Evidence-Based Complementary and Alternative Medicine Mechanisms, Efficacy, and Safety of Bacopa monnieri (Brahmi) for Cognitive and Brain Enhancement Guest Editors: Con Stough, Hemant Singh, and Andrea Zangara Mechanisms, Efficacy, and Safety of Bacopa monnieri (Brahmi) for Cognitive and Brain Enhancement Evidence-Based Complementary and Alternative Medicine Mechanisms, Efficacy, and Safety of Bacopa monnieri (Brahmi) for Cognitive and Brain Enhancement Guest Editors: Con Stough, Hemant Singh, and Andrea Zangara Copyright © 2015 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Evidence-Based Complementary and Alternative Medicine.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Mona Abdel-Tawab, Germany Il-Moo Chang, Republic of Korea Brett Froeliger, USA Jon Adams, Australia Chun-Tao Che, USA Maria pia Fuggetta, Italy GabrielA.Agbor,Cameroon Kevin Chen, USA Joel J. Gagnier, Canada Ulysses P. Albuquerque, Brazil Evan P. Cherniack, USA Siew Hua Gan, Malaysia Samir Lutf Aleryani, USA Salvatore Chirumbolo, Italy Jian-Li Gao, China Ather Ali, USA Jae Youl Cho, Korea Mary K. Garcia, USA A.-Shtayeh, Palestinian Authority K. Christensen, Denmark S. Garcia de Arriba, Germany Gianni Allais, Italy Shuang-En Chuang, Taiwan D. G. Gimenez,´ Spain Terje Alraek, Norway Y. Clement, Trinidad And Tobago Gabino Garrido, Chile Shrikant Anant, USA Paolo Coghi, Italy Ipek Goktepe, Qatar Isabel Andujar,´ Spain Marisa Colone, Italy Michael Goldstein, USA Letizia Angiolella, Italy Lisa A. Conboy, USA Yuewen Gong, Canada Virginia A. Aparicio, Spain Kieran Cooley, Canada Settimio Grimaldi, Italy Makoto Arai, Japan Edwin L. Cooper, USA Gloria Gronowicz, USA Hyunsu Bae, Republic of Korea Olivia Corcoran, UK Maruti Ram Gudavalli, USA Onesmo B. Balemba, USA Muriel Cuendet, Switzerland Alessandra Guerrini, Italy Winfried Banzer, Germany RobertoK.N.Cuman,Brazil Narcis Gusi, Spain Panos Barlas, UK Vincenzo De Feo, Italy Svein Haavik, Norway Vernon A. Barnes, USA Roco De la Puerta, Spain Solomon Habtemariam, UK Samra Bashir, Pakistan Laura De Martino, Italy Abid Hamid, India Purusotam Basnet, Norway Nunziatina De Tommasi, Italy Michael G. Hammes, Germany Jairo Kennup Bastos, Brazil Alexandra Deters, Germany K. B. Harikumar, India Arpita Basu, USA Farzad Deyhim, USA Cory S. Harris, Canada Sujit Basu, USA Manuela Di Franco, Italy Jan Hartvigsen, Denmark George David Baxter, New Zealand Claudia Di Giacomo, Italy Thierry Hennebelle, France Andre-Michael´ Beer, Germany Antonella Di Sotto, Italy Lise Hestbaek, Denmark Alvin J. Beitz, USA M. Dijoux-Franca, France Eleanor Holroyd, Australia Louise Bennett, Australia Luciana Dini, Italy Markus Horneber, Germany Maria Camilla Bergonzi, Italy Tieraona L. Dog, USA Ching-Liang Hsieh, Taiwan Anna R. Bilia, Italy Caigan Du, Canada BennyT.K.Huat,Singapore Yong C. Boo, Republic of Korea Jeng-Ren Duann, USA Roman Huber, Germany Monica Borgatti, Italy Nativ Dudai, Israel Helmut Hugel, Australia Francesca Borrelli, Italy Thomas Efferth, Germany Ciara Hughes, UK Gloria Brusotti, Italy Abir El-Alfy, USA Attila Hunyadi, Hungary Arndt Bussing,¨ Germany Tobias Esch, USA