Supplementary Table 3: Functional pathways altered between HN5-ER vs HN5 cells © 2000-2012 Ingenuity Systems, Inc. All rights reserved. Category Functions Annotation p-Value Predicted ActivationRegulation State z-score Cancer tumorigenesis 5.56E-21 0.729 Cancer neoplasia 5.15E-20 1.678 Cancer carcinoma 6.94E-20 Cancer cancer 1.53E-19 1.650 Cancer solid tumor 2.17E-19 Dermatological Diseases and Conditions psoriasis 1.79E-18 Genetic Disorder psoriasis 1.79E-18 Cancer colorectal cancer 5.47E-17 Gastrointestinal Disease colorectal cancer 5.47E-17 Cancer gastrointestinal tract cancer 4.08E-16 Gastrointestinal Disease gastrointestinal tract cancer 4.08E-16 Cancer digestive organ tumor 1.18E-13 Gastrointestinal Disease digestive organ tumor 1.18E-13 Cancer colon cancer 2.49E-13 Genetic Disorder colon cancer 2.49E-13 Gastrointestinal Disease colon cancer 2.49E-13 Cellular Movement invasion of cells 1.50E-11 Increased 2.671 Cellular Movement invasion of tumor cell lines 2.46E-11 Increased 2.227 Cancer genital tumor 2.98E-11 Reproductive System Disease genital tumor 2.98E-11 Cellular Movement cell movement of tumor cell lines 1.06E-10 Increased 2.433 Cellular Growth and Proliferation proliferation of cells 6.20E-09 -0.978 Cellular Movement migration of tumor cell lines 1.10E-08 Increased 2.041 Cancer mammary tumor 1.82E-08 Cancer prostate cancer 8.23E-08 Genetic Disorder prostate cancer 8.23E-08 Reproductive System Disease prostate cancer 8.23E-08 Cancer metastatic colorectal cancer 8.84E-08 Gastrointestinal Disease metastatic colorectal cancer 8.84E-08 Genetic Disorder Dupuytren contracture 6.48E-07 Connective Tissue Disorders Dupuytren contracture 6.48E-07 Cellular Movement invasion of prostate cancer cell lines 7.40E-07 0.392 Cellular Growth and Proliferation growth of cells 8.98E-07 -1.014 Cancer uterine cancer 2.02E-06 Reproductive System Disease uterine cancer 2.02E-06 Cancer uterine serous papillary cancer 2.34E-06 Reproductive System Disease uterine serous papillary cancer 2.34E-06 Cellular Movement cell movement 2.38E-06 Increased 3.027 Cellular Movement migration of cells 2.56E-06 Increased 2.752 Cancer ovarian tumor 2.95E-06 Reproductive System Disease ovarian tumor 2.95E-06 Cancer gonadal tumor 3.09E-06 Reproductive System Disease gonadal tumor 3.09E-06 Cancer ovarian cancer 3.12E-06 Reproductive System Disease ovarian cancer 3.12E-06 Cellular Growth and Proliferation proliferation of tumor cell lines 4.00E-06 -0.294 Cancer breast cancer 5.97E-06 Reproductive System Disease breast cancer 5.97E-06 Cellular Movement invasion of breast cancer cell lines 7.07E-06 Increased 2.149 Embryonic Development development of epidermis 8.20E-06 Hair and Skin Development and Function development of epidermis 8.20E-06 Organ Development development of epidermis 8.20E-06 Organismal Development development of epidermis 8.20E-06 Tissue Development development of epidermis 8.20E-06 Cancer endometrial carcinoma 8.59E-06 Reproductive System Disease endometrial carcinoma 8.59E-06 Genetic Disorder relapsing-remitting multiple sclerosis 1.06E-05 Increased 3.737 Inflammatory Disease relapsing-remitting multiple sclerosis 1.06E-05 Increased 3.737 Neurological Disease relapsing-remitting multiple sclerosis 1.06E-05 Increased 3.737 Skeletal and Muscular Disorders relapsing-remitting multiple sclerosis 1.06E-05 Increased 3.737 Cell Death apoptosis of tumor cell lines 1.17E-05 0.632 Cancer squamous cell tumor 1.47E-05 Cancer tumorigenesis of cells 1.53E-05 0.944 Dermatological Diseases and Conditions ulcer 1.58E-05 Gastrointestinal Disease ulcer 1.58E-05 Organismal Injury and Abnormalities ulcer 1.58E-05 Embryonic Development skin development 1.80E-05 Hair and Skin Development and Function skin development 1.80E-05 Organ Development skin development 1.80E-05 Organismal Development skin development 1.80E-05 Tissue Development skin development 1.80E-05 Cell Cycle mitosis of breast cancer cell lines 2.07E-05 -1.519 Inflammatory Response inflammation 2.45E-05 Embryonic Development organogenesis 2.64E-05 Organ Development organogenesis 2.64E-05 Organismal Development organogenesis 2.64E-05 Cancer endometrial cancer 4.31E-05 Reproductive System Disease endometrial cancer 4.31E-05 Cell Death cell death of breast cancer cell lines 4.64E-05 0.083 Cancer hematologic cancer 4.85E-05 Hematological Disease hematologic cancer 4.85E-05 Cell Death cell death of tumor cell lines 4.98E-05 0.270 Cancer benign tumor 5.05E-05 Cell Death apoptosis of breast cancer cell lines 5.86E-05 -0.475 Tissue Development tissue development 6.01E-05 0.243 Cellular Growth and Proliferation growth of tumor cells 6.55E-05 -0.227 Cellular Development growth of tumor cells 6.55E-05 -0.227 Dermatological Diseases and Conditions ectodermal dysplasia 7.53E-05 Genetic Disorder ectodermal