TABLE OF CONTENT Welcome letter 4 Committees 6 Sponsors 8 Programme and Venue 11 MAY 27, 2009 OPENING CEREMONY AND INAUGURAL LEctURE 18 Welcome 19 Inaugural Lecture Ignasi Carrio 20 ORAL PRESENTATIONS MAY 28, 2009 TECHNOLOGY, PROBES, VEctORS, CELLs 23 Plenary Lecture 1: Harald Mikkers 24 Parallel Session 1: Technology 27 Parallel Session 2: Probes 34 Parallel Session 3: Probe Design 41 Parallel Session 4: Gene and Cell Therapy1 48 Plenary Lecture 2: Spencer Shorte 55 Parallel Session 5:Technology and Probes in OI 58 Parallel Session 6: Imaging Infection/ Gene and Cell Therapy2 65 MAY 29, 2009 NEUROSCIENCE AND CARDIOVASCULAR DISEASE 72 Plenary Lecture 3: Joerg Schulz 74 Parallel Session 7: Neuroscience – from bench to bedside1 77 Parallel Session 8: Cardiovascular – from bench to bedside 84 Parallel Session 9: Neuroscience – from bench to bedside2 91 Parallel Session 10: Cardiovascular – from bench to bedside2 98 Plenary Lecture 4: Industry and basic research A Panel Discussion 105 Parallel Session 11: Inflammation 112 Parallel Session 12: Metabolic Disorders 119 MAY 30, 2009 CANCER 126 Plenary Lecture 5: Juri Gelovani 127 Parallel Session 13: Cancer – from bench to bedside1 130 Parallel Session 14: Cancer –Drug Development 137 Parallel Session 15: Cancer –from bench to bedside2 143 Parallel Session 16: Cancer – Biology 150 POSTER PRESENTATIONs 157 Technology – Technical Advances in MI instrumentation 158 Probe Design – Innovative Approaches to Molecular Imaging Probes 181 New Developments in Optical Imaging – Probes and Instrumentation 203 Imaging Guided Gene and Cell based Therapy 210 MI of Infection and Inflammation 222 Molecular Neuroimaging – from bench to bedside 230 Imaging in Cardiovascular Disease– from bench to bedside 253 Cancer from Bench to Bedside – Translational Research in Oncology 258 Imaging in AntiCancer Drug Development 268 MI in cancer biology – Visualisation of Extra- and Intracellular Processes 285 INDEX 301 4th European Molecular Imaging Meeting WELCOME LETTER Dear Colleagues, on behalf of the ESMI and EANM as well as of the EU NoEs and IPs, CliniGene, DiMI, EMIL, and MOLIM it is our great pleasure to welcome you to Barcelona for the 4th European Molecular Imaging Meeting. EMIM 2009 brings together top European scientists from two societies, three European Networks of Excellence (NoEs) and one Integrated Project (IP). With great honour we may state that your fellow attendees represent not only colleagues from all over Europe, but also from Australia, China, Japan, and the US. The societies and networks with primary responsibility for organising the meeting are: - European Society for Molecular Imaging (ESMI) - NoE European Molecular Imaging Laboratories (EMIL) - NoE Diagnostic Molecular Imaging (DiMI) We also gratefully acknowledge the contribution from the following participating organisations: - European Association of Nuclear Medicine (EANM) - IP Integrated Technologies for In-vivo Molecular Imaging (MOLIM) - NoE Clinical Gene Transfer and Therapy (CliniGene) All these organisations were working together, with input from a scientifically diverse, international scientific steering committee, to develop a strong scientific programme which integrates developments in imaging technologies and molecular imaging agents with applications for drug development, basic science investigations, and clinical translation with special emphasis in the main disease burdens of our society such as cancer, cardiovascular disease and neurodegeneration. We developed the 4th EMIM scientific programme primarily on the outstanding strength of submitted abstracts. About 200 abstracts were submitted, reviewed and scored. Then, each of the concurrent session co-chairs reviewed the scored abstracts which were considered relevant to their particular sessions. Session co-chairs selected abstracts for oral presentation based on average abstract score, session content and structure. Attention was also paid to diversity of disciplines and geographical distribution. From this effort 43 abstracts were integrated into the Parallel Sessions that bring attendees from different disciplines together for a comprehensive examination of the role of molecular imaging in particular biomedical problems. Furthermore, special Poster sessions have been scheduled on Thursday and Friday afternoon with no other competing sessions in order to provide an exciting opportunity to exchange cutting-edge scientific advances, to renew long time friendships and to perhaps meet new colleagues. We are especially thankful that Prof. Dr. Ignasi Carrió will give the inaugural lecture, entitled, “Interplay and endpoints in molecular imaging biomarkers; A look to the future”. In addition, we have planned 6 exciting plenary sessions, two for each day covering