Abuse of Amphetamine, 119 Cocaine, 109 Diethylpropion, 127 Ephedrine

Abuse of Amphetamine, 119 Cocaine, 109 Diethylpropion, 127 Ephedrine

INDEX Abuse of 6-(2-Aminopropyl)-2,2-dimethyl-5-methoxy- amphetamine, 119 2,2-dihydrofuran, 313 cocaine, 109 Aminorex, 19,20 diethylpropion, 127 Arninoxaphen, 19 ephedrine, 128 Amitryptyline, 46,184,185 high dose, 144 AMP, see Adenosine monophosphate phenmetrazine, 124 Amphetamine, 1-98,106,111-124,258,276, Acepromazine, 47 351-359 Acetylcholine (Ach), 59, 67, 68,75-76 abuse, 120-121,352 nicotine mimics, 437 activity-structure relationship, 1-39 Acetylcholinergic transmission, 59 bacteria in, 117 N-Acetyl-3,4-dimethoxyphenethylamine, behavior due to, 41-98 274 benzedrine, 112-115, 197 N-Acetylmescaline, 274-275 inhaler, 137 Acid-head, 417 chlorinated derivatives, 9-11 Acarus calamus, 234, 284 dependence, 113, 116 Acrolein, 437 dextro-, 127, 151, 175, 178, 200 Activity-structure generalizations, 257, 272 first synthesized in 1887, 111 Additives in food, 177 metabolic pathways, 351-358 Adenosine monophosphate, cyclic, 74 murders due to, 143 Adenylate cyclase, 73-74 and narcolepsy, 148 Adrenalin, 124 and obesity, 149 hypothesis, 414 production in U_S_A_ (1958-1970), 119 Adrenochrome, 363 and psychosis, paranoid, due to, 30, 113- conversion of epinephrine to, 414 119, 121, 135, 137, 139, 277 Aguacol/a, 232 and schizophrenia, 118, 130, 137,139,141, Alcohol dehydrogenase, 342 416 Alcoholics treated with LSD, 410 and sexual maladjustment, 143 Alcoholism, 410-411 sulfate, 100,114 Aldehyde dehydrogenase, 342 use, clinical, 43 Alkaloids, 259-263 Amphetarninics, 186, 197 Alkocyphenylisopropy1amine, 298-302 Anadenanthera peregrina, 231 Alkylphenylisopropylamine, 302-313 Anesthetics, 245 Amanita muscaria, 220,222,245 Anhalonidine, 263 Amfonelic acid, 49, 50,61,74 Anhalonium lewinii, 259 Amine Animals, behavioral effects biogenic (see also separate compounds), 2-12 pretreated with drugs which modify cate­ cyclic, 344 cholaminergic neurotransmission pro­ oxidative metabolism, 348 cesses, 44-5 8 465 466 INDEX Anorexia nervosa, 18, 187-189 Bovet-Gatti profile procedure, 253, 278,302 Anticholinergics, 183 Box of Skinner, 71 Anticonvulsants in children, 201-203 Brew of witches, 224 Antidepressant, tricyclic see also separate 4-Bromo-2,5-dimethoxyamphetamine, 316 compounds, 46, 61,78,169,181,188 4-Bromo-2,5-dimethoxyphenylisopropylamine Apomorphine, 55, 56, 75 (DOB),316-317 Aptrol,302 4-Bromo-3,5-dimethoxyphenylisopropylamine, Arbol de los brujos, 225 318 Arecoline, 59 5-Bromo-2,4-dimethoxyphenylisopropylamine, Arene oxide, 341 317 Arhuaca Indians 2-Bromolysergic acid diethylamide (BOL), first to use coca, 101 252 Ariocarpus, 260 p-Bromomethamphetamine, 316 As~one,234,283,284 2-Bromo-4,5-methylenedioxyphenylisopropyl­ Assaultiveness, 143 amine, 317-318 Astrophylum, 260 4-Bromo-N-methylphenylisopropylamine, 315- Atarax, see Hydroxyzine 316 Atropa belladonna, 224 Bronchitis, chronic Atropine, 59 in smokers, 435 Austrocylindropuntia cylindrica, 260 Brugmansia, 225 Ayahuasca, 230 Brunfelsia, 233 plant extract, 258 Bufotenine, 231,414,415 Aztekium, 260 Button of peyote, 220 Butyrophenone, 47, 170 Banisteriopsis snuffs, 230, 245 B~biturate, 47, 244 Cactus (see also Peyote) Behavior aguacolla, 