GenScript Your Innovation Partner in Drug Discovery! Service GenScript The Biology CRO Biological Service Guide Bio-Reagent Center Contact Us Gene Services Protein Services GenScript is dedicated to serving pharmaceutical, biotech, and academic customers in the areas of drug discovery, development, GenScript Biological Service Guide Peptide Services and life science research. With a global presence and local access, GenScript provides high-quality biology CRO services and Antibody Services around-the-clock account support to our customers all over the world. Contact us any time. Cell Line Services Bio-Assay Center Contact: Lead Optimization Center All Correspondence Email: [email protected] GenScript USA Inc. Tel: 1-877-436-7274 (Toll-Free) 120 Centennial Ave. Tel: 1-732-885-9188, 1-732-885-9688 Antibody Drug Piscataway, NJ 08854 Fax: 1-732-210-0262, 1-732-885-5878 Development Center U.S.A. Business Development: Email: [email protected] Tel: 1-732-317-5088 Regional Numbers: Australia: 1-800-172-605 (Toll-Free) Japan: 81-3-6206-8985 Belgium: 32-27-470-921 Netherlands: 31-20-890-5456 2010–2011 Denmark: 8088-7617 (Toll-Free) Norway: 800-19-172 (Toll-Free) France: 08-05-10-22-28 (Toll-Free) Portugal: 800-815-627 (Toll-Free) Finland: 0800-913-020 (Toll-Free) Singapore: 800-120-4549 (Toll-Free) Germany: 0-800-0006-320 (Toll-Free) Spain: 800-098-920 (Toll-Free) Hong Kong: 800-964-684 (Toll-Free) Sweden: 0200-884-573 (Toll-Free) Ireland: 1800-932-547 (Toll-Free) Switzerland: 0800-369-254 (Toll-Free) Israel: 1-809-216-068 (Toll-Free) United Kingdom: 08082-380203 (Toll-Free) 2010–2011 CALL NOW FOR MORE INFORMATION GenScript 1-732-885-9188 The Biology CRO Date Version: 05/14/2010 Fax: 1-732-210-0262 Web: www.genscript.com Email: [email protected] Your Innovation Partner in Drug Discovery! Table of Contents Service Overview ................................................................................................ 1 Bio-Reagent Center Molecular Biology Services Gene Synthesis .................................................................................................... 10 Mutagenesis Services ............................................................................................ 15 Mutant Libraries (Protein Engineering) ....................................................................... 17 PCR Cloning and Subcloning Services ........................................................................ 19 Custom Plasmid DNA Preparation Services ................................................................. 20 Custom ORF Cloning Services .................................................................................. 22 Custom Vector Construction Services......................................................................... 23 Knock-in and Knock-out Vector Construction Services .................................................... 24 GenScript USA Inc. siRNA and miRNA Services...................................................................................... 25 Vector-Based siRNA Services Vector-Based miRNA Services Large-scale DNA Sequencing Services ....................................................................... 28 CloneArchTM Clone Storage and Management Center ..................................................... 30 Custom Protein Services Bacterial Expression System .................................................................................... 33 Yeast Expression System ........................................................................................ 36 Insect Cell Expression System .................................................................................. 38 Mammalian Cell Expression System ........................................................................... 40 Large-scale Protein Production Service....................................................................... 42 Protein Purification and Characterization ..................................................................... 44 Custom Peptide Services Standard Peptide Synthesis ..................................................................................... 46 Peptide Modifications ............................................................................................. 47 Custom Peptide Library Services ............................................................................... 48 Cosmetic Peptide Services....................................................................................... 51 Click Peptide Service .............................................................................................. 52 Custom Recombinant Peptides ................................................................................. 53 cGMP Peptide Synthesis ......................................................................................... 54 Peptide Purity and Application .................................................................................. 56 Email: [email protected] Tel: 1-732-885-9188 - i - Table of Contents Table of Contents Bio-Reagent Center Bio-Assay Center Custom Antibody Services GPCR Assay Services ........................................................................................... 90 Custom Polyclonal Antibody Services ........................................................................ 58 Ion Channel Assay Services ................................................................................... 92 Custom Polyclonal Antibody Services (Rabbit).......................................................... 59 Kinase Assay Services .......................................................................................... 94 Custom Polyclonal Antibody Services (Goat) ............................................................ 62 Protease Assay Services ....................................................................................... 95 Custom Polyclonal Antibody Services (Mouse) ......................................................... 63 Miscellaneous Enzyme Assay Services ...................................................................... 97 Custom Polyclonal Antibody Services (Rat) ............................................................. 64 Cardiac Safety Testing Services............................................................................... 99 Custom Polyclonal Antibody Services (Chicken)........................................................ 65 One-stop Assay Services ....................................................................................... 100 Western-GUARANTEED Antibody Service .................................................................. 67 Custom Monoclonal Antibody Services ...................................................................... 68 Custom Monoclonal Antibody Services (Mouse/Rat) Lead Optimization Center Customized Monoclonal Antibody Services Monoclonal Antibody Production Service ................................................................... 70 Medicinal Chemistry............................................................................................. 103 Ascites Production Services Discovery Biology ................................................................................................ 104 Roller Bottle Cell Culture Services Express Antibody Services ...................................................................................... 72 MonoExpressTM Antibody Services Antibody Drug Development Center Express Rabbit Polyclonal Antibody Services Immunochemistry Services .................................................................................... 74 Antibody Humanization ......................................................................................... 107 Antibody Purification Services Affinity Maturation ............................................................................................... 107 Antibody Modification Services Stable Cell Line Development and Antibody Production ................................................ 107 Additional Services Supporting Services ............................................................................................. 108 Large-scale Antibody Production Services ................................................................. 76 Immunoassay Development Services ........................................................................ 77 Custom Cell Line Services Stable Cell Line Services for Protein and Monoclonal Antibody Production.............................................................................. 79 Custom Stable Cell Line Services for Assay Development ............................................... 81 Transient Gene Expression Service ........................................................................... 82 Process Development and Transfer .......................................................................... 83 Catalog Stable Cell Lines ........................................................................................ 83 Ready-to-UseTM Frozen Cells ................................................................................... 85 - ii - Your Innovation Partner in Drug Discovery! Email: [email protected] Tel: 1-732-885-9188 - iii - GenScript Service Overview Innovation Partner in Drug Discovery! GenScript—Your Custom Protein Services Molecular Biology Services Custom Antibody Services ● Bacterial Expression System ● Custom Polyclonal Antibody Services ● Gene Synthesis ● Yeast Expression System ● Custom Monoclonal Antibody Services ● Mutagenesis Services ● Insect Cell Expression System