topics of stem cell biology, infectious diseases, neurodegeneration, and cancer. For our industry sponsors, this year we have especially dedicated one of the plenary sessions for a joint panel discussing on “What are the scientific needs of industry from basic research and vice versa?” bringing representatives of industry in close interaction with scientists from basic as well as clinical molecular imaging sciences. We would like to take this opportunity to acknowledge the continued interest and support from the DG Research of the European Commission and the European Science Foundation (ESF) as well as extraordinary collaborative efforts between academia and industry that have come together to make this meeting possible. We would like to give also our thanks to you for your continued and growing interest and contributions to the ESMI. We hope, you will enjoy this wonderful seaside city, especially the science and interactions with other colleagues whose work may inspire you to achieve greater success in your scientific and clinical pursuits.O ur intention is that this high-level meeting will foster the coherence of a sustainable European Molecular Imaging Community with the common goal to translate fundamental research discoveries into medical application and health benefit for the European Society. Sincerely, The 4th European Molecular Imaging Meeting Executive Committee Andreas H. Jacobs, ESMI President Anna Planas, ESMI Local Organiser Clemens W.G.M. Lowik, ESMI Vice President Bertrand Tavitian, ESMI Past President Silvio Aime, ESMI Secretary Simone Mergui, ESMI Treasurer Heike Brucherseifer, ESMI Management Office COMMITTEES EXECUTIVE COMMITTEE LOCAL ORGANIZING COmmIttEE Andreas H. Jacobs, ESMI President Ignasi Carrio, Hospital de Sant Pau Anna Planas, ESMI Local Organizer Carlos Justicia, IIBB-CSIC, IDIBAPS Clemens W.G.M. Lowik, ESMI Vice President Javier Pavia, Hospital Clínic Bertrand Tavitian, ESMI Past President Anna Planas, IIBB-CSIC, IDIBAPS Silvio Aime, ESMI Secretary Domenec Ros, University of Barcelona IDIBAPS Simone Mergui, ESMI Treasurer Lupe Soria IIBB-CSIC, IDIBAPS SCIENTIFIC STEERING COMMITTEE Helmut Maecke, CH Silvio Aime, I Christoph Bremer, D Adriana Maggi, I Ignasi Carrio, E Serge Maitrejean, F Harald Carlsen, N Chrit Moonen, F John Clark, GB Robert Muller, B Silvana del Vecchio, I Klaas Nicolay, NL Denis Guilloteau, F Vasilis Nziachristos, D Uwe Haberkorn, D David Parker, GB Karl Herholz, GB Anna Planas, E Mathias Hoehn, D Jorge Ripoll, GR Andreas H. Jacobs, D Markus Rudin, CH Fabian Kießling, D Michael Schäfers, D Gitte Knudsen, DK Markus Schwaiger, D Tony Lahoutte, B Bertrand Tavitian, F Bengt Långström, S Annemie van der Linden, B Adriaan Lammertsma, NL Koen van Laere, B Clemens W.G.M. Lowik, NL Andrea Varrone, S YOUNG INVEstIGATOR AwARD COmmIttEE Chair: Andrea Varrone Stockholm, Sweden Fabian Kiessling Aachen, Germany Tony Lahoutte Brussels, Belgium Klaas Nicolay Eindhoven, The Netherlands Sabina Pappata Naples, Italy Michael Schaefers Muenster, Germany Annemie van der Linden Antwerp, Belgium SPONSORS Platinum Sponsor Gold Sponsors together with Silver sponsors Friend of the meeting PROGRAMME AND VENUE AXA Convention Centre Av. Diagonal, 547 08029 Barcelona. T. 34 93 290 11 02. Fax 34 93 290 96 88. www.axa.es Rooms LEVEL Rooms FUNCTION Ground Floor Main Entrance registration Ground Floor "Win-Café" poster area and lunch breaks Ground Floor Speaker's room speaker's room First Floor Auditori plenary lectures First Floor Foyer exhibition area and coffee breaks Souterrain DEU I Mata sala no. 1 2nd meeting room Souterrain DEU I Mata sala no. 2 3rd meeting room Port of Barcelona Sala Maremagnum Gala Dinner Day 0 Wednesday, May 27 Programme of 4th European Molecular Imaging Meeting Auditori AXA Convention Centre - Barcelona, Spain 27-30 May 2009 DAY 0: Wednesday, May 27: AUDITORI DEU I Mata sala DEU I Mata sala no. 2 no. 1 09:00-12:00 ESMI Executive Committee Meeting (Closed Meeting) 14:00-18:00 REGISTRATION Posters' set up Exhibitors' set up Speakers' documents set up 14:00-16:00 ESMI Council Meeting (Closed Meeting) 16:00-17:30 DiMI Scientific Management Board Meeting (Closed Meeting) 18:00-19:30 Opening Ceremony Welcome, Andreas Jacobs (ESMI President) Welcome, Anna Planas (ESMI Local Organiser) Catalan context of R&D Juan Roca (General Director for Research, Catalan Government) Jean-Luc Sanne (DG Research, European Commission) Helmut Maecke (EANM Representative) Inaugural Lecture Interplay and endpoints in molecular imaging biomarkers; a look to the future, Ignasi Carrio (Barcelona, Spain) 19:30-21:00 Opening Reception Day 1 Thursday, May 28 DAY 1: Thursday, May 28: Technology, Probes, Vectors, Cells (non-disease orientated) AUDITORI DEU I Mata sala no. 1 DEU I Mata sala no. 2 7:30-9:00