232 disorders of mentally ret~ded, 173-176 San Pedro, 232 hyperkinetic children, 148-149 Trichocereus pachanoi, 232 modification, 177 Caffeine, 109, 127, 178,244 peer and smoking, 429 Calea zacatechichi, 229 repetitious, 142 Cannabis, 220, 223 stereotyped, 9, 142, 152 Cannulation, push-pull, 67 tests in animals, 253 C~bamazapine(Tegretol), 202 therapy, 173 ~bamazepine(Tegretol), 202 Belladonna, 224 used in treatment for psychomotor epilepsy, Benadryl,169 202 Benzedrine, see Amphetamine C~boline,tricyclic, 258 Benzene ethaneamine, 352-359 C~bon monoxide, 437 Benzodiazepine,47 ~bon Benzoic acid, 358 oxidation of attached heteroatoms, 343-346 major urinary metabolite of amphetamine C~cinogen, 340, 346 in man, 358 C~cinogenesis, 4-5, 407 Benzoyl ecgonine, methyl ester of, 107 C~cinogenicity, 340 Benzphetamine, 18-20 Catatonia in mouse, 267 Benztropine, 61, 70, 78 Catecholamine, 44, 48, 58, 60, 62-73, 83, 84 4-Benzyloxy-3 ,5-dimethoxyphenylisopropyl- blocking, 76 amine, 299-300 in brain identified: dopamine,44 Betel nut, 244 epinephrine, 44 Biotransformation, oxidative, 351 norepinephrine, 44 Biperidin, 404 drugs which deplete, 48 Bleph~ospasm, 186 release, 58, 65-73, 83-84 BOL, see Bromolysergic acid diethylamide synthesis, 49-54, 62-63 (bromo-LSD) uptake, 46, 65-67 INDEX 467 Catecholaminergic receptor, 47-48 Cigarette (cont'd) transmission, 45-58 nicotine content of 130 brands, 428 Catechol-O-methyltransferase(COMT), 44,298 production in the U.S.A. (1886-1968),427 Catha edulis, 99 tramonium, 396 Cathidine, 100 Cimora, 232 Cathine, 100, 101 Coca (see also Cocaine), 99-105,109,220 Cathinine, 100 Coca-Cola (1888), 110 Catnip, 397 Cocaine, 66,80, 104-111,124,244 Central nervous system anesthetic, local, 105 and stimulant use, 129-148 clubs, 110 Cerebrospinal fluid (CSF), 67,72,73 Freud's interest in, 107 Cerebroventricular perfusion, 68, 80 isolation from Peruvian coco leaves, 104,107 Cereus peruvian us, 261 self-administration, 18 Channa of Hottentots, 233 Coffee, 244 CheWing khat, 99 Cohoba powder of Taino Indians, 231 Chicha, 231 Coleus blumei, 228 Children C. pumila, 228 epileptic, 201-203 Color distortion, 248 anticonvulsants for, 201-203 COMT, see Catechol.Q-methyltransferase and hyperactivity, 201 Conocybe, 225 hyperactive Coriaria thymifolia, 233 and epileptic, 201 Cresol,437 and mentally retarded, 180 Cryogenine, 229 psychotic, treatments for CSF, see Cerebrospinal fluid electroshock, 168 Cults see also separate entries megavitamin,172 jurema, 230 tranquilizer, major, 172-173 peyote, 228 p-Chloramphetamine, 9,11,19,20,42,314 San Pedro, 232 p-Chlorbenzphetamine, 20 Cyclopropane ring, 28 Chlordiazepoxide, 169, 174, 183, 184, 193, Cylert (see Pemoline) 244 Cyproheptadine, 188 p-Chlormethamphetamine, 8, 315 Cytisine, 229, 234 4-Chloro-2,5-dimethoxyphenylisopropylamine, Cynsuscanarien~, 234 320 Cytochrome-P45o electron transport system, p-Chloro-Il-methylbenzylamine, 8 338 p-Chloro-N-methylphenethylamine, 8 Cytomel, 171 p-Chlorophenylalanine,58 4-Chloro-N-methylphenylisopropylamine, 315 D, see Dopamine Chlorphentermine, 19 Dj3H, see Dopamine j3-hydroxylase 4-Chlorophenylisopropylamine, 314-315 Datura, 224, 232 Chlorpromazine, 47, 63, 136, 169, 172, 174, D. suaveolens, 230 180,188,189,195,198,199,306 