Supplementary Table S3. Mutations found only in block Q tumor focus. Gene Symbol Genbank ID Chromosome Position Change Classification Type Reference Variant Q Reference Q Variant dbSNP COSMIC ABCB1 NM_000927 chr7 87144722 T1036I MISSENSE SNV G A 56 9 COSM1195596 ABCD3 NM_002858 chr1 94964360 R496C MISSENSE SNV C T 6 3 COSM913502 ABHD12 NM_015600 chr20 25284257 H320Y MISSENSE SNV G A 145 41 ACE NM_000789 chr17 61560826 K498M MISSENSE SNV A T 28 6 ACOT11 NM_015547 chr1 55013998 G6R MISSENSE SNV G A 62 17 ADAMTS12 NM_030955 chr5 33576716 P1139S MISSENSE SNV G A 19 15 COSM482731 ADD3 NM_016824 chr10 111878395 L206F MISSENSE SNV G T 18 6 AIFM1 NM_004208 chrX 129281788 G138V MISSENSE SNV C A 25 14 COSM1555996 AKAP10 NM_007202 chr17 19839697 V457I MISSENSE SNV C T 41 8 AKAP9 NM_005751 chr7 91631983 D918Y MISSENSE SNV G T 26 9 ALDH3A1 NM_000691 chr17 19643657 R314H MISSENSE SNV C T 23 10 COSM1381458 ALDOC NM_005165 chr17 26901130 A252T MISSENSE SNV C T 142 40 ALPK2 NM_052947 chr18 56246277 Q577H MISSENSE SNV C A 35 15 ANK3 NM_020987 chr10 61831926 R2905C MISSENSE SNV G A 13 5 COSM673798 ANO10 NM_018075 chr3 43596868 L524I MISSENSE SNV A T 46 10 ANO10 NM_018075 chr3 43596867 L524X NONSENSE SNV A T 40 10 ARAP2 NM_015230 chr4 36075330 L1575S MISSENSE SNV A G 19 6 ARFGEF2 NM_006420 chr20 47558459 P71S MISSENSE SNV C T 28 7 ARFGEF2 NM_006420 chr20 47632850 A1405T MISSENSE SNV G A 5 3 COSM1245314 ARHGAP15 NM_018460 chr2 144525593 T427M MISSENSE SNV C T 79 12 COSM1494595 ARHGAP33 NM_052948 chr19 36279057 S1036L MISSENSE SNV C T 37 9 ARHGEF6 NM_004840 chrX 135757198 T668S MISSENSE SNV G C 12 8 ATP10D NM_020453 chr4 47517614 D138N MISSENSE SNV G A 36 9 COSM1618868 ATP6V0A2 NM_012463 chr12 124212338 S177F MISSENSE SNV C T 8 4 COSM1322672 ATP6V1C2 NM_001039362 chr2 10863001 A9V MISSENSE SNV C T 29 6 COSM224645 ATP7B NM_000053 chr13 52520548 V978M MISSENSE SNV C T 34 8 B4GALT4 NM_003778 chr3 118945838 Q102X NONSENSE SNV G A 39 13 BAHD1 NM_014952 chr15 40751321 E220K MISSENSE SNV G A 50 11 BARX2 NM_003658 chr11 129306690 R78C MISSENSE SNV C T 64 12 COSM301747 BICD1 NM_001714 chr12 32481442 R685W MISSENSE SNV C T 46 9 BMPR2 NM_001204 chr2 203397422 E415Q MISSENSE SNV G C 35 10 COSM1306312 BOD1L1 NM_148894 chr4 13602442 E2028K MISSENSE SNV C T 37 6 COSM384444 C10orf91 NM_173541 chr10 134261486 G120E MISSENSE SNV G A 70 14 C1orf109 NM_017850 chr1 38149006 Q187X NONSENSE SNV G A 39 