CLEVELAND 2017 CLEVELAND $2.3 BILLION INVESTED IN MORE THAN 400 BIOMEDICAL START-UP COMPANIES* 60 EXITS** 38 CLEVELAND-AREA BIOMEDICAL INVESTORS 96 NATIONAL & INTERNATIONAL INVESTORS IN CLEVELAND COMPANIES $5.6 BILLION BIOMEDICAL SECTOR 700 BIOMEDICAL COMPANIES *SINCE 2001 **SINCE 2002 CLEVELAND Internationally renowned clinical, educational, and research institutions, supportive philanthropies, government and economic development engines, funding, talent, strong biomedical innovation, and an abundant workforce. ASSETS & RESOURCES $650M EDUCATIONAL INSTITUTIONS IN SPONSORED RESEARCH The Medical Capital is home to 25 universities that offer graduate and undergraduate programs, as well as certificates and diplomas, serving the region’s healthcare, health IT, and bioscience industry. Since 2006, these institutions have awarded more than CLINICAL AND RESEARCH INSTITUTIONS 18,000 bioscience degrees. Globally recognized clinical and research institutions provide SELECTED INSTITUTIONS INCLUDE: the platform for Cleveland’s biomedical industry. Together these CLEVELAND STATE UNIVERSITY organizations conduct $650 million in annual sponsored research Among the top 20 percent of U.S. universities and are nationally ranked in multiple specialty areas. The for research and development, the College of institutions collaborate closely with regional biopharmaceutical, Sciences and Health Professions enrolls more than medical device and health IT companies to advance innovation. 2,600 students annually, and includes 14 master’s programs and 16 undergraduate programs focused SELECTED INSTITUTIONS INCLUDE: on educating future researchers, clinicians and bioscience workers. CLEVELAND CLINIC Nationally ranked #2 in Best Hospitals Honor Roll. 23 specialty KENT STATE UNIVERSITY rankings include #1 heart and heart surgery for 22 years in The birthplace of liquid crystal displays, Kent State a row; #2 in gastroenterology & GI surgery, nephrology, and is home to the world’s first Liquid Crystal Institute. urology* NEOMED UNIVERSITY HOSPITALS For more than 40 years, Northeast Ohio Medical Nationally ranked in 18 specialties, including cancer, University (NEOMED) has worked in collaboration gastroenterology and GI surgery, gynecology, and orthopedics* with its educational, clinical and research partners to successfully train health professionals and AKRON CHILDREN’S HOSPITAL medical researchers who serve and impact the Nationally ranked in 6 specialties, including diabetes & region and beyond. The University trains students endocrinology, neonatology, and neurology & neurosurgery* in a team-based, interprofessional environment and offers Doctor of Medicine (M.D.) and Doctor METROHEALTH MEDICAL CENTER of Pharmacy (Pharm.D.) degrees, in addition Nationally ranked in diabetes & endocrinology* and home to master’s and doctoral degrees and research to the only adult and pediatric burn unit in the State of Ohio opportunities in other medical areas. LOUIS STOKES CLEVELAND VA MEDICAL CENTER THE AKRON UNIVERSITY Eight centers of excellence, including open heart surgery and The Akron University maintains the nation’s largest geriatric evaluation and management Ph.D. student body in polymer science and polymer engineering. The program is the largest and CASE WESTERN RESERVE UNIVERSITY broadest in the U.S., dating from 1910. School of Medicine ranked Top 25 in research; Biomedical Engineering department ranked Top 17* *U.S. News & World Report, 2016-17 Northeast Ohio institutions have been awarded over $500 million to develop centers of innovation in cardiovascular therapies, biomaterials, neurostimulation, medical imaging, and regenerative medicine. INNOVATION HUBS ENTREPRENEURIAL SUPPORT GLOBAL CENTER FOR HEALTH INNOVATION BIOENTERPRISE Part of the Cleveland Convention Center complex, BioEnterprise guides the growth of biotechnology, medical device, and health the Global Center for Health Innovation brings IT and services companies and provides: together large corporations, healthcare systems, educational institutions and developing companies to • Access to bioscience venture capital, private equity and grant funding discover possibilities in healthcare. The collaborative opportunities atmosphere encourages inspired, innovative and • Privileged relationships with world-class research and clinical institutions forward-thinking ideas that can lead to future • Experienced bioscience management guidance advancements in the industry. Selected partners • A network of technical services, equipment, professional service providers, include HIMSS, GE Healthcare, Forbo, SmartShape, and flexible development space Cisco, and Cardinal Health. • Business development and alliance support for strategic partnerships • Strategic marketing and communications guidance