
<p><a href="/goto?url=http://www.denniskunkel.com" target="_blank">www.denniskunkel.com </a></p><p>Tour of the Cell </p><p>part 1 </p><p>Today’s Topics </p><p><strong>Cells </strong></p><p>•ꢀ Finish Nucleic Acids •ꢀ Properties of all cells </p><p>–ꢀ Prokaryotes and Eukaryotes </p><p>•ꢀ Functions of Major Cellular Organelles </p><p>–ꢀ Information –ꢀ Synthesis&Transport –ꢀ Energy Conversion –ꢀ Recycling –ꢀ Structure and Movement </p><p><strong>Animal Cell (Eukaryote)</strong><sup style="top: -0.1711em;">2 </sup></p><p><strong>Bacterial cell </strong><br><strong>(Prokaryote) </strong></p><p>9/12/12 </p><p><a href="/goto?url=http://www.denniskunkel.com" target="_blank">www.denniskunkel.com </a></p><p>Common features of all cells </p><p>•ꢀ <strong>Plasma Membrane </strong></p><p>–ꢀdefines inside from outside </p><p>•ꢀ <strong>Cytosol </strong></p><p>–ꢀSemifluid “inside” of the cell </p><p>•ꢀ <strong>DNA “chromosomes” </strong></p><p>-ꢀ Genetic material – hereditary instructions </p><p>•ꢀ <strong>Ribosomes </strong></p><p>–ꢀ“factories” to synthesize proteins </p><p>4</p><p><strong>Plasma membrane </strong></p><p><strong>Bacterial (Prokaryotic) Cell </strong></p><p><strong>Ribosomes! </strong></p><p><strong>Plasma membrane! </strong><br><strong>Cell wall! </strong><br><strong>Bacterial </strong></p><p><strong>chromosome! </strong></p><p>Phospholipid </p><ul style="display: flex;"><li style="flex:1">bilayer </li><li style="flex:1">Proteins </li></ul><p></p><p><strong>0.5 !m! </strong></p><p><strong>Flagella! </strong></p><p>No internal membranes </p><p></p><ul style="display: flex;"><li style="flex:1">5</li><li style="flex:1">6</li></ul><p></p><p>1</p><p>Figure 6.2b </p><p><strong>1 cm 1 mm </strong></p><p><strong>Eukaryotic Cell </strong></p><p><strong>Frog egg Human egg </strong><br><strong>100 µm </strong></p><p><strong>Most plant and animal cells </strong><br><strong>10 µm </strong></p><p><strong>1 µm </strong><br><strong>Nucleus Most bacteria Mitochondrion </strong></p><p><strong>Super- resolution microscopy </strong></p><p><strong>Smallest bacteria Viruses </strong><br><strong>100 nm </strong><br><strong>10 nm </strong><br><strong>1 nm </strong><br><strong>Ribosomes Proteins Lipids Small molecules Atoms </strong></p><p>Contains internal organelles </p><p>7</p><p><strong>0.1 nm </strong></p><p></p><ul style="display: flex;"><li style="flex:1"><strong>ENDOPLASMIC RETICULUM (ER) </strong></li><li style="flex:1"><strong>ENDOPLASMIC RETICULUM (ER) </strong></li></ul><p></p><p><strong>endoplasmic reticulum </strong></p><p><strong>NUCLEUS </strong></p><p><strong>nucleus </strong></p><p><strong>NUCLEUS </strong></p><p><strong>Nucleus </strong></p><p></p><ul style="display: flex;"><li style="flex:1">Rough ER </li><li style="flex:1">Smooth ER </li><li style="flex:1">Rough ER </li><li style="flex:1">Smooth ER </li></ul><p></p><p></p><ul style="display: flex;"><li style="flex:1"><strong>Plasma membrane </strong></li><li style="flex:1"><strong>Plasma membrane </strong></li></ul><p></p><ul style="display: flex;"><li style="flex:1"><strong>Centrosome </strong></li><li style="flex:1"><strong>Centrosome </strong></li></ul><p></p><p><strong>cytoskeleton </strong></p><p></p><ul style="display: flex;"><li style="flex:1"><strong>CYTOSKELETON </strong></li><li style="flex:1"><strong>CYTOSKELETON </strong></li></ul><p><strong>Microfilaments </strong><br><strong>Intermediate filaments </strong><br><strong>Microtubules </strong><br><strong>Microfilaments </strong><br><strong>Intermediate filaments </strong><br><strong>Microtubules </strong></p><p>You should know everything in Fig 6.9 </p><p><strong>Ribosomes </strong></p><p><strong>ribosomes </strong></p><p><strong>Ribosomes </strong></p><p><strong>cytosol </strong></p><p></p><ul style="display: flex;"><li style="flex:1"><strong>Golgi apparatus </strong></li><li style="flex:1"><strong>Golgi apparatus </strong></li></ul><p></p><p><strong>Golgi apparatus </strong></p><p></p><ul style="display: flex;"><li style="flex:1"><strong>Peroxisome </strong></li><li style="flex:1"><strong>Peroxisome </strong></li></ul><p><strong>Figure 6.9 </strong></p><p><strong>In animal cells but not plant cells: </strong></p><p>Lysosomes </p><p><strong>In animal cells but not plant cells: </strong></p><p>Lysosomes