NTICANCER ESEARCH InternationalA Journal of Cancer ResearchR and Treatment ISSN: 0250-7005 Volume 24, Number 4, July-August 2004 Contents Experimental Studies Inhibition of the Human Apurinic/Apyrimidinic Endonuclease (Ape1) Repair Activity and Sensitization of Breast Cancer Cells to DNA Alkylating Agents with Lucanthone. M. LUO, M.R. KELLEY (Indianapolis, Indiana, USA)........................................................................................................................................................... 2127 Androgen Withdrawal Inhibits Tumor Growth and is Associated with Decrease in Angiogenesis and VEGF Expression in Androgen-Independent CWR22Rv1 Human Prostate Cancer Model. L. CHENG, S. ZHANG, C.J. SWEENEY, C. KAO, T.A GARDNER, J.N. EBLE (Indianapolis, Indiana, USA) .................................. 2135 In Vitro Generation of Cytolytic T Cells Against Human Melanoma Cells Overexpressing HDM2. A. SORURI, A. FAYYAZI, S. GANGL, C. GRIESINGER, C.A. ALBRECHT, T. SCHLOTT (Goettingen; Langen, Germany) .................................................................................................................................................... 2141 Artemisinin: An Alternative Treatment for Oral Squamous Cell Carcinoma. E. YAMACHIKA, T. HABTE, D. ODA (Seattle, WA, USA; Okayama City, Japan).............................................................................................. 2153 S19-mRNA Expression in Squamous Cell Carcinomas of the Upper Aerodigestive Tract. V. SENGPIEL, T. ROST, T. GÖRÖGH, I.O. RATHCKE, J.A. WERNER (Marburg; Kiel, Germany) ........................................ 2161 Three-dimensional Culture System as a Model for Studying Cancer Cell Invasion Capacity and Anticancer Drug Sensitivity. C.J. DOILLON, E. GAGNON, R. PARADIS, M. KOUTSILIERIS (Quebec, Canada; Athens, Greece)......................................................................................................................................................... 2169 Targeting Chemotherapy-induced VEGF Up-regulation by VEGF Antisense Oligonucleotides in HNSCC Cell Lines. F. RIEDEL, K. GÖTTE, U. GOESSLER, H. SADICK, K. HÖRMANN (Mannheim, Germany) ......................................................................................................................................................... 2179 Contents continued on the back cover Contents continued Cyclin D1 Expression in Endometrioid-type Endometrial Adenocarcinoma is Correlated with Histological Grade and Proliferative Activity, but not with Prognosis. Y. NISHIMURA, J. WATANABE, T. JOBO, N. KATO, T. FUJISAWA, Y. KAMATA, H. KURAMOTO (Kanagawa, Japan) ................................................. 2185 Low Renal Toxicity of Lipoplatin Compared to Cisplatin in Animals. P. DEVARAJAN, R. TARABISHI, J. MISHRA, Q. MA, A. KOURVETARIS, M. VOUGIOUKA, T. BOULIKAS (Cincinnati, OH; Mountain View, VA, USA; Athens, Greece).............................................................................................................................. 2193 TZT-1027 Elucidates Antitumor Activity through Direct Cytotoxicity and Selective Blockade of Blood Supply. N. HASHIGUCHI, T. KUBOTA, J.-I. KOH, Y. YAMADA, Y. SAIKAWA, Y. OTANI, M. WATANABE, K. KUMAI, M. KITAJIMA, J.-I. WATANABE, M. KOBAYASHI (Tokyo; Saitama; Kanagawa, Japan).......... 2201 Probucol, a Hypocholesterolemic Agent, Prevents the Development of Uterine Adenomyosis Induced by Pituitary Grafting in Mice. Y.-F. ZHOU, T. MORI, H. NAGASAWA, T. NAKAYAMA, T. KUBOTA, S. SAKAMOTO (Beijing, China; Chiba; Kanagawa; Tokyo, Japan) ........................................................................ 2209 Growth-inhibitory Effects of the Ketone Body, Monoacetoacetin, on Human Gastric Cancer Cells with Succinyl-CoA: 3-Oxoacid CoA-Transferase (SCOT) Deficiency. M. SAWAI, M. YASHIRO, Y. NISHIGUCHI, M. OHIRA, K. HIRAKAWA (Osaka, Japan)........................................................................... 2213 Clinical Relevance of HER-2/neu Expression in Germ-cell Testicular Tumors. L. MÁNDOKY, L. GÉCZI, I. BODROGI, J. TÓTH, O. CSUKA, M. KÁSLER, M. BAK (Budapest, Hungary) ......................................... 2219 Antineoplastic Effect of Immunostimulatory DNA (CpG-ODN) in a Murine C57-BL6 / MB-49 Transitional Cell Carcinoma Model. A. HEGELE, A. DALPKE, P. BARTH, Z. VARGA, K. HEEG, R. HOFMANN, P. OLBERT (Marburg, Germany)........................................................................................................................... 2225 Effective Knock Down of Very High ABCG2 Expression by a Hammerhead Ribozyme. P. KOWALSKI, K.M. FARLEY, H. LAGE, E. SCHNEIDER (Albany, NY, USA; Berlin, Germany) ........................................ 