "GO:0032550 ""GO:0032550"" ""purine ribonucleoside binding"" ""50/1859"" ""353/22744"" 9.56087939009404e-05 0.00493819420498357 0.00413130630487748 ""Agap1/Rab7b/Dnm3/Hhat/Rhobtb1/Eef2/Arl1/Mtif2/ Irgm1/Anxa6/Arf1/Eral1/Rab34/Tubg1/Arl4d/Rab10/Arhgap5/Arf6/Eif5/Rala/ Rhobtb3/Rap2a/Tuba1b/Hsp90ab1/Rab31/Atl2/Atl3/Rem1/Tgm2/Pck1/Rap2b/ Gnat2/Rragc/Rasl11b/Sept11/Gtpbp6/Gpn3/Rasl11a/Suclg1/Suclg2/Arl8b/ Arhgap35/Lrrk1/Rab30/Insr/Rab3a/Tubb3/Rab11a/Eef1a1/Rap2c"" 50" "GO:0005525 ""GO:0005525"" ""GTP binding"" ""49/1859"" ""347/22744"" 0.000120485324335005 0.00565733363809363 0.00473294025258559 ""Agap1/ Rab7b/Dnm3/Hhat/Rhobtb1/Eef2/Arl1/Mtif2/Irgm1/Anxa6/Arf1/Eral1/Rab34/ Tubg1/Arl4d/Rab10/Arhgap5/Arf6/Eif5/Rala/Rhobtb3/Rap2a/Tuba1b/ Hsp90ab1/Rab31/Atl2/Atl3/Rem1/Tgm2/Pck1/Rap2b/Gnat2/Rragc/Rasl11b/ Sept11/Gtpbp6/Gpn3/Rasl11a/Suclg2/Arl8b/Arhgap35/Lrrk1/Rab30/Insr/ Rab3a/Tubb3/Rab11a/Eef1a1/Rap2c"" 49" "GO:1990841 ""GO:1990841"" ""promoter-specific chromatin binding"" ""13/1859"" ""52/22744"" 0.000214162507834287 0.00790106680688637 0.00661005334330637 ""Dhx9/Hnrnpu/Hdac2/Polr2a/Suz12/Ddx5/Prdm15/Egr1/ Bmi1/Setdb1/Gtf2b/Klf4/Pou4f2"" 13" "GO:0045499 ""GO:0045499"" ""chemorepellent activity"" ""9/1859"" ""28/22744"" 0.000263307387760406 0.0083344103194924 0.00697258966964208 ""Flrt2/Sema5b/Sema6d/Sema6c/Epha7/Sema3c/Sema4b/ Nrg1/Sema7a"" 9" "GO:0005543 ""GO:0005543"" ""phospholipid binding"" ""54/1859"" ""410/22744"" 0.000339538832379461 0.0103159886425877 0.00863038332456771 ""Sgk3/Plekhb2/Pard3b/Rufy4/Agap1/Nr5a2/Pla2g4a/ Rps6kc1/Snx3/Psap/Ccdc88a/Rapgef6/Anxa6/Nf1/Pitpnc1/Pxk/Golph3/ Laptm4b/Asap1/Cpne8/Pcyt1a/Tiam1/Tulp4/Myof/Plekha3/Nup35/Pla2g4b/ Snx5/Cpne1/Pfn2/F3/Sdcbp/Unc13b/Epb41/Pla2g5/Rph3a/Scarb1/Hip1/Hmgb1/ Snx10/Plekha5/Arhgap35/Axl/Picalm/Gab2/Sbf2/Pik3c2a/Plekha1/Gas6/ Snx25/Exoc8/Pard3/Arhgap32/Esyt3"" 54" "GO:0001085 ""GO:0001085"" ""RNA polymerase II transcription factor binding"" ""26/1859"" ""156/22744"" 0.000377984699641769 0.0107316581673089 0.0089781335459934 ""Dhx9/Hnrnpu/Cited2/Hdac2/ Gtf2a1/Yy1/Mier3/Gata4/Zfpm2/Atf4/Sp1/Ercc4/Mta3/Tcf7l2/Nfe2l2/Klf4/ Jun/Rere/Ruvbl1/Bhlhe40/Mef2a/Tead1/Gtf2e2/Wwp2/Ctnnb1/Ar"" 26" "GO:0035257 ""GO:0035257"" ""nuclear hormone receptor binding"" ""25/1859"" ""148/22744"" 0.000393984334568236 0.0107316581673089 0.0089781335459934 ""Ncoa2/Trip12/Ncoa7/Sirt1/Grip1/Med1/Ddx5/Wbp2/ Pik3r1/Med4/Nr4a1/Nrip1/Rxrb/Tcf7l2/Gtf2b/Arid1a/Ywhah/Ncor2/Flt3/ Trim24/Kdm3a/Tacc2/Pkn1/Ctnnb1/Ar"" 25" "GO:0008022 ""GO:0008022"" ""protein C-terminus binding"" ""35/1859"" ""235/22744"" 0.000394775421449893 0.0107316581673089 0.0089781335459934 ""Xrcc5/Prrc2c/Akap7/Sirt1/Yeats4/Grip1/Polr2a/ Cltc/Ywhaq/Ppm1a/Pik3r1/Pxk/Ercc6/Atf4/Sp1/Ercc4/Cd2ap/Sh3gl1/Lama1/ Tjp2/Sdcbp/Epb41/Atxn2/Psmd9/Ppp1r9a/Grip2/Tjp1/Mki67/Rab3a/Yap1/ Nedd4/Rasgrf1/Ctnnb1/Mid1ip1/Tbl1x"" 35" "GO:0032452 ""GO:0032452"" ""histone demethylase activity"" ""8/1859"" ""25/22744"" 0.000598883755345587 0.0154661729817998 0.0129390411352297 ""Jmjd1c/Kdm6b/Kdm3b/Kdm2a/Kdm2b/Kdm7a/Kdm3a/Phf8"" 8" "GO:0031490 ""GO:0031490"" ""chromatin DNA binding"" ""18/1859"" ""95/22744"" 0.000619163366301068 0.015599896521683 0.013050914601622 ""Dhx9/Hnrnpu/Hdac2/Foxo3/Jmjd1c/Kdm6b/Suz12/Med1/Rara/H3f3b/Wbp2/ Hist1h1c/Hmgn1/Prdm15/Kdm3b/Prdm6/Prdm11/Kdm3a"" 18" "GO:0005085 ""GO:0005085"" ""guanyl-nucleotide exchange factor activity"" ""29/1859"" ""191/22744"" 0.000873082848064176 0.0204878168776081 0.0171401616716933 ""Rab3gap1/Rabif/Ralgps2/Ric8b/ Rapgef6/Itsn2/Elmo1/Arhgef3/Trio/Cyth4/Kalrn/Tiam1/Sos1/Rasgrp2/Hps1/ Rapgef4/Bcar3/Eif2b3/Plekhg5/Rasgef1b/Eps8/Arhgef1/Plekhg2/Akap13/ Arhgef17/St5/Sbf2/Rasgrf1/Iqsec2"" 29" "GO:0003729 ""GO:0003729"" ""mRNA binding"" ""36/1859"" ""256/22744"" 0.000972006930086809 0.0213634714633973 0.017872736609211 ""Tsn/Dhx9/ Rc3h1/Hnrnpu/Eif4enif1/Larp1/Srsf1/Luc7l3/Rara/Ddx5/Zfp36l1/Hnrnpk/ Xpo5/Hnrnpll/Zfp36l2/Celf4/Cpeb3/Celf2/Rbms1/Ssb/Hnrnpa3/Secisbp2l/ Fxr1/Noct/Dhx36/Rbm15/Mettl14/Pabpc4/Hnrnpd/Luc7l2/Supt5/Samd4b/ Hnrnpl/Rpl13a/Mir23a/Eef1a1"" 36" "GO:0001098 ""GO:0001098"" ""basal transcription machinery binding"" ""12/1859"" ""54/22744"" 0.0011577463245627