www.thieme.de/fz/plantamedica l www.thieme-connect.com/ejournals Planta Medica Journal of Medicinal Plant and Natural Product Research Editor-in-Chief Advisory Board Publishers Luc Pieters, Antwerp, Belgium Georg Thieme Verlag KG John T. Arnason, Ottawa, Canada Stuttgart · New York Yoshinori Asakawa, Tokushima, Japan Rüdigerstraße 14 Senior Editor Lars Bohlin, Uppsala, Sweden D-70469 Stuttgart Adolf Nahrstedt, Münster, Germany Mark S. Butler, S. Lucia, Australia Postfach 30 11 20 João Batista Calixto, Florianopolis, Brazil D-70451 Stuttgart Claus Cornett, Copenhagen, Denmark Review Editor Hartmut Derendorf, Gainesville, USA Thieme Publishers Leandros A. Skaltsounis, Athens, Greece Alfonso Garcia-Piñeres, Frederick MD, USA 333 Seventh Avenue Jürg Gertsch, Zürich, Switzerland New York, NY 10001, USA Simon Gibbons, London, UK www.thieme.com Editors De-An Guo, Shanghai, China Rudolf Bauer, Graz, Austria Matthias Hamburger, Basel, Switzerland Veronika Butterweck, Muttenz, Andreas Hensel, Münster, Germany Switzerland Kurt Hostettmann, Geneva, Switzerland Thomas Efferth, Mainz, Germany Peter J. Houghton, London, UK Irmgard Merfort, Freiburg, Germany Ikhlas Khan, Oxford MS, USA Nigel B. Perry, Dunedin, New Zealand Jinwoong Kim, Seoul, Korea Jose-Luis Rios, Valencia, Spain Wolfgang Kreis, Erlangen, Germany Hermann Stuppner, Innsbruck, Austria Roberto Maffei Facino, Milan, Italy Yang-Chang Wu, Taichung, Taiwan Andrew Marston, Bloemfontein, South Africa † Matthias Melzig, Berlin, Germany Editorial Offices Eduardo Munoz, Cordoba, Spain Claudia Schärer, Basel, Switzerland Nicholas H. Oberlies, Greensboro NC, USA Tess De Bruyne, Antwerp, Belgium Joseph Pfeilschifter, Frankfurt, Germany Peter Proksch, Düsseldorf, Germany Kurt Schmidt, Graz, Austria Thomas Schmidt, Münster, Germany Thomas Simmet, Ulm, Germany Leandros Skaltsounis, Athens, Greece Han-Dong Sun, Kunming, China Ping-Jyun Sung, Pingtung, Taiwan Deniz Tasdemir, Galway, Ireland Arnold Vlietinck, Antwerp, Belgium Günter Vollmer, Dresden, Germany Heikki Vuorela, Helsinki, Finland Jean-Luc Wolfender, Geneva, Switzerland Yang Ye, Shanghai, China www.thieme-connect.de/ejournals | www.thieme.de/fz/plantamedica Planta Medica September 2013 · Page 1097 – 1288 · Volume 79 13 · 2013 1097 Editorial 1128 Poster presentations 1128 A. Natural products against neglected diseases 1098 Lectures 1140 B. In vivo phytopharmacology 1153 C. Skin-active natural products 1100 Workshops 1158 D. Glycobiology and carbohydrate-based active compounds 1100 Regulatory Affairs Workshop: Harmonisation of Health Claims in Europe 1160 E. Ethnopharmacology of African medicine 1101 8th Young Researchers Workshop 1171 F. Ethnopharmacology of Amazonian medicine 1104 Challenges and Limitations in Metabolic Pathway 1174 G. Computational methods in natural products Engineering of Secondary Natural Products chemistry 1105 Current Aspects in Manufacturing of Herbal APIs 1176 H. Hyphenated analytical techniques and target (Extracts): GACP Regulations/GMP Implementation/ fishing Process Development 1180 I. Natural product chemistry 1210 J. Plant phenols: structures, analytics and activities 1106 Short lectures 1224 K. Quality control methods for medicinal plants, 1106 Natural products against neglected diseases extracts and isolated natural products 1108 In vivo phytopharmacology 1237 L. Herbal medicinal products in animal healthcare and veterinary medicine 1110 Skin-active natural products 1244 M. Metabolic pathway engineering of secondary 1112 Ethnopharmacology of African medicine natural products 1113 Ethnopharmacology of Amazonian medicine 1247 N. Miscellaneous 1113 Computational methods in natural products chemistry 1279 Authors’ Index 1114 Hyphenated analytical techniques and target fishing 1116 Natural product chemistry 1288 Masthead 1120 Plant phenols: structures, analytics and activities 1121 Quality control methods for medicinal plants, extracts and isolated natural products 1123 Herbal medicinal products in animal healthcare and veterinary medicine 1125 Miscellaneous " Cover picture: Foto Presseamt Mnster / Angelika Klauser Editorial 1097 Book of Abstracts 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research Date/Location: 1. – 5. September 2013, Mnster, Germany Chairmen: Andreas Hensel, Thomas J. Schmidt Issue Editors: Andreas Hensel, Matthias Lechtenberg, Thomas J. Schmidt Dear Colleagues, The Society for Medicinal Plant and Natural Product Research (GA) invites scientists from academia and industry dealing with all aspects of medicinal plant and natural product research as well as phytotherapy to its 61st International Congress and Annual Meeting. This important scientific meeting will be held in Mnster, a picturesque city surrounded by beautiful countryside in the