Supplementary figure 1. A. Distribution of the total injury score in the backcross. B. Genome‐wide lod plot of the total injury score A B Supplementary Figure 2 Genome­wide distrubution of genotypes in 26 MHMC­TgFVB mice. Each row represents a mouse, each column a marker. Markers are grouped by marker FVB alleles are presented in red, BALB alleles in blue (autosomes) or green (X‐chromosome). The first and second row represent genotypes from an FVB/NJ and an Balb/cJ mouse. Only two intervals show homozygosity for Balb/cJ alleles. Supplementary table. Genes located within compatible haploype blocks in the HIVAN4 lod-2 interval (the interval delineated by the admixed strain is shown in blue) Location HIV- Nonsynonymous Damaging Damaging Gene Symbol (Mb) Description Description interaction? Glomerular enriched? variant? variant? SNP ID Wnk1 119.873545 MGI:2442092 WNK lysine deficient protein kinase 1 - - - - - Ninj2 120.041726 MGI:1352751 ninjurin 2 - - - - - B4galnt3 120.15186 MGI:3041155 beta-1,4-N-acetyl-galactosaminyl transferase 3 - - - - - Jarid1a 120.310673 MGI:2136980 jumonji, AT rich interactive domain 1A (Rbp2 like) - - - - - Il17ra 120.411546 MGI:107399 interleukin 17 receptor A - - YES - - Cecr5 120.457527 MGI:2136976 cat eye syndrome chromosome region, candidate 5 homolog (human) - - - - - 1700072O05Rik 120.502874 MGI:1920755 RIKEN cDNA 1700072O05 gene - - - - - Cecr2 120.614746 MGI:1923799 cat eye syndrome chromosome region, candidate 2 homolog (human) - - - - - Slc25a18 120.721731 MGI:1919053 solute carrier family 25 (mitochondrial carrier), member 18 - - - - - Atp6v1e1 120.743344 MGI:894326 VATPase, H+ transporting, lysosomal V1 subunit E1 - - - - - Bcl2l13 120.784809 MGI:2136959 BCL2-like 13 (apoptosis facilitator) - - YES - - Bid 120.841357 MGI:108093 BH3 interacting domain death agonist YES - - - - BC030863 120.881725 MGI:2673704 cDNA sequence BC030863 - - - - - Mical3 120.951381 MGI:2442733 microtubule associated monoxygenase, calponin and LIM domain containing 3 - - YES - - LOC100043793 121.012523 Entrez100043793 - - - YES - - Pex26 121.133685 MGI:1921293 peroxisome biogenesis factor 26 - - - - - Usp18 121.194084 MGI:1344364 ubiquitin specific peptidase 18 - - - - - Slc6a13 121.248356 MGI:95629 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 - - - - - Iqsec3 121.321361 MGI:2677208 IQ motif and Sec7 domain 3 - - - - - A2m 121.576011 MGI:2449119 alpha-2-macroglobulin YES YES YES YES rs50350755 Mug1 121.786989 MGI:99837 murinoglobulin 1 - - - - - Mug2 121.956816 MGI:99836 murinoglobulin 2 - - YES - - LOC677375 122.395336 Entrez677375 - - - - - - 4933426K21Rik 122.402698 MGI:1918325 RIKEN cDNA 4933426K21 gene - - - - - Mfap5 122.461859 MGI:1354387 microfibrillar associated protein 5 - YES - - - Aicda 122.501832 MGI:1342279 activation-induced cytidine deaminase YES - - - - Apobec1 122.52683 MGI:103298 apolipoprotein B editing complex 1 - - - - - Gdf3 122.553968 MGI:95686 growth differentiation factor 3 - - - - - Dppa3 122.574467 MGI:1920958 developmental pluripotency-associated 3 - - - - - Clec4a4 122.938533 MGI:3624119 C-type lectin domain family 4, member a4 - - - - - Clec4b1 122.998101 MGI:1917060 C-type lectin domain