ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 32, Number 1, January 2012 Contents Experimental Studies * Review: Novel Therapeutic Approaches for Targeting Tumor Angiogenesis. A.G. LINKOUS, E.M. YAZLOVITSKAYA (Bethesda, MD; Nashville, TN, USA) .................................................................... 1 Growth Effect of Neutrophil Elastase on Breast Cancer: Favorable Action of Sivelestat and Application to Anti-HER2 Therapy. M. NAWA, S. OSADA, K. MORIMITSU, K. NONAKA, M. FUTAMURA, Y. KAWAGUCHI, K. YOSHIDA (Gifu, Japan) ....................................................................................... 13 Chemopreventive Potential of Black Cohosh on Breast Cancer in Sprague-Dawley Rats. L.S. EINBOND, M. SOFFRITTI, D.D. ESPOSTI, E. TIBALDI, M. LAURIOLA, L. BUA, K. HE, G. GENOVESE, T. SU, L. HUGGINS, X. WANG, M. ROLLER, H.-A. WU (New York, NY; Hackensack, NJ, USA; Bologna, Italy) ...... 21 The Cyano Fluorescent Protein Nude Mouse as a Host for Multicolor-coded Imaging Models of Primary and Metastatic Tumor Microenvironments. A. SUETSUGU, M.K. HASSANEIN, J. REYNOSO, Y. OSAWA, M. NAGAKI, H. MORIWAKI, S. SAJI, M. BOUVET, R.M. HOFFMAN (San Diego, CA, USA; Gifu, Japan) ...... 31 Color-coded Real-time Subcellular Fluorescence Imaging of the Interaction between Cancer and Host Cells in Live Mice. K. YAMAUCHI, Y. TOME, N. YAMAMOTO, K. HAYASHI, H. KIMURA, H. TSUCHIYA, K. TOMITA, M. BOUVET, R.M. HOFFMAN (San Diego, CA, USA; Fukui; Okinawa; Kanazawa, Ishikawa, Japan) ............................................................................................................................ 39 Effects of Vitamin D-binding Protein-derived Macrophage-activating Factor on Human Breast Cancer Cells. S. PACINI, T. PUNZI, G. MORUCCI, M. GULISANO, M. RUGGIERO (Firenze, Italy) ....................... 45 Contents continued on the back cover Contents continued Combinations of Resveratrol, Cisplatin and Oxaliplatin Applied to Human Ovarian Cancer Cells. M.U. NESSA, P. BEALE, C. CHAN, J.Q. YU, F. HUQ (Lidcombe; Concord, NSW, Australia) ...................... 53 Dual-mode Interaction between Quercetin and DNA-damaging Drugs in Cancer Cells. T. SAMUEL, K. FADLALLA, L. MOSLEY, V. KATKOORI, T. TURNER, U. MANNE (Tuskegee; Birmingham, AL, USA) ...... 61 Mutated in Colorectal Cancer Protein Modulates the NF κB Pathway. N.D. SIGGLEKOW, L. PANGON, T. BRUMMER, M. MOLLOY, N.J. HAWKINS, R.L. WARD, E.A. MUSGROVE, M.R.J. KOHONEN- CORISH (Sydney, Australia; Freiburg, Germany) ............................................................................... 73 Combination of Glucan, Resveratrol and Vitamin C Demonstrates Strong Anti-tumor Potential. V. VETVICKA, J. VETVICKOVA (Louisville, KY, USA) ........................................................................ 81 2+ The Hedgehog Pathway Inhibitor GDC-0449 Alters Intracellular Ca Homeostasis and Inhibits Cell Growth in Cisplatin-resistant Lung Cancer Cells. F. TIAN, K. SCHRÖDL, R. KIEFL, R.M. HUBER, A. BERGNER (Munich, Germany) ........................................................................................................ 89 Anticancer Effects of Synthetic Phosphoethanolamine on Ehrlich Ascites Tumor: An Experimental Study. A.K. FERREIRA, R. MENEGUELO, A. PEREIRA, O.M.R. FILHO, G.O. CHIERICE, D.A. MARIA (Sao Paulo; Sao Carlos; Belo Horizonte, Minas Gerais, Brazil) .................................................................. 95 Trastuzumab Has Opposing Effects on SN-38-induced Double-strand Breaks and Cytotoxicity in HER2- positive Gastric Cancer Cells Depending on Administration Sequence. M. YAMADE, M. SUGIMOTO, M. NISHINO, T. UOTANI, S. SAHARA, M. IWAIZUMI, T. YAMADA, S. OSAWA, K. SUGIMOTO, H. MIYAJIMA, T. FURUTA (Hamamatsu, Japan) .................................................................................. 105 Somatostatin Receptor Subtype 2 A (SSTR2A) and HER2 Expression in Gastric Adenocarcinoma. A. ROMITI, R. DI ROCCO, M. MILIONE, L. RUCO, V. ZIPARO, A. ZULLO, E. DURANTI, I. SARCINA, V. BARUCCA, C. D’ANTONIO, P. MARCHETTI (Rome; Milan, Italy) ............................................... 115 Inhibition of Cyclin D1 by shRNA Is Associated with Enhanced Sensitivity to Conventional Therapies for Head and Neck Squamous Cell Carcinoma. V. KOTHARI, R. MULHERKAR (Kharghar, Navi Mumbai, India) ..... 121 Naringin Inhibits Tumor Growth and Reduces Interleukin-6 and Tumor Necrosis Factor α Levels in Rats with Walker 256 Carcinosarcoma. C.A. CAMARGO, M.C.C. GOMES-MARCONDES, N.C. WUTZKI, H. AOYAMA (Sao Paulo, Brazil) ......................................................................................................... 129 Synthesis of Trans-bis -(2-hydroxypyridine)dichloroplatinum(II) and its Activity in Human Ovarian Tumour Models. N. DEQNAH, J.Q. YU, P. BEALE, K. FISHER, F. HUQ (Sydney, Australia) ........................... 