Supplementary file 2A. Differentially expressed genes in aldosteronomas compared to all other samples, ranked according to statistical significance. Missing values were not allowed in aldosteronomas, but to a maximum of five in the other samples. Acc UGCluster Name Symbol log Fold Change P - Value Adj. P-Value B R99527 Hs.8162 Hypothetical protein MGC39372 MGC39372 2,17 6,3E-09 5,1E-05 10,2 AA398335 Hs.10414 Kelch domain containing 8A KLHDC8A 2,26 1,2E-08 5,1E-05 9,56 AA441933 Hs.519075 Leiomodin 1 (smooth muscle) LMOD1 2,33 1,3E-08 5,1E-05 9,54 AA630120 Hs.78781 Vascular endothelial growth factor B VEGFB 1,24 1,1E-07 2,9E-04 7,59 R07846 Data not found 3,71 1,2E-07 2,9E-04 7,49 W92795 Hs.434386 Hypothetical protein LOC201229 LOC201229 1,55 2,0E-07 4,0E-04 7,03 AA454564 Hs.323396 Family with sequence similarity 54, member B FAM54B 1,25 3,0E-07 5,2E-04 6,65 AA775249 Hs.513633 G protein-coupled receptor 56 GPR56 -1,63 4,3E-07 6,4E-04 6,33 AA012822 Hs.713814 Oxysterol bining protein OSBP 1,35 5,3E-07 7,1E-04 6,14 R45592 Hs.655271 Regulating synaptic membrane exocytosis 2 RIMS2 2,51 5,9E-07 7,1E-04 6,04 AA282936 Hs.240 M-phase phosphoprotein 1 MPHOSPH -1,40 8,1E-07 8,9E-04 5,74 N34945 Hs.234898 Acetyl-Coenzyme A carboxylase beta ACACB 0,87 9,7E-07 9,8E-04 5,58 R07322 Hs.464137 Acyl-Coenzyme A oxidase 1, palmitoyl ACOX1 0,82 1,3E-06 1,2E-03 5,35 R77144 Hs.488835 Transmembrane protein 120A TMEM120A 1,55 1,7E-06 1,4E-03 5,07 H68542 Hs.420009 Transcribed locus 1,07 1,7E-06 1,4E-03 5,06 AA410184 Hs.696454 PBX/knotted 1 homeobox 2 PKNOX2 1,78 2,0E-06 1,5E-03 4,93 N91117 Hs.518326 Stress-associated endoplasmic reticulum protein 1 SERP1 1,19 2,4E-06 1,7E-03 4,73 AI016010 Hs.446438 G protein-coupled receptor, family C, group 5, membe GPRC5C 1,73 2,6E-06 1,7E-03 4,68 R96914 Data not found 1,22 3,0E-06 1,9E-03 4,54 AA693510 Hs.270084 Neural precursor cell expressed, developmentally dowNEDD1 -1,20 3,5E-06 2,1E-03 4,39 AA046067 Hs.682066 Transcribed locus 1,17 3,9E-06 2,2E-03 4,3 R34240 Hs.713576 Transcribed locus 1,11 5,5E-06 2,9E-03 3,98 H73731 Hs.591518 Amine oxidase (flavin containing) domain 2 AOF2 1,04 5,6E-06 2,9E-03 3,97 AA454554 Hs.405873 Myo-inositol 1-phosphate synthase A1 ISYNA1 1,36 5,9E-06 3,0E-03 3,91 AI005572 Data not found -1,61 6,6E-06 3,0E-03 3,83 N63644 Hs.532363 Homeodomain interacting protein kinase 1 HIPK1 0,81 6,5E-06 3,0E-03 3,83 R24201 Hs.533237 WD repeat domain 36 WDR36 -1,20 7,1E-06 3,2E-03 3,75 AA457038 Hs.467662 Integrin beta 1 binding protein 1 ITGB1BP1 1,37 8,2E-06 3,2E-03 3,62 T71965 Hs.100874 ATP synthase mitochondrial F1 complex assembly facATPAF1 1,11 8,1E-06 3,2E-03 3,62 AA459363 Hs.236361 RNA binding motif protein 38 RBM38 2,81 8,3E-06 3,2E-03 3,6 AA463517 Hs.466165 6-phosphogluconolactonase PGLS -0,95 8,5E-06 3,2E-03 3,58 AA453765 Hs.514870 ATP synthase, H+ transporting, mitochondrial F0 com ATP5F1 1,23 8,5E-06 3,2E-03 3,58 AA464612 Hs.655329 Mitochondrial ribosomal protein S18B MRPS18B 1,02 9,7E-06 3,4E-03 3,46 H29322 Hs.434875 Calcium/calmodulin-dependent protein kinase I CAMK1 1,90 9,8E-06 3,4E-03 3,45 AA417247 Hs.97858 Kinesin family member 1B KIF1B 0,99 9,9E-06 3,4E-03 3,44 T71316 Hs.695943 ADP-ribosylation factor 4 ARF4 