Figure S1 HPLC fingerprint of water decoction(a), supernatant(b) and essential oil(c) fractions of T. patula. Notes: (1) patuletin, (2) quercetin-7-O-α-L-rhamnosepyranoside, (3) quercetin-3-O-α-L- arabinopyranoside, (4) kaempferol-3-O-β-D-glucopyranoside, (5) kaempferol-3-O-β-D- xylopyranoside, (6) kaempferol-3-O-α-L-rhamnosepyranoside, (7) kaempferol, (8) kaempferol-3- O-α-L-arabonipyranoside. LZY--SOG-1A 1: TOF MS ES+ 10.91 100 TIC 1.96e5 9.21 4.28 9.56 3.77 % 8.56 0.530.74 1.66 4.82 10.68 4.56 9.00 0.98 2.35 4.02 3.57 5.75 9.96 5.96 2.11 5.27 6.91 2.61 3.15 7.007.69 8.10 10.22 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 LZY--MOG-1B 1: TOF MS ES+ 10.91 100 TIC 2.12e5 9.56 3.77 4.56 % 0.73 0.82 1.66 2.37 4.29 0.53 0.94 3.57 5.77 10.68 4.83 9.23 1.21 5.27 9.03 2.13 2.44 5.96 9.96 3.23 6.47 6.91 8.79 7.667.75 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 C LZY--LHG-1 1: TOF MS ES+ 10.91 100 TIC 1.82e5 9.56 4.29 % 3.78 10.67 4.56 0.53 4.02 9.23 0.921.00 2.11 2.38 4.83 3.15 5.75 9.03 1.65 3.23 5.23 5.96 10.22 2.61 6.44 7.14 7.75 8.10 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 LZY--TCM-1D 1: TOF MS ES+ 10.91 100 TIC 1.86e5 9.56 % 0.76 1.00 4.29 10.67 9.21 1.07 3.78 0.53 1.66 2.64 4.61 9.02 2.11 3.15 4.19 5.23 3.56 5.98 6.46 7.12 7.30 8.04 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 LZY--WDG-1E 1: TOF MS ES+ 10.91 100 TIC 1.64e5 9.56 % 3.78 4.29 0.71 10.69 0.88 5.75 3.57 4.83 0.52 9.21 1.40 2.37 3.20 4.02 5.23 5.96 6.50 6.91 9.03 2.58 7.66 8.56 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 LZY--EOG-1F 1: TOF MS ES+ 10.91 100 TIC 1.67e5 % 9.56 10.68 3.77 4.28 0.981.07 3.57 4.02 4.56 5.75 9.21 1.65 2.37 3.15 6.46 6.82 9.12 0.58 2.11 4.82 5.23 7.30 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 LZY--POG-1G 1: TOF MS ES+ 10.91 100 TIC 1.59e5 % 9.56 10.67 9.23 0.73 0.98 3.77 4.28 0.53 2.11 2.37 1.16 3.15 9.02 5.23 2.79 4.02 4.82 5.75 8.10 8.56 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 LZY--SUG-1H 1: TOF MS ES+ 10.91 100 TIC 1.41e5 % 9.56 4.28 10.67 3.77 9.20 0.71 0.98 10.22 4.19 5.75 8.56 2.37 4.82 1.65 2.11 3.15 5.23 6.26 6.82 7.30 7.98 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 Figure S2 TIC chromatograms on positive ion mode Notes: A. Sham-operated Group E. Water Decoction Treatment Group B. CNP Model Group F. Essential Oil Treatment Group C. Levofloxacin Treatment Group G. Polysaccharide Treatment Group D. Pule’ an Tablet Treatment Group H. Supernatant Treatment Group A SOG-1 1: TOF MS ES- 3.63 100 TIC 1.16e5 3.75 4.28 4.61 3.09 4.88 0.89 4.94 % 5.96 9.21 5.84 8.58 9.56 0.59 2.35 2.59 5.30 6.92 1.07 7.93 6.13 1.71 7.69 9.62 9.9610.73 11.63 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 B MOG-1 1: TOF MS ES- 3.77 100 TIC 1.34e5 4.28 0.92 3.69 9.56 3.21 5.84 % 4.41 5.96 2.74 2.86 5.23 6.90 2.64 0.86 2.37 6.49 0.58 1.18 1.71 7.06 9.039.23 7.398.08 8.77 9.74 10.91 11.62 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 LHG-1C 1: TOF MS ES- 4.29 100 TIC 9.48e4 3.78 4.01 1.03 4.38 9.56 % 3.65 5.96 4.82 0.97 3.21 5.23 1.18 0.58 2.38 2.79 0.77 1.71 5.48 6.50 9.23 10.91 7.12 5.72 7.96 8.08 9.11 10.22 11.56 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 D TCM-1 1: TOF MS ES- 3.98 100 3.78 4.29 TIC 6.92e4 5.13 4.61 9.56 1.07 3.42 3.21 5.96 % 0.77 5.38 0.59 9.20 1.18 1.68 2.65 5.83 2.56 6.50 7.12 1.78 9.11 10.75 10.91 9.74 7.44 7.98 8.08 11.54 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 E WDG-1 1: TOF MS ES- 3.77 100 TIC 5.98e4 4.28 3.20 0.95 9.56 4.82 5.24 5.96 6.50 3.65 0.59 7.08 % 1.04 5.47 6.91 2.77 2.89 1.21 8.08 9.20 10.91 2.19 6.26 7.98 10.73 7.20 2.07 8.41 8.59 9.74 11.54 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 EOG-1F 1: TOF MS ES- 3.78 100 TIC 9.19e4 4.29 4.62 1.07 3.44 % 0.98 5.24 6.90 6.50 6.97 0.79 4.82 5.84 1.16 3.21 5.96 9.56 2.74 10.91 1.42 2.22 10.73 7.21 7.96 8.61 8.77 9.74 11.54 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 POG-1G 1: TOF MS ES- 3.77 100 TIC 8.81e4 4.29 1.00 9.56 5.96 4.82 5.23 6.50 % 3.23 4.01 1.09 9.21 10.22 5.84 7.98 9.02 0.58 6.97 9.62 1.18 2.79 2.91 2.37 7.06 2.20 8.56 1.40 7.12 10.73 10.91 11.62 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 SUG-1H 1: TOF MS ES- 3.77 100 TIC 9.17e4 4.28 3.06 5.19 0.92 3.18 4.61 6.50 7.07 9.56 % 0.80 9.21 0.98 5.95 6.97 7.98 0.59 1.09 5.72 2.35 8.08 8.77 6.26 7.45 2.17 9.74 1.75 10.73 10.91 11.56 0 Time 1.00 2.00 3.00 4.00 5.00 6.00 7.00 8.00 9.00 10.00 11.00 12.00 13.00 Figure S3 TIC chromatograms on negative ion mode Notes: A.