CURRICULUM VITAE Mohammad A Qasim Department of Chemistry Indiana University Purdue University Fort Wayne Fort Wayne, IN 46805 Tel: (765) 714-6597(C); (260)481-6678 (O) E-mail:[email protected] EDUCATION: 1978: Ph. D. (Biochemistry), Aligarh M. University, India 1975: M. Phil. (Biochemistry), Aligarh M. University, India 1973: M. Sc. (Biochemistry), Aligarh M. University, India 1971: B. Sc. (Chemistry & Biology), Aligarh M. University, India TEACHING EXPERIENCE: 2010 - 2012: Taught following courses during the years 2010 to 2012: (i) Introduction to Biochemistry (CHM53400) (ii) Biochemistry Lab (CHM53500) (iii) Introduction to Biochemistry (CHM53300) (iv) General Chemistry Lecture and Lab (CHM11200) (v) General Chemistry Lab (CHM11100) (vi) General Chemistry Lecture (CHM11100) (vii) Seminars in Chemistry (CHM49500) (viii) Advances in Chemistry I (CHM49600) (ix) Advances in Chemistry II (CHM49700) Fall 2009 Taught following courses at IPFW during Fall 2009 semester: (i) Introductory Biochemistry (CHM533) (ii) General Chemistry Lecture and Lab (CHM112) (iii) General Chemistry Lab (CHM111) 2006-2009: Taught following courses to undergraduate students at Xavier University of Louisiana, New Orleans: (i) Introduction to Biochemistry (CHEM4130) (ii) Introduction to Biochemistry Lab (CHEM4130L) (iii) General Chemistry Lab I (CHEM1011L) (iv) General Chemistry Lab II (CHEM1021L) 1981-1994: Taught Biochemistry lecture and laboratory courses to Medical students at J. N. Medical College, Aligarh M. University, Aligarh (INDIA). Topics covered in the lecture course included chemistry and metabolism of carbohydrates, lipids, proteins and nucleic acids, membrane structure and transport across membranes. The lab. course involved qualitative tests on carbohydrates and lipids and quantitative determinations of biologically important compounds such as glucose, urea, uric acid, creatinin, cholesterol, bilirubin etc. EXPERIENCE AS RESEARCH MENTOR: 2009-2012: Guided eight undergraduate research students in the Chemistry Department at IPFW 2006-2009: Guided three undergraduate research students at Xavier University of Louisiana. 1994- 2005 While working in various research capacities at Purdue University, I guided several undergraduate students in their research. These students were registered with Professor Michael Laskowski Jr. at Purdue who gave me the responsibility for their day to day guidance. 1981-1994: Successfully guided six Ph. D. students to their graduate degrees. Several research papers were published during this time in peer reviewed journals. They are listed in “list of publications” below. Many of my graduate students are serving as faculty in academic institutions in different countries such as Malasia, Saudi Arabia, and United States. RESEARCH FUNDING: 2009-2011: Submitted following research proposals in the year 2009, 2010, and 2011. All of them were accepted for funding. (i) IPFW Faculty summer research grant, December 2009. (ii) Senior Research grant of Indiana Academy of Science, October 2010. (iii) IPFW Faculty summer research grant, December 2010. 2006-2009: Submitted two research grant applications to Center for Undergraduate Research (CUR) at Xavier. Both of these applications were accepted for funding – one in March 2007 and the other in October 2008. 1981-1994: As independent researcher in India I applied for three major research grants to central granting agencies such as Indian Council of Medical Research (ICMR), Council of Scientific and Industrial Research (CSIR), and Department of Science and Technology (DST). All of these grant applications were approved for funding. JOB HISTORY: 2009- Assistant Professor, Department of Chemistry, Indiana University Purdue University at Fort Wayne, IN 46805 2006-2009: Associate Professor of Chemistry, Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125 1999-2005: Research Scientist/Associate Research Scientist Purdue University, Department of Chemistry West Lafayette, Indiana, USA 1999 –1999: Assistant Research Scientist, Purdue University, Department of Chemistry, West Lafayette, Indiana, USA 1997 -1999 Research Associate, Purdue University, Department of Chemistry, West Lafayette, Indiana, USA 1994 -1997: Postdoctoral Research Fellow,Purdue University, Department of Chemistry, West Lafayette, Indiana USA 1990 -1994: Reader, Aligarh M. University, Department of Biochemistry, J. N. Medical College, Aligarh, India 1992 -1993: DAAD Fellow, Westfalische Wilhelms U., Institut fur Physikalische Chemie, Munster, Germany, 1987 -1990: Postdoctoral Research Fellow, Purdue University, Department of Chemistry, West Lafayette, Indiana USA. 1981 -1987 Lecturer, Aligarh M. University, Department of Biochemistry, J. N. Medical College, Aligarh, India 1979 -1980 DANIDA Fellow, Danish Institute of Protein Chemistry Horsholm, Denmark AFFILIATIONS: I have been or am a member of various prestigious scientific societies: Member of Society of Biological Chemists, India, 1975. Member, American Association for the Advancement of Science, 1979. Member, Protein Society, 1988. Nominated member, Purdue University Chapter of Sigma Xi, 1995. Nominated member, American Society for Biochemistry and Molecular Biology, 1996. Member of Indiana Academy of Science. 