dysplasia 7.53E-05 Developmental Disorder ectodermal dysplasia 7.53E-05 Cellular Movement migration of brain cancer cell lines 9.43E-05 0.851 Genetic Disorder Bethlem myopathy 9.81E-05 Skeletal and Muscular Disorders Bethlem myopathy 9.81E-05 Genetic Disorder Ullrich congenital muscular dystrophy 9.81E-05 Skeletal and Muscular Disorders Ullrich congenital muscular dystrophy 9.81E-05 Dermatological Diseases and Conditions folliculitis 9.81E-05 Inflammatory Disease folliculitis 9.81E-05 Inflammatory Response folliculitis 9.81E-05 Cancer tumorigenesis of pancreatic cancer cell lines 9.81E-05 Cancer hematological neoplasia 1.03E-04 Hematological Disease hematological neoplasia 1.03E-04 Tissue Development adhesion of tumor cell lines 1.08E-04 1.992 Cell-To-Cell Signaling and Interaction adhesion of tumor cell lines 1.08E-04 1.992 Cell Death apoptosis 1.13E-04 0.084 Cell Death cell death 1.23E-04 1.124 Cellular Movement cell movement of brain cancer cell lines 1.29E-04 0.272 Dermatological Diseases and Conditions burn 1.32E-04 Embryonic Development development of organ 1.36E-04 Organ Development development of organ 1.36E-04 Organismal Development development of organ 1.36E-04 Tissue Development development of organ 1.36E-04 Cancer head and neck cancer 1.45E-04 Tissue Development aggregation of cells 1.53E-04 0.170 Reproductive System Disease endometriosis 1.55E-04 Dermatological Diseases and Conditions plaque psoriasis 1.74E-04 Genetic Disorder plaque psoriasis 1.74E-04 Dermatological Diseases and Conditions lichen planus 1.75E-04 Inflammatory Disease lichen planus 1.75E-04 Immunological Disease lichen planus 1.75E-04 Immunological Disease delayed hypersensitive reaction 1.90E-04 Cancer squamous-cell carcinoma 2.02E-04 Cellular Movement invasion of hepatoma cell lines 2.19E-04 1.206 Cancer tumorigenesis of tumor cell lines 2.59E-04 0.113 Cancer skin squamous cell carcinoma 2.83E-04 Dermatological Diseases and Conditions skin squamous cell carcinoma 2.83E-04 Cancer ductal carcinoma 2.96E-04 Reproductive System Disease ductal carcinoma 2.96E-04 Cancer metastasis 3.16E-04 Increased 2.227 Cell Cycle cell cycle progression 3.19E-04 -0.998 Cancer oral cancer 3.42E-04 Cell Cycle cell cycle progression of hepatocytes 3.79E-04 Hepatic System Development and Function cell cycle progression of hepatocytes 3.79E-04 Cell Morphology cell flattening of bone cancer cell lines 3.79E-04 Cell Morphology morphology of hepatoma cell lines 3.79E-04 RNA Post-Transcriptional Modification processing of tRNA 3.79E-04 Cellular Growth and Proliferation proliferation of connective tissue cells 4.13E-04 1.165 Organismal Development development of blood vessel 4.24E-04 0.855 Cardiovascular System Development and Function development of blood vessel 4.24E-04 0.855 Cellular Movement chemotaxis of neutrophils 4.33E-04 Increased 2.703 Inflammatory Response chemotaxis of neutrophils 4.33E-04 Increased 2.703 Antigen Presentation chemotaxis of neutrophils 4.33E-04 Increased 2.703 Hematological System Development and Function chemotaxis of neutrophils 4.33E-04 Increased 2.703 Immune Cell Trafficking chemotaxis of neutrophils 4.33E-04 Increased 2.703 Organismal Development vasculogenesis 4.35E-04 0.415 Cardiovascular System Development and Function vasculogenesis 4.35E-04 0.415 Cellular Movement chemoattraction of granulocytes 4.71E-04 1.655 Inflammatory Response chemoattraction of granulocytes 4.71E-04 1.655 Cell-To-Cell Signaling and Interaction chemoattraction of granulocytes 4.71E-04 1.655 Hematological System Development and Function chemoattraction of granulocytes 4.71E-04 1.655 Immune Cell Trafficking chemoattraction of granulocytes 4.71E-04 1.655 Connective Tissue Development and Function cleavage of cartilage tissue 4.71E-04 1.842 Skeletal and Muscular System Development and Functioncleavage of cartilage tissue 4.71E-04 1.842 Tissue Morphology cleavage of cartilage tissue 4.71E-04 1.842 Cancer tumorigenesis of brain cancer cell lines 4.71E-04 -0.719 Neurological Disease tumorigenesis of brain cancer cell lines 4.71E-04 -0.719 Inflammatory Response antiviral response 5.03E-04 Antimicrobial Response antiviral response 5.03E-04 Inflammatory Response immune response 5.14E-04 Increased 3.147 Cell Morphology morphology of cells 5.15E-04 Cellular Movement cell movement of neutrophils 5.56E-04 Increased 2.579 Inflammatory Response cell movement of neutrophils 5.56E-04 Increased 2.579 Hematological System Development and Function cell movement of neutrophils 5.56E-04 Increased 2.579 Immune Cell Trafficking cell movement of neutrophils 5.56E-04 Increased 2.579 Cellular Movement cell movement of endothelial cells 5.87E-04 1.321 Cardiovascular System Development and Function cell movement of endothelial cells 5.87E-04 1.321 Cellular Growth and Proliferation