1,03 1,0E-05 3,5E-03 3,41 W91980 Hs.488835 Transmembrane protein 120A TMEM120A 1,11 1,1E-05 3,7E-03 3,31 AA872041 Hs.31856 Ubiquitin specific peptidase 42 USP42 -0,84 1,2E-05 3,8E-03 3,26 R54972 Hs.444135 Centrosomal protein 97kDa CEP97 0,79 1,2E-05 3,9E-03 3,23 AI017231 Hs.469331 StAR-related lipid transfer (START) domain containingSTARD7 1,08 1,4E-05 4,1E-03 3,14 AA634381 Hs.502528 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30NDUFS3 1,18 1,4E-05 4,2E-03 3,09 AA127069 Hs.713019 Transcribed locus, strongly similar to NP_033135.2 ryanodine rece 1,68 1,5E-05 4,2E-03 3,07 AA448691 Hs.74137 Transmembrane emp24-like trafficking protein 10 (yeaTMED10 1,09 1,6E-05 4,2E-03 3,01 N77877 Hs.709397 Transducin (beta)-like 1 X-linked receptor 1 TBL1XR1 1,11 1,6E-05 4,2E-03 2,98 AA733203 Hs.604479 Hexosaminidase A (alpha polypeptide) HEXA 1,13 1,6E-05 4,2E-03 2,98 AA485898 Hs.9527 Chromosome 2 open reading frame 28 C2orf28 1,09 1,7E-05 4,2E-03 2,97 AA421046 Hs.567582 F-box protein 31 FBXO31 0,83 1,7E-05 4,2E-03 2,96 AA171718 Data not found 2,45 1,9E-05 4,7E-03 2,86 AA872091 Hs.708155 Transcription factor-like 5 (basic helix-loop-helix) TCFL5 -0,89 1,9E-05 4,7E-03 2,85 AA496800 Hs.293689 Multiple coagulation factor deficiency 2 MCFD2 1,22 1,9E-05 4,7E-03 2,82 AA454840 Hs.563560 MRNA; cDNA DKFZp686E0389 (from clone DKFZp686E0389) 1,21 2,0E-05 4,7E-03 2,8 H10011 Data not found 1,35 2,1E-05 4,7E-03 2,76 W45148 Hs.644026 Transcribed locus 1,07 2,1E-05 4,7E-03 2,75 N26671 Hs.471610 Armadillo repeat containing 9 ARMC9 1,71 2,1E-05 4,7E-03 2,73 R53911 Hs.518602 Wolfram syndrome 1 (wolframin) WFS1 0,87 2,2E-05 4,7E-03 2,71 H41522 Hs.462529 Tumor necrosis factor receptor superfamily, member 2TNFRSF25 -0,75 2,2E-05 4,7E-03 2,71 T52674 Hs.654360 Fms-related tyrosine kinase 1 (vascular endothelial groFLT1 -0,84 2,2E-05 4,7E-03 2,69 W69799 Data not found 0,86 3,5E-05 5,7E-03 2,28 T68739 Data not found -0,95 3,6E-05 5,7E-03 2,26 AA461166 Hs.507948 Component of oligomeric golgi complex 3 COG3 -1,08 3,6E-05 5,7E-03 2,25 AA452566 Hs.703022 Transcribed locus, strongly similar to NP_001073336.1 peroxin 2 [ 0,92 3,6E-05 5,8E-03 2,24 H67876 Hs.118241 Chaperone, ABC1 activity of bc1 complex homolog (S CABC1 1,61 3,8E-05 5,8E-03 2,21 T72068 Hs.592053 RNA binding motif protein 35B RBM35B 0,99 3,8E-05 5,8E-03 2,21 AA458956 Hs.567482 Acyl-Coenzyme A dehydrogenase family, member 9 ACAD9 0,77 4,1E-05 6,2E-03 2,12 AA459650 Hs.304362 PHD finger protein 20-like 1 PHF20L1 0,88 4,1E-05 6,2E-03 2,12 T69603 Hs.524224 Complement component 1, r subcomponent C1R 0,85 4,2E-05 6,3E-03 2,11 AA403295 Hs.526521 Malate dehydrogenase 1, NAD (soluble) MDH1 1,27 4,3E-05 6,3E-03 2,09 AA455999 Hs.247460 Neurolysin (metallopeptidase M3 family) NLN -1,17 4,3E-05 6,3E-03 2,07 AA491249 Hs.356440 Coiled-coil domain containing 72 CCDC72 1,17 4,4E-05 6,4E-03 2,06 H16736 Hs.501127 Attractin-like 1 ATRNL1 1,52 4,7E-05 6,7E-03 2,02 AA705793 Hs.189641 SEC24 related gene family, member D (S. cerevisiae) SEC24D -1,33 5,0E-05 7,0E-03 1,98 AA135958 Hs.489033 ATP-binding cassette, sub-family B (MDR/TAP), mem ABCB1 1,51 5,3E-05 7,3E-03 1,91 AA757457 Hs.187873 Family with sequence similarity 19 (chemokine (C-C mFAM19A4 