family 4, member b1 - - YES - - EG546913 123.559776 Entrez546913 - - - - - - EG545874 123.771406 Entrez545874 - - - YES - - V2r1b 123.973582 Entrez56552 - - - - - - Vmn2r26 123.974776 MGI:2678394 vomeronasal 2, receptor 26 - - - - - Cd163 124.254532 MGI:2135946 CD163 antigen - - - - - C1r 124.461202 MGI:1355313 complement component 1, r subcomponent - - - - - Ncapd2 125.116061 MGI:1915548 non-SMC condensin I complex, subunit D2 - - - - - Tmem16b 125.658841 MGI:2387214 transmembrane protein 16B - - - - - Parp11 127.401896 MGI:2141505 poly (ADP-ribose) polymerase family, member 11 - - - - - Efcab4b 127.526039 MGI:2685919 EF-hand calcium binding domain 4B - - - - - Prmt8 127.637041 MGI:3043083 protein arginine N-methyltransferase 8 - - - - - Tspan11 127.835693 MGI:1915748 tetraspanin 11 - - YES - - Tspan9 127.910308 MGI:1924558 tetraspanin 9 - - - - - ENSMUSG00000056771 128.137864 MGI:3641978 predicted gene, ENSMUSG00000056771 - - - - - Tead4 128.175172 MGI:106907 TEA domain family member 4 - - - - - Tulp3 128.269499 MGI:1329045 tubby-like protein 3 - - - - - Itfg2 128.358417 MGI:1915450 integrin alpha FG-GAP repeat containing 2 - - - - - Pzp 128.431673 MGI:87854 pregnancy zone protein - - - - - BC048546 128.488385 MGI:3039594 cDNA sequence BC048546 - - - - - Klrb1a 128.559225 MGI:107540 killer cell lectin-like receptor subfamily B member 1A - - YES - - LOC677440 128.598277 Entrez677440 - - - - - - Clec2h 128.610407 MGI:2136934 C-type lectin domain family 2, member h - - YES - - LOC100043863 128.62405 Entrez100043863 - - - YES - - LOC100043861 128.656526 Entrez100043861 - - - YES - - Klrb1c 128.726546 MGI:107538 killer cell lectin-like receptor subfamily B member 1C - - YES - - Klrb1b 128.728507 MGI:107539 killer cell lectin-like receptor subfamily B member 1B - - YES - - LOC667706 128.83385 Entrez667706 - - - - - - Clec2i 128.835633 MGI:2136650 C-type lectin domain family 2, member i - - - - - Clec2g 128.882408 MGI:1918059 C-type lectin domain family 2, member g - - YES - - LOC667715 128.926519 Entrez667715 - - - - - - BC064078 128.942979 MGI:3040692 cDNA sequence BC064078 - - - - - Clec2f 128.964152 MGI:3522133 C-type lectin domain family 2, member f - - YES - - Klrb1f 128.993971 MGI:2442965 killer cell lectin-like receptor subfamily B member 1F - - - - - 4922502D21Rik 129.270245 MGI:2685920 RIKEN cDNA 4922502D21 gene - - - - - Clec12a 129.299402 MGI:3040968 C-type lectin domain family 12, member a - - - - - Clec1a 129.374717 MGI:2444151 C-type lectin domain family 1, member a - - - - - Clec7a 129.409864 MGI:1861431 C-type lectin domain family 7, member a - - YES - - Olr1 129.433371 MGI:1261434 oxidized low density lipoprotein (lectin-like) receptor 1 - - - - - D630042F21Rik 129.460607 MGI:2442838 RIKEN cDNA D630042F21 gene - - - - - Klrk1 129.558366 MGI:1196250 killer cell lectin-like receptor subfamily K, member 1 - - - - - Klrc3 129.587119 MGI:1929720 killer cell lectin-like receptor subfamily C, member 3 - - - - - Klrc2 129.596062 MGI:1336162 killer cell lectin-like receptor subfamily C, member 2 - - - - - Klrc1 129.616039 MGI:1336161 killer cell lectin-like receptor subfamily C, member 1 - - - - - Klri1 129.645237 MGI:3530275 killer