2 0 1 0 Research Report DRIVING HEALTH INNOVATION Research Report 2010 University Health Network Research Report 2010 University Health Network Office of the Vice President, Research University Health Network 610 University Avenue 7th Floor, Room 7-504 Toronto, Ontario, Canada M5G 2M9 www.uhnresearch.ca Lupus Clinical Trials Consortium Ontario Clinical Oncology Group Society of Uroradiology Lymphoma Foundation Canada Ontario Genomics Institute Solutions by Sequence Mayo Clinic Ontario HIV Treatment Network St. Jude Medical Canada McMaster University Ontario Innovation Trust Steba Biotech Medpace Ontario Institute for Cancer Research Susan G. Komen Breast Cancer Foundation Medtronic Ontario Neurotrauma Foundation Synta Pharmaceuticals Merck Ontario Problem Gambling Research Centre Talecris Biotherapeutics Mesothelioma Applied Research Foundation Ontario Research Development & Taro Pharmaceuticals MethylGene Challenge Fund Taylor & Francis Group Publishing Michael J. Fox Foundation Organon Canada Terumo Cardiovascular Systems for Parkinson’s Research Ortho Biotech Teva Neuroscience Microscopy Society of America Osiris Therapeutics Therakos Microvention Paracor Medical Thoratec Miikana Therapeutics Parkinson Society Canada Thornhill Research Millenium Pfizer Canada Threshold Pharmaceuticals Ministry of Health and Long-Term Care Pharmacia Tibotec Pharmaceuticals Ministry of Research and Innovation Philips Electronics North America Toronto General & Western Hospital Foundation Mitsubishi Tanabe Pharma Photopharmacia Toronto Institute of Pharmaceutical Technology Momenta Pharmaceuticals Physicians’ Services Inc. Foundation Toronto Medical Laboratories Motorcycle Ride for DAD Plastic Surgery Educational Foundation Toshiba Medical Systems Mount Sinai Hospital Princess Margaret Hospital Foundation Trillium Therapeutics Multiple Myeloma Research Foundation Procter & Gamble Pharmaceuticals University of Pennsylvania Multiple Sclerosis Society of Canada Prostate Cancer Canada University of Toronto National Alliance for Research on Proteolix University Renal Research and Schizophrenia and Depression Proteomic Methods Education Association National Cancer Institute of Canada Public Health Agency of Canada U.S. Army Medical Research Acquisition Activity National Institutes of Health Purdue Pharma Vertex Pharmaceuticals National Sanitarium Association Questcor Pharmaceuticals VINNOVA National Surgical Adjuvant Breast Quintiles ViroPharma and Bowel Project Repligen VistaGen Therapeutics Natural Sciences and Engineering ResMed Foundation Vitrolife Research Council Rheuminations Viventia Biotechnologies Networks of Centres of Excellence of Canada Royal College of Physicians and Workplace Safety and Insurance Board NCE: Canadian Institute for Surgeons of Canada Wyeth Canada Photonic Innovations SAIC Frederick YM BioSciences NCE: Canadian Network for Salix Pharmaceuticals University Health Network (UHN) consists of Toronto General, Toronto Western and Improved Outcomes in SLE Sanofi-aventis Princess Margaret Hospitals. The scope of research and complexity of cases at University NCE: PrioNet Schering Canada Health Network have made it a national and international source for discovery, education NCE: Stem Cell Network Schering-Plough Research Institute NMT Medical Seattle Genetics and patient care. It has the largest hospital-based research program in Canada, with major North American Spine Society Semafore Pharmaceuticals research in transplantation, cardiology, neurosciences, oncology, surgical innovation, Northwestern University Sentinelle Medical infectious diseases and genomic medicine. University Health Network is a research hospital Novartis Servier Canada Novo Nordisk Canada Sjögren’s Society of Canada affiliated with the University of Toronto. NPS Pharmaceuticals Social Sciences and Humanities Research Ontario Centres of Excellence Council of Canada University Health Network Research Report 2010 / Published by the Office of the Vice President, Research, UHN / Produced by Research Communications, UHN / Data provided by Research Support Services, UHN. Respective data types are accurate as of December 31, 2009 (publication count year-end), March 31, 2010 (fiscal year-end) and June 30, 2010 (academic year-end) / Graphic design by Clear Space Design & Communications Inc. / Photographs courtesy of Yuan Lew, UHN and various sources including John Loper, Woodbine Entertainment Group and AARCF, Ride to Conquer Cancer and Sandler Photography. Some figures may be rounded and/or may include data not represented in institute-specific data. Publications jointly authored by investigators at multiple UHN institutes are counted once in UHN Research total. STRATEGIC PLANNING 10 A Blueprint for the Future INFRASTRUCTURE The Krembil