PDF Output of CLIC (clustering by inferred co-expression) Dataset: Num of genes in input gene set: 6 Total number of genes: 16493 CLIC PDF output has three sections: 1) Overview of Co-Expression Modules (CEMs) Heatmap shows pairwise correlations between all genes in the input query gene set. Red lines shows the partition of input genes into CEMs, ordered by CEM strength. Each row shows one gene, and the brightness of squares indicates its correlations with other genes. Gene symbols are shown at left side and on the top of the heatmap. 2) Details of each CEM and its expansion CEM+ Top panel shows the posterior selection probability (dataset weights) for top GEO series datasets. Bottom panel shows the CEM genes (blue rows) as well as expanded CEM+ genes (green rows). Each column is one GEO series dataset, sorted by their posterior probability of being selected. The brightness of squares indicates the gene's correlations with CEM genes in the corresponding dataset. CEM+ includes genes that co-express with CEM genes in high-weight datasets, measured by LLR score. 3) Details of each GEO series dataset and its expression profile: Top panel shows the detailed information (e.g. title, summary) for the GEO series dataset. Bottom panel shows the background distribution and the expression profile for CEM genes in this dataset. Overview of Co-Expression Modules (CEMs) with Dataset Weighting Scale of average Pearson correlations Num of Genes in Query Geneset: 6. Num of CEMs: 1. 0.0 0.2 0.4 0.6 0.8 1.0 Rfc5 Rfc4 Rfc3 Pcna Rfc2 Chtf18 Rfc5 Rfc4 Rfc3 CEM 1 (641 datasets) Pcna Rfc2 Chtf18 Symbol Num ofCEMGenes:6.Predicted424.SelectedDatasets:641.Strength:10.9 CEM 1,Geneset"[C]PCNA-CHL12-RFC2-5complex",Page1 Rad51ap1 Ncapd2 Chaf1b Cenph Chtf18 Cenpk Ncaph Cdc20 Cks1b Kif20a Cdca8 Cdca5 Cdc45 Rad51 Spc24 Fignl1 Aurkb Gmnn Mcm4 Mcm2 Mcm6 Mcm7 Mcm5 Gins1 Prim1 Prim2 Gins2 Asf1b Uhrf1 Rrm1 Birc5 Bub1 Kif22 Cdc6 Rpa2 Cdk1 Exo1 Pcna Tipin Fen1 Melk Hat1 Rfc2 Rfc3 Rfc4 Rfc5 Pole Lig1 Pbk Tk1 0.0 1.0 GSE38031 [8] GSE40513 [6] GSE31028 [6] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE54215 [13] GSE20954 [14] GSE23200 [6] GSE18135 [18] GSE27605 [8] GSE15741 [6] GSE4694 [6] GSE12498 [12] GSE39449 [6] GSE20100 [15] GSE6998 [32] GSE51883 [30] GSE12454 [13] GSE21393 [6] GSE21379 [10] GSE12465 [14] GSE13302 [30] GSE48204 [6] GSE17794 [44] GSE57543 [6] GSE51628 [15] GSE21900 [12] GSE28093 [6] GSE38257 [14] GSE28457 [24] GSE13225 [6] GSE48397 [10] GSE13693 [9] GSE16073 [6] GSE31313 [22] GSE33308 [10] GSE51243 [7] GSE51075 [12] GSE23833 [12] GSE32386 [13] GSE46797 [6] GSE54490 [12] GSE19004 [9] GSE24628 [16] GSE17796 [39] GSE44260 [10] GSE14004 [9] GSE13873 [27] GSE50813 [24] GSE17266 [59] GSE31359 [8] GSE22180 [60] GSE51385 [8] GSE21309 [9] GSE20696 [8] GSE54653 [6] GSE38693 [8] GSE6875 [8] GSE13874 [14] GSE46209 [21] GSE30160 [6] GSE46090 [12] GSE16925 [15] GSE29241 [6] GSE12993 [6] GSE5041 [8] GSE44101 [6] GSE11220 [44] GSE45895 [27] GSE51608 [6] GSE17316 [12] GSE18660 [10] GSE51804 [10] GSE10176 [6] GSE6689 [12] GSE15155 [12] GSE53951 [10] GSE13692 [8] GSE24512 [29] GSE25257 [6] GSE9763 [20] GSE28621 [21] GSE7503 [6] GSE46091 [8] GSE15872 [18] GSE5891 [6] GSE9287 [8] GSE6065 [100] GSE48203 [9] GSE39034 [9] GSE17462 [8] GSE16675 [72] GSE46942 [7] GSE13563 [6] GSE9247 [15] GSE11358 [8] GSE39621 [51] GSE52474 [154] GSE21278 [48] GSE11222 [42] GSE7694 [12] GSE40655 [6] GSE51213 [16] GSE30192 [6] GSE19436 [8] GSE15541 [12] GSE1435 [27] GSE41342 [26] GSE46970 [15] GSE28389 [20] GSE20426 [35] GSE21299 [12] GSE23845 [15] GSE12464 [23] GSE16110 [16] GSE32598 [11] GSE4768 [18] GSE19403 [12] GSE6837 [8] GSE48004 [6] GSE51365 [28] GSE16679 [8] GSE22005 [23] GSE26355 [6] GSE38277 [18] GSE42047 [24] GSE7020 [8] GSE19925 [6] GSE10895 [8] GSE7875 [16] GSE24210 [16] GSE29632 [42] GSE21224 [16] GSE20620 [22] GSE27901 [23] GSE10525 [18] GSE14012 [24] GSE16874 [12] GSE30962 [16] GSE18042 [18] GSE18326 [8] GSE44175 [18] GSE39984 [18] GSE28593 [9] GSE14308 [12] GSE40230 [15] GSE51483 [45] GSE4260 [6] GSE30485 [15] GSE13493 [6] GSE47967 [18] GSE11775 [12] GSE33156 [18] GSE14753 [6] GSE14769 [24] GSE10192 [24] CEM+ CEM GSE5332 [12] GSE39766 [6] GSE30488 [52] GSE15267 [8] GSE15580 [14] GSE25423 [10] 0.0 GSE34729 [6] GSE19517 [6] GSE45465 [39] Scale ofaveragePearsoncorrelations GSE13044 [59] GSE23925 [6] GSE36814 [20] GSE55705 [10] GSE27114 [6] GSE54207 [9] 0.2 GSE55855 [6] GSE39897 [36] GSE17513 [12] GSE30138 [51] GSE5245 [16] GSE8678 [6] GSE4518 [12] GSE45143 [6] GSE58307 [20] 0.4 GSE11759 [6] GSE43419 [20] GSE19885 [9] GSE18534 [15] GSE5976 [12] GSE14406 [54] GSE42049 [8] GSE16992 [48] GSE23496 [9] 0.6 GSE23502 [8] GSE13259 [10] GSE21606 [6] GSE56777 [8] GSE29318 [9] GSE31598 [12] GSE20500 [6] GSE16684 [6] GSE32277 [33] 0.8 GSE18136 [12] GSE46185 [6] GSE21568 [12] GSE46242 [12] Score 1122.54 1128.94 1129.73 1131.22 1134.96 1145.55 1153.29 1161.31 1169.33 1173.82 1179.42 1182.92 1186.72 1188.05 1193.93 1198.91 1198.94 1209.80 1211.97 1214.64 1225.42 1227.00 1234.16 1259.79 1267.00 1272.46 1274.57 1279.29 1292.98 1311.22 1316.52 1319.16 1337.66 1338.09 1343.70 1349.66 1351.20 1374.93 1409.46 1429.05 1472.49 1479.41 1504.07 1531.32 1.0 Notes Symbol Num ofCEMGenes:6.Predicted424.SelectedDatasets:641.Strength:10.9 CEM 1,Geneset"[C]PCNA-CHL12-RFC2-5complex",Page2 BC055324 Racgap1 Mms22l Shcbp1 Topbp1 Wdhd1 Dnajc9 Cenpw Incenp Zwilch Cenpu Cenpp Cenpn Dnmt1 Apitd1 Bub1b Dtymk Nup85 Ccnb2 Ncapg Ercc6l Spag5 Ndc80 Trip13 Ube2c Ccna2 Fbxo5 Hirip3 Aurka Brca1 Ube2t Cenpi Kntc1 Spdl1 Sgol1 Espl1 Eme1 Pola1 Pole2 Rrm2 Kif11 Ppil1 Hells Tpx2 Orc6 Dbf4 Nuf2 Cdt1 Plk4 Plk1 0.0 1.0 GSE38031 [8] GSE40513 [6] GSE31028 [6] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE54215 [13] GSE20954 [14] GSE23200 [6] GSE18135 [18] GSE27605 [8] GSE15741 [6] GSE4694 [6] GSE12498 [12] GSE39449 [6] GSE20100 [15] GSE6998 [32] GSE51883 [30] GSE12454 [13] GSE21393 [6] GSE21379 [10] GSE12465 [14] GSE13302 [30] GSE48204 [6] GSE17794 [44] GSE57543 [6] GSE51628 [15] GSE21900 [12] GSE28093 [6] GSE38257 [14] GSE28457 [24] GSE13225 [6] GSE48397 [10] GSE13693 [9] GSE16073 [6] GSE31313 [22] GSE33308 [10] GSE51243 [7] GSE51075 [12] GSE23833 [12] GSE32386 [13] GSE46797 [6] GSE54490 [12] GSE19004 [9] GSE24628 [16] GSE17796 [39] GSE44260 [10] GSE14004 [9] GSE13873 [27] GSE50813 [24] GSE17266 [59] GSE31359 [8] GSE22180 [60] GSE51385 [8] GSE21309 [9] GSE20696 [8] GSE54653 [6] GSE38693 [8] GSE6875 [8] GSE13874 [14] GSE46209 [21] GSE30160 [6] GSE46090 [12] GSE16925 [15] GSE29241 [6] GSE12993 [6] GSE5041 [8] GSE44101 [6] GSE11220 [44] GSE45895 [27] GSE51608 [6] GSE17316 [12] GSE18660 [10] GSE51804 [10] GSE10176 [6] GSE6689 [12] GSE15155 [12] GSE53951 [10] GSE13692 [8] GSE24512 [29] GSE25257 [6] GSE9763 [20] GSE28621 [21] GSE7503 [6] GSE46091 [8] GSE15872 [18] GSE5891 [6] GSE9287 [8] GSE6065 [100] GSE48203 [9] GSE39034 [9] GSE17462 [8] GSE16675 [72] GSE46942 [7] GSE13563 [6] GSE9247 [15] GSE11358 [8] GSE39621 [51] GSE52474 [154] GSE21278 [48] GSE11222 [42] GSE7694 [12] GSE40655 [6] GSE51213 [16] GSE30192 [6] GSE19436 [8] GSE15541 [12] GSE1435 [27] GSE41342 [26] GSE46970 [15] GSE28389 [20] GSE20426 [35] GSE21299 [12] GSE23845 [15] GSE12464 [23] GSE16110 [16] GSE32598 [11] GSE4768 [18] GSE19403 [12] GSE6837 [8] GSE48004 [6] GSE51365 [28] GSE16679 [8] GSE22005 [23] GSE26355 [6] GSE38277 [18] GSE42047 [24] GSE7020 [8] GSE19925 [6] GSE10895 [8] GSE7875 [16] GSE24210 [16] GSE29632 [42] GSE21224 [16] GSE20620 [22] GSE27901 [23] GSE10525 [18] GSE14012 [24] GSE16874 [12] GSE30962 [16] GSE18042 [18] GSE18326 [8] GSE44175 [18] GSE39984 [18] GSE28593 [9] GSE14308 [12] GSE40230 [15] GSE51483 [45] GSE4260 [6] GSE30485 [15] GSE13493 [6] GSE47967 [18] GSE11775 [12] GSE33156 [18] GSE14753 [6] GSE14769 [24] GSE10192 [24] CEM+ CEM GSE5332 [12] GSE39766 [6] GSE30488 [52] GSE15267 [8] GSE15580 [14] GSE25423 [10] 0.0 GSE34729 [6] GSE19517 [6] GSE45465 [39] Scale ofaveragePearsoncorrelations GSE13044 [59] GSE23925 [6] GSE36814 [20] GSE55705 [10] GSE27114 [6] GSE54207 [9] 0.2 GSE55855 [6] GSE39897 [36] GSE17513 [12] GSE30138 [51] GSE5245 [16] GSE8678 [6] GSE4518 [12] GSE45143 [6] GSE58307 [20] 0.4 GSE11759 [6] GSE43419 [20] GSE19885 [9] GSE18534 [15] GSE5976 [12] GSE14406 [54] GSE42049 [8] GSE16992 [48] GSE23496 [9] 0.6 GSE23502 [8] GSE13259 [10] GSE21606 [6] GSE56777 [8] GSE29318 [9] GSE31598 [12] GSE20500 [6] GSE16684 [6] GSE32277 [33] 0.8 GSE18136 [12] GSE46185 [6] GSE21568 [12] GSE46242 [12] Score 906.01 907.52 913.88 916.92 919.95 922.71 936.32 939.71 942.30 949.93 950.67 952.89 954.42 957.95 962.01 967.04 972.23 980.34 983.71 987.12 991.52 992.76 995.93 1019.15 1020.81 1025.69 1029.59 1031.45 1031.94 1032.11 1034.87 1040.91 1041.29 1045.19 1053.91 1055.68 1065.19 1072.81 1086.83 1089.16 1089.36 1094.65 1095.16 1096.99 1102.37 1103.51 1105.27 1110.72 1112.74 1115.09 1.0 Notes Symbol Num ofCEMGenes:6.Predicted424.SelectedDatasets:641.Strength:10.9 CEM 1,Geneset"[C]PCNA-CHL12-RFC2-5complex",Page3 Rnaseh2b Mis18bp1 Timeless Suv39h1 Ranbp1 Nup133 Nup107 Ncapg2 Nusap1 Rad54b Cdc25c Cenpm Dnaaf2 Cenpe Kif18b Kpna2 Haus5 Ckap2 Cdca2 Haus1 Poc1a Esco2 Mybl2 Cenpf Mki67 Gins4 Atad5 Atad2 Pold2 Pold1 H2afx Tfdp1 Lsm2 Tcf19 Lsm3 Gsg2 Rpa3 Cks2 Nek2 Ska3 Ezh2 Orc1 Oip5 Ccnf Prc1 Ect2 Dhfr Blm Kif4 Ttf2 0.0 1.0 GSE38031 [8] GSE40513 [6] GSE31028 [6] Only showingfirst200datasets-Seetxtoutputforfulldetails. GSE54215 [13] GSE20954 [14] GSE23200 [6] GSE18135 [18] GSE27605 [8] GSE15741 [6] GSE4694 [6] GSE12498 [12] GSE39449 [6] GSE20100 [15] GSE6998 [32] GSE51883 [30] GSE12454 [13] GSE21393 [6] GSE21379 [10] GSE12465 [14] GSE13302 [30]