Posters A-Z Ali, Mehreen Systematic modeling of pan-cancer drug responses using Bayesian 26 multi-source regression Avican, Kemal PATHOGENEX: Human bacterial pathogen gene expression database 27 Bao, Jie SOX9 is selectively required for adenocarcinoma progression in 28 non-small cell lung cancer histopathologies Barandun, Jonas Evolutionary compaction and adaptation visualized by the structure of 29 the dormant microsporidian ribosome Bauer, Moritz Rapid reactivation of the inactive X in a novel iPSC system 30 Belova, Tatiana Annotation and mapping of genes encoding allergenicity proteins in 31 wheat Caglayan, Safak A human embryonic stem cell model of optic atrophy 1 deficiency 32 reveals the mitochondrial homeostasis as a regulator of neuronal differentiation Castro-Mondragon, Jaime Combining transcriptional and post-transcriptional regulation to predict 33 mutations altering the gene regulatory program in cancer cells Chotiwan, Nunya Whole tissue Ex Vivo Imaging Sheds Light on Tropism and 34 Neuroinvasion of Tick-borne Flavivirus in mouse brain Christiansen, Line Marie Neo1, the essential lipid flippase? 35 Page 11 EMBL Partnership Conference: Perspectives in Translational Medicine Cieslar-Pobuda, Artur DNMT3B deficiency alters mitochondrial biogenesis and a-ketoglutarate 36 levels in human embryonic stem cells Cunha, Eva Cryo EM Structure of Helicobacter pylori inhibitor-bound urease at 2.3 Å 37 resolution del Peso-Santos, Teresa Presenter: Bala, Anju Understanding biofilm related regulatory networks in Vibrio cholerae 38 Denham, Mark Identifying genetic risk variants for Parkinson’s Disease 39 Dyla, Mateusz Kinase signaling complexes: The effect of protein linkers on tethered 40 catalysis el Azhar, Yasmine Signalling dynamics in the developing neural tube 41 Esguerra, Camila New insights into the early mechanisms underlying epileptogenesis in a 42 zebrafish model of Dravet syndrome Fu, Yu Incomplete X chromosome inactivation is reflected in complex trait 43 genetic architecture García, Laura Does chromatin metabolism drive breast cancer evolution? 44 Goradia, Nishit Bharat RAI2-induced polymerization regulates corepressor activity of 45 tumorigenic CtBP proteins Gulyas-Onodi, Zsofia Inflammasome activation in end-stage failing heart 46 Gutierrez-Fernandez, Javier Reactivation of p53 tumor suppressor function 47 Page 12 Posters A-Z Haapaniemi, Emma Presenter: Soppa, Inkeri Targeted CRISPR editing to S cell cycle phase 48 Hassan, Shabbeer No effects of high resolution population-specific genetic map on 49 downstream genomic analyses Hautakangas, Heidi A genome-wide meta-analysis of migraine with over 102,000 cases 50 identifies 124 risk loci Henriksson, Johan Inferring mechanism from high-throughput data - CD4 T cells 51 Hermjakob, Henning Reactome pathway analysis and visualization 52 Hernandez Alias, Xavier Translation efficiency across healthy and tumor tissues is 53 proliferation-dependant Hsieh, Ping-Han Correlation adjustment to improve the modeling of association-based 54 networks Ivanova, Maria Systematic characterisation of the role of exported proteins in malaria 55 parasite-host interactions Jann, Cosimo Dissecting the heat shock response in yeast by CRISPRi 56 Kowalski, Antoni Alpha-synuclein is a novel activator of the plasma membrane calcium 57 ATPase Kumar, Rajender Genomic diversity of the genus Francisella and associated pathogenicity 58 island Page 13 EMBL Partnership Conference: Perspectives in Translational Medicine Lafita, Aleix The role of protein domain repeat stalks in bacterial surface adhesins 59 Lang, Benjamin Beyond the peaks: A better processing method for eCLIP protein–RNA 60 interaction data? Langenbach, Dorothee What are the cellular and molecular targets of extracellular ATP, a key 61 pro-inflammatory signal during intestinal infection? Lundgren, Sara Epigenetic aging in BMI-discordant monozygotic twin pairs 62 Malyutina, Alina Drug combination sensitivity scoring facilitates the discovery of 63 synergistic