Discovery Centre Ushers NEW FUNDING 14 in a New Era of Discovery Ontario Ministry Makes Major Investments 12 in UHN-led Research Projects INDUSTRY PARTNERSHIps 16 UHN and Merck Join Forces in Global Cancer Clinical Trials Network 18 COMMERCIALIZATION COLLABORATIONS Med BioGene and LungExpress Dx New California Partnership Spurs Stem Cell Research 20 OUR FOUNDATIONS Supporting Research 21 TABLE OF CONTENTS 03 Welcome 37 Institutes 04 Year in Review – Ontario Cancer Institute (OCI) 07 Honour Roll – Toronto General Research Institute (TGRI) 09 Drivers of Innovation – Toronto Western Research Institute (TWRI) 25 Research 44 Financial Information – Basic Research 46 UHN Research Committees – Translational Research 48 External Sponsors – Clinical Research UHN Research: Senior Scientists 150 A Snapshot Scientists 44 Affiliate Scientists 74 Assistant Scientists 4 CSRC /CRU Members 263 TOTAL RESEARCHERS 535 Fellows 435 Graduate Students 469 TOTAL TRAINEES 904 TECHNICAL AND SUppORT STAFF 1,637 RESEARCH SPACE 745,000 SQ FT PUBLICATIONs 1,781 TOTAL FUNDING $267,655,000 International Research Philip E. Branton, Chair 02 Gilman Cheney Professor, Goodman Cancer Advisory Board Centre, Departments of Biochemistry and Oncology, McGill University Victor J. Dzau Chancellor for Health Affairs, James B. Duke Professor of Medicine and Director of Molecular and Genomic Vascular Biology, Duke University; President and CEO, Duke University Health System John A. Parrish Chief Executive Officer, Center for Integration of Medicine & Innovative Technology Ralph Steinman Henry G. Kunkel Professor and Senior Physician, Laboratory of Cellular Physiology and Immunology, The Rockefeller University Hans Wigzell Professor Emeritus in Immunology, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet Quality patient care is enriched by innovative research— something we are proud to embody at UHN. Every day, our scientists search for solutions to medical mysteries and, in doing so, push the boundaries of our knowledge of human health and disease. These scientific discoveries pave the way for novel technologies and enhanced therapeutics, which ultimately allow for improved care for our patients, our community and the world. Please read on to learn more about some of the fascinating discoveries that are enabled at UHN every day and are set to help Robert S. Bell, change our future. MDCM, MSc, FACS, FRCSC President & CEO Robert S. Bell University Health Network WELCOME Some of the best medical researchers in the world work at UHN. They seek to understand health at the cellular, biochemical and genetic level to prevent diseases from arising, as well as to offer targets for potential treatment. 03 They invent better tools to diagnose disease and monitor response to therapeutic interventions. They study how best to deliver treatment and improve both outcomes and quality of life. And they study how the health care system itself works, hoping to make it more efficient and effective. They work at UHN because Christopher J. Paige, PhD Vice President, Research at UHN they have top flight laboratory facilities, the latest research equipment, a University Health Network large and stimulating biomedical research environment anchored by the University of Toronto and the affiliated research hospitals, excellent trainees, supportive fundraising foundations, leading hospitals treating the most challenging medical problems and, most of all, colleagues whose research accomplishments and international stature match their own. Having a large and diversified research staff offers the opportunity for UHN researchers to form multidisciplinary teams—teams which have the diversity of expertise to tackle the toughest research questions. In parallel, UHN preserves an environment that also fosters individual creativity allowing researchers the freedom to follow their own inventive instincts, a well-proven approach that leads to major medical breakthroughs. Sustained research success requires that all of these individual elements flourish as part of an integrated program, thus building a vibrant community of scholarship with a common mission of improving health. However, sustained positive impact on health requires even more: the integration of research and health care. It requires that all members of the hospital community including health care professionals, administrators, researchers, support staff and patients and their families share a common commitment to working together to improve health. At UHN, these elements coalesce into what we have termed the Creative Domain. It is one of UHN’s five strategic planning domains–We, Caring, Accountable, Creative, and Academic. Over the last year, as we have worked to update the Creative Domain’s strategic plan, it is exciting