PHYSICAL SCIENCES-ONCOLOGY CENTER PROGRAM Program Update: Year Three Fall 2012 Table of Contents 1. Executive Summary .................................................................................................................................................................1 2. Physical Sciences-Oncology Program Organization ...............................................................................................................5 2.1. Introduction ..................................................................................................................................................................7 2.2. Office of Physical Sciences-Oncology Mission ............................................................................................................7 2.3. Program History ...........................................................................................................................................................8 2.3.1 Overview of Spring 2008 Think Tank Meetings ................................................................................................8 2.3.2 Program Development and Funding History ...................................................................................................10 2.4. Strategic Approach and Objectives ...........................................................................................................................11 2.4.1 A Focus on Addressing “Big Questions” in Oncology ....................................................................................11 2.4.2 Structure of the PS-OC Network .....................................................................................................................12 2.4.3 Overall Goals of the PS-OC Program ..............................................................................................................12 2.5. Program Infrastructure ...............................................................................................................................................13 2.5.1 Introduction to the 12 PS-OCs ........................................................................................................................13 2.5.2 Organization and Policies of Individual PS-OCs .............................................................................................16 2.6. Organization and Activities of the PS-OC Network ...................................................................................................18 2.6.1 PS-OC Steering Committee .............................................................................................................................18 2.6.2 Data Sharing ...................................................................................................................................................19 2.6.3 Trans-Network Projects ..................................................................................................................................20 2.6.4 Annual PS-OC Network Investigators’ Meeting .............................................................................................21 2.6.5 PS-OC Network Working Groups ....................................................................................................................21 2.6.6 PS-OC Program Evaluation ..............................................................................................................................24 2.7. PS-OC Network Resources ........................................................................................................................................26 2.7.1 Network Bioresources ....................................................................................................................................26 2.7.2 Data Collection and Coordination ...................................................................................................................28 2.7.3 Genomic Characterization ...............................................................................................................................29 Program Update - Fall 2012 i 3. Program Performance ...........................................................................................................................................................31 3.1. Reported Scientific Outputs and Research Highlights ..............................................................................................33 3.2. Key Scientific Advancements with a Physical Sciences Perspective ........................................................................34 3.2.1 Evolution and Evolutionary Theory .................................................................................................................34 3.2.2 Physics Principles and Technologies in Cancer ..............................................................................................44 3.2.3 Information Transfer and Decoding ................................................................................................................55 3.2.4 De-convoluting Cancer’s Complexity ..............................................................................................................65 3.3. Reported Outputs of the PS-OC Network ..................................................................................................................74 3.3.1 Publications .....................................................................................................................................................74 3.3.2 Patents ............................................................................................................................................................77 3.3.3 PS-OC Related Clinical Trials ..........................................................................................................................77 3.3.4 Leveraged Funds .............................................................................................................................................79 4. PS-OC Pilot Projects ..............................................................................................................................................................81 4.1. PS-OC Center Pilot Projects ............................................................................................................................83 4.2. PS-OC Outreach Pilot Project ..........................................................................................................................93 5. PS-OC Network Projects and Activities ..............................................................................................................................101 5.1. Trans-Network Projects: Answering the “Big Questions” .......................................................................................103 5.2. PS-OC Cell Line Pilot Study .....................................................................................................................................111 5.3. “United Nations” (UN) of Cell Modulus ..................................................................................................................114 5.4. PS-OC Scientific orkingW Groups ............................................................................................................................117 5.4.1 Evolution of Drug Resistance Working Group ..............................................................................................117 5.4.2 Physics in Cancer Working Group .................................................................................................................118 5.4.3 Circulating Tumor Cell (CTC) Transport Working Group ................................................................................121 5.5. PS-OC Network Retreat ...........................................................................................................................................123 6. PS-OC Program Center Highlights ......................................................................................................................................125 iiProgram Update - Fall 2012 Physical Sciences-Oncology Center Programii 7. Outreach Activities .............................................................................................................................................................145 7.1. PS-OC Outreach Programs .......................................................................................................................................147 7.2. Outreach and Dissemination Working Group ..........................................................................................................154 7.3. PS-OC Investigators in the Media/Conferences ......................................................................................................157 7.4. OPSO Outreach Activities ........................................................................................................................................159 7.4.1 OPSO Website ..............................................................................................................................................159 7.4.2 OPSO Publications and Collections ..............................................................................................................160 7.4.3 Scientific Conferences ..................................................................................................................................162 7.4.4 NIH Symposiums ...........................................................................................................................................163