Table of Contents Welcome 4 Committees 5 Conference Venue 6 Gala Dinner 7 Program 8 Abstracts of invited speakers 12 Abstracts of oral communications 34 Posters list 59 Welcome The national symposium “Journées de Formulation” is organized annually by the Formulation Group of the Chemical Society of France (SCF) to bring academic and industry experts and PhD and MSc students together to discuss the latest developments and ideas in the area of Formulation. This year, as part of the 19th version of the “Journées de Formulation”, the Formulation Group of the French Chemical Society and the International Society of Drug Delivery and Pharmaceutical Technology (APGI) have worked together to present a Europe wide conference entitled Formulation Days 2019: “Advances in Formulation of Active Ingredients”. This event, located in Lyon, is dedicated to advances in the formulation of active molecules for applications in cosmetics and pharmaceuticals. Locally organized by the Automation, Process & Pharmaceutical Engineering Laboratory (LAGEPP), this conference aims to: - be a forum where industry experts and universities researchers working in the field of formulations for health applications meet to exchange, - allow students to meet the main actors in this field and develop their knowledge through access to presentations and poster sessions. For this edition, the scientific program covers 4 themes: • Materials & biomaterials • Formulations for dermal administration or mucosal routes • Nanoparticles: nanomedicine, toxicology & regulation • Processes, characterization & modeling 4 Committees Organization committee Claire BORDES, LAGEPP, Université Lyon 1, Lyon Sandrine BOURGEOIS, LAGEPP, Université Lyon 1, Lyon Giovanna LOLLO, LAGEPP, Université Lyon 1, Lyon Pierre LANTERI, ISA, Université Lyon 1, Lyon Catharina KROLING, APGI, Châtenay-Malabry Scientific committee Florence AGNELY, Institut Galien, Université Paris-Sud, Châtenay-Malabry Amélie BOCHOT, Institut Galien, Université Paris-Sud, Châtenay-Malabry Cécile BONNET-GONNET, IPSEN, Boulogne-Billancourt Claire BORDES, LAGEPP, Université Lyon 1, Lyon Sandrine BOURGEOIS, LAGEPP, Université Lyon 1, Lyon Stéphanie BRIANCON, LAGEPP, Université Lyon 1, Lyon Odile CHAMBIN, UMR PAM, Université de Bourgogne, Dijon Alain DURAND, LCPM, Université de Lorraine, Nancy Giovanna LOLLO, LAGEPP, Université Lyon 1, Lyon Juergen SIEPMANN, APGI, INSERM U1008, Université de Lille, Lille 5 Conference Venue École Supérieure de Chimie Physique Électronique de Lyon Bâtiment CPE (Rue Victor Grignard) Domaine scientifique de la Doua 3, rue Victor Grignard 69100 Villeurbanne France 6 Gala Dinner Restaurant Vatel Lyon 8 rue Duhamel 69002 Lyon From the Conference venue with public transport : 35min Take Tramway 1 to « Charpennes » Take Metro line A to Perrache - Stop at Ampère Victor Hugo Walk 9 min Conference Venue Gala Dinner 7 DAY 1 : Thursday, January 10 th 2019 8h30 Registration 9h00 Opening session - A. Durand (SCF), A. Bochot (SCF,APGI) and S. Briançon (Dir. LAGEPP) Session 1 : Materials, Biomaterials Chairmen : S. Briançon & A.Bochot 9h30 Pr S. Lecommandoux, University of Bordeaux, France - I.01 Biomimetic biofunctional and bioactive polymer-based vesicles 10h15 Dr. C. Le Visage, INSERM, University of Nantes, France - I.02 Polysaccharide hydrogels and cell therapies: application to osteoarticular regenerative medicine 10h45 F. Carton, University of Verona, Italy - O.01 Development of hyaluronic acid-based nano-complexes for pentamidine encapsulation 11h00 Coffee break/ Posters and stand sessions 11h30 Pr F. Goycoolea, Procter Dpt of Food Science, University of Leeds, UK - I.03 New approaches to deal with antimicrobial resistance bacterial pathogens 12h00 Dr L. David, University of Lyon, France - I.04 Physical chitosan hydrogels for biomedical applications 12h30 S. Charaabi EBInnov, Cergy-Pontoise, France - O.02 Formulation of organosilicates particles complexed with bioactive molecules: adsorption and release studies 12h45 J. Mahe, University of Bourgogne, France - O.03 Pectin modification by esterification with Octenyl Succinic Anhydride (OSA) to obtain new drug delivery systems 13h00 Lunch / Posters and stand sessions Session 2 : Formulations for cutaneous or mucosal administration Chairmen: C. Bonnet-Gonnet & F. Agnely 14h30 Pr M.A. Bolzinger and Pr Y. Chevalier, University of Lyon, France - I.05 New dosage forms for skin absorption 15h30 Dr M. Eeman, Dow Corning, Belgium - I.06 Tuning Silicone Systems to Maximize the Release Rate and Skin Penetration of Actives 16h00 E. Munnier, University of Tours, France - O.04 Core-shell encapsulation systems as a help to formulate active cosmetic ingredients and enhance their skin penetration 16h15 Coffee break/ Posters and stand sessions 16h45 Pr. M. Lane, School of London, UK - I.07 Skin penetration enhancement - where do we go now? 17h15 Dr O. Aubrun, L'Oréal, France - I.08 A new galenic for best sensory with high active concentration 17h45 A.-C. Groo, University of Caen, France - O.05 Development of a nasal drug delivery composite nanosystem for Alzheimer’s desease treatment 18h00 M. Tarnowska, University of Lyon, France - O.06 Skin absorption of ions from thermal spring waters 20h00 Gala Dinner 8 DAY 2 : Friday, January 11 th 2019 Session 3 : Nanoparticles: nanomedicine, toxicology and regulation Chairmen: O. Chambin & G. Lollo 8h45 Pr E. Fattal, Institut Galien Paris-Sud, Châtenay-Malabry, France - I.09 Nanotoxicology a crucial step in order to bring nanomedicines to the market 9h30 Dr K. Remaut, Lab. of General Biochemistry and Phys. Pharmacy, Belgium - I.10 Effect of peritoneal fluids and nebulization on the colloidal stability and distribution of intraperitoneally administered nanoparticles ou Potential and pitfalls of ocular mRNA delivery for neuroprotection 10h00 J. Balegamire, University of Lyon, France - O.07 Iodinated Polymer Nanoparticles as a Contrast Agent for Computed Tomography using a Spectral Photon counting 10h15 L. Séguy, University of Caen, France - O.08 Nanoemulsions as a useful tool for drug development 10h30 Coffee break/ Posters and stand sessions 11h00 Dr F. Dalençon, SANOFI, France - I.11 New adjuvants for vaccines 11h30 Dr S. Acker, BASF, France - I.12 Nanoparticles for Suncare application 12h00 K. Matha, University of Angers, France - O.09 A new 5-FU derivative encapsulated in lipid nanocapsules : in vitro evaluation on 2D and 3D models. 12h15 Dr J. Richard, IPSEN, France - I.13 Therapeutic Peptide Delivery : How Can Nanosystems Help Address Present and Future Challenges 13h00 Lunch / Posters and stand sessions Session 4 : Process Engineering, characterization, modelling Chairmen: A. Durand et C. Bordes 14h15 Pr C. Marquette, ICBMS, University of Lyon, France - I.14 Printing for life sciences : 3d.FAB platform activities. 15h00 Dr V. Faivre, Institut Galien Paris-Sud, Châtenay-Malabry, France - I.15 Lipid-based drug delivery systems: Influence of excipient structural properties on their preparation processes 15h30 R. Ramsch, FORMULACTION, France - O.10 High shear microfluidic rheology rheometer Rheology optimization of ophthalmic eye drops 15h45 F. Dormont, Institut Galien, Châtenay-Malabry, France - O.11 Translation of Nanoparticle Formulations from Lab to Industrial Scale Synthesis: The Case of Squalene- Adenosine Nanoparticles 16h00 E. Akanny, University of Lyon, France - O.12 Development of Gold nanoparticles for the characterization of different bacteria by Surface Enhanced Raman Scattering 16h15 Coffee break/ Posters and stand sessions 16h45 Dr C. Nouvel, University of Lorraine, France - I.16 Product engineering : a combined approach for the design and the processing of drug delivery particles 17h15 Dr I. Pitault and Pr C. Jallut, University of Lyon, France - I.17 Mass transfer studies through biological membranes. A chemical engineering approach. 17h45 Alain Foissy Award for best poster (Formulaction) 9 10 11 Abstracts of invited speakers 12 I.01 Biomimetic polymer self-assemblies as innovative biomaterials Sebastien Lecommandoux1 1 Laboratoire de Chimie des Polymères Organiques Univ. Bordeaux, CNRS UMR 5629, Bordeaux-INP ENSCBP, Pessac, France Keywords. Block copolymers, self-assembly, biomimetic, polypeptide, drug-delivery We report here an overview on the self-assembly in water of amphiphilic block copolymers developed at LCPO into different nanomedicines, mainly focusing on polymer vesicles, also referred as polymersomes, and their applications in loading and controlled release of both hydrophilic and hydrophobic molecules and biomolecules. We pay special attention to polysaccharide and polypeptide-based block copolymer vesicles and their development in nanomedicine.[1-5] Indeed, the field of synthetic polypeptides has seen many significant advances in recent years, including studies on block and hybrid copolypeptides that form vesicles, fibrils, and other structures with potential applications in medicine and materials chemistry. However, the development of glycosylated polypeptides has not kept pace, primarily due to the inability to readily synthesize glycopolypeptides in a controlled manner. Glycosylation of natural proteins provides diverse functionality such as mediation of recognition events, modification of protein conformations, ect, that may find interest and application in biomedical field. In this context, we developed over the last years synthetic strategies for the design of glycosylated polypeptides and polysaccharide-polypeptide biohybrids with controlled placement of sugar functionality. We were especially