HEALTH-TECH CORRIDOR Located in the heart of Cleveland, the Health-Tech GLOBAL CARDIOVASCULAR INNOVATION CENTER Corridor is a 1,600 acre, three-mile thoroughfare for The Global Cardiovascular Innovation Center (GCIC) houses start-up biomedical, healthcare and technology companies companies developing innovative solutions for the diagnosis and treatment looking to take advantage of close proximity to of cardiovascular diseases. Strategically located near the main campuses of healthcare institutions, including Cleveland Clinic Cleveland Clinic, Case Western Reserve University and University Hospitals, and University Hospitals, academic centers, the incubator offers 50,000 sq. ft. of state-of-the-art space. Clients enjoy including Case Western Reserve University, customizable laboratory facilities for new product research and development business incubators, and more than 170 high-tech activities, flexible office space and conference rooms. The facility provides companies engaged in the business of innovation. clients with convenient access to world-leading clinicians and investigators along with all of GCIC’s business support services. AKRON BIOMEDICAL CORRIDOR Focusing on orthopedics, wound healing, burns, REDIZONE imaging and biomaterials, the Akron Biomedical Located on the campus of the Northeast Ohio Medical University, the Corridor connects three hospitals, including the Research, Entrepreneurship, Discovery, and Innovation Zone (REDIzone) is Summa Health System, Akron General Medical a biomedical business incubator focused on company attraction and growth Center, and Akron Children’s Hospital, and two in the areas of auditory neuroscience, community-based mental health, universities, the Northeast Ohio Medical University metabolic and cardiovascular disease, and musculoskeletal biology. and the University of Akron. The Corridor is home to the Akron Global Business Accelerator and the Akron SEARS THINK[BOX] BioInvestments Funds. An innovative home for out-of-the-box thinkers, Case Western Reserve University’s think[box] provides a space for product design, development, and commercialization. The facility is open to students, faculty and staff, and community entrepreneurs for collaboration and innovation. FLASHSTARTS Flashstarts is an accelerator and venture fund focused on the innovation of software and technology. The accelerator provides entrepreneurs with mentors, capital, office space, and other customized resources. MORE THAN TEAMNEO A regional, private-sector organization, TeamNEO markets Northeast Ohio to the world and collaborates with its partners and others to attract new 230,000 businesses, help those that are here to grow, and accelerate the pace and impact of innovation in the region. HEALTHCARE AND BIOSCIENCES EMPLOYEES IN NORTHEAST OHIO CONTRACT RESEARCH, REGULATORY AND MANUFACTURING Northeast Ohio is home to some of the industry’s leading CRO and regulatory experts including NAMSA, Clinical Research Management, IMARC and Charles River Labs. The region also has a robust biomedical manufacturing base, from full-service custom product design to component and finished product manufacturing. CRITICAL MASS Cleveland’s biomedical industry has grown from 300 companies in 2002 to over 700 companies in 2016. Medical device companies make up half of the total and include firms such as Philips, Hitachi, Steris, Medtronic, Siemens, and GE Healthcare. Biopharmaceutical companies – Oakwood Labs, Ricerca, Charles Rivers Labs, and Abeona Therapeutics – are located in the region. A growing number of 60 EXITS healthcare IT and services companies, including Hyland Software, Explorys (an IBM Company), COMS, CoverMyMeds, and Lexi-Comp SINCE 2002 (a Wolters Kluwer company) complete the industry composite. Not only are start-up bioscience and health IT companies raising record amounts of private capital and exiting at an increasing pace, but mature companies are actively merging and acquiring companies. In 2016, six Northeast Ohio biomedical companies made acquisitions to further build their capabilities. In 2016, four Northeast Ohio biomedical 6 ACQUISITIONS IN 2016 companies were acquired by global concerns. CLE ACQUIRER TARGET 4 EXITS IN 2016 Aris Radiology US Teleradiology Compass Health Meridian Medical ACQUIRER CLE TARGET Steris MedSafe Holdings Isto Holdings Arteriocyte (business line) MedData Cardon Outreach Patterson Medical Performance Health Hyland Software AcroSoft Thermo Fisher Scientific Affymetrix MedData Duet Health Charles River Labs WIL Research Labs INNOVATION START-UP ACTIVITY 38 CLEVELAND-AREA BIOMEDICAL INVESTORS An ever-growing pipeline of funded start-up companies demonstrates the vibrant biomedical environment in Cleveland. VENTURE CAPITAL & GROWTH EQUITY FUNDS Acquire Investments Arsenal Venture