19 C2orf49 NM_024093 chr2 105959534 H166D MISSENSE SNV C G 31 8 CAPN7 NM_014296 chr3 15288887 E709D MISSENSE SNV G T 28 6 CARD10 NM_014550 chr22 37888746 P847H MISSENSE SNV G T 152 69 CCDC14 NM_022757 chr3 123665920 R318X NONSENSE SNV G A 8 4 CCDC141 NM_173648 chr2 179718210 E1068K MISSENSE SNV C T 26 8 CCDC166 NM_001162914 chr8 144790063 N73H MISSENSE SNV T G 28 13 CD46 NM_172359 chr1 207934695 P193S MISSENSE SNV C T 7 6 CHD9 NM_025134 chr16 53326835 R1794H MISSENSE SNV G A 19 7 COSM1201019 CHST4 NM_001166395 chr16 71570653 H25N MISSENSE SNV C A 38 11 CILP NM_003613 chr15 65491173 R484Q MISSENSE SNV C T 65 14 COSM1201212 CLC NM_001828 chr19 40225125 P34L MISSENSE SNV G A 17 13 COSM1494273 CLEC7A NM_197947 chr12 10280396 G51E MISSENSE SNV C T 14 4 COSM122193 CNGA3 NM_001298 chr2 99013218 V529M MISSENSE SNV G A 134 39 rs104893619 COSM77490 COL6A1 NM_001848 chr21 47422272 R736K MISSENSE SNV G A 24 12 CRLS1 NM_019095 chr20 5990515 N134S MISSENSE SNV A G 5 2 COSM1190209 CRYZ NM_001130042 chr1 75184968 P118L MISSENSE SNV G A 28 7 CTNNA1 NM_001903 chr5 138253514 W491X NONSENSE SNV G A 5 4 CYFIP1 NM_014608 chr15 22935935 N291Y MISSENSE SNV A T 16 6 DCAF7 NM_005828 chr17 61657272 V166M MISSENSE SNV G A 155 61 DCC NM_005215 chr18 50278721 R130Q MISSENSE SNV G A 52 12 COSM271921 DCHS2 NM_017639 chr4 155180777 D1782N MISSENSE SNV C T 2 2 COSM1695109 DENND2C NM_001256404 chr1 115142958 R658X NONSENSE SNV G A 66 16 COSM1203338 DMRT1 NM_021951 chr9 916902 A321E MISSENSE SNV C A 38 7 COSM1331451 DSP NM_004415 chr6 7575559 S823L MISSENSE SNV C T 22 5 rs141834182 COSM1487922 DYNC1H1 NM_001376 chr14 102446846 G307V MISSENSE SNV G T 8 4 EID1 NM_014335 chr15 49170926 D185N MISSENSE SNV G A 34 17 EIF2D NM_006893 chr1 206769077 S500F MISSENSE SNV G A 22 7 ERGIC2 NM_016570 chr12 29494115 P370S MISSENSE SNV G A 25 6 FAM184A NM_024581 chr6 119399345 M40I MISSENSE SNV C A 26 8 FAM3D NM_138805 chr3 58631311 A63V MISSENSE SNV G A 80 20 FAM49A NM_030797 chr2 16769321 E23K MISSENSE SNV C T 37 10 COSM1690222 FAM98A NM_015475 chr2 33820655 A35S MISSENSE SNV C A 48 9 FANCA NM_000135 chr16 89842155 P632L MISSENSE SNV G A 107 32 FBXL19 NM_001099784 chr16 30941800 G419E MISSENSE SNV G A 55 24 FBXO47 NM_001008777 chr17 37093483 A435V MISSENSE SNV G A 25 8 FLG2 NM_001014342 chr1 152327060 E1068K MISSENSE SNV C T 21 5 COSM1293190 FMN2 NM_020066 chr1 240494024 P1520L MISSENSE SNV C T 26 4 COSM1473674 