Sumiko Hyuga, Japan Rainer W. Bussmann, USA Giuseppe Esposito, Italy H. Stephen Injeyan, Canada Andrew J. Butler, USA Keturah R. Faurot, USA Chie Ishikawa, Japan Gioacchino Calapai, Italy Yibin Feng, Hong Kong Angelo A. Izzo, Italy Giuseppe Caminiti, Italy Nianping Feng, China Chris J. Branford-White, UK Raffaele Capasso, Italy Patricia D. Fernandes, Brazil Suresh Jadhav, India Francesco Cardini, Italy Josue Fernandez-Carnero, Spain G. K. Jayaprakasha, USA Opher Caspi, Israel Antonella Fioravanti, Italy Stefanie Joos, Germany Subrata Chakrabarti, Canada Fabio Firenzuoli, Italy ZeevLKain,USA Pierre Champy, France Peter Fisher, UK Osamu Kanauchi, Japan Shun-Wan Chan, Hong Kong Filippo Fratini, Italy Wenyi Kang, China Shao-Hsuan Kao, Taiwan Albert S Mellick, Australia Elia Ranzato, Italy Juntra Karbwang, Japan A. G. Mensah-Nyagan, France Ke Ren, USA Kenji Kawakita, Japan Andreas Michalsen, Germany Man-Hee Rhee, Republic of Korea D. A. Kennedy, Canada Oliver Micke, Germany Luigi Ricciardiello, Italy Youn C. Kim, Republic of Korea Roberto Miniero, Italy Daniela Rigano, Italy C. Kim, Republic of Korea Giovanni Mirabella, Italy JoseL.R´ ´ıos, Spain Yoshiyuki Kimura, Japan David Mischoulon, USA Paolo Roberti di Sarsina, Italy Toshiaki Kogure, Japan Francesca Mondello, Italy Mariangela Rondanelli, Italy Jian Kong, USA Albert Moraska, USA Omar Said, Israel Tetsuya Konishi, Japan Giuseppe Morgia, Italy Avni Sali, Australia Karin Kraft, Germany Mark Moss, UK Mohd Z. Salleh, Malaysia Omer Kucuk, USA Yoshiharu Motoo, Japan A. Sandner-Kiesling, Austria Victor Kuete, Cameroon KamalD.Moudgil,USA Manel Santafe, Spain Yiu W. Kwan, Hong Kong Yoshiki Mukudai, Japan Tadaaki Satou, Japan Kuang C. Lai, Taiwan Frauke Musial, Germany Michael A. Savka, USA Ilaria Lampronti, Italy MinKyun Na, Republic of Korea Claudia Scherr, Switzerland Lixing Lao, Hong Kong Hajime Nakae, Japan G. Schmeda-Hirschmann, Chile Christian Lehmann, Canada Srinivas Nammi, Australia Andrew Scholey, Australia Marco Leonti, Italy Krishnadas Nandakumar, India Roland Schoop, Switzerland Lawrence Leung, Canada Vitaly Napadow, USA Sven Schroder,¨ Germany Shahar Lev-ari, Israel Michele Navarra, Italy Herbert Schwabl, Switzerland Chun G. Li, Australia Isabella Neri, Italy Veronique Seidel, UK Xiu-Min Li, USA Pratibha V. Nerurkar, USA Senthamil Selvan, USA Min Li, China Karen Nieber, Germany Felice Senatore, Italy Ho Lin, Taiwan Menachem Oberbaum, Israel Hongcai Shang, China Bi-Fong Lin, Taiwan Martin Offenbaecher, Germany Ronald Sherman, USA C. G. Lis, USA Junetsu Ogasawara, Japan Karen J. Sherman, USA G. Litscher, Austria Ki-Wan Oh, Republic of Korea Kuniyoshi Shimizu, Japan I-Min Liu, Taiwan Yoshiji Ohta, Japan Kan Shimpo, Japan Yijun Liu, USA Olumayokun A. Olajide, UK Yukihiro Shoyama, Japan V. L opez,´ Spain Thomas Ostermann, Germany Morry Silberstein, Australia T. Lundeberg, Sweden Siyaram Pandey, Canada K. S. Sirajudeen, Malaysia Filippo Maggi, Italy Bhushan Patwardhan, India Graeme Smith, UK V. Ma g g i n i , It a l y BeritS.Paulsen,Norway Chang-Gue Son, Korea Gail B. Mahady, USA Philip Peplow, New Zealand Rachid