and efficacious drug combinations in cancer Mereu, Elisabetta Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas 64 Projects Mohammadi, Nasibeh The role of Guanylate-Binding Proteins (GBPs) during intracellular 65 infection with Francisella tularensis Muraleedharan, Samada A defensive host cell death program that is actively suppressed by the 66 intracellular pathogen Chlamydia trachomatis Neguembor, Maria Victoria Investigating the role of transcription in 3D genome folding and loop 67 extrusion Nissen, Josephine Dannersø Investigating the ultrastructure of the axon initial segment by 68 cryo-electron tomography Page 14 Posters A-Z Ovesen, Peter Deficiency for the neurexin-receptor SorCS1 impairs synaptic plasticity, 69 alters GABAA receptor expression and causes autism-like behavior Pardo Lorente, Natalia Integration of genome-wide PAX8 and HNF1B binding with 70 transcriptomics to deconvolute their contribution in clear cell renal carcinoma Abstract cancelled 71 Rogalska, Malgorzata Ewa Self-regulatory network of the core spliceosome 72 Rosendal, Ebba Viperin restricts Zika virus and tick-borne encephalitis virus replication 73 by targeting NS3 for proteasomal degradation Saad, Joseph FLT3 Activating Mutations Confer Significant Sensitivity to BET Inhibition 74 in AML Saarentaus, Elmo Most rare and high-risk CNV carriers do not have major health, 75 cognitive or socioeconomic consequences Salasova, Alena The proneurotrophin receptor SorCS2 is a novel regulator of Wnt/PCP 76 pathway during embryogenesis and midbrain development Sandblad, Linda Presenter: Söderholm, Niklas Novel Streptomyces growth morphology alters the metabolome and 77 promotes antimicrobial activity Sayers, Claire Designing a systematic screen for fertility genes in Plasmodium berghei 78 Page 15 EMBL Partnership Conference: Perspectives in Translational Medicine Schröder, Björn O. Impaired colonic mucus barrier in genetically obese mice 79 Sevillano-Quispe, Oscar G Structural dynamics of glutamate NMDA receptors 80 Sharma, Atin Identification of novel determinants of intracellular adaptation in Shigella 81 flexneri Sinha, Vishal Variants in regulatory elements of PDE4D associate with major mental 82 illness in the Finnish population Sixt, Barbara The Chlamydia inclusion membrane protein CpoS recruits Rab GTPases 83 to subvert the host cellular surveillance system Subramani, Saranya Identification of the magnesium-sensing region in Esherichia coli MgtA 84 Takeuchi, Tomonori Presenter: Henningsen, Kim Memory consolidation, dopamine and two distinct novelty systems 85 Thomasen, Pernille B. SorCS2: A novel progranulin receptor and regulator of motor neuron 86 outgrowth Tynell, Janne Analyzing the cellular interactomes of the hantavirus N and NSs proteins 87 Uckelmann, Michael Swipe right for DNA repair - Target selection of two epigenetic modifiers 88 Urpa, Lea Genetic architecture of intellectual disability in Northern Finland 89 Page 16 Posters A-Z van der Ent, Wietske Toward novel therapeutic interventions for SNARE complex pathologies 90 Vereb, Zoltan Immunological properties of adipose tissue derived mesenchymal stem 91 cells under inflammatory conditions Vielfort, Katarina Presenters: Bergström, Sven; Vielfort, Katarina Development of antibacterial compounds against Chlamydia 92 trachomatis Wang, Tianduanyi Target deconvolution to understand cellular drug responses 93 Wang, Wenyu Combined gene essentiality scoring improves the prediction of cancer 94 dependency map Wang, Yinyin Revisiting the concept of Meridian in Chinese Traditional Medicine using 95 machine learning approaches Wilmanns, Matthias A cidal toxin/antitoxin pair from Mycobacterium tuberculosis: A suitable 96 drug target? Xing, Mengtan Genetic interaction between non-homologous end joining factors in 97 mice and humans Zagidullin, Bulat DrugComb: An integrative cancer drug combination data portal 98 Zerbino, Daniel Functional annotation of GWAS regulatory variants powered by Ensembl 99 Page 17 .