FMN2 NM_020066 chr1 240494024 P1520L MISSENSE SNV C T 26 4 COSM1473674 FNBP4 NM_015308 chr11 47767904 E317K MISSENSE SNV C T 77 12 FPGT NM_003838 chr1 74670968 V413L MISSENSE SNV G T 10 5 COSM682189 GABRQ NM_018558 chrX 151820033 R316W MISSENSE SNV C T 29 6 COSM1582818 GALNT3 NM_004482 chr2 166613573 A459E MISSENSE SNV G T 6 5 GALR1 NM_001480 chr18 74963012 V170M MISSENSE SNV G A 45 19 GPR113 NM_001145168 chr2 26533073 M1023I MISSENSE SNV C T 126 29 GPR32 NM_001506 chr19 51274417 G187D MISSENSE SNV G A 32 15 GPR98 NM_032119 chr5 90106906 R5277C MISSENSE SNV C T 31 6 COSM1158970 GPSM2 NM_013296 chr1 109440206 C124Y MISSENSE SNV G A 75 16 GREB1L NM_001142966 chr18 19085502 T1401I MISSENSE SNV C T 28 18 GZMB NM_004131 chr14 25101144 E174K MISSENSE SNV C T 34 7 COSM1369431 HEATR1 NM_018072 chr1 236748396 P724S MISSENSE SNV G A 5 3 COSM1690000 HIST1H2BH NM_003524 chr6 26251954 D26N MISSENSE SNV G A 29 10 COSM1076752 HMCN1 NM_031935 chr1 186024704 L2348I MISSENSE SNV C A 57 13 HMGCLL1 NM_019036 chr6 55360350 I251N MISSENSE SNV A T 8 4 HS3ST5 NM_153612 chr6 114379025 S146F MISSENSE SNV G A 17 6 COSM232507 IFIT1B NM_001010987 chr10 91143394 M108I MISSENSE SNV G A 76 15 IGDCC4 NM_020962 chr15 65677303 D1111N MISSENSE SNV C T 56 17 IGSF9 NM_001135050 chr1 159904002 G361E MISSENSE SNV C T 59 10 ISLR2 NM_001130138 chr15 74426437 Q448X NONSENSE SNV C T 58 22 ITGA4 NM_000885 chr2 182360586 E488K MISSENSE SNV G A 7 4 ITGA6 NM_001079818 chr2 173349861 D575N MISSENSE SNV G A 19 4 COSM441507 ITIH1 NM_002215 chr3 52813491 V152I MISSENSE SNV G A 48 9 rs147534607 COSM236766 JHDM1D NM_030647 chr7 139824444 G343V MISSENSE SNV C A 21 6 KBTBD7 NM_032138 chr13 41766650 R582X NONSENSE SNV G A 21 4 COSM1255212 KDM5A NM_001042603 chr12 432830 R696W MISSENSE SNV G A 76 13 COSM939275 KIAA0895 NM_001100425 chr7 36396605 D258A MISSENSE SNV T G 9 11 KIF15 NM_020242 chr3 44879775 M1060I MISSENSE SNV G T 52 8 COSM371412 KIT NM_000222 chr4 55597547 V732A MISSENSE SNV T C 24 4 COSM1430172 KLHL20 NM_014458 chr1 173721027 Y241F MISSENSE SNV A T 8 4 KRT1 NM_006121 chr12 53072390 D248N MISSENSE SNV C T 16 4 COSM75184 KRTAP5-5 NM_001001480 chr11 1651615 Y182C MISSENSE SNV A G 8 8 rs74396270 COSM1321770 L3MBTL2 NM_031488 chr22 41605733 E20K MISSENSE SNV G A 83 18 LANCL2 NM_018697 chr7 55467697 P193L MISSENSE SNV C T 22 7 LCE1C NM_178351 chr1 152777810 G49R MISSENSE SNV C T 26 8 COSM1319951 LDB1 