1,28 5,3E-05 7,3E-03 1,89 AA664389 Hs.507916 TSC22 domain family, member 1 TSC22D1 -1,18 5,4E-05 7,3E-03 1,87 N52772 Hs.8769 Transmembrane protein 47 TMEM47 1,28 5,6E-05 7,6E-03 1,84 R67918 Hs.28780 Zinc finger protein 449 ZNF449 0,57 5,8E-05 7,7E-03 1,82 N95381 Hs.486063 ATG5 autophagy related 5 homolog (S. cerevisiae) ATG5 0,79 5,9E-05 7,7E-03 1,79 H70612 Hs.514373 Myotubularin related protein 4 MTMR4 1,54 6,1E-05 7,7E-03 1,78 AA495786 Hs.521482 Src homology 2 domain containing adaptor protein B SHB -1,41 6,0E-05 7,7E-03 1,77 AA057620 Hs.306083 Chromosome 22 open reading frame 32 C22orf32 0,95 6,1E-05 7,7E-03 1,76 AA449693 Hs.323489 Small nucleolar RNA, C/D box 94 PTCD3 0,89 6,7E-05 8,4E-03 1,68 R43449 Hs.106529 NADH dehydrogenase (ubiquinone) 1 alpha subcomplNDUFAF1 1,14 6,8E-05 8,4E-03 1,67 AA954189 Hs.522090 Galactose-1-phosphate uridylyltransferase GALT 0,74 6,9E-05 8,4E-03 1,65 R86843 Hs.154652 Family with sequence similarity 110, member B FAM110B 0,83 7,1E-05 8,4E-03 1,63 W81371 Hs.700870 Transcribed locus, strongly similar to NP_062458.1 homeobox D8 1,50 7,1E-05 8,4E-03 1,63 R99331 Hs.379548 Ubiquitin protein ligase E3 component n-recognin 3 UBR3 0,83 7,2E-05 8,4E-03 1,61 AA497033 Hs.442378 Cysteine dioxygenase, type I CDO1 2,48 7,2E-05 8,4E-03 1,61 AA179391 Hs.278277 3-oxoacid CoA transferase 1 OXCT1 1,41 7,3E-05 8,4E-03 1,61 AA970729 Hs.461131 Cytochrome b5 type B (outer mitochondrial membraneCYB5B 1,33 7,3E-05 8,4E-03 1,6 AA496022 Hs.296049 Microfibrillar-associated protein 4 MFAP4 0,75 7,6E-05 8,4E-03 1,58 N26546 Hs.115617 Corticotropin releasing hormone binding protein CRHBP 1,36 7,6E-05 8,4E-03 1,58 H68309 Data not found 0,87 7,5E-05 8,4E-03 1,56 AA490855 Hs.485041 Tripartite motif-containing 26 TRIM26 0,99 7,6E-05 8,4E-03 1,56 W89071 Data not found 0,91 7,6E-05 8,4E-03 1,56 AA917868 Hs.435126 SLC2A4 regulator SLC2A4RG -1,43 8,4E-05 9,2E-03 1,51 AA482230 Hs.332795 Leucine zipper, down-regulated in cancer 1-like LDOC1L 0,83 8,7E-05 9,3E-03 1,44 AI356709 Hs.332197 Peroxidasin homolog (Drosophila) PXDN -1,01 8,7E-05 9,3E-03 1,44 AA451861 Hs.372633 Dipeptidase 2 DPEP2 1,03 8,7E-05 9,3E-03 1,43 AA446865 Hs.534261 Mitochondrial ribosomal protein L46 MRPL46 1,06 8,8E-05 9,3E-03 1,42 N66003 Hs.159492 Spastic ataxia of Charlevoix-Saguenay (sacsin) SACS 1,13 8,9E-05 9,3E-03 1,42 AA469975 Hs.578109 Solute carrier family 25, member 29 SLC25A29 1,22 9,1E-05 9,4E-03 1,41 H14348 Hs.494163 Guanine deaminase GDA -0,75 9,2E-05 9,5E-03 1,38 AA701412 Hs.352548 Transmembrane protein 149 TMEM149 0,93 9,3E-05 9,5E-03 1,38 AA456646 Hs.654545 Choroideremia-like (Rab escort protein 2) CHML -0,82 9,5E-05 9,5E-03 1,36 AA398025 Hs.658033 KIAA0240 KIAA0240 -0,96 9,6E-05 9,5E-03 1,36 AA505082 Hs.475812 STT3, subunit of the oligosaccharyltransferase compleSTT3B 1,29 9,7E-05 9,5E-03 1,35 W73797 Hs.356273 ER degradation enhancer, mannosidase alpha-like 2 EDEM2 0,77 9,6E-05 9,5E-03 1,35 AA069372 Hs.519385 Forkhead box D1 FOXD1 0,94 9,6E-05 9,5E-03 1,34 T52999 Hs.9521 Zinc finger protein 92 ZNF92 1,17 9,8E-05 9,5E-03 1,33 T69767 Data not found 1,08 9,9E-05 9,5E-03 1,32 R73672 Data not found 1,60 1,0E-04 9,7E-03 1,3 AA610066 Hs.98428 Homeobox B6 HOXB6 0,95 1,0E-04