Supplemental Table 1: List of the 570 genes with conserved Stat3 binding sites (CBS) in at least four species differentially expressed between C56BL/6 and FVB/N remnant kidneys 60 days after nephron reduction. Gene Symbol Ratio CBS in Name Abhd1 27.86 5 species abhydrolase domain containing 1 Pi4k2b 19.99 4 species phosphatidylinositol 4-kinase type 2 beta Pik3c2g 11.64 4 species phosphoinositide-3-kinase, class 2, gamma polypeptide Snap91 11.31 4 species synaptosomal-associated protein, 91kDa homolog (mouse) Ocel1 10.58 ≥ 6 species occludin/ELL domain containing 1 Slc34a2 8.86 4 species solute carrier family 34 (sodium phosphate), member 2 Psmc3ip 8.68 ≥ 6 species PSMC3 interacting protein Hddc3 7.17 ≥ 6 species HD domain containing 3 Lcn2 6.52 4 species lipocalin 2 Pea15a 5.09 5 species phosphoprotein enriched in astrocytes 15 Gfra1 5.09 4 species GDNF family receptor alpha 1 H2-DMb2 4.94 4 species major histocompatibility complex, class II, DM beta Atf3 4.88 4 species activating transcription factor 3 Wdfy1 4.85 4 species WD repeat and FYVE domain containing 1 Serpina10 4.73 4 species serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 Pm20d1 4.71 4 species peptidase M20 domain containing 1 Aldh4a1 4.35 4 species aldehyde dehydrogenase 4 family, member A1 Wasf2 4.10 4 species WAS protein family, member 2 Edn1 4.07 4 species endothelin 1 Zkscan1 3.98 4 species zinc finger with KRAB and SCAN domains 1 Cyr61 3.94 4 species cysteine-rich, angiogenic inducer, 61 Adamts1 3.76 5 species ADAM metallopeptidase with thrombospondin type 1 motif, 1 Fst 3.70 ≥ 6 species follistatin Egr2 3.63 4 species early growth response 2 (Krox-20 homolog, Drosophila) Cep55 3.56 4 species centrosomal protein 55kDa Aspm 3.43 4 species asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 671322 3.43 4 species chromosome 4 open reading frame 33 Itga1 3.34 4 species integrin, alpha 1 Sik1 3.28 ≥ 6 species SNF1-like kinase Timp1 3.27 4 species TIMP metallopeptidase inhibitor 1 Ctps 3.24 4 species CTP synthase Lrg1 3.18 4 species leucine-rich alpha-2-glycoprotein 1 Il17rb 3.15 4 species interleukin 17 receptor B Ubtd2 3.12 4 species ubiquitin domain containing 2 Rcan1 3.05 4 species regulator of calcineurin 1 Socs3 3.03 4 species suppressor of cytokine signaling 3 Egr1 3.00 4 species early growth response 1 Anxa4 2.99 4 species annexin A4 Col12a1 2.98 4 species collagen, type XII, alpha 1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal Ammecr1 2.96 4 species region, gene 1 Tlr2 2.91 4 species toll-like receptor 2 Rrm2 2.91 5 species ribonucleotide reductase M2 polypeptide Ccl2 2.88 4 species chemokine (C-C motif) ligand 13 Bcl3 2.88 4 species B-cell CLL/lymphoma 3 Rragd 2.87 4 species Ras-related GTP binding D Cygb 2.84 4 species cytoglobin transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma- Tgm1 2.80 4 species glutamyltransferase) LOC100045442 2.79 4 species stromal antigen 1 Prc1 2.78 5 species protein regulator of cytokinesis 1 Fgg 2.73 4 species fibrinogen gamma chain Cdca8 2.73 4 species cell division cycle associated 8 Fos 2.70 4 species v-fos FBJ murine osteosarcoma viral oncogene homolog Zwilch 2.69 4 species Zwilch, kinetochore associated, homolog (Drosophila) LOC636537 2.63 4 species signal sequence receptor, alpha (translocon-associated protein alpha) Aldh1a2 2.61 4 species aldehyde dehydrogenase 1 family, member A2 Myc 2.58 4 species v-myc myelocytomatosis viral oncogene homolog (avian) Tmem82 2.57 4 species transmembrane protein 82 Egr3 2.53 4 species early growth response 3 Adal 2.52 4 species adenosine deaminase-like Hpcal4 2.52 ≥ 6 species hippocalcin like 4 Ccna2 2.51 4 species cyclin A2 Lgi2 2.49 4 species leucine-rich repeat LGI family, member 2 Cks1b 2.48 4 species CDC28 protein kinase regulatory subunit 1B 1 F3 2.47 4 species coagulation factor III (thromboplastin, tissue factor) Abcc9 2.45 4 species ATP-binding cassette, sub-family C (CFTR/MRP), member 9 Tgfb2 2.43 4 species transforming growth factor, beta 2 Tgif1 2.41 4 species TGFB-induced factor homeobox 1 Gm71 2.40 4 species gene model 71. (NCBI) Slc40a1 2.39 ≥ 6 species solute carrier family 40 (iron-regulated transporter), member 1 Steap1 2.39 4 species six transmembrane epithelial antigen of the prostate 1 LOC100046232 2.37 4 species nuclear factor, interleukin 3 regulated Socs2 2.36 5 species suppressor of cytokine signaling 2 Rpl12 2.35 4 species small nucleolar RNA, H/ACA box 65 Nr4a1 2.35 5 species nuclear receptor subfamily 4, group A, member 1 Uchl1 2.32 4 species ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) Csf1 2.31 4 species colony stimulating factor 1 (macrophage) Cnot7 2.30 5 species CCR4-NOT transcription complex, subunit 