cell lectin-like receptor family I member 1 - - YES - - Klri2 129.677163 MGI:2443965 killer cell lectin-like receptor family I member 2 - - YES - - Gm156 129.714753 MGI:2685002 gene model 156, (NCBI) - - YES YES rs46035388 Klra17 129.779204 MGI:2180674 killer cell lectin-like receptor, subfamily A, member 17 - - YES YES rs36722353, rs36828428, rs37223080, rs37236681 Klra5 129.847056 MGI:101903 killer cell lectin-like receptor, subfamily A, member 5 - - YES YES rs37892132 Klra6 129.961162 MGI:101902 killer cell lectin-like receptor, subfamily A, member 6 - - YES YES rs38914815, rs37814296 LOC100038893 129.961162 Entrez100038893 - - - YES - - Klra19 129.963051 MGI:2136936 killer cell lectin-like receptor, subfamily A, member 19 - - YES YES rs38914815, rs37814296 LOC100038894 129.99177 Entrez100038894 - - - YES - - LOC100038895 129.99177 Entrez100038895 - - - - - - Klra4 129.992222 MGI:101904 killer cell lectin-like receptor, subfamily A, member 4 - - YES - - Klra16 129.99375 MGI:1351669 killer cell lectin-like receptor, subfamily A, member 16 - - YES - - EG654449 130.032616 MGI:3644243 predicted gene, EG654449 - - YES - - Klra14 130.065237 MGI:1321089 killer cell lectin-like receptor subfamily A, member 14 - - - - - Klra9 130.126879 MGI:1321153 killer cell lectin-like receptor subfamily A, member 9 - - YES - - Klra7 130.166698 MGI:101901 killer cell lectin-like receptor, subfamily A, member 7 - - - - - LOC100038898 130.21416 Entrez100038898 - - - - - - Klra12 130.214482 MGI:1321091 killer cell lectin-like receptor subfamily A, member 12 - - YES - - Klra10 130.217292 MGI:1321093 killer cell lectin-like receptor subfamily A, member 10 - - YES YES rs38861679 Klra13 130.239327 MGI:1321090 killer cell lectin-like receptor subfamily A, member 13 - - YES - - Klra3 130.271914 MGI:101905 killer cell lectin-like receptor, subfamily A, member 3 - - - - - Klra1 130.313936 MGI:101907 killer cell lectin-like receptor, subfamily A, member 1 - - YES - - LOC100038902 130.313937 Entrez100038902 - - - - - - LOC100038903 130.313942 Entrez100038903 - - - YES - - EG667798 130.615388 MGI:3648641 predicted gene, EG667798 - - YES - - EG625558 130.678446 MGI:3643376 predicted gene, EG625558 - - - - - EG636947 130.750525 MGI:3648824 predicted gene, EG636947 - - YES - - EG625648 130.936083 MGI:3645795 predicted gene, EG625648 - - - - - EG434094 131.113318 MGI:3643462 predicted gene, EG434094 - - - - - Klra2 131.167499 MGI:101906 killer cell lectin-like receptor, subfamily A, member 2 - - YES - - 2010012C16Rik 131.23243 MGI:1913691 RIKEN cDNA 2010012C16 gene - - - - - Styk1 131.247319 MGI:2141396 serine/threonine/tyrosine kinase 1 - - YES - - Csda 131.312986 MGI:2137670 cold shock domain protein A - YES - - - LOC625758 131.434468 Entrez625758 - - - - - - 5430401F13Rik 131.492175 MGI:1918642 RIKEN cDNA 5430401F13 gene - - YES - - LOC625781 131.556525 Entrez625781 - - - YES YES rs45775618, rs46068285, rs51503960, rs46783363 Tas2r107 131.608537 MGI:2681207 taste receptor, type 2, member 107 - - YES - - Tas2r106 131.6264 MGI:2681203 taste receptor, type 2, member 106 - - - - - Tas2r104 131.633142 MGI:2681185 taste receptor, type 2, member 104 - - - - - Tas2r105 131.634753