Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_001591825Cyc: Bacillus vietnamensis NBRC 101237 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari sn-glycerol phosphate phosphate pro phosphate phosphate phosphate thiamine molybdate D-xylose D-ribose glutathione 3-phosphate D-mannitol L-cystine L-djenkolate lanthionine α,β-trehalose phosphate phosphate [+ 3 more] α,α-trehalose predicted predicted ABC ABC FliY ThiT XylF RbsB RS10935 UgpC TreP PutP RS10200 PstB PstB RS10385 RS03335 RS20030 RS19075 transporter transporter of molybdate of phosphate α,β-trehalose 6-phosphate L-cystine D-xylose D-ribose sn-glycerol D-mannitol phosphate phosphate thiamine glutathione α α phosphate phosphate phosphate phosphate L-djenkolate 3-phosphate , -trehalose 6-phosphate pro 1-phosphate lanthionine molybdate phosphate [+ 3 more] Metabolic Regulator Amino Acid Degradation Amine and Polyamine Biosynthesis Macromolecule Modification tRNA-uridine 2-thiolation Degradation ATP biosynthesis a mature peptidoglycan a nascent β an N-terminal- an N-terminal- a peptide with DNA combined and selenation (bacteria) L-valine degradation I -D-fructofuranose D-sedoheptulose [2Fe-2S] iron-sulfur Cofactor, Carrier, and Vitamin Biosynthesis L-arginine degradation V (meso-diaminopimelate adenosylcobinamide a purine peptidoglycan KDGP adenosylcobinamide L-methionyl-L- NMN L-methionyl-L- an N-terminal with exogenous superpathway of menaquinol-7 biosynthesis adenosylcobinamide-GDP adenosylcobinamide-GDP superpathway of coenzyme A biosynthesis I (bacteria) thiamine flavin biosynthesis I (bacteria and plants) menaquinol-9 biosynthesis ppGpp metabolism L-isoleucine degradation I L-threonine L-arginine degradation L-arginine 4-aminobutanoate 1-phosphate 1,7-bisphosphate cluster biosynthesis molybdenum Aromatic Compound Biosynthesis (arginine deiminase pathway) containing) ribonucleoside (meso-DAP bifunctional threonyl-[protein] bifunctional seryl-[protein] L-methionine DNA to form a salvage from cobinamide I salvage from cobinamide II diphosphate ADP degradation I XIII (reductive degradation degradation I cofactor biosynthesis cys 5'-triphosphate containing) adenosylcobinamide metallophosphatase/ recombinational 3-methyl-2- a 5,10- salvage III F0F1 ATP synthase: val Stickland reaction) III (arginine Holliday chorismate demethylmenaquinol-9 pppGpp chorismate biosynthesis I ile bifunctional kinase/ fructose 5'-nucleotidase: fructose junction L-cysteine desulfurase cob(II)inamide cob(II)inamide oxobutanoate methylenetetrahydrofolate GTP dipicolinate biosynthesis BVI01S_RS01215 arg thr decarboxylase/ 4-aminobutanoate bifunctional lytic type I methionyl type I methionyl type I methionyl junction thiamine demethylmenaquinone molybdate cysteine arg bifunctional adenosylcobinamide- bisphosphate BVI01S_RS05000 bisphosphate serine serine isochorismate cob(I)yrinic acid bifunctional (p)ppGpp atpB atpE atpF branched-chain- threonine agmatinase pathway) transglycosylase/ bifunctional lytic 4-hydroxy-2- aminopeptidase: aminopeptidase: aminopeptidase: resolvase RS09595 cysteine cob(I)yrinic acid thiamine methyltransferase: D-erythrose desulfurase: branched-chain- arg adenosylcobinamide phosphate aldolase: aldolase: thr thr synthase: a,c-diamide 3-methyl-2-oxobutanoate predicted synthetase/guanosine- BVI01S_RS01235 amino-acid arginine deiminase: ammonia- arginine deiminase: C40 family transglycosylase/ oxoglutarate map bifunctional map map RuvX: ruvX desulfurase: diphosphokinase: BVI01S_RS08450 molybdopterin guanosine 3'- 4-phosphate BVI01S_RS13985 amino-acid kinase/ guanylyltransferase: BVI01S_RS13780 BVI01S_RS13780 a,c-diamide hydroxymethyltransferase: bifunctional ABC 3',5'-bis(diphosphate) 3'- bifunctional 3-deoxy-7- asp atpA BVI01S_RS01245 transaminase: ilvE lyase: ilvA BVI01S_RS07215 succinate peptidase: C40 family aldolase/2- metallophosphatase/ BVI01S_RS14885 adenosyltransferase: BVI01S_RS07650 menaquinol-9 diphosphate 5'- [+ 3 isozymes] transaminase: BVI01S_RS07215 (2Z)-2-aminobut- adenosylcobinamide- type I methionyl type I methionyl type I methionyl Holliday BVI01S_RS13985 adenosyltransferase: panB 3,4-dihydroxy- phosphoheptulonate aspartate kinase: atpD BVI01S_RS01255 semialdehyde peptidase: dehydro-3-deoxy- BVI01S_RS08710 fructose- 5'-nucleotidase: fructose- BVI01S_RS15385 thiamine transporter pyrophosphohydrolase: triphosphate 3'- an [L-cysteine 3-methyl-2-oxobutanoate 2-enoate L-citrulline BVI01S_RS12875 phosphate aminopeptidase: aminopeptidase: aminopeptidase: junction serine serine [+ 3 isozymes] isochorismate BVI01S_RS15385 2-butanone- synthase/ BVI01S_RS11555 ilvE agmatine NAD-dependent phosphogluconate bisphosphate BVI01S_RS20420 bisphosphate RS09600 cob(I)yrinic acid superpathway of tetrahydrofolate biosynthesis diphosphate of molybdate: BVI01S_RS19350 diphosphatase: desulfurase]-S- ATP synthase subunit L-citrulline [+ 3 isozymes] guanylyltransferase: BVI01S_RS12875 bifunctional map 1-(β-D map map resolution resolvaseof thr thr cob(I)yrinic acid asp 4-phosphate chorismate mutase: [+ 3 isozymes] (3S)-3-methyl-2- ornithine succinate- aldolase: aldolase: aldolase: an S-sulfanyl-[L- a,c-diamide modB modA BVI01S_RS19350 sulfanyl-L-cysteine B: BVI01S_RS09665 BVI01S_RS08695 [+ 3 isozymes] adenosylcobinamide ribofuranosyl) recombinationalRecU: recU 2-succinyl-6- a,c-diamide 2-dehydropantoate synthase/GTP molybdopterin BVI01S_RS21200 oxopentanoate carbamoyltransferase: agmatinase: semialdehyde BVI01S_RS00415 BVI01S_RS15835 BVI01S_RS15835 cysteine desulfurase] adenosyltransferase: 3-deoxy- L-aspartyl-4-phosphate kinase/ hydroxy-2, 4- aspartate 1- cyclohydrolase II: adenine speB a mature peptidoglycan a mature peptidoglycan an N-terminal L- nicotinamide an N-terminal junction BVI01S_RS08690 adenosyltransferase: 2-dehydropantoate molybdate ATP ornithine argF dehydrogenase: bifunctional adenosylcobinamide- scaffold protein cyclohexadiene- [corrinoid decarboxylase: GTP BVI01S_RS15110 dinucleotide D-arabino- 2-iminobutanoate with (L-alanyl-γ-D- strand (non- a mature a nascent met threonyl-[protein] met L-seryl-[protein] met a peptide formation of two trp RS20045 trp BVI01S_RS08690 2-reductase: carbamoyltransferase: BVI01S_RS05370 adenosylcobinamide phosphate D-erythrose for iron-sulfur 1-carboxylate adenosyltranferase]- panD GTP ppGpp heptulosonate aspartate-semialdehyde a [TusA sulfur- isobutanoyl-CoA putrescine glutamyl-meso-2,6- reducing terminus) peptidoglycan peptidoglycan D-glyceraldehyde DHAP D-glyceraldehyde DHAP intact strands [corrinoid BVI01S_RS07940 2,5-diamino-6-(5-phospho-D- argF L-ornithine kinase/ pyruvate 4-phosphate cob(II)inamide molybdopterin 7-phosphate dehydrogenase: asd (2S)-2- diaminopimeloyl-D- (meso-DAP 3-phosphate guanylyltransferase: cluster assembly: synthase: menH adenosyltranferase]- GTP carrier protein]-S- succinate adenosylcobinamide- with (L-alanyl- β ribosylamino)pyrimidin-4(3H)-one 3-dehydroquinate BVI01S_RS08695 BVI01S_RS20400 (R)-pantoate -alanine cyclohydrolase molybdotransferase sulfanyl-L-cysteine methylbutanoyl-CoA ornithine--oxo-acid alanine) tetrapeptide γ-D-glutamyl- containing) with 2-succinyl-5- cob(II)inamide bifunctional nucleoside- synthase: carbamoyl phosphate adenosyl-cobinamide F0F1 ATP an S-sulfanyl-[cysteine I FolE: folE MoeA: L-aspartate 4-semialdehyde transaminase: meso-2,6- GlcNAc terminus H + H + enolpyruvyl- diaminohydroxyphosphoribosylaminopyrimidine GDP L-ornithine guanylyltransferase: synthase desulfurase]-[disordered- 7,8- BVI01S_RS17775 diphosphate BVI01S_RS08425 phosphate 2-oxobutanoate BVI01S_RS13965 diaminopimeloyl- phosphate 6-hydroxy-3- [corrinoid deaminase/5-amino-6-(5-phosphoribosylamino) pyrophosphokinase: bifunctional (p)ppGpp methylacrylyl-CoA BVI01S_RS08710 form scaffold pantoate--beta- dihydroneopterin superpathway of thiamine diphosphate biosynthesis II kinase: ndk D-alanine) cyclohexene- adenosyltranferase]- synthetase/guanosine- 3-dehydroquinate 4-hydroxy- a [TusD sulfur- carbamoyl L-glutamate-5- protein] complex [corrinoid alanine ligase: 3'-triphosphate uracil reductase RibD: ribD MoO - BVI01S_RS19350 (E)-2- adenosyl- cob(I)inamide 2 tetrahydrodipicolinate enoyl-CoA phosphate synthase: tetrapeptide [cysteine desulfurase]-S- 1-carboxylic- adenosyltranferase]- molybdopterin 3',5'-bis(diphosphate) 3'- carrier protein]-S- methylcrotonoyl-CoA semialdehyde cobinamide H + RS09665 H + BVI01S_RS08305 5-amino-6-(5-phospho- a [ThiS sulfur- type II 3- synthase: dapA hydratase: BVI01S_RS12380 sulfanylcysteine:[acceptor acid synthase: cob(I)yrinic acid cob(I)inamide cys cofactor pyrophosphohydrolase: sulfanyl-L-cysteine enoyl-CoA phosphate a purine D-ribosylamino)uracil carrier protein] dehydroquinate (2S,4S)-4-hydroxy-2,3,4,5- BVI01S_RS20125 BVI01S_RS12385 L-tryptophan degradation to protein]-cysteine menD a,c-diamide D-ribulose 5-phosphate BVI01S_RS19350 hydratase: propanoyl-CoA ribonucleoside cob(I)yrinic acid 7,8- bifunctional dehydratase: aroQ 2-amino-3-carboxymuconate sulfurtransferase: 2-succinyl-5- adenosyltransferase: (R)-pantothenate sulfur carrier cysteine tetrahydrodipicolinate