Anti-SEMA6A (aa 36-65) polyclonal antibody (DPABH-11186) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Immunogen Synthetic peptide within Human Sema6A aa 36-65 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q9H2E6 Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB Format Liquid Size 400 μl Buffer Constituent: 99% PBS Preservative 0.09% Sodium Azide Storage Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. GENE INFORMATION Gene Name SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved 6A [ Homo sapiens ] Official Symbol Sema6A Synonyms SEMA6A; sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; SEMAQ; semaphorin-6A; HT018; KIAA1368; SEMA; sema VIa; SEMA6A1; SEMA6A-1; semaphorin VIA; semaphorin 6A-1; semaphorin-6A-1; VIA; Entrez Gene ID 57556 Protein Refseq NP_065847 UniProt ID Q9H2E6 Chromosome Location 5q23 Pathway Axon guidance; Developmental Biology; Other semaphorin interactions; Semaphorin interactions; Function protein binding; receptor activity; semaphorin receptor binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.