Ganirelix Acetate Injection Instructional Quick Guide READYSETINJECT Before you begin Ganirelix Acetate Injection is supplied in a sterile, prefilled syringe and should be injected subcutaneously (under the skin) only. Read all instructions carefully before using your Ganirelix Acetate Injection. Important information about ✓ You will need: Ganirelix Acetate Injection • Ganirelix Acetate Always use Ganirelix Acetate Injection as prescribed for you. Injection Do not inject Ganirelix Acetate Injection until you have • alcohol pads received instructions from your health care provider regarding the • a safety container administration of Ganirelix Acetate Injection. Close care by your to discard used health care provider is very important. supplies Do not mix Ganirelix Acetate Injection with any other medicines in ✓ Wash your hands thoroughly the same syringe. with soap and water. Ganirelix Acetate Injection is approved for the inhibition of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation. Important Safety Information Do not use Ganirelix Acetate Injection if you are allergic to ganirelix stomach and chest areas. Call your health care professional right acetate or any of its components, gonadotropin releasing hormone away if you get any of the following symptoms: severe pelvic pain (GnRH) or any other GnRH analog (including GnRH agonists and (lower stomach area), nausea, vomiting, sudden weight gain, or antagonists), or if you are pregnant or think you might be pregnant. reduced urine output. Ganirelix Acetate Injection should only be prescribed by physicians Other side effects with Ganirelix Acetate Injection include experienced in infertility treatments. Before starting treatment with abdominal pain, death of unborn child, headache, vaginal bleed- Ganirelix, pregnancy must be excluded. ing, injection site reaction, and nausea. If you get any side effects Hypersensitivity (allergic) reactions, some severe, have been reported that concern you, call your health care professional. after the first dose of Ganirelix Acetate Injection. Call your health care You are encouraged to report negative side effects of prescription professional right away if you get any of the following symptoms: drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800- hives, difficulty breathing, chest tightness, high or low blood FDA-1088. pressure, vomiting, or diarrhea. The packaging of this product contains natural rubber latex which may cause allergic reactions. Please see accompanying important product information. Ganirelix Acetate Injection may cause ovarian hyperstimulation For more information, call 1-800-631-1253 syndrome (OHSS), which is a serious medical problem that can or visit www.ganirelix.com. happen when the ovaries are overstimulated. In rare cases it has For support services, please visit www.fertilityjourney.com. caused death. OHSS causes fluid to build up suddenly in the Please turn page ➔ Using Your Ganirelix Acetate Injection This instruction sheet complements, but does not replace instructions by your health care provider regarding the administration of Ganirelix Acetate Injection. It should be used only after receiving instruction from your health care provider. READY Select and prepare your injection site The most convenient injection sites are in the abdomen around the navel, or the upper thigh. With an alcohol pad, clean a two-inch space around the point where the needle will be insert- ed. Let dry at least one minute. Vary the injection site a little with each injection. SET Uncap your syringe With the syringe held upward, remove the needle cover. Never touch the needle and never place an open needle on any surface. INJECT Inject your Ganirelix Acetate Injection Pinch up a large area of skin between your finger and thumb. Insert the needle at the base of the pinched-up skin at a 45-90° angle to the skin surface. Pull back gently on the plunger. If the needle is correctly inserted, it will be difficult to pull the plunger back. If you see blood in the syringe after you pull back gently on the plunger, the needle tip has penetrated a vein or artery. If this happens, withdraw the needle slightly and reposition the needle without removing it from the skin. Alternatively, pull out the needle and apply pressure to the site with an alcohol pad. The bleeding should stop within two minutes. Discard the original needle and syringe immediately. Using a new, sterile, prefilled syringe, repeat the injection step. Once the needle is properly inserted, slowly and steadily depress the plunger until the syringe is empty. Pull the needle out quickly and apply pressure to the injection site with an alcohol pad. Maintaining pressure, gently massage the site to disperse Ganirelix Acetate Injection and help relieve any discomfort. Dispose of the needle and syringe as instructed by your health care provider. DO NOT REUSE. You have completed your injection! Copyright © 2009, Schering Corporation, Kenilworth, NJ 07033. All rights reserved. Printed in USA. GX2015 1/09.