2231 Diffuse Growth Pattern Affects E-Cadherin Expression in Invasive Breast Cancer. U. BRINCK, S. JACOBS, M. NEUSS, K. TORY, W. RATH, B. KULLE, L. FÜZESI (Göttingen; Aachen, Germany) ......... 2237 * Involvement of Endothelial Monocyte Activating Polypeptide II in Tumor Necrosis Factor-alpha-based Anti-cancer Therapy. T.E. LANS, R. VAN HORSSEN, A.M.M. EGGERMONT, T.L.M. TEN HAGEN (Rotterdam, The Netherlands).................................................................................................................................. 2243 Chemoimmunotherapy of Murine Mammary Adenocarcinomas. I.H. AMES (Syracuse, NY, USA)............... 2249 Perivascular Mast Cells in Advanced Gastric Adenocarcinomas: An Electron Microscopic Study. R.A. CARUSO, A. IENI, V. FABIANO, G. BASILE, C. INFERRERA (Messina, Italy)........................................ 2257 Pre-clinical Immunogenicity and Anti-tumour Efficacy of a Deleted Recombinant Human Papillomavirus Type 16 E7 Protein. S. HALLEZ, J.-M. BRULET, C. VANDOOREN, F. MAUDOUX, S. THOMAS, M. HEINDERICKX, A. BOLLEN, R. WATTIEZ, A. JACQUET (Gosselies; Mons, Belgium)........................... 2265 Artemisinin Induces Apoptosis in Human Cancer Cells. N.P. SINGH, H.C. LAI (Seattle, WA, USA)........... 2277 Effects of the Polyacetylene Capillin on Human Tumour Cell Lines. L.C. WHELAN, M.F. RYAN (Dublin, Ireland)...................................................................................................................................................................... 2281 Involvement of Pattern Recognition Receptors in the Induction of Cytokines and Reactive Oxygen Intermediates Production by Human Monocytes/Macrophages Stimulated with Tumour Cells. B. MYTAR, M. WOLOSZYN, A. MACURA-BIEGUN, B. HAJTO, I. RUGGIERO, B. PIEKARSKA, M. ZEMBALA (Cracow; Poland)........ 2287 Isolated Limb Perfusion Based Anti-p21ras Gene Therapy in a Rat Rhabdomyosarcoma. B. VAN ETTEN, S.T. VAN TIEL, G. AMBAGTSHEER, A.M.M. EGGERMONT, T.L.M. TEN HAGEN (Rotterdam, The Netherlands)............................................................................................................................ 2295 Contents continued on the preceding page Contents continued Acoustic Energy: A New Transfection Method for Cancer of the Prostate, Cancer of the Bladder and Benign Kidney Cells. M.S. MICHEL, P. ERBEN, L. TROJAN, A. SCHAAF, K. KIKNAVELIDZE, T. KNOLL, P. ALKEN (Mannheim, Germany) .................................................................................................... 2303 Epstein-Barr Virus LMP1 Status in Relation to Apoptosis, P53 Expression and Leucocyte Infiltration in Nasopharyngeal Carcinoma. J.-Y. SHAO, I. ERNBERG, P. BIBERFELD, T. HEIDEN, Y.-X. ZENG, L.- F. HU (Stockholm, Sweden; Guangzhou, China)................................................................................................... 2309 Can Recurrence of Meningiomas be Predicted? J.-P. KALALA, D. BENOIT, L. DE RIDDER (Ghent, Belgium) .................................................................................................................................................................... 2319 Erythroid Differentiation in K562 Chronic Myelogenous Cells Induced by Crambescidin 800, a Pentacyclic Guanidine Alkaloid. S. AOKI, D. KONG, K. MATSUI, M. KOBAYASHI (Osaka, Japan)........................... 2325 Somatostatin Controls LFA-1 Gene Expression by Altering Neuraminidase Expression in Spleen Cells. W.- K. YOON, H.-J. KIM, H.-Y. SON, K.-S. JEONG, S.-J. PARK, T.-H. KIM, S.-H. KIM, S.-R. KIM, S.-Y. RYU (Daejon; Daegu; Kwangju, South Korea) ...................................................................................................... 2331 Amifostine Protects Against Chemotherapy-induced Neurotoxicity: An In Vitro Investigation. C.C.P. VERSTAPPEN, T.J. POSTMA, A.A. GELDOF, J.J. HEIMANS (Amsterdam, The Netherlands) ................. 2337 Antitumour Effectiveness of Hyperthermia is Potentiated by Local Application of Electric Pulses to LPB Tumours in Mice. K.B. KARNER, H. LESNICAR, M. CEMAZAR, G. SERSA (Ljubljana, Slovenia)........ 2343 Elevated Cyclooxygenase-2 Expression Correlates with Distant Metastases in Breast Cancer. G.S. RANGER, V. THOMAS, A. JEWELL, K. MOKBEL (London, UK) ............................................................... 2349 Changes in Serum Soluble VEGFR-1 and Tie-2 Receptors in Colorectal Cancer Patients Following Surgical Resections. K.-F. CHIN, J. GREENMAN, P. REUSCH, E. GARDINER, D. MARME, J. MONSON (Hull, UK; Freiburg, Germany) .......................................................................................................................................... 2353 Clinical Studies Correlation of FDG-PET Interpretation with Survival in a Cohort of Glioma Patients. F.S. PARDO, H.J. ARONEN, M. FITZEK, D.N. KENNEDY, J. EFIRD, B.R. ROSEN,