Osaka University Freedom and enthusiasm . Where people grow and dream. Tekijuku(適塾) Koan Ogata(緒方洪庵) A pioneer in Japanese modern medical science Medicine Science Engineering Yuichi Shiro Engineering Nobuaki Yamamura IMCB Akabori Science KiKumagai Innovation by fusion World leading immunologists A pioneer in imaging Kishimoto Akira Yanagida Order of culture NAS member The imperial prize The imppperial prize Immunology Frontier Research Center World Premier Initiative (WPI) Program Why is a spatiotemporal approach important in immunology? Innate response Adaptive response Dynamic immune cellular networks Characteristics of immune system T cell differentiation • Largg(e number (1011))y and variety of cells • Migration whole through the body • Dynamic cellular interaction A variety of immune cells move around and form a dynamic network in the body Individual cells are influenced byyg interacting with other cells in the network The balance of immune resppyonses in the body cannot be deduced from isolated cell studies Imaging of spatiotemporal immune reactions in the body Development of imaging techniques Single molecule imaging Multiphoton microscopy MRI (11.7T) ligand GPCR PIP2 Lymph node PTEN Lyypmph node PIP3 Intracellular signaling Cell movement and interaction Immune cell localization From immuno-imaging to translational research Imaging of the immune system Evaluation of cancer immunotherapy Patterning of immune cell dynamics Imaging of lymph node Therapy Cancer- Normal Cancer Allergy attacking T cell Autoimmune disease Cancer Successful Diagnosis and treatment of immune diseases Cancer Infectious disease Failure Allergy Autoimmune disease Organization chart Core Research Groups Cooperative Institutions International Immunology Groups Overseas Advisory HtDfHost Defense（Shizuo Akira） National Institutes of Health Review Board Immunoglycobiology（Taroh Kinoshita） New York University Immunopathology（Atsushi Kumanogoh） Stanford University Director Immunochemistry（Hisashi Arase） California Institute of Technology Shizuo Akira Immune Regulation（Tadamitsu Kishimoto） Harvard University Management Developmental Immunology （Toshio Hirano） University of California San Francisco Committee Immunodynamics（Masayuki Miyasaka） Domestic Mucosal Immunology（Kiyoshi Takeda） Deputy Director RIKEN Molecular Immunology（Hitoshi Kikutani） Board of Institute for Frontier Medical Sciences, Representatives Experimental immunology（Shimon Sakaguchi） Kyoto University Cell Signaling（Takashi Saito） Ly mphocyte Differentiation （Tomohiro Ku rosaki） Lymphocyte Development（Fritz Melchers） Gastrointestinal Immunology（Jang Myong Ho） Imaging Groups Single Molecule Imaging（Toshio Yanagida） Biomedical Optics（Junji Seki ） Biofunctional Imaging（Yoshichika Yoshioka） Nano-bio Materials（Takashi Jin ） Information System（Yutaka Hata） Research Management Section Administrative General Affairs Section Director Accounting Section.