Methyl acrylate sc-215333 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Methyl acrylate STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY3 HEALTH3 HAZARD INSTABILITY2 SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY: ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS C4-H6-O2, H2C=CHCOOCH3, "acrylic acid, methyl ester", "propenoic acid, methyl ester", "methyl propenate", "methyl propenoate", "methyl 2-propenoate" Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 3 Toxicity: 2 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 2 Moderate=2 High=3 Chronic: 2 Extreme=4 CANADIAN WHMIS SYMBOLS 1 of 13 EMERGENCY OVERVIEW RISK May cause SENSITISATION by inhalation and skin contact. Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Highly flammable. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. EYE ! Irritation of the eyes may produce a heavy secretion of tears (lachrymation). ! The vapour when concentrated has pronounced eye irritation effects and this gives some warning of high vapour concentrations. If eye irritation occurs seek to reduce exposure with available control measures, or evacuate area. ! There is evidence that material may produce eye irritation in some persons and produce eye damage 24 hours or more after instillation. Severe inflammation may be expected with pain. SKIN ! Skin contact with the material may be harmful; systemic effects may resultfollowing absorption. ! The material may cause moderate inflammation of the skin either following direct contact or after a delay of some time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering. ! Minor exposure to methyl acrylate may cause sensitisation in some cases In a vase study involving 105 exposed workers 53. 7 % showed the clinical presence of three allergies (dermatitis, eczema, urticaria). ! Open cuts, abraded or irritated skin should not be exposed to this material. ! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ! Inhalation of vapors or aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful. ! The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. ! Inhalation of quantities of liquid mist may be extremely hazardous, even lethal due to spasm, extreme irritation of larynx and bronchi, chemical pneumonitis and pulmonary edema. ! If exposure to highly concentrated vapor atmosphere is prolonged this may lead to narcosis, unconsciousness, even coma and unless resuscitated - death. ! There is some evidence to suggest that this material can cause, if inhaled once, irreversible damage of organs. ! The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere developing. Before starting consider control of exposure by mechanical ventilation. CHRONIC HEALTH EFFECTS ! Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population. Skin contact with the material is more likely to cause a sensitization reaction in some persons compared to the general population. There has been some concern that this material can cause cancer or mutations but there is not enough data to make an assessment. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. In a 13-week study of methyl acrylate, rats were given up to 20 mg/kg/day in drinking water. Treatment related effects were seen in rats receiving higher doses and included spontaneous renal disease. The no-observed-effect level (NOEL) was 5 mg/kg/day. In an inhalation study rats, rabbits and guinea pigs were exposed to methyl methacrylate 7 hours/day. All animals exposed at 578 ppm (two-seven times) died. These animals exhibited ocular and respiratory tract irritation, salivation, laboured breathing, lethargy and/or convulsions. Signs of toxicity at 237 ppm were similar to those at 578 ppm. Rats exposed to methyl methacrylate vapour for up to 2 years showed concentration-related changes in the transitional region between the respiratory and olfactory nasal epithelium ranging from very mild to mild atrophy of ciliated and olfactory cells. No animals showed signs of squamous cell metaplasia at concentrations up to 135 ppm. Corneal opacification and vascularisation occurred at all concentrations. Severity was dependent on concentration and duration. 2 of 13 Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS NAME CAS RN % methyl acrylate 96-33-3 >98 inhibitor stabiliser, must be present for transport and storage; more inhibitor means longer storage life typically 4-methoxyphenol (MEHQ) 150-76-5 0.001-0.1 Section 4 - FIRST AID MEASURES SWALLOWED · IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. · Where Medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise: EYE ! If this product comes in contact with the eyes: · Wash out immediately with fresh running water. · Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. SKIN ! If skin contact occurs: · Immediately remove all contaminated clothing, including footwear · Flush skin and hair with running water (and soap if available). INHALED · If fumes or combustion products are inhaled remove from contaminated area. · Lay patient down. Keep warm and rested. NOTES TO PHYSICIAN ! for poisons (where specific treatment regime is absent): ----------------------------------------------------------------------------------------------------------------BASIC TREATMENT ---------------------------------------------------------------------------------------------------------------- · Establish a patent airway with suction where necessary. · Watch for signs of respiratory insufficiency and assist ventilation as necessary. Treat symptomatically. If exposure has been severe and/or symptoms marked, observation in hospital for 48 hours should be considered due to possibility of delayed pulmonary edema. Section 5 - FIRE FIGHTING MEASURES Vapor Pressure (mmHg): 67.806 @ 20C Upper Explosive Limit (%): 12.0 Specific Gravity (water=1): 0.956 @ 25C Lower Explosive Limit (%): 2.5 EXTINGUISHING MEDIA · Foam. · Dry chemical powder. FIRE FIGHTING · Alert Emergency Responders and tell them location and nature of hazard. · May be violently or explosively reactive. When any large container (including road and rail tankers) is involved in a fire, consider evacuation by 1000 metres in all directions. GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS · Liquid and vapor are highly flammable. · Severe fire hazard when exposed to heat, flame and/or oxidizers. Combustion products include: carbon dioxide (CO2), other pyrolysis products typical of burning organic material. Contains low boiling substance: Closed containers may rupture due to pressure buildup under fire conditions. FIRE INCOMPATIBILITY ! Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids,chlorine bleaches, pool chlorine etc. as ignition may result. PERSONAL PROTECTION Glasses: Chemical goggles. Gloves: 3 of 13 1.BUTYL 2.TEFLON 3.PVA Respirator: Type A Filter of sufficient capacity Section 6 - ACCIDENTAL RELEASE MEASURES MINOR SPILLS · Remove all ignition sources. · Clean up all spills immediately. MAJOR SPILLS · Clear area of personnel and move upwind. · Alert Emergency Responders and tell them location and nature of hazard. Section 7 - HANDLING AND STORAGE PROCEDURE FOR HANDLING · Most acrylic monomers have low viscosity therefore pouring, material transfer and processing of these materials do not necessitate heating. · Viscous monomers may require heating to facilitate handling. To facilitate product transfer from original containers, product must be heated to no more than 60 deg. C. (140 F.), for not more than 24 hours. · Containers, even those that have been emptied, may contain explosive vapours. · Do NOT cut, drill, grind, weld or perform similar operations on or near containers. Contains low boiling substance: Storage in sealed containers may result in pressure buildup causing violent rupture of containers not rated appropriately. · Check for bulging containers. · Vent periodically. · DO NOT allow clothing wet with material to stay in contact with skin. · Avoid all personal contact, including inhalation. · Wear protective clothing when risk of exposure occurs. RECOMMENDED STORAGE