Centrioles </p><p></p><ul style="display: flex;"><li style="flex:1"><strong>Lysosome </strong></li><li style="flex:1"><strong>Lysosome </strong></li></ul><p><strong>Figure 6.9 </strong></p><p>Centrioles Flagella (in some </p><p><strong>lysosome </strong></p><p><sub style="top: 0.1241em;">plant</sub>9 </p><p>10 </p><p></p><ul style="display: flex;"><li style="flex:1"><strong>Mitochondrion </strong></li><li style="flex:1"><strong>Mitochondrion </strong></li></ul><p></p><p></p><ul style="display: flex;"><li style="flex:1">sperm) </li><li style="flex:1">Flagella (in some plant sperm) </li></ul><p></p><p><strong>mitochondrion </strong></p><p><strong>Nuclear envelope </strong></p><p>Nucleus <br>Nucleus </p><ul style="display: flex;"><li style="flex:1">1</li><li style="flex:1">!m </li></ul><p>Nucleolus </p><p>Chromatin </p><p>Nuclear envelope: Inner membrane Outer membrane </p><p><strong>Pores </strong></p><p>Pore complex <br>Rough ER </p><p><strong>Surface of nuclear envelope. </strong></p><p></p><ul style="display: flex;"><li style="flex:1">1</li><li style="flex:1">!m </li><li style="flex:1">Ribosome </li></ul><p></p><p>0.25 !m </p><p><strong>Close-up of nuclear envelope </strong></p><p><strong>Figure 6.10 </strong></p><p></p><ul style="display: flex;"><li style="flex:1">11 </li><li style="flex:1">12 </li></ul><p></p><p></p><ul style="display: flex;"><li style="flex:1"><strong>Nuclear lamina (TEM). </strong></li><li style="flex:1"><strong>Pore complexes (TEM). </strong></li></ul><p></p><p>2</p><p><strong>ENDOPLASMIC RETICULUM (ER) </strong></p><p><strong>Ribosomes </strong></p><p><strong>NUCLEUS </strong></p><p><strong>Endoplasmic</strong><sub style="top: 0.0611em;">Smooth ER </sub><strong>Reticulum </strong></p><p>Rough ER </p><p><strong>Cytosol </strong></p><p><strong>Free Ribosomes </strong></p><p>Make Cytoplasmic Proteins </p><p>ER </p><p><strong>Plasma membrane </strong><br><strong>Centrosome </strong></p><p>–ꢀ Carry out protein synthesis </p><p><strong>CYTOSKELETON </strong></p><p><strong>Membrane Bound </strong></p><p><strong>Microfilaments </strong><br><strong>Intermediate filaments </strong><br><strong>Microtubules </strong></p><p><strong>Ribosomes </strong></p><p>Make Proteins to be Exported </p><p><strong>Ribosomes </strong></p><p><strong>Ribosomes </strong></p><p>Large subunit </p><p><strong>Golgi apparatus </strong></p><p><strong>Golgi apparatus </strong></p><p><strong>TEM showing ER and ribosomes </strong><br><strong>Peroxisome </strong></p><p>0.5 !m </p><p><strong>In animal cells but not plant cells: </strong></p><p>Small subunit </p><p><strong>Diagram of a ribosome </strong></p><p>Lysosomes Centrioles Flagella (in some plant sperm) </p><p><strong>Lysosome </strong><br><strong>Figure 6.9 </strong></p><p></p><ul style="display: flex;"><li style="flex:1">13 </li><li style="flex:1">14 </li></ul><p></p><p><strong>Mitochondrion </strong></p><p><strong>RNA & Protein Complex </strong></p><p><strong>Figure 6.11 </strong></p><p>1</p><p>Nucleus </p><p>Nuclear envelope is connected to ER </p><p><strong>Smooth ER </strong></p><p>Rough ER <br>Smooth ER </p><p>2</p><p>transport vesicles </p><p>•ꢀ Synthesis of membrane lipids </p><p>Golgi </p><p>•ꢀ Synthesizes steroids •ꢀ Stores calcium </p><p>3</p><p>Golgi pinches off Transport Vesicles, Lysosomes, etc. </p><p>•ꢀ Detoxifies poison </p><p>Plasma<sub style="top: 0.1393em;">6</sub>membrane expands </p><p></p><ul style="display: flex;"><li style="flex:1">4</li><li style="flex:1">5</li></ul><p></p><p><strong>Figure 6.16 </strong></p><p></p><ul style="display: flex;"><li style="flex:1">15 </li><li style="flex:1">16 </li></ul><p></p><p>by fusion of vesicles. </p><p><strong>Golgi Apparatus: </strong></p><p>protein secretion </p><p><strong>Rough ER </strong></p><p>Has attached ribosomes </p><p>Processing, packaging and sorting center </p><p>•ꢀ <strong>Synthesis of </strong><br>–ꢀ<strong>secreted proteins </strong>–ꢀ<strong>membrane proteins </strong></p><p><strong>Cis </strong></p><p><strong>Trans </strong></p><p><strong>Golgi </strong></p><p><strong>Golgi </strong></p><p>Close To Rough ER <br>Away From Rough ER </p><p></p><ul style="display: flex;"><li style="flex:1">17 </li><li style="flex:1">18 </li></ul><p></p><p>3</p>
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