heart of Westphalia, in the Northwest of Germany. Mnster once played an outstanding role in history. The peace treaty of Mnster was signed here as part of the “Westphalian Peace” of 1648, which ended the Thirty Years War and paved the way to a modern Europe as we know it. Today, Mnster is a lively young city with the University “Westflische Wilhelms-Universitt” (WWU) as a major employer and regional center of research and education. With more than 40.000 students and an exciting research profile WWU is one of the biggest and leading universities in Germany. The conference will take place in the central university area, in front of the historic castle of Mnster which is located in the middle of the city’s historic downtown area. Our scientific programme has attracted the interest of a true host of researchers worldwide so that we look forward to welcoming more than 600 scientists from over 60 countries. The main topics of the congress are: – Natural products against neglected diseases – In vivo phytopharmacology – Skin-active natural products – Glycobiology and carbohydrate-based active compounds – Ethnopharmacology of African medicine – Ethnopharmacology of Amazonian medicine – Computational methods in natural products chemistry – Hyphenated analytical techniques and target fishing – Natural product chemistry – Plant phenols: structures, analytics and activities – Quality control methods for medicinal plants, extracts and isolated natural products – Herbal medicinal products in animal healthcare and veterinary medicine The program is highlighted by nine invited lectures delivered by distinguished speakers covering the major scientific topics of the conference. More than 75 short lectures will present the current state of the art in natural product science, and especially younger scientists, but also researchers from industry will present high quality results for intense discussion. Workshops dedicated to topics of particular interest will provide in-depth insights into various aspects of medicinal plant and natural products research. Three poster sessions, scheduled within central time frames during the congress, will bring together scientists from different disciplines and stimulate the exchange of experiences and knowledge. It is a pleasure to the organizers that the European Cooperation in Science and Technology within the COST 1006 framework will be integrated into the meeting by a presymposium “Challenges and Limitations in Metabolic Pathway Engineering of Secondary Natural Products” highlighting the latest insights in biotechnical production of natural products for medicinal applications. In addition to presentation and discussion of excellent research it will be a major goal of this conference to provide a basis for intense networking between scientists of academia and industry from all over the world. The present issue of Planta Medica devoted to the congress was realized by the efficient and excellent work of Dr. Matthias Lechtenberg and by many staff members from the Institute of Pharmaceutical Biology and Phytochemistry. We express our deepest gratitude to all of them for helping us to publish high quality abstracts in this volume. We also thank the many members of the scientific committee, for their meticulous help in evaluating more than 700 abstracts and – last but not least – the many dedicated researchers who submitted so much of their excellent work! We wish you all a pleasant and fruitful meeting with science, culture and hospitality! Andreas Hensel and Thomas J. Schmidt Planta Med 2013; 79: 1097–1288 Georg Thieme Verlag KG Stuttgart · New York · ISSN 0032-0943 1098 Book of Abstracts | 61st International Congress and Annual Meeting of the GA | 1. – 5. September 2013, Mnster, Germany Lectures portunities and responsibilities. This presentation describes the role southern Africa has played in contributing to the worldwide increase [Opening Lecture] of knowledge in the field of ethnopharmacology. Emphasis will be L1 Natural products and drug discovery for tropical placed on the screening of medicinal plants in southern African for diseases – successes, failures and lessons learned ethnopharmacological properties which primarily focus on investigating Fairlamb AH the efficacy of these plants in the search for new therapeutic products. Division of Biological Chemistry & Drug Discovery, College of Other important aspects of medicinal plant research related to safety of Life Sciences, University of Dundee, Scotland, UK indigenous medicinal plants and the conservation and sustainable use will be highlighted. Issues on the preservation of indigenous knowledge Infectious diseases of poverty are responsible for countless deaths and systems will be tackled. Emerging research areas