135 Circulating Transforming Growth Factor- β and Epidermal Growth Factor Receptor as Related to Virus Infection in Liver Carcinogenesis. R. DIVELLA, A. DANIELE, C. GADALETA, A. TUFARO, M.T. VENNERI, A. PARADISO, M. QUARANTA (Bari, Italy) .................................................................. 141 A High-throughput Cell-based Screening for L858R/T790M Mutant Epidermal Growth Factor Receptor Inhibitors. W.-H. LIN, J.-S. SONG, T.-W. LIEN, C.-Y. CHANG, S.-H. WU, Y.-W. HUANG, T.-Y. CHANG, M.-Y. FANG, K.-J. YEN, C.-W. CHEN, C.-Y. CHU, H.-P. HSIEH, Y.-R. CHEN, Y.-S. CHAO, J.T.-A. HSU (Miaoli; Hsinchu, Taiwan, ROC) ................................................................................. Clinical Studies 147 Intense CD44 Expression Is a Negative Prognostic Factor in Tonsillar and Base of Tongue Cancer. D. LINDQUIST, A. ÄHRLUND-RICHTER, M. TARJÁN, T. TOT, T. DALIANIS (Falun; Stockholm, Sweden) .... 153 Clinical Application of MAGE A1-6 RT-Nested PCR for Diagnosis of Lung Cancer Invisible by Bronchoscopy. K.-C. SHIN, E.Y. CHOI, J.H. CHUNG, C. JEON, K.H. LEE (Daegu, South Korea) ....... 163 Contents continued on the preceding page Contents continued Relationship between Interval from Surgery to Radiotherapy and Local Recurrence Rate in Patients with Endometrioid-type Endometrial Cancer: a Retrospective Mono-institutional Italian Study. M.G. FABRINI, A. GADDUCCI, F. PERRONE, C. LA LISCIA, S. COSIO, S. MODA, M.E. GUERRIERI, A. GRANDINETTI, C. GRECO (Pisa, Italy) ......................................................................................... 169 Vinorelbine versus Paclitaxel for Patients with Advanced Non–small Cell Lung Cancer (NSCLC) and a Performance Status of 2. P.A. KOSMIDIS, K. SYRIGOS, H.P. KALOFONOS, M.-A. DIMOPOULOS, D. SKARLOS, N. PAVLIDIS, I. BOUKOVINAS, D. BAFALOUKOS, D. PECTASIDES, C. BACOYIANNIS, G. FOUNTZILAS (Athens; Piraeus; Ioannina; Thessaloniki, Greece) .................................................... 175 The Carcinoembryonic Antigen as a Potential Prognostic Marker for Neuroendocrine Carcinoma of the Breast. C.-H. SU, H. CHANG, C.-J. CHEN, L.-C. LIU, H.-C. WANG, H.-Y. LANE, D.-T. BAU (Taichung, Taiwan, ROC) ................................................................................................................................ 183 A Population-based Study of the Pattern of Terminal Care and Hospital Death in Patients with Non-small Cell Lung Cancer. C. NIEDER, T. TOLLÅLI, J NORUM, A. PAWINSKI, R.M. BREMNES (Bodø; Tromsø, Norway) ........................................................................................................................... 189 Efficacy and Feasibility of Induction Chemotherapy and Radiotherapy plus Cetuximab in Head and Neck Cancer. M. RAMPINO, A. BACIGALUPO, E. RUSSI, M. SCHENA, L. LASTRUCCI, C. IOTTI, A. REALI, A. MUSU, V. BALCET, C. PIVA, S. BUSTREO, F. MUNOZ1, R. RAGONA, R CORVÒ, U. RICARDI (Torino; Genova; Cuneo; Arezzo; Reggio Emilia, Italy) ........................................................ 195 Analysis of Failures in Patients with FIGO Stage IIIc 1-IIIc 2 Endometrial Cancer. A. GADDUCCI, S. COSIO, M.G. FABRINI, M.E. GUERRIERI, C. GRECO, A.R. GENAZZANI (Pisa, Italy) .................... 201 Proceedings of the 4th International Symposium on Vitamin D and Analogs in Cancer Prevention and Therapy, May 20-21, 2011, Homburg/Saar, Germany. Edited by J. Reichrath, M. Friedrich, Th. Vogt 207-396 Preface: Vitamin D and its Analogs in Cancer Prevention and Therapy. J. REICHRATH, M. FRIEDRICH, T. VOGT (Homburg/Saar; Krefeld, Germany) .................................................................................... 207 * Review: Vitamin D: Potential in the Prevention and Treatment of Lung Cancer. R. NORTON, M.A. O’CONNELL (Norwich, UK) .......................................................................................................... 211 * Review: Ecological Studies of the UVB.Vitamin D. Cancer Hypothesis. W.B. GRANT (San Francisco, CA, USA) ................................................................................................................................. 223 * Review: The Scots’ Paradox: Can Sun Exposure, or Lack of it, Explain Major Paradoxes in Epidemiology? O. GILLIE (London, UK) ................................................................................................................ 237 1Alpha,25-dihydroxyvitamin D 3 Induces de novo E-cadherin Expression in Triple-negative Breast Cancer Cells by CDH1 -promoter Demethylation. N. LOPES, J. CARVALHO, C. DURÃES, B. SOUSA, M. GOMES, J.L. COSTA, C. OLIVEIRA, J. PAREDES, F. SCHMITT (Porto, Portugal) .......................... 249 Determination