7 Ccnl2 2.30 ≥ 6 species cyclin L2 Cxcr4 2.29 4 species chemokine (C-X-C motif) receptor 4 Med1 2.29 4 species mediator complex subunit 1 LOC100045677 2.27 4 species minichromosome maintenance complex component 3 Pck1 2.25 ≥ 6 species phosphoenolpyruvate carboxykinase 1 (soluble) Ptrh1 2.24 4 species peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae) Id1 2.24 4 species inhibitor of DNA binding 1, dominant negative helix-loop-helix protein Josd1 2.23 ≥ 6 species Josephin domain containing 1 Aff2 2.23 4 species --- Clcf1 2.23 4 species cardiotrophin-like cytokine factor 1 Tpm3 2.21 4 species tropomyosin 3 Ctgf 2.21 4 species connective tissue growth factor Il6st 2.19 5 species interleukin 6 signal transducer (gp130. oncostatin M receptor) Olfm4 2.16 4 species olfactomedin 4 Dpysl3 2.16 4 species dihydropyrimidinase-like 3 Icam1 2.16 5 species intercellular adhesion molecule 1 (CD54), human rhinovirus receptor methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2. Mthfd2 2.16 4 species methenyltetrahydrofolate cyclohydrolase 1300014I06Rik 2.15 4 species chromosome 6 open reading frame 145 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, Gart 2.15 4 species phosphoribosylaminoimidazole synthetase Zfp185 2.14 4 species zinc finger protein 185 (LIM domain) Myo1c 2.14 5 species myosin IC OTTMUSG00000007332 2.14 4 species sushi domain containing 1 Frg1 2.14 4 species FSHD region gene 1 Plek 2.13 4 species pleckstrin Adm 2.11 4 species adrenomedullin Tsr1 2.11 4 species TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) Net1 2.09 4 species neuroepithelial cell transforming gene 1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta Ywhah 2.09 4 species polypeptide Rhobtb3 2.07 4 species Rho-related BTB domain containing 3 Rrad 2.07 4 species Ras-related associated with diabetes Dennd2a 2.07 4 species DENN/MADD domain containing 2A Btg2 2.06 4 species BTG family, member 2 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), Slc25a17 2.06 4 species member 17 Kras 2.06 4 species v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog Parvb 2.06 4 species parvin, beta Per2 2.05 4 species period homolog 2 (Drosophila) Plau 2.04 4 species plasminogen activator, urokinase Gng10 2.03 4 species guanine nucleotide binding protein (G protein), gamma 10 Jun 2.03 4 species jun oncogene Crnkl1 2.02 4 species crooked neck pre-mRNA splicing factor-like 1 (Drosophila) Ier2 2.01 4 species immediate early response 2 Commd2 2.01 4 species COMM domain containing 2 Sec61a1 2.00 4 species Sec61 alpha 1 subunit (S. cerevisiae) Dynll1 2.00 4 species dynein, light chain, LC8-type 1 Rnase4 2.00 4 species ribonuclease, RNase A family, 4 Klf6 1.99 5 species Kruppel-like factor 6 Abca1 1.99 4 species ATP-binding cassette, sub-family A (ABC1), member 1 P2ry6 1.99 4 species pyrimidinergic receptor P2Y, G-protein coupled, 6 Pprc1 1.97 4 species peroxisome proliferator-activated receptor gamma, coactivator-related 1 Shoc2 1.97 ≥ 6 species soc-2 suppressor of clear homolog (C. elegans) Anxa2 1.97 4 species annexin A2 Hs6st2 1.97 4 species heparan sulfate 6-O-sulfotransferase 2 Nfkbie 1.97 4 species nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon Tuft1 1.96 4 species tuftelin 1 Trib1 1.95 4 species tribbles homolog 1 (Drosophila) Mobkl2a 1.95 4 species MOB1, Mps One Binder kinase activator-like 2A (yeast) Mettl6 1.95 4 species methyltransferase like 6 2 Pdlim7 1.95 4 species PDZ and LIM domain 7 (enigma) Trim47 1.95 5 species tripartite motif-containing 47 Akt1 1.94 4 species v-akt murine thymoma viral oncogene homolog 1 asparagine-linked glycosylation 12 homolog (S. cerevisiae, alpha-1,6- Alg12 1.94 4 species mannosyltransferase) Marcksl1 1.93 4 species MARCKS-like 1 1810013L24Rik 1.93 5 species chromosome 16 open reading frame 72 Kpna2 1.92 5 species karyopherin alpha 2 (RAG cohort 1, importin alpha 1) Acy1 1.92 4 species aminoacylase 1 Fermt3 1.92 4 species fermitin family homolog 3 (Drosophila) Ier5 1.91 4 species immediate early response 5 Coro1c 1.91 4 species coronin, actin binding protein, 1C Rgs5 1.90 4 species regulator of G-protein signaling 5 S100a6 1.90 4 species S100 calcium binding protein A6 Sphk1 1.89 5 species sphingosine kinase 1 Plp2 1.89 4 species proteolipid protein 2 (colonic epithelium-enriched) Nasp 1.89 ≥ 6 species nuclear autoantigenic sperm protein (histone-binding) Mcm4 1.88 4 species minichromosome maintenance complex component 4 Plekho1 1.88 4 species pleckstrin homology domain containing, family O member 1 Mad2l2 1.88 4 species MAD2 mitotic arrest deficient-like 2 (yeast) Smc2 1.87 4 species structural maintenance of chromosomes 2 Creld2 1.87 4 species cysteine-rich with EGF-like domains