Soulimani, France Jamal Mahajna, Israel Florian Pfab, Germany Didier Stien, France Juraj Majtan, Slovakia Sonia Piacente, Italy Con Stough, Australia Francesca Mancianti, Italy Andrea Pieroni, Italy Annarita Stringaro, Italy Carmen Mannucci, Italy Richard Pietras, USA Shan-Yu Su, Taiwan Arroyo-Morales Manuel, Spain Andrew Pipingas, Australia Barbara Swanson, USA Fulvio Marzatico, Italy Jose M. Prieto, UK Giuseppe Tagarelli, Italy Marta Marzotto, Italy Haifa Qiao, USA O. Taglialatela-Scafati, Italy James H. McAuley, Australia Waris Qidwai, Pakistan Takashi Takeda, Japan Kristine McGrath, Australia Xianqin Qu, Australia Ghee T. Tan, USA James S. McLay, UK E. Ferreira Queiroz, Switzerland Hirofumi Tanaka, USA Lewis Mehl-Madrona, USA Roja Rahimi, Iran Lay Kek Teh, Malaysia Peter Meiser, Germany Khalid Rahman, UK Norman Temple, Canada Karin Meissner, Germany Cheppail Ramachandran, USA Mayank Thakur, Germany Menaka C. Thounaojam, USA Giuseppe Venturella, Italy Jenny M. Wilkinson, Australia Evelin Tiralongo, Australia Pradeep Visen, Canada D. R. Williams, Republic of Korea Stephanie Tjen-A-Looi, USA Aristo Vojdani, USA C. Worsnop, Australia MichaThlfj Tomczyk, Poland Dawn Wallerstedt, USA Haruki Yamada, Japan Loren Toussaint, USA Shu-Ming Wang, USA Nobuo Yamaguchi, Japan Yew-Min Tzeng, Taiwan Chong-Zhi Wang, USA Ling Yang, China Dawn M. Upchurch, USA Yong Wang, USA Junqing Yang, China Konrad Urech, Switzerland Jonathan L. Wardle, Australia Eun J. Yang, Republic of Korea Takuhiro Uto, Japan Kenji Watanabe, Japan Ken Yasukawa, Japan Sandy van Vuuren, South Africa J. Wattanathorn, Thailand Albert S. Yeung, USA Alfredo Vannacci, Italy Michael Weber, Germany Armando Zarrelli, Italy Subramanyam Vemulpad, Australia Silvia Wein, Germany C. Zaslawski, Australia Carlo Ventura, Italy Janelle Wheat, Australia Ruixin Zhang, USA Contents Mechanisms, Efficacy, and Safety of Bacopa monnieri (Brahmi) for Cognitive and Brain Enhancement, Con Stough, Hemant Singh, and Andrea Zangara Volume 2015, Article ID 717605, 2 pages Bacopa monniera (CDRI-08) Upregulates the Expression of Neuronal and Glial Plasticity Markers in the Brain of Scopolamine Induced Amnesic Mice, Arpita Konar, Akash Gautam, and M. K. Thakur Volume 2015, Article ID 837012, 9 pages Molecular and Functional Characterization of Bacopa monniera:ARetrospectiveReview, Koilmani Emmanuvel Rajan, Jayakumar Preethi, and Hemant K. Singh Volume 2015, Article ID 945217, 12 pages ASpecialExtractofBacopa monnieri (CDRI-08) Restores Learning and Memory by Upregulating Expression of the NMDA Receptor Subunit GluN2B in the Brain of Scopolamine-Induced Amnesic Mice,RakeshRai,HemantK.Singh,andS.Prasad Volume 2015, Article ID 254303, 13 pages CDRI-08 Attenuates REST/NRSF-Mediated Expression of NMDAR1 Gene in PBDE-209-Exposed Mice Brain,PriyaVerma,RajaneeshK.Gupta,BehroseS.Gandhi,andPoonamSingh Volume 2015, Article ID 403840, 10 pages Bacopa monnieri Extract (CDRI-08) Modulates the NMDA Receptor Subunits and nNOS-Apoptosis Axis in Cerebellum of Hepatic Encephalopathy Rats, Papia Mondal and Surendra Kumar Trigun Volume 2015, Article ID 535013, 8 pages Bacopa