Deamination, oxidative, 344 in treatment for amphetamine poisoning, 141 Decarboxylase of L-amino acid, 53 Chloprothine, 174 Dehydration, 144 Cholesterol biosynthesis, 341 Demethylation of foreign compound, 345 Chromosome, 405-407 Dependency Cigar, li ttIe on stimulant, 151 nicotine content of brands, 428 without psychosis, 116 Cigarette (see also Nicotine, Smoking) Deprenyl, 29, 30 adult incidence of smoking in the U.S.A., Depression, 146, 150-151,409-410 430 and demoralization, 151 blended, 428 withdrawal, 146 industry, 427 Desfontania spinosa, 233 lettuce, 436 Desipramine, 46, 66, 80,184 468 INDEX Detoxification via urinary excretion, 350 3,5-Dimethoxy-4(n )-propoxyphenethylamine, Dexamphetamine, 124 269 Dexedrine, 197 proscaline,269 Dexphenmet~ne,123 2,5-Dimethoxy+propylphenylisopropolamine Dextroamphetamine, see d-Amphetamine (DOPR), 310-311 N-Dialkylation, 24, 25 N,N-Dimethylmescaline, 273-274 Diazepam(Valium), 169, 181, 186, 190,244 trichocerine, 273 2,4-Dichloroamphetamine, 9 N,N-Dimethylphenethylamine, 3 Diethyldithiocarbamate, 51,53 N,N-Dimethyltryptamine, 230, 231, 258,415 Diethylpropion, 18,20,124,126-128 identical with nigerine, 231 3,4-Dihydroxyphenylacetic acid (DOPAC), 61 Diphenhydramine (Benadryl), 169, 182 DihydroxyphenyIaIanine (dopa), 44, 49, 55, Diphenylhydantoin(DPH), 182, 202 64,71,118,144,171 a,a-Diphenyl-2-piperidine ethanol, 17 Dihydroxypheny1serine (DOPS), 52 a,a-Diphenyl-4-piperidinemethanol, 17 5,6-Dihydroxytryptamine, 8 Disability 5,7-Dihydroxytryptamine, 58, 59 of learning, 196 Dilapidation of reading, 196 striking in stimulant abusers, 144 Disulfiram, 51-53 2,5-Dimethoxy-4-amylphenylisopropylamine Ditran, 396, 409 (DOAM),312-313 for treating depression, 410 2,5-Dimethoxy-4-bromopheny1ethylamine, DMA, see Dimethoxyphenylisopropylamine 271 DMPEA, see Dimethoxyphenethylamine 2,5-Dimethoxy-4-butylphenylisopropylamine DMT, see Dimethyltryptamine (DOBU),312 DOAM, see 2,5-Dimethoxy-4-amylphenyl­ 3,5-Dimethoxy-4-ethoxyphenylethylamine, isopropylamine 268-269 DOB, see 4-Bromo-2,5-dimethoxyphenyl­ escaline, 268 isopropylamine 2,5-Dimethoxy-4-ethylphenylisopropylamine DOBU, see 2,5-Dimethoxy-4-butylphenyl­ (DOET), 308-310 isopropylamine 2,5-Dimethoxy-4-iodophenethylamine, 271- DOET, see 2,5-Dimethoxy-4-ethylphenyl­ 272 isopropylamine 2,5-Dimethoxy-4-methyIamphetamine (DOM), Dolichothele, 260 30,34,42,305-306,364,365,393 DOM, see 2,5-Dimethoxy-4-methylamphet- 2,3-Dimethoxy-4,5-methy1enedioxyamphet­ amine amine,298 Dopa, see Dihydroxyphenylalanine 2,5-Dimethoxy-3,4-methylenedioxyamphet­ DOP AC, see 3,4-Dihydroxyphenylacetic acid amine, 297 Dopamine, 5-8,44,45,48-59,61-78,80-85, 2,3-Dimethoxy-4,5-methylenedioxyphenyl­ 261,267,343,413 isopropylamine (DMMDA-2), 298, 298 Dopamine ,,-hydroxylase, 44, 63, 83, 343 2,5-Dimethoxy-3,4-methy1enedioxyphenyl­ DOPR, see 2,5-Dimethoxy-4-propylphenyl- isopropylamine (DMMDA), 297-298 isopropylamine 2,6-Dimethoxy-4-methylisopropylamine, 307- OOPS, see Dihydroxyphenylserine 308 Double-conscious technique, 255 2,5-Dimethoxy-4-methylphenethylamine, 270- DPH, see Diphenylhydantoin 271 Dreams, frightening, 189 2,5-Dimethoxy-4-methylphenylisopropylainine, Drug 281-282,304-307 addiction, 101 3,4-Dimethoxyphenylethylamine

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