20th Annual International Meeting of the Institute of Human Virology 1 Contents CONTENTS Click on any content title to link to that section. 03 Program Information and Acknowledgements 13 Events Schedule 16 Speaker Index 23 Abstract Index 27 Poster Index 20th Annual International Meeting of the Institute of Human Virology 2 Welcome 20th Annual International Meeting of the Institute of Human Virology at the University of Maryland School of Medicine Dear Colleagues and Friends, You are invited to join us on Monday, October 22 through Thursday, October 25 for IHV2018, “Virus Threats and Cancers – A Special Joint International Meeting of the Institute of Human Virology and the Global Virus Network.” Sessions for this year’s meeting will focus on: The 40th Anniversary of the Discovery of the First Human Retrovirus, HTLV, Exosomes in Health and Disease, Cancer Immunology, Cancer Epigenetics, Cancer Microenvironments, Viruses, the Emerging Global Health Challenge, PEPFAR: Towards HIV Epidemic Control, Targeting Early Infections,Approaches to Eliminate Persistent Viruses, Early stage investigators are invited to submit research abstracts for poster presentation – please share this opportunity with your faculty and colleagues. A special mini-symposium, “The 15th Anniversary of PEPFAR” will honor PEPFAR as the largest public health program in global history, and its sustainable impact on global health priorities. This year’s meeting will honor IHV Lifetime Achievement Awardees: Lifetime Achievement Award for Excellence in Medical Education, Clinical Care and Clinical Research: Henry Masur, MD, Chief of Critical Care Medicine Department, NIH Clinical Center and the Lifetime Achievement Award for Excellence in Clinical Research: Kiyoshi Takatsuki, MD, PhD, Professor Emeritus, Kumamoto University The Annual Awards Gala will be held Wednesday, October 24 at the Four Seasons Hotel, Baltimore. A gala reception will begin at 6:30 pm followed by dinner at 7:15 pm. We look forward to welcoming you to Baltimore this October as we continue our annual tradition of excellent science and provocative discussion. Sincerely, Robert C. Gallo, MD Manhattan Charurat, PhD Homer and Martha Gudelsky Director, Division of Epidemiology and Prevention Distinguished Professor in Medicine Professor of Medicine, Institute of Human Virology Director, Institute of Human Virology Co-Founder and Director, Global Virus Network 20th Annual International Meeting of the Institute of Human Virology 3 Program Information and Acknowledgements Mission Statement The Institute was established to create and develop a world-class center of excellence focusing on chronic viral diseases, especially HIV/AIDS, and virally-linked cancers. The IHV is dedicated to the discovery, research, treatment and prevention of these disease. Its unique structure seeks to connect cohesive, multi-disciplinary research and clinical programs so that new treatments are streamlined from discovery to patient. The IHV serves patients locally and the scientific community globally. Robert Gallo, MD Director Man Charurat, PhD Director, Division of Epidemiology and Prevention Shyam Kottilil, MBBS, PhD Director, Division of Clinical Care & Research George Lewis, PhD Director, Division of Vaccine Research Yang Liu, PhD Director, Divisioni of Immunotherapy Wuyuan Lu, PhD Co-Director, Division of Basic Science Eric Sundberg, PhD Co-Director, Division of Basic Science Anthony Amoroso, MD Associate Director, Division of Clinical Care & Research Deus Bazira, DrPH, MPH, MBA Director, Center for International Health, Education & Biosecurity (CIHEB) Dave Wilkins Chief Operating Officer 20th Annual International Meeting of the Institute of Human Virology 4 Program Information and Acknowledgements Institute of Human Virology (IHV) Board of Advisors Terry Lierman, Co-Chair Mark H. Kapan, MD, FACP Peter Palese, PhD Summit Global Ventures University of Michigan Health System Mount Sinai School of Medicine John Evans, Co-Chair John R. Kelly James P. Pinkerton Evans Telecommunications Kelly & Associates Insurance Group RATE Coalition (KELLY) Peter Angelos, Esquire KELLY Benefit Strategies & KELLY The Honorable Catherine E. Pugh The Law Offices of Peter Angelos Advisory Mayor of Baltimore Joseph Berardino William E. Kirwan, PhD Ellen Ratner Alvarez & Marsal University System of Maryland Talk Radio News Service William A. Blattner, MD The Honorable Nancy Kopp Guangqi Tian Institute of Human Virology, Retired Maryland State Treasurer Sino Invest Limited Christian Bréchot, MD, PhD Anna B. Laakmann, Esquire The Honorable Kathleen Kennedy Global Virus Network (GVN) Greenberg Traurig