Annexure‐ I : Specifications of FDA approved drug library All compounds should have been approved by FDA Bioactivity and safety of each compound should have been confirmed by clinical trials Compounds should be related to oncology, cardiology, anti‐inflammatory, immunology, neuropsychiatry, analgesia etc. The compounds should be structurally diverse, medicinally active, and cell permeable Compounds should have rich documentation with structure and IC50 should be known Compounds which are supplied should have been validated by NMR and HPLC to ensure high purity Each compound should be supplied as 10mM solution in DMSO and at least 100µl of each compound should be supplied. Compounds should be supplied in screw capped vial arranged as 96 well plate format. Should be compatible for high throughput screening (HTS) and high content screening (HCS) The library should contain following 1443 compounds: Sl. No Name of the compound 1. ABT‐263 (Navitoclax) 2. Linifanib (ABT‐869) 3. Veliparib (ABT‐888) 4. Axitinib 5. Saracatinib (AZD0530) 6. FG‐4592 7. Selumetinib (AZD6244) 8. Nintedanib (BIBF 1120) 9. Afatinib (BIBW2992) 10. Bortezomib (PS‐341) 11. Bosutinib (SKI‐606) 12. Cediranib (AZD2171) 13. Dovitinib (TKI‐258, CHIR‐258) 14. Dasatinib 15. Erlotinib HCl (OSI‐744) 16. Gefitinib (ZD1839) 17. Imatinib Mesylate (STI571) 18. Lapatinib (GW‐572016) Ditosylate 19. Lenalidomide (CC‐5013) 20. Panobinostat (LBH589) 21. Nilotinib (AMN‐107) 22. Pazopanib HCl 23. Rapamycin (Sirolimus) 24. Sorafenib Tosylate 25. Sunitinib Malate 26. Temsirolimus (CCI‐779, NSC 683864) 27. Vandetanib (ZD6474) 28. Vorinostat (SAHA, MK0683) 29. VX‐680 (Tozasertib, MK‐0457) 30. Entinostat (MS‐275) 31. Enzastaurin (LY317615) 32. Olaparib (AZD2281, Ku‐0059436) 33. Masitinib (AB1010) 34. GDC‐0941 35. Crizotinib (PF‐02341066) 36. Vismodegib (GDC‐0449) 37. Belinostat (PXD101) 38. Iniparib (BSI‐201) 39. PCI‐24781 (Abexinostat) 40. OSI‐906 (Linsitinib) 41. Quisinostat (JNJ‐26481585) 42. Rucaparib (AG‐014699,PF‐01367338) 43. Vatalanib (PTK787) 2HCl 44. Foretinib (GSK1363089) 45. Triciribine 46. Cabozantinib (XL184, BMS‐907351) 47. Everolimus (RAD001) 48. Mocetinostat (MGCD0103) 49. YM155 (Sepantronium Bromide) 50. Alisertib (MLN8237) 51. Malotilate 52. 17‐AAG (Tanespimycin) 53. Ivacaftor (VX‐770) 54. Barasertib (AZD1152‐HQPA) 55. Docetaxel 56. Paclitaxel 57. Roscovitine (Seliciclib,CYC202) 58. Capecitabine 59. CEP‐18770 (Delanzomib) 60. Ganetespib (STA‐9090) 61. AT13387 62. Lenvatinib (E7080) 63. Valproic acid sodium salt (Sodium valproate) 64. Regorafenib (BAY 73‐4506) 65. Ritonavir 66. Anastrozole 67. Aprepitant 68. Bicalutamide 69. Fulvestrant 70. Raltitrexed 71. Thalidomide 72. CUDC‐101 73. TAK‐700 (Orteronel) 74. Exemestane 75. Finasteride 76. Irinotecan 77. Cladribine 78. Decitabine 79. Dimesna 80. Dutasteride 81. Melatonin 82. Bisoprolol fumarate 83. Tivozanib (AV‐951) 84. Doxorubicin (Adriamycin) 85. Fluorouracil (5‐Fluoracil, 5‐FU) 86. Methotrexate 87. Imiquimod 88. Bendamustine HCl 89. Nelarabine 90. Bleomycin Sulfate 91. Clofarabine 92. Dacarbazine 93. Dexrazoxane HCl (ICRF‐187, ADR‐529) 94. Epirubicin HCl 95. Oxaliplatin 96. Etoposide 97. Raloxifene HCl 98. Fludarabine Phosphate 