© Mik Man / fotolia.com 30th European Congress of Pathology Pathology: Path to Precision medicine 8 – 12 September 2018 Euskalduna Conference Centre, Bilbao, Spain Final www.esp-congress.org Programme ECP 2018 · Bilbao Table of Contents page page Welcome Address 4 Two-Day Symposium for Molecular Biologists 69 Committees and Organisers 5 Monday, 10 September 2018 70 Tuesday, 11 September 2018 71 Keynote Speakers 7 One-Day Computational Bursaries 11 Pathology Symposium 73 Sunday, 9 September 2018 74 CME Accreditation 13 Poster Sessions 75 Venue Overview 15 Sunday, 9 September 2018 76 Monday, 10 September 2018 87 Programme Overview 16 Tuesday, 11 September 2018 99 Colour Legend 16 Wednesday, 12 September 2018 111 Saturday, 8 September 2018 17 Sunday, 9 September 2018 18 E-Posters 123 Monday, 10 September 2018 20 Tuesday, 11 September 2018 22 Congress Information 165 Wednesday, 12 September 2018 24 Industry Symposia 171 Scientific Programme 27 Saturday, 8 September 2018 28 Acknowledgements 177 Sunday, 9 September 2018 28 Monday, 10 September 2018 38 Exhibition Floor Plan 179 Tuesday, 11 September 2018 50 Wednesday, 12 September 2018 62 List of Exhibitors 182 Social Events 187 Index of Authors 191 e Host Organisation e Congress and Exhibition Office European Society of Pathology Rue Bara 6 1070 Brussels, Belgium CPO HANSER SERVICE GmbH www.esp-pathology.org Paulsborner Str. 44 14193 Berlin, Germany e Scientific Contact Phone: +49 – 30 – 300 669-0 Raed Al Dieri Fax: +49 – 30 – 305 73 91 ESP Director General Email: [email protected] Rue Bara 6 1070 Brussels, Belgium e Congress Venue Email: [email protected] Euskalduna Conference Centre 4, Abandoibarra Av. 48011 Bilbao, Spain www.euskalduna.eus 3 Welcome Address ECP 2018 · Bilbao Dear Colleague, On behalf of the European Society of Pathology and the Span- ish Society of Pathology we would like to welcome you to Bilbao. This year, pathologists and scientists from all over the world celebrate the 30th anniversary of ECP – while getting updated on all aspects of diagnostic and molecular pathology. The theme for the ECP 2018, “Pathology: Path to Precision medicine” highlights Pathology as the cornerstone of pre- Dina Tiniakos cision medicine and underlines the central role of the pa- thologist in the multidisciplinary teams that guide patient management in the 21st century. Pathologists collaborating with molecular biologists, geneticists, bioinformaticians, and information technologists provide accurate diagnoses, prog- nostic and predictive information essential for treatment deci- sions tailored to the individual patient. ECP 2018 has organ-based sessions prepared by the ESP working groups, joint sessions with other pathology and clinical scientifi c societies, trainee-led sessions, and special sessions focusing on advances in molecular and digital pa- thology, quality assessment, education, histotechnology and José Ignacio López public awareness. Keynote lectures, as every year, are the highlight of the pro- gramme with eminent colleagues enlightening us on differ- ent aspects of pathology and beyond. The ECP 2018 oral free paper and best poster sessions are a great platform to present and discuss exciting new translational research in all areas of pathology, while the challenging diagnosis of rare entities is showcased in poster sessions. We are happy to have you here and wish you an unforgettable time in vibrant Bilbao! Dina Tiniakos, Greece / UK President of the European Society of Pathology José Ignacio López, Spain Chair of the Local Organising Committee of ECP 2018 4 ECP 2018 · Bilbao Committees and Organisers e Brief Description of the ESP e Scientific / Organising Committee The European Society of Pathology (ESP) Dina Tiniakos, Greece / UK was founded by a small group of eminent Fátima Carneiro, Portugal pathologists in 1963. The Society was of- Pierre Bedossa, France ficially registered in Brussels, Belgium as Raed Al Dieri, Belgium an international non-profit organization on José Ignacio López, Spain November 7th, 1964. The ESP is a leading José Palacios, Spain force in European pathology and, as such, Francisco Nogales, Spain is pivotal to the future of the specialty in Eu- Enrique de Álava, Spain rope and beyond. As a scientific society, the ESP has, as its primary aim, the promotion of high quality diagnostic practice, applied e ESP Executive Comittee and and translational research and under- and Council postgraduate education in the field of hu- President: man pathology. This is achieved through its Dina Tiniakos, Greece / UK congresses, its journal Virchows Archiv and President-elect: various other activities. The ESP interacts Holger Moch, Switzerland with national pathology societies in Europe Secretary: and has developed links with other EU