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PCT No.: PCT/UP2008/065.365 DE 3541716 A1 5, 1987 S 371 (c)(1), (Continued)Continued (2), (4) Date: Sep. 23, 2010 OTHER PUBLICATIONS (87) PCT Pub. No.: WO2009/028588 Communication pursuant to Article 94(3) EPC issued Jul. 30, 2013 in European Patent Application No. 05743758.4. PCT Pub. Date: Mar. 5, 2009 (Continued) (65) Prior Publication Data US 2011 FOOO9619 A1 Jan. 13, 2011 Primary Examiner — Susanna Moore (74) Attorney, Agent, or Firm — Birch, Stewart, Kolasch & (30) Foreign Application Priority Data Birch, LLP Aug. 31, 2007 (JP) ................................. 2007-225045 (57) ABSTRACT E30 SEM. O.C. Disclosed is a compound represented by the formula (1) (51) Int. Cl. (I) CO7D 47L/04 (2006.01) A6 IK 3/437 (2006.01) G) ()-X-G) CO7D 487/04 (2006.01) CO7D 49.8/04 (2006.01) CO7D 403/0 (2006.01) or a pharmacologically acceptable salt thereof, which is A61 P 25/28 (2006.01) effective as a therapeutic or prophylactic agent for a disease CO7D 403/04 (2006.01) induced by AB, wherein Ari represents an imidazolyl group (52) U.S. Cl. which may be substituted with a C1-6 alkyl group, or the CPC ........... C07D 403/10 (2013.01); C07D 471/04 like; Ara represents a phenyl group which may be substituted (2013.01); C07D 487/04 (2013.01); C07D with a C1-6 alkoxy group, or the like: X represents a double 498/04 (2013.01) bond, or the like; and Het represents a triazolyl group or the (58) Field of Classification Search like which may be substituted with a C1-6 alkyl group or the CPC ........................... A61K 31/437; C07D 471/04 like, or the like. 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