99. Flavopiridol (Alvocidib) 100. Topotecan HCl 101. Letrozole 102. Temozolomide 103. Tamoxifen 104. Vincristine 105. Agomelatine 106. Amuvatinib (MP‐470) 107. Leflunomide 108. Enzalutamide (MDV3100) 109. Dienogest 110. Entecavir Hydrate 111. Nepafenac 112. Rufinamide 113. Posaconazole 114. Prasugrel 115. Ramelteon 116. Cinacalcet HCl 117. Celecoxib 118. Avagacestat (BMS‐708163) 119. Vemurafenib (PLX4032, RG7204) 120. Acarbose 121. Adapalene 122. Altretamine 123. Amisulpride 124. Aniracetam 125. Artemisinin 126. Asenapine 127. Benazepril HCl 128. Budesonide 129. Bumetanide 130. Carmofur 131. Cetirizine DiHCl 132. Cilnidipine 133. Cilostazol 134. Floxuridine 135. FT‐207 (NSC 148958) 136. Ifosfamide 137. Megestrol Acetate 138. Mercaptopurine (6‐MP) 139. Streptozotocin (STZ) 140. Dexamethasone (DHAP) 141. Doxazosin Mesylate 142. Edaravone 143. Ellagic acid 144. Etodolac 145. Etomidate 146. Felbamate 147. Fluconazole 148. Flumazenil 149. Fluoxetine HCl 150. Fluvoxamine maleate 151. Gatifloxacin 152. Genistein 153. Glimepiride 154. Ivermectin 155. Ketoconazole 156. Lansoprazole 157. Levetiracetam 158. Lidocaine 159. Loratadine 160. Losartan Potassium (DuP 753) 161. Rigosertib (ON‐01910) 162. Epothilone B (EPO906, Patupilone) 163. Amonafide 164. Acitretin 165. Bafetinib (INNO‐406) 166. Doripenem Hydrate 167. Gestodene 168. Drospirenone 169. Ruxolitinib (INCB018424) 170. Isotretinoin 171. Lopinavir 172. Meropenem 173. Mianserin HCl 174. Mosapride Citrate 175. Nafamostat Mesylate 176. Omeprazole 177. Ondansetron HCl 178. Oxcarbazepine 179. Pelitinib (EKB‐569) 180. Pizotifen Malate 181. Resveratrol 182. Rocuronium Bromide 183. Stavudine (d4T) 184. Tenofovir Disoproxil Fumarate 185. Tenofovir 186. Tigecycline 187. Trilostane 188. Vecuronium Bromide 189. Linezolid 190. Alfuzosin HCl 191. Clopidogrel 192. Prazosin HCl 193. Ranolazine 2HCl 194. Repaglinide 195. Rolipram 196. Sildenafil Citrate 197. Sumatriptan Succinate 198. Tamsulosin 199. Tianeptine sodium 200. Tizanidine HCl 201. Topiramate 202. Tranilast 203. Venlafaxine 204. Voriconazole 205. Zileuton 206. Ziprasidone HCl 207. Zonisamide 208. Ispinesib (SB‐715992) 209. Cilomilast 210. Zibotentan (ZD4054) 211. Atazanavir Sulfate 212. Ofloxacin 213. Marbofloxacin 214. Moxifloxacin HCl 215. Doxercalciferol 216. Alfacalcidol 217. TSU‐68 (SU6668, Orantinib) 218. Safinamide Mesylate 219. Pimasertib (AS‐703026) 220. VX‐222 (VCH‐222, Lomibuvir) 221. Zosuquidar (LY335979) 3HCl 222. Daclatasvir (BMS‐790052) 223. Iloperidone 224. Naratriptan 225. Ponatinib (AP24534) 226. Fludarabine 227. Pralatrexate 228. Betamethasone 229. Mycophenolate Mofetil 230. Dyphylline 231. Aztreonam 232. Irbesartan 233. Alprostadil 234. Norfloxacin 235. Lactulose 236. Tadalafil 237. Cyclosporine 238. Pracinostat (SB939) 239. Natamycin 240. SAR245409 (XL765) 241. Quizartinib (AC220) 242. Telaprevir (VX‐950) 243. Saxagliptin 244. EX 527 (Selisistat) 245. Febuxostat 246. Dapagliflozin 247. Nebivolol 248. Pimobendan 249. VX‐809 (Lumacaftor) 250. Pomalidomide 251. Tazarotene 252. Fasudil (HA‐1077) HCl 253. BIRB 796 (Doramapimod) 254. Sulfasalazine 255. Candesartan 256. Apixaban 257. Semagacestat (LY450139) 258. Reserpine 259. Furosemide 