bod- Aurelio Ariza, Spain ies in close collaboration with UEMS (Union Treasurer: Européenne des Médecins Spécialistes) and Marco Santucci, Italy EAPCP (European Association of Pathology Past President: Chairs and Programme Directors). Pierre Bedossa, France The European School of Pathology under the Members: auspices of the ESP and with the support of Peter Schirmacher, Germany 20 Working Groups and 5 Affiliated Societies Metka Volavšek, Slovenia representing different fields of pathology is Tibor Tot, Sweden involved in the organisation of courses to Cord Langner, Austria meet the needs of young pathologists. The Xavier Matias-Guiu, Spain ESP has recently established ESPQA Foun- Glenn McCluggage, UK dation which stimulates external quality as- Maria Rosaria Raspollini, Italy sessment programmes for several biomark- Anastasia Konstantinidou, Greece ers where diagnostic laboratories worldwide Chair of the Advisory Board: participate in the organised schemes such as Fátima Carneiro, Portugal Lung and Colon. ESP Director General: Raed Al Dieri, Belgium Office of the ESP Rue Bara 6, 1070 Brussels, Belgium Phone: +32 – 25208036 Email: [email protected] www.esp-pathology.org 5 Committees and Organisers ECP 2018 · Bilbao e Working Groups of the ESP Chair of the ESP Working Groups: Pierre Bedossa, France 1. Autopsy Pathology 12. IT (Computational) Chair: C. Alfsen, Norway Chair: K. Kayser, Germany Secretary: M. Haab, Germany 13. Molecular Pathology 2. Breast Pathology Chair: G. Stanta, Italy Chair: A. Sapino, Italy Secretary: G. Hoefler, Austria Secretary: G. Cserni, Hungary 14. Nephropathology 3. Cytopathology Chair: K. Amann, Germany Chair: B. Cochand-Priollet, France Secretary: H. Hopfer, Switzerland Secretary: P. Vielh, Luxembourg 15. Paediatric and Perinatal Pathology 4. Dermatopathology Chair: P. Borralho Nunes, Portugal Chair: E. Calonje, UK Secretary: I. Colmenero, Spain Secretary: B. Luzar, Slovenia 16. Pathology in Favour of Developing 5. Digestive Diseases Pathology Countries Chair: J.-F. Fléjou, France Chair: S. Guzzetti, Italy Secretary: C. Sempoux, Switzerland Secretary: G. de Falco, Italy 6. Electron Microscopy 17. Pulmonary Pathology Chair: J. Lloreta-Trull, Spain Chair: F. Calabrese, Italy Secretary: A. Franchi, Italy Secretary: I. Kern, Slovenia 7. Endocrine Pathology 18. Soft Tissue and Bone Pathology Chair: O. Nilsson, Sweden Chair: P. C. W. Hogendoorn, Secretary: S. La Rosa, Switzerland The Netherlands 8. Gynaecological Pathology Secretary: F. Le Loarer, France Chair: S. Stolnicu, Romania 19. Thymic and Mediastinal Pathology Secretary: A. Vidal, Spain Chair: A. Marx, Germany 9. Head and Neck Pathology 20. Uropathology Chair: T. R. Helliwell, UK Chair: A. Lopez-Beltran, Spain Secretary: N. Zidar, Slovenia Secretary: M. Colecchia, Italy 10. History of Pathology Chair: G. Nesi, Italy 11. Infectious Diseases Pathology Chair: G. Gorkiewicz, Austria Secretary: P. Castillo, Spain e Affiliated Societies e Cardiovascular Pathology e Ophthalmic Pathology President: M. N. Sheppard, UK President: R. M. Verdijk, Secretary: K. Michaud, Switzerland The Netherlands e Haematopathology e Paediatric Pathology President: G. Ott, Germany President: G. Vujanic, Qatar Secretary: L. Quintanilla-Fend, Germany Secretary: S. Holden, UK e Neuropathology (Euro – CNS) President: A. Vital, France Secretary: P. Ince, UK 6 ECP 2018 · Bilbao Keynote Speakers e Manuel Serrano (Spain) Manuel Serrano obtained his PhD in 1991, at the University of Madrid (UAM). From 1991 to 1996, Serrano worked as a postdoctoral researcher in the team of David Beach in Cold Spring Harbor Laboratory, NY. During this period, Serrano made his most important discovery with the identification and characterization of the gene p16, one of the most important genes for anti-cancer protection and a key inducer of cellu- lar senescence. Serrano returned to Spain in 1997 to lead a research group, first at the National Center of Biotechnology (CNB), and then, from 2003 to 2017, at the Spanish National Cancer Research Center (CNIO), both in Madrid. In 2017, Serrano moved to the Institute for Research in Biomedicine (IRB), in Barcelona. Manuel Serrano is internationally recognized in the field of tumour suppression and aging. In addition to the discovery of p16, one of his main discoveries has been the identification of cel- lular senescence as a main anti-oncogenic response. The Serrano team was also pioneer in the generation of genetically-modifed long-lived mice resistant to damage and cancer, through the regulated enhancement of the key tumour suppressors p53 and p16. Recently, his laboratory has also shown that cellular senescence participates in several tissue remodeling processes during embryo development. During the last years, the research interests