NM_001113407 chr10 103870647 E111X NONSENSE SNV C A 40 16 LHFPL1 NM_178175 chrX 111903900 E146K MISSENSE SNV C T 16 6 LMOD1 NM_012134 chr1 201868559 G528W MISSENSE SNV C A 251 77 LOXL1 NM_005576 chr15 74219254 Q44X NONSENSE SNV C T 18 11 LPHN3 NM_015236 chr4 62598825 H250Y MISSENSE SNV C T 43 12 LRP2 NM_004525 chr2 170066149 R2095X NONSENSE SNV G A 29 5 COSM1213761 LRRC47 NM_020710 chr1 3701701 A382P MISSENSE SNV C G 124 31 MAN1A1 NM_005907 chr6 119669720 L171M MISSENSE SNV G T 32 8 MAP3K4 NM_005922 chr6 161470575 W424X NONSENSE SNV G A 84 17 MCM6 NM_005915 chr2 136624217 V233M MISSENSE SNV C T 43 16 MCM7 NM_005916 chr7 99698914 A2S MISSENSE SNV C A 21 9 MERTK NM_006343 chr2 112786035 R865Q MISSENSE SNV G A 49 10 COSM271387 METRN NM_024042 chr16 765976 G166V MISSENSE SNV G T 24 11 METTL3 NM_019852 chr14 21969168 A335T MISSENSE SNV C T 41 8 MFSD6 NM_017694 chr2 191301002 G83S MISSENSE SNV G A 19 10 MLLT4 NM_001207008 chr6 168325721 V994M MISSENSE SNV G A 17 10 MORN1 NM_024848 chr1 2288966 G314E MISSENSE SNV C T 53 13 COSM905201 MRPL37 NM_016491 chr1 54678309 A323V MISSENSE SNV C T 29 6 COSM1687717 MTG1 NM_138384 chr10 135212728 E140K MISSENSE SNV G A 43 15 MTTP NM_000253 chr4 100532397 R623C MISSENSE SNV C T 8 7 MUS81 NM_025128 chr11 65628512 H68Q MISSENSE SNV C G 54 11 MUSK NM_005592 chr9 113459626 L170F MISSENSE SNV C T 66 14 MYO9A NM_006901 chr15 72190522 R1441I MISSENSE SNV C A 3 2 COSM964548 NAIP NM_004536 chr5 70308532 E71K MISSENSE SNV C T 32 8 NAV3 NM_014903 chr12 78513083 R1036I MISSENSE SNV G T 59 8 COSM943624 NEB NM_001271208 chr2 152408319 K6626I MISSENSE SNV T A 34 7 NEB NM_001271208 chr2 152552115 V551I MISSENSE SNV C T 47 7 COSM387101 NGF NM_002506 chr1 115828746 R224Q MISSENSE SNV C T 64 10 COSM1294771 NLN NM_020726 chr5 65073345 P181L MISSENSE SNV C T 23 18 NLRX1 NM_024618 chr11 119045219 V303M MISSENSE SNV G A 34 6 rs147720831 COSM686914 NOC4L NM_024078 chr12 132633393 A285G MISSENSE SNV C G 49 12 NR2F6 NM_005234 chr19 17351500 R118Q MISSENSE SNV C T 80 16 NR3C2 NM_000901 chr4 149356799 A405D MISSENSE SNV G T 4 7 NUP155 NM_153485 chr5 37348685 G306V MISSENSE SNV C A 29 6 OR10A3 NM_001003745 chr11 7960899 V57I MISSENSE SNV C T 75 14 COSM271435 OR2AK2 NM_001004491 chr1 248129556 R308K MISSENSE SNV G A 57 11 OR2L2 NM_001004686 chr1 248202305 V246I MISSENSE SNV G A 35 13 OR4K2 NM_001005501 chr14 20344535 A37T MISSENSE SNV G A 13 6 OR52B6 NM_001005162