Guidance Framework for Testing the Sterile Insect Technique as a Vector Control Tool against Aedes-Borne Diseases WHO Technical Report.indd 1 24/01/2020 16:13 Guidance Framework fo r Testin g th e Steril e Inse ct Techniqu e a s a Vec t or Cont rol T o ol agai nst Aedes -Bo rne D iseases ISBN 978-92-4-000237-1 (electronic version) ISBN 978-92-4-000238-8 (print version) © World Health Organization 2020 Published under licence from the International Atomic Energy Agency. Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/IGO). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that IAEA or WHO endorse any specific organization, products or services. 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WHO Technical Report.indd 4 24/01/2020 16:13 Contributors IkeOluwapo Ajayi, Romeo Bellini, Pascal Boireau, Steven Bradbury, Salome A. Bukachi, Lee Ching Ng, Fang Jing, Pattamaporn Kittayapong, Pablo Liedo, Kenneth Linthicum, John Mumford, Manju Rahi, Matthew Thomas, Yesim Tozan, Alia Zayed ʴ˙Ё˟˜˔˧˜ˢˡ˦ IkeOluwapo O. Ajayi, Department of Epidemiology and Medical Statistics, Faculty of Public Health, University of Ibadan, Ibadan, Nigeria Romeo Bellini, Centro Agricoltura Ambiente “G. Nicoli” IAEA Collaborating Centre, Via Sant’Agata 835, 40014 Crevalcore, Italy Pascal Boireau, ANSES, Animal Health Laboratory, Maisons Alfort and High Council for Biotechnology, Paris, France Steven Bradbury, Department of Entomology, Iowa State University, Ames, Iowa, 50011, USA Salome A. Bukachi, Institute of Anthropology, Gender and African Studies, University of Nairobi, P.O. Box 30197-00100, Nairobi, Kenya Lee Ching Ng, Environmental Health Institute, National Environment Agency, Singapore Fang Jing, Institute for Health Sciences, Kunming Medical University, 1168# Chun Rong Xi Lu, Yuhua Jiedao, Cheng Gong Xinqu, Kunming City, 650500, Yunnan Province, P.R. China Pattamaporn Kittayapong, Center of Excellence for Vectors and Vector-Borne Diseases, Faculty of Science, Mahidol University at Salaya, Nakhon Pathom 73170, Thailand Pablo Liedo, Departamento de Entomología, El Colegio de la Frontera Sur, Tapachula, Chiapas 30700, Mexico Kenneth Linthicum, USDA-ARS Center for Medical, Agricultural and Veterinary Entomology, Gainesville, FL 32608, USA John Mumford, Imperial College London, Centre for Environmental Policy, Silwood Park Campus, Ascot, Berkshire, UK Manju Rahi, Scientist-F, Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India Matthew Thomas, Department of Entomology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA Yesim Tozan, New York University, College of Global Public Health, New York, NY 10012, USA Alia Zayed, Cairo University/U.S. Naval Medical Research Unit No. 3, Cairo Detachment, Cairo, Egypt WHO Technical Report.indd 2 24/01/2020 16:13 Reviewers Rafael Argiles Herrero, Livestock and Human Health Pests, Insect Pest Control Section, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture (NAFA) | Department of Nuclear Application | International Atomic Energy Agency | Vienna International Centre, PO Box 100, 1400 Vienna, Austria Rui Cardoso Pereira, Insect Pest Control Section, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture (NAFA) | Department of Nuclear Application | International Atomic Energy Agency | Vienna International Centre, PO Box 100, 1400 Vienna, Austria Lauren Carrington, Vector Ecology and Management, Department of Control of Neglected Tropical Diseases (CDS/NTD), World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland Walther R. Enkerlin Hoeflich, PPlant Pests, Insect Pest Control Section, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture (NAFA) | Department of Nuclear Application | International Atomic Energy Agency | Vienna International Centre, PO Box 100, 1400 Vienna, Austria Elkhan Gasimov, Malaria, NTDs and other Vector-borne Diseases Division of Health Emergencies & Communicable Diseases, World Health Organization Regional Oªice for Europe, UN City, Marmorvej 51, 2100 Copenhagen, Denmark Tessa B. Knox, Malaria and other vector-borne and parasitic diseases, World Health Organization, Port Vila, Vanuatu Raman Velayudhan, Vector Ecology and Management, Department of Control of Neglected Tropical Diseases (CDS/NTD), World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland ˆ˘˖˥˘˧˔˥˜˔˧ Jérémy Bouyer, Human Disease Vectors | Insect Pest Control Laboratory | Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture (NAFA) | Department of Nuclear Application | International Atomic Energy Agency | Vienna International Centre, PO Box 100, 1400 Vienna, Austria Anna Drexler, Western Pacific/Regional Oice/WHO Health Emergencies/Country health Emergency Preparedness (WP/RGO/WHE/CPI), Manila, Philippines Florence Fouque, UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) based at the World Health Organization, 20, avenue Appia, 1211 Geneva 27, Switzerland Patricia Godoy-Kain, Division for Latin America and Caribbean Technical Cooperation Department, International Atomic Energy Agency, Vienna International Centre, Wagramer Strasse 5, PO Box 100, 1400 Vienna, Austria !"#$%& Eva Ciabattoni WHO Technical Report.indd 3 24/01/2020 16:13 ʴ˖˞ˡˢ˪˟˘˗˚˘ˠ˘ˡ˧˦ The Secretariat thanks the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) based at the World Health Organization and its director, Dr John Reeder, as well the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture and its director, Mr Qu Liang, and the Department of Technical Cooperation for Latin America and Caribbean of IAEA and its Section Head, Mr Raùl Ramirez Garcia, for having allowed the development of this work. The authors also express their sincere gratitude to Makiko Kitamura, Communication Oicer in TDR for the help in the design and layout of the final document, and to all collaborators from both agencies’ operational units and programmes for their feedback, support and advice. This document was developed through an extensive consultation process, including an advisory committee covering different disciplines. Declarations of interest were provided by all experts as required by WHO and no conflicts of interest were found. WHO Technical Report.indd 5 24/01/2020 16:13 WHO Technical