2010 RESEARCH PUBLICATIONS/ARTICLES: 1. Qasim. M. A. and Taha, M. (2013) “Investigation of the influence of guanidine hydrochloride on inhibitor-protease association ” Protein and peptide Letters 20, 187-191. 2. Qasim, M. A. (2012) “Streptogrisin A” in Handbook of Proteolytic Enzymes, 3rd edition, Elsevier Academic Press (Eds. Barrett, A. J., Rawlings, N. D., Woessner, J. F.), pp 2546-2548. 3. Qasim, M. A. (2012) “Streptogrisin B” in Handbook of Proteolytic Enzymes, 3rd edition, Elsevier Academic Press (Eds. Barrett, A. J., Rawlings, N. D., Woessner, J. F.) pp. 2549-2555. 4. Cleavage of peptide bonds bearing ionizable amino acids at P1 by serine proteases with hydrophobic S1 pocket. Qasim, M. A., Song, J., Markley, J. L. and Laskowski, M. Jr. (2010) Biochem. Biophys. Res. Commun. 400, 507-510. 5. Structural insights into the non-additivity effects in the sequence to reactivity algorithm for serine peptidases and their inhibitors. Lee, T-W., Qasim, M. A., Laskowski, M. Jr., and James, M. N. G. (2007) J. Mol. Biol. 367, 527-546. 6. Despite having a common P1 Leu, eglin c inhibits α-lytic proteinase a million- fold more strongly than does turkey ovomucoid third domain. Qasim, M. A., Van Etten, R. L., Yeh, T., Saunders, C., Ganz, P. J., Qasim, S., Wang, L., and Laskowski, M. Jr. (2006) Biochemistry 45, 11342-11248. 7. Functional evolution within a protein superfamily. Yi, Z., Vitek, O., Qasim, M. A., Lu, S. M., Lu, W., Ranjbar, M., Laskowski, M. C., Bailey-Kellogg, C. and Laskowski, M. Jr. (2006) Proteins, 63, 697-708. 8. Ring-Toss: Capping highly exposed tyrosyl or tryptophyl residues in proteins with beta-cyclodextrin. Yi, Z., Qasim, M. A., Qasim, S., Warrington, T. L. and Laskowski, M. Jr. (2005) Biochim. Biophys. Acta 1760, 372-377. 9. The role of scaffolding in standard mechanism serine proteinase inhibitors. Kelly, C. A., Laskowski, M. Jr. and Qasim, M. A. (2005) Prot. Peptide Lett. 12, 465- 471. 10. From the discovery of the reactive site of inhibitors to their sequence to reactivity algorithm. Qasim, M. A. (2005) Prot. Peptide Lett. 12, 397-401. 11. Structure of the subtilisin Carlsberg-OMTKY3 complex reveals two different ovomucoid conformations. Maynes, J. T., Cherney, M. M., Qasim, M. A., Laskowski, M. Jr. and James, M. N. (2005) Acta Crystallogr. D Biol. Crystallogr. 61, 580-588. 12. Testing of the additivity-based protein sequence to reactivity algorithm. Qasim, M. A., Lu, W., Lu, S., Ranjbar, M., Yi, Z-Y., Chiang, Y-W., Ryan, K., Anderson, S., Zhang, W-L., Qasim, S. and Laskowski, M. Jr. (2003) Biochemistry 42, 6460-6466. 13. Two conformational states of turkey ovomucoid third domain at low pH three- dimensional structures, internal dynamics, and interconversion kinetics and thermodynamics. Song, J., Laskowski, M. Jr., Qasim, M. A. and Markley, J. L. (2003) Biochemistry 42, 6380-6391. 14. NMR Determination of pKa values for Asp, Glu, His, and Lys mutants at each variable contiguous enzyme-inhibitor contact position of the turkey ovomucoid third domain. Song, J., Laskowski, M. Jr., Qasim, M. A. and Markley, J. L. (2003) Biochemistry 42, 2847-2856 15. Additivity based prediction of equilibrium constants for some protein-protein associations. Laskowski, M. Jr., Qasim, M. A., and Yi, Z-P. (2003) Cur. Opin. Str. Biol. 13, 130-139. 16. Contribution of peptide bonds to inhibitor-protease binding: crystal structures of the turkey ovomucoid third domain backbone variants OMTKY3-Pro18I and OMTKY3-ψ[COO]-Leu18I in complex with Streptomyces griseus proteinase B + (SGPB) and the structure of the free inhibitor, OMTKY3-ψ[CH2NH2 ]-Asp19I. Bateman, K. S., Huang, K., Anderson, S., Lu, W., Qasim, M. A., Laskowski, M. Jr. and James, M. N. G. (2001) J. Mol. Biol. 305, 839-849. 17. Predicting the reactivity of proteins from their sequence alone: Kazal family of protein inhibitors of serine proteinases. Lu, S. M., Lu, W., Qasim, M. A., Anderson, S., Apostol, I., Ardelt, W., Bigler, T., Chiang, Y-W., Cook, J., James, M. N. G., Kato, I., Kelly, C., Kohr, W., Komiyama, T., Lin, T-Y., Ogawa, M., Otlewski, J., Park, S. J., Qasim, S., Ranjbar, M., Tashiro, M., Warne, N., Whatley, H., Wieczorek, A., Wieczorek, M., Wilusz, T., Wynn, R., Zhang, W. and Laskowski, M. Jr. (2001) Proc. Nat. Acad. Sci. 98, 1410-1415. 18. Deleterious effects of β-branched