260. Olmesartan Medoxomil 261. Cefdinir 262. Clotrimazole 263. Rizatriptan Benzoate 264. Pyridostigmine Bromide 265. Methimazole 266. Metolazone 267. Cefoperazone 268. Silodosin 269. Riluzole 270. Risperidone 271. Sulfapyridine 272. Sulfameter 273. Prilocaine 274. Darunavir Ethanolate 275. Theophylline 276. Prednisone 277. Acetylcysteine 278. Alendronate 279. Ethinyl Estradiol 280. Naproxen 281. Nitazoxanide 282. Triamcinolone Acetonide 283. Orlistat 284. Allopurinol 285. Zafirlukast 286. Acetaminophen 287. Erythromycin 288. Amphotericin B 289. Ibuprofen 290. Amprenavir 291. Albendazole 292. Chlorothiazide 293. Methyldopa 294. Ursodiol 295. Nitrofural 296. Ketoprofen 297. Ketorolac 298. Adenosine 299. Zolmitriptan 300. Telbivudine 301. Monobenzone 302. Tretinoin 303. Phenylbutazone 304. Ezetimibe 305. Enalaprilat Dihydrate 306. Dofetilide 307. Isradipine 308. Estrone 309. Flucytosine 310. Trichlormethiazide 311. Loteprednol etabonate 312. （6‐）ε‐Aminocaproic acid 313. Aminoglutethimide 314. Aminophylline 315. Amorolfine HCl 316. Chloramphenicol 317. Flurbiprofen 318. Disulfiram 319. Mesalamine 320. Ipratropium Bromide 321. Sulfanilamide 322. Betamethasone Dipropionate 323. Meprednisone 324. Betamethasone valerate (Betnovate) 325. Praziquantel 326. Busulfan 327. Carbamazepine 328. Hydrocortisone 329. Torsemide 330. Desonide 331. Didanosine 332. Divalproex Sodium 333. Emtricitabine 334. Progesterone 335. Lamivudine 336. Eplerenone 337. Hydrochlorothiazide 338. Estradiol 339. Deferasirox 340. Piroxicam 341. Gemcitabine 342. Glipizide 343. Glyburide 344. Fomepizole 345. Adefovir Dipivoxil 346. Zalcitabine 347. Azathioprine 348. Indomethacin 349. Paliperidone 350. Terbinafine 351. Levonorgestrel 352. Gemfibrozil 353. Indapamide 354. Mitotane 355. Methylprednisolone 356. Meloxicam 357. Mesna 358. Methocarbamol 359. Prednisolone 360. Telmisartan 361. Thiabendazole 362. Guaifenesin 363. Rifabutin 364. Nevirapine 365. Esomeprazole Magnesium 366. Nicotinic Acid 367. Nimodipine 368. Nisoldipine 369. Oxybutynin 370. Enoxacin 371. Pitavastatin Calcium 372. Rifapentine 373. Suprofen 374. Pyrazinamide 375. Quetiapine Fumarate 376. Rifampin 377. Cefditoren Pivoxil 378. Sulfadiazine 379. Chlorprothixene 380. Oxytetracycline (Terramycin) 381. Toremifene Citrate 382. Ethionamide 383. Trifluridine 384. Azacitidine 385. Vidarabine 386. Teniposide 387. Stanozolol 388. Tetrabenazine (Xenazine) 389. Rifaximin 390. Simvastatin 391. Ramipril 392. Fenofibrate 393. Ranolazine 394. Ranitidine 395. Acadesine 396. Acetylcholine Chloride 397. Acipimox 398. Aciclovir 399. Nifedipine 400. Amiloride HCl 401. Amlodipine besylate (Norvasc) 402. Chlorpheniramine Maleate 403. Fenoprofen Calcium 404. Erdosteine 405. Betaxolol hydrochloride (Betoptic) 406. Proparacaine HCl 407. Pranlukast 408. Oxfendazole 409. Carvedilol 410. Atracurium Besylate 411. Butoconazole nitrate 412. Azithromycin 413. Albendazole Oxide 414. Flubendazole 415. Chloroxine 416. Lomustine 417. Chenodeoxycholic Acid 418. Cimetidine 419. Clemastine Fumarate 420. Curcumin 421. Bifonazole 422. Pefloxacin Mesylate 423. Metoprolol Tartrate 424. Diethylstilbestrol 425. Diltiazem HCl 426. Diphenhydramine HCl 427. Dapoxetine