LLP Townsend The Rock Creek Group Robert L. Caret, PhD Thomas G. Lynch University System of Maryland Ireland East Hospital Group Jeff B. Trammell Trammell and Company Barbara Culliton John McHutchison, MD Science Journalist and Policy Gilead Sciences, Inc. Lenny Wilkens Consultant NBA Hall of Fame Coach and Player Charles Modica, JD The Honorable Elijah Cummings St. George’s University Danny Wong US House of Representatives Medisun Timothy Moynahan, Esquire The Honorable Arthur J. Gajarsa The Moynahan Law Firm, LLC Ambassador R. James Woolsey WilmerHale Lux Capital Management Franco Nuschese Michael Greenebaum Georgetown Entertainment Group Steven Wozencraft Greenebaum Enterprises John D. Evans Foundation Joseph S. Pagano, MD Sheilah A. Kast University of North Carolina at The Honorable Ernest F. Hollings, On the Record, WYPR Chapel Hill Honorary Princess Chulabhorn Mahidol, Honorary 20th Annual International Meeting of the Institute of Human Virology 5 Program Information and Acknowledgements IHV Scientific Advisory Board Joseph Pagano, MD, Chair Diane E. Griffin, MD, PhD Peter Palese, PhD University of North Carolina Johns Hopkins Bloomberg School of Mount Sinai School of Medicine Public Health Edward Berger, PhD Jeffrey V. Ravetch, MD, PhD NIAID, NIH Mark H. Kaplan, MD Rockefeller University University of Michigan Carlo M. Croce, MD Health System Michael Saag, MD The Ohio State University University of Alabama at Birmingham Michel Klein, MD Center for AIDS Research William DeGrado, PhD VaxiBio, Inc. University of California, Erica Ollmann Saphire, PhD San Francisco John W. Mellors, MD The Scripps Research Institute University of Pittsburgh Max Essex, DVM, PhD Mario Stevenson, PhD Harvard AIDS Institute Douglas Nixon, MD, PhD University of Miami The George Washington University Warner C. Greene, MD, PhD David Thomas, MD, MPH Gladstone Institute of Virology and Erling C. J. Norrby, MD, PhD Johns Hopkins Medicine Immunology The Royal Swedish Academy of Sciences Sten H. Vermund, MD, PhD Yale School of Public Health 20th Annual International Meeting of the Institute of Human Virology 6 Program Information and Acknowledgements Organizing Committees The Institute of Human Virology at the University of Maryland School of Medicine is grateful for the assistance provided by our International and Local Organizing Committees. International Organizing Committee Robert C. Gallo, MD Quarraisha Abdool Salim, PhD Director, Institute of Human Virology CAPRISA Roberto Accolla, MD, PhD Alash’le Abimiku, MON, PhD University of Insubria Institute of Human Virology Local Organizing Committee Anthony DeVico, PhD George Lewis, PhD Institute of Human Virology Institute of Human Virology Eric Sundberg, PhD Nadia Sam-Agudu, MD Institute of Human Virology Institute of Human Virology Yang Lui, PhD Shyamasundaran Kottilil, MD, PhD Institute of Human Virology Institute of Human Virology Deus Mubangizi, DrPH, MPH Yutaka Tagaya, MD, PhD Institute of Human Virology Institute of Human Virology Clement Adebamowo, BM, ChB Hons, FWACS, ScD Institute of Human Virology 20th Annual International Meeting of the Institute of Human Virology 7 Program Information and Acknowledgements Communications and Press Policy To enhance the exchange of information and communication among attendees of IHV2018, the following must be adhered to by all participants: • All comments at sessions are off-the-record and not for attribution. • No coverage, reporting or publication of scientific data or presentations at IHV2018 is permitted without the written consent of the presenter(s) and Nora Samaranayake (info below). This rule applies to all forms of media, including blogging, tweeting, etc. • Alternatively, if content comprises public comments made during the closed meeting, media are acceptable without written consent. If you are not sure if the comments can be publicized, please err on the side of caution and contact Nora Samaranayake. One-on-one interviews with scientists and media may be arranged by contacting Nora Samaranayake, Director of Public Relations and Marketing, Institute of Human Virology, (410) 706-8614 or [email protected]. Those registering for the meeting as “press” must provide their credentials within 3 days of registration to Amina Teal, [email protected]. 20th Annual International Meeting of the Institute of Human Virology 8 Program Information and Acknowledgements Special Acknowledgements The Institute of Human Virology wishes to recognize, with gratitude, the following sponsors. *Funding for this conference was made possible in part by 2 R13 AI 046078 - 19 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices,