US 2004O234450A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0234450 A1 HOWes (43) Pub. Date: Nov. 25, 2004 (54) COMPOSITIONS, METHODS, (60) Provisional application No. 60/262,635, filed on Jan. APPARATUSES, AND SYSTEMS FOR 22, 2001. SINGLET OXYGEN DELIVERY Publication Classification (76) Inventor: Randolph M. Howes, Kentwood, LA (US) (51) Int. Cl." ........................ A61K 51/00; A61M 36/14; A61K 33/40 Correspondence Address: (52) U.S. Cl. ........................................... 424/1.11; 424/616 CALFEE HALTER & GRISWOLD, LLP 800 SUPERIORAVENUE SUTE 1400 (57) ABSTRACT CLEVELAND, OH 44114 (US) (21) Appl. No.: 10/874,438 Methods of treating tumors, lesions, and cancers comprising delivering to the affected Site a combination of peroxide and (22) Filed: Jun. 23, 2004 hypochlorite anion. Hydrogen peroxide and Sodium hypochlorite are possible Sources of peroxide and hypochlo Related U.S. Application Data rite anion, respectively. The reactants may be injected Simul taneously or Sequentially, and combine at the Site to produce (60) Division of application No. 10/331,773, filed on Dec. Singlet oxygen. Singlet oxygen may be delivered to the 31, 2002, which is a continuation-in-part of applica treatment Site or generated at the treatment site. Isotopes are tion No. 10/050,121, filed on Jan. 18, 2002, which is also Synergistically used in conjunction with Singlet oxygen. a continuation-in-part of application No. 10/023,754, The isotopes may be radioactive isotopes, non-radioactive filed on Dec. 21, 2001. isotopes, or both. Patent Application Publication Nov. 25, 2004 Sheet 1 of 65 US 2004/0234450 A1 Fig. 1A Patent Application Publication Nov. 25, 2004 Sheet 2 of 65 US 2004/0234450 A1 Fig. 1B Patent Application Publication Nov. 25, 2004 Sheet 3 of 65 US 2004/0234450 A1 Fig. 1C Patent Application Publication Nov. 25, 2004 Sheet 4 of 65 US 2004/0234450 A1 35 - N N M N 1 >z% N \ W N 1 - - - e 34 48 Fig. 1D Patent Application Publication Nov. 25, 2004 Sheet 5 of 65 US 2004/0234450 A1 Fig. 2A Patent Application Publication Nov. 25, 2004 Sheet 6 of 65 US 2004/0234450 A1 S8 Fig. 2B Patent Application Publication Nov. 25, 2004 Sheet 7 of 65 US 2004/0234450 A1 Patent Application Publication Nov. 25, 2004 Sheet 8 of 65 US 2004/0234450 A1 70 76 72 74 78 76 Fig. 4 Patent Application Publication Nov. 25, 2004 Sheet 9 of 65 US 2004/0234450 A1 90 92 94 96 Patent Application Publication Nov. 25, 2004 Sheet 10 of 65 US 2004/0234450 A1 1OO 102 104 106 108 110 Patent Application Publication Nov. 25, 2004 Sheet 11 of 65 US 2004/0234450 A1 120 124 Fig. 7 Patent Application Publication Nov. 25, 2004 Sheet 12 of 65 US 2004/0234450 A1 150 152 156 154 158 SAA 160 i\sy 159162 Y Y-164 \aN 166 170 s 168 Fig. 8 Patent Application Publication Nov. 25, 2004 Sheet 13 of 65 US 2004/0234450 A1 220 Patent Application Publication Nov. 25, 2004 Sheet 14 of 65 US 2004/0234450 A1 300 Patent Application Publication Nov. 25, 2004 Sheet 15 of 65 US 2004/0234450 A1 Fig.11 340 Fig. 12 Patent Application Publication Nov. 25, 2004 Sheet 16 of 65 US 2004/0234450 A1 350 358 354 K7 358 354 354 352 358 Fig. 13A Fig. 13B Fig. 13C 366 370 360 362 s 364 372 372 Fig. 13D Fig. 13E Fig. 13F Patent Application Publication Nov. 25, 2004 Sheet 17 of 65 US 2004/0234450 A1 38O - 382 Fig. 14 Patent Application Publication Nov. 25, 2004 Sheet 18 of 65 US 2004/0234450 A1 400 A 410 412 10." 10." 10, B Patent Application Publication Nov. 25, 2004 Sheet 19 of 65 US 2004/0234450 A1 424 428 Fig. 16 Patent Application Publication Nov. 25, 2004 Sheet 21 of 65 US 2004/0234450 A1 182 198 190 Patent Application Publication Nov. 25, 2004 Sheet 22 of 65 US 2004/0234450 A1 Fig. 19 Patent Application Publication Nov. 25, 2004 Sheet 23 of 65 US 2004/0234450 A1 F g . 20 Patent Application Publication Nov. 25, 2004 Sheet 24 of 65 US 2004/0234450 A1 Fig. 21 Patent Application Publication Nov. 25, 2004 Sheet 25 of 65 US 2004/0234450 A1 . 22 Patent Application Publication Nov. 25, 2004 Sheet 26 of 65 US 2004/0234450 A1 F . 23 Patent Application Publication Nov. 25, 2004 Sheet 27 of 65 US 2004/0234450 A1 Fig. 24 Patent Application Publication Nov. 25, 2004 Sheet 28 of 65 US 2004/0234450 A1 Fig. 25 Patent Application Publication Nov. 25, 2004 Sheet 29 of 65 US 2004/0234450 Al 7 - IIIHill" a M . a - w a Fig. 26 Patent Application Publication Nov. 25, 2004 Sheet 30 of 65 US 2004/0234450 A1 Fig. 27 Patent Application Publication Nov. 25, 2004 Sheet 31 of 65 US 2004/0234450 A1 Fig. 28 Patent Application Publication Nov. 25, 2004 Sheet 32 of 65 US 2004/0234450 A1 Fig. 29 Patent Application Publication Nov. 25, 2004 Sheet 33 of 65 US 2004/0234450 A1 F g ... 30 Patent Application Publication Nov. 25, 2004 Sheet 34 of 65 US 2004/0234450 A1 Fig. 31 Patent Application Publication Nov. 25, 2004 Sheet 35 of 65 US 2004/0234450 A1 Fig. 32 Patent Application Publication Nov. 25, 2004 Sheet 36 of 65 US 2004/0234450 A1 Fig. 33 Patent Application Publication Nov. 25, 2004 Sheet 37 of 65 US 2004/0234450 A1 Fig. 34 Patent Application Publication Nov. 25, 2004 Sheet 38 of 65 US 2004/0234450 A1 Fig. 35 Patent Application Publication Nov. 25, 2004 Sheet 39 of 65 US 2004/0234450 A1 Fig. 36 Patent Application Publication Nov. 25, 2004 Sheet 40 of 65 US 2004/0234450 A1 Fig. 37 Patent Application Publication Nov. 25, 2004 Sheet 41 of 65 US 2004/0234450 A1 Fig. 38 Patent Application Publication Nov. 25, 2004 Sheet 42 of 65 US 2004/0234450 A1 Fig. 39 Patent Application Publication Nov. 25, 2004 Sheet 43 of 65 US 2004/0234450 A1 Fig. 40 Patent Application Publication Nov. 25, 2004 Sheet 44 of 65 US 2004/0234450 A1 Fig. 41 Patent Application Publication Nov. 25, 2004 Sheet 45 of 65 US 2004/0234450 A1 Fig. 42 Patent Application Publication Nov. 25, 2004 Sheet 46 of 65 US 2004/0234450 A1 Fig. 43 Patent Application Publication Nov. 25, 2004 Sheet 47 of 65 US 2004/0234450 A1 Fig. 44 Patent Application Publication Nov. 25, 2004 Sheet 48 of 65 US 2004/0234450 A1 Fig. 45 Patent Application Publication Nov. 25, 2004 Sheet 49 of 65 US 2004/0234450 A1 ************).-?-, 19 . 46 Patent Application Publication Nov. 25, 2004 Sheet 50 of 65 US 2004/0234450 A1 ig. 47 Patent Application Publication Nov. 25, 2004 Sheet 51 of 65 US 2004/0234450 A1 Fig. 48 Patent Application Publication Nov. 25, 2004 Sheet 52 of 65 US 2004/0234450 A1 it. F . 49 Patent Application Publication Nov. 25, 2004 Sheet 53 of 65 US 2004/0234450 A1 Fig. 50 Patent Application Publication Nov. 25, 2004 Sheet 54 of 65 US 2004/0234450 A1 Fig. 51 Patent Application Publication Nov. 25, 2004 Sheet 55 of 65 US 2004/0234450 A1 Fig. 52 Patent Application Publication Nov. 25, 2004 Sheet 56 of 65 US 2004/0234450 A1 Fig. 53 Patent Application Publication Nov. 25, 2004 Sheet 57 of 65 US 2004/0234450 A1 Fig. 54 Patent Application Publication Nov. 25, 2004 Sheet 58 of 65 US 2004/0234450 A1 Fig. 55A Patent Application Publication Nov. 25, 2004 Sheet 59 of 65 US 2004/0234450 A1 Fig. 55B Patent Application Publication Nov. 25, 2004 Sheet 60 of 65 US 2004/0234450 A1 Fig. 55C Patent Application Publication Nov. 25, 2004 Sheet 61 of 65 US 2004/0234450 A1 Fig. 56A Patent Application Publication Nov. 25, 2004 Sheet 62 of 65 US 2004/0234450 A1 Fig. 56B Patent Application Publication Nov. 25, 2004 Sheet 63 of 65 US 2004/0234450 A1 Fig. 56C Patent Application Publication Nov. 25, 2004 Sheet 64 of 65 US 2004/0234450 A1 Fig. 56D Patent Application Publication Nov. 25, 2004 Sheet 65 of 65 US 2004/0234450 A1 Y - - - - - - Y 1 N N C M N / N ? N A M - - - - - - s a f y/ - s Ya e 1 V 1 V | 1 1 f ^ W M M / / M 1 / 22 Y 24-173-2 Y 1 - 1 V 1 N - 1 B s - Fig. 57 US 2004/0234450 A1 Nov. 25, 2004 COMPOSITIONS, METHODS, APPARATUSES, AND 0006 Antiseptic agents are generally used in controlling SYSTEMS FOR SINGLET OXYGEN DELIVERY or reducing the population of pathogens that have already contacted a living being, or in areas where prophylaxis is RELATED APPLICATIONS important. For example, topical antiseptics are applied to skin abrasions and wounds to prevent infection. Antiseptics 0001. This application is a continuation-in-part of a U.S. are also formulated in washes, Such as in Shampoos, Soaps, patent application Ser. No. 10/050,121, filed Jan. 18, 2002, or detergents, which may be used to topically reduce and which is a continuation-in-part of a U.S. patent application control pathogen population. Antiseptic formulations, how Ser. No. 10/023,754, filed Dec. 21, 2001, and further claims ever, are generally too toxic to be taken internally by humans priority under 35 U.S.C. S 119(e) to U.S. provisional appli or animals. cation No. 60/262,635, filed Jan. 22, 2001, the entire dis closure of each of which is incorporated herein by reference. 0007 Antibiotic compositions may be administered to humans and animals.