Outcome Evaluation of the National Institutes of Health (NIH) Director’s Pioneer Award (NDPA), FY 2004–2005 Case Studies July 22, 2011 Prepared for the NATIONAL INSTITUTES OF HEALTH G. Stephane Philogene, Ph.D. Project Officer Office of Behavioral and Social Sciences Research Division of Program Coordination, Planning, and Strategic Initiatives Office of the Director, NIH Prepared by Bhavya Lal—Task Leader Elizabeth C. Lee, Amy Marshall Richards, Adrienne Zhu, Mary Elizabeth Hughes, Stephanie Shipp IDA Science and Technology Policy Institute 1899 Pennsylvania Avenue NW, Suite 520 Washington DC 20006 Contents 1. Introduction .............................................................................................................................1 2. Aggregate Analyses .................................................................................................................7 3. Case Studies ...........................................................................................................................15 A. Larry Abbott (2004) ......................................................................................................15 1. Research Summary ..................................................................................................15 2. NDPA Reviewer Panel Opinions ............................................................................16 3. Nature of Project Risks and Outcomes ....................................................................16 4. Value of the NDPA Program ...................................................................................19 5. Descriptive Bibliometrics ........................................................................................20 B. Vicki Chandler (2005) ...................................................................................................29 1. Research Summary ..................................................................................................29 2. NDPA Reviewer Panel Opinions ............................................................................30 3. Nature of Project Risks and Outcomes ....................................................................30 4. Value of the NDPA Program ...................................................................................32 5. Descriptive Bibliometrics ........................................................................................34 C. Hollis Cline (2005) ........................................................................................................43 1. Research Summary ..................................................................................................43 2. NDPA Reviewer Panel Opinions ............................................................................44 3. Nature of Project Risks and Outcomes ....................................................................44 4. Value of the NDPA Program ...................................................................................47 5. Descriptive Bibliometrics ........................................................................................49 D. Leda Cosmides (2005) ...................................................................................................57 1. Research Summary ..................................................................................................57 2. NDPA Reviewer Panel Opinions ............................................................................58 3. Nature of Project Risks and Outcomes ....................................................................58 4. Value of the NDPA Program ...................................................................................61 5. Descriptive Bibliometrics ........................................................................................63 E. George Daley (2004) .....................................................................................................71 1. Research Summary ..................................................................................................71 2. NDPA Reviewer Panel Opinions ............................................................................72 3. Nature of Project Risks and Outcomes ....................................................................72 4. Value of the NDPA Program ...................................................................................75 5. Descriptive Bibliometrics ........................................................................................76 F. Titia de Lange (2005) ....................................................................................................85 1. Research Summary ..................................................................................................85 2. NDPA Reviewer Panel Opinions ............................................................................86 3. Nature of Project Risks and Outcomes ....................................................................86 4. Value of the NDPA Program ...................................................................................89 5. Descriptive Bibliometrics ........................................................................................90 i G. Karl Deisseroth (2005) ..................................................................................................97 1. Research Summary ..................................................................................................97 2. NDPA Reviewer Panel Opinions ............................................................................98 3. Nature of Project Risks and Outcomes ....................................................................98 4. Value of the NDPA Program .................................................................................101 5. Descriptive Bibliometrics ......................................................................................103 H. Pehr Harbury (2005) ....................................................................................................111 1. Research Summary ................................................................................................111 2. NDPA Reviewer Panel Opinions ..........................................................................112 3. Nature of Project Risks and Outcomes ..................................................................112 4. Value of the NDPA Program .................................................................................114 5. Descriptive Bibliometrics ......................................................................................116 I. Homme Hellinga (2004) ..............................................................................................123 1. Research Summary ................................................................................................123 2. NDPA Reviewer Panel Opinions ..........................................................................124 3. Nature of Project Risks and Outcomes ..................................................................124 4. Value of the NDPA Program .................................................................................126 5. Descriptive Bibliometrics ......................................................................................128 J. Erich Jarvis (2005) ......................................................................................................135 1. Research Summary ................................................................................................135 2. NDPA Reviewer Panel Opinions ..........................................................................136 3. Nature of Project Risks and Outcomes ..................................................................136 4. Value of the NDPA Program .................................................................................139 5. Descriptive Bibliometrics ......................................................................................141 K. Joseph (Mike) McCune (2004) ....................................................................................149 1. Research Summary ................................................................................................149 2. NDPA Reviewer Panel Opinions ..........................................................................150 3. Nature of Project Risks and Outcomes ..................................................................150 4. Value of the NDPA Program .................................................................................153 5. Descriptive Bibliometrics ......................................................................................155 L. Steven McKnight (2004) .............................................................................................162 1. Research Summary ................................................................................................162 2. NDPA Reviewer Panel Opinions ..........................................................................163 3. Nature of Project Risks and Outcomes ..................................................................163 4. Value of the NDPA Program .................................................................................165 5. Descriptive Bibliometrics ......................................................................................167 M. Chad Mirkin (2004) .....................................................................................................173 1. Research