United States Office of Chemical Safety Environmental Protection Agency and Pollution Prevention Final Risk Evaluation for Cyclic Aliphatic Bromides Cluster (HBCD) Systematic Review Supplemental File: Supplemental Information on General Population, Environmental and Consumer Exposures CASRN:25637-99-4 CASRN:3194-55-6 CASRN:3194-57-8 September 2020 Table of Contents TABLE OF CONTENTS ............................................................................................................................ 2 LIST OF TABLES ...................................................................................................................................... 5 LIST OF FIGURES .................................................................................................................................... 8 LIST OF EQUATIONS ............................................................................................................................ 11 OVERVIEW OF THE SYSTEMATIC REVIEW PROCESS .......................................................... 12 1.1 DATA EXTRACTION METHODS AND APPROACH ..................................................................... 12 1.2 DATA INTEGRATION METHODS AND APPROACH .................................................................... 13 1.3 STATISTICAL APPROACH OF EXPOSURE ESTIMATES DERIVED FROM MEASURED CONCENTRATIONS ................................................................................................................................... 14 1.3.1 Fitting lognormal distributions ........................................................................................ 15 1.3.2 Fitting normal distributions ............................................................................................ .15 1.3.3 Quality control of derived exposure estimates ................................................................. 15 1.3.4 Final risk estimates by media and location type .............................................................. 15 ENVIRONMENTAL MONITORING MEDIA .................................................................................. 20 2.1. AMBIENT AIR ....................................................................................................................................20 2.1.1. Ambient Air (ng/g) – Particulate Fraction ........................................................................... 20 2.1.2. Ambient Air (ng/m3) – Gas and/or Particulate Fraction ...................................................... 20 2.2. BIOSOLIDS ....................................................................................................................................... 23 2.2.1. Biosolids (ng/g) – Dry Fraction ........................................................................................... 23 2.3. CONSUMER PRODUCTS .................................................................................................................... 25 2.3.1. Consumer Products (ng) – Bulk Fraction ............................................................................ 25 2.3.2. Consumer Products (ng/g) – Bulk Fraction ......................................................................... 26 2.3.3. Consumer Products (ng/cm2) – Dry Fraction ...................................................................... 28 2.4. DIET – DAIRY................................................................................................................................... 28 2.4.1. Dairy (ng/g) – Dry Fraction ................................................................................................. 28 2.4.2. Dairy (ng/g) – Lipid Fraction ............................................................................................... 29 2.4.3. Dairy (ng/g) – Wet Fraction ................................................................................................. 30 2.5. DIET – FATS ..................................................................................................................................... 32 2.5.1. Fats (ng/g) – Lipid Fraction ................................................................................................. 32 2.5.2. Fats (ng/g) – Wet Fraction ................................................................................................... 33 2.6. DIET – FRUIT .................................................................................................................................... 34 2.6.1. Fruit (ng/g) – Dry Fraction .................................................................................................. 34 2.6.2. Fruit (ng/g) – Wet Fraction .................................................................................................. 34 2.7. DIET – GRAIN................................................................................................................................... 36 2.7.1. Grain (ng/g) – Dry Fraction ................................................................................................. 36 2.7.2. Grain (ng/g) – Lipid Fraction .............................................................................................. 36 2.7.3. Grain (ng/g) – Wet Fraction ................................................................................................. 37 2.8. DIET – MEAT ................................................................................................................................... 38 2.8.1. Meat (ng/g) – Dry Fraction .................................................................................................. 38 2.8.2. Meat (ng/g) – Lipid Fraction ................................................................................................ 38 2.8.3. Meat (ng/g) – Wet Fraction .................................................................................................. 40 2.9. DIET – OTHER FOOD ........................................................................................................................ 42 2.9.1. Other Food (ng/g) – Dry Fraction ....................................................................................... 42 2.9.2. Other Food (ng/g) – Lipid Fraction ..................................................................................... 42 Page 2 of 160 2.9.3. Other Food (ng/g) – Wet Fraction ....................................................................................... 43 2.10. DIET – SEAFOOD ............................................................................................................................ 44 2.10.1. Seafood (ng/g) – Lipid Fraction ......................................................................................... 44 2.10.2. Seafood (ng/g) – Wet Fraction ........................................................................................... 46 2.11. DIET – VEGETABLE ........................................................................................................................ 49 2.11.1. Vegetable (ng/g) – Dry Fraction ........................................................................................ 49 2.11.2. Vegetable (ng/g) – Wet Fraction ........................................................................................ 49 2.12. INDOOR AIR ................................................................................................................................... 50 2.12.1. Indoor Air (ng/m3) .............................................................................................................. 50 2.13. INDOOR DUST ................................................................................................................................ 53 2.13.1. Indoor Dust (ng/g) – Dry Fraction ..................................................................................... 53 2.14. LANDFILL LEACHATE .................................................................................................................... 59 2.14.1. Landfill Leachate (ng/g) – Dry Fraction ............................................................................ 59 2.14.2. Landfill Leachate (ng/g) – Wet Fraction ............................................................................ 59 2.14.3. Landfill Leachate (ng/L) – Wet Fraction ............................................................................ 60 2.15. PRECIPITATION .............................................................................................................................. 61 2.15.1. Precipitation (ng/L) – Wet Fraction ................................................................................... 61 2.16. SEAWATER ..................................................................................................................................... 61 2.16.1. Seawater (ng/L) – Wet Fraction ......................................................................................... 61 2.17. SEDIMENT ...................................................................................................................................... 63 2.17.1. Sediment (ng/g) – Dry Fraction ......................................................................................... 63 2.17.2. Sediment (ng/g) – Wet Fraction ......................................................................................... 68 2.18. SOIL ............................................................................................................................................... 70 2.18.